Abstract:
BACKGROUND AND AIMS:The effectiveness of surveillance for hepatocellular carcinoma (HCC) in the USA is largely unknown. The objective of this study was to evaluate the effectiveness of HCC surveillance in a national Veterans Administration (VA) practice setting, using the national VA hepatitis C virus (HCV) Clinical Case Registry. METHOD:The cohort consisted of 1480 HCV-infected patients who developed HCC during 1998-2007. The timing and intensity of receiving α-fetoprotein (AFP) and abdominal ultrasound (US) for HCC surveillance were evaluated. Overall mortality risk was examined using Cox proportional hazards regression models adjusting for demographics, clinical features and receipt of HCC-specific treatment. RESULTS:The mean survival was 1.8 years following the HCC diagnosis date. Surveillance AFP or US were recorded in 77.8% of patients within 2 years prior to HCC diagnosis. Annual surveillance with both AFP and US was observed in only 2% of patients. The presence of either AFP or US surveillance during both 0-6 month and 7-24 month periods before HCC diagnosis was associated with a lower mortality risk (HR 0.71, 95% CI 0.62 to 0.82) compared with no surveillance. Receipt of two or more surveillance tests in the 0-6 months (HR 0.76 95% CI 0.66 to 0.88) and to a lesser extent in the 7-12 months (HR 0.81 95% CI 0.1 to 0.99) prior to HCC diagnosis was also associated with reduced mortality risk. CONCLUSIONS:Most patients with HCV-related cirrhosis do not receive regular imaging-based surveillance. The effectiveness of HCC surveillance tests in current clinical practice is rather modest in reducing HCC-related mortality.
journal_name
Gutjournal_title
Gutauthors
El-Serag HB,Kramer JR,Chen GJ,Duan Z,Richardson PA,Davila JAdoi
10.1136/gut.2010.230508subject
Has Abstractpub_date
2011-07-01 00:00:00pages
992-7issue
7eissn
0017-5749issn
1468-3288pii
gut.2010.230508journal_volume
60pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.127167
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. DESIGN:Through analysis of...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-320007
更新日期:2020-12-01 00:00:00
abstract::The experience of The Middlesex Hospital in the investigation and management of chronic intestinal arterial occlusion (IAO) over a 20 year period is presented. Of some 100 patients referred only 28 were found to have IAO and these were critically evaluated in terms of insorptive and exsorptive function. No relation wa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.7.656
更新日期:1985-07-01 00:00:00
abstract::Gastroparesis is defined by the presence of delayed gastric emptying (GE) in the absence of mechanical obstruction. Symptoms that have been attributed to gastroparesis include postprandial fullness, early satiation nausea and vomiting. Gastroprokinetic drugs are the preferred treatment option. A number of problems wit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306084
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND AND AIMS:While patients with Barrett's oesophagus develop oesophageal adenocarcinoma more frequently than the general population, it has controversially been suggested that gastro-oesophageal reflux (GORD) itself is a more important determinant of risk. In order to assess the validity of this suggestion, we ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.028076
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. Howe...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2005.078303
更新日期:2006-06-01 00:00:00
abstract::An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.3.285
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:Early detection and early treatment are of vital importance to the successful treatment of various cancers. The development of a novel screening method that is as economical and non-invasive as the faecal occult blood test (FOBT) for early detection of colorectal cancer (CRC) is needed. A study was undertaken...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2010.218305
更新日期:2011-06-01 00:00:00
abstract::Colorectal cancer is the second commonest cause of cancer death in the UK. An effective national screening programme is urgently required to reduce the substantial morbidity and mortality from the disease. The success of any screening programme will depend on the screening test detecting early Dukes's A carcinomas and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.4.590
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the neutrophil activating protein (NapA) and alkyl hydroperoxide reductase (AphC). These antigens were ident...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.025494
更新日期:2005-01-01 00:00:00
abstract::Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchang...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.9.1107
更新日期:1987-09-01 00:00:00
abstract::The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.12.1680
更新日期:1988-12-01 00:00:00
abstract:OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention,...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319804
更新日期:2020-12-01 00:00:00
abstract::As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.9.1173
更新日期:1988-09-01 00:00:00
abstract::Relatives of patients with colorectal cancer have on average a two to threefold increased risk for developing bowel neoplasia although in some families the risk is much higher. This study examined the compliance for endoscopic screening and faecal occult blood testing among first degree relatives of patients with colo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.1.96
更新日期:1993-01-01 00:00:00
abstract::Four different dosage regimens of interferon (IFN) alfa-2b (3 million units (MU) three times weekly for three months, 3 MU three times weekly for six months, 6 MU two times weekly for six months, and 6 MU three times weekly for six months) were compared in patients with chronic hepatitis C. There was no significant di...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.2_suppl.s135
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310148
更新日期:2017-02-01 00:00:00
abstract::Four asymptomatic patients are described with raised serum alkaline phosphatase values and a positive serum mitochondrial antibody test. In all four needle liver biopsy showed destructive bile duct lesions. Lymphocyte transformation to phytohaemagglutinin was normal in three and impaired in one who also suffered from ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.6.444
更新日期:1973-06-01 00:00:00
abstract::Patients with Crohn's disease commonly develop ileal and less commonly colonic strictures, containing various degrees of inflammation and fibrosis. While predominantly inflammatory strictures may benefit from a medical anti-inflammatory treatment, predominantly fibrotic strictures currently require endoscopic balloon ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-318081
更新日期:2019-06-01 00:00:00
abstract::Plasminogen activator activity was studied in bile and perfusate during extracorporeal pig liver perfusion. Plasminogen activator activity in bile was up to 58 times greater than in perfusate. A high level of plasminogen activator activity in bile was also found after the addition of urokinase to the perfusate. These ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.1.54
更新日期:1972-01-01 00:00:00
abstract:BACKGROUND:Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic therapies, there is a need for cell lines that preserve the in vivo phenotype of human HSCs to elucidate pathways of human...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.042127
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations. AIM AND METHODS:In all layers of the colon, nerve fibre densities of SP(+) and sympathetic nerve fibres were investigated (22 Crohn's disease, six diverticuliti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.125401
更新日期:2008-07-01 00:00:00
abstract::Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals produced alterations in adaptation similar to those seen after vagal division. It is concluded that alterations in gastr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.11.874
更新日期:1972-11-01 00:00:00
abstract::Sucralfate possesses site protective and cytoprotective actions and heals ulcers effectively, but its effect on gastric mucosal blood flow is unknown. Using an ex vivo gastric chamber preparation, we studied the effect of sucralfate on gastric mucosal blood flow in rats by laser doppler flowmetry. Under both fasting a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.11.1544
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:The development of endocrine tumours of the duodenopancreatic area (ETDP) is thought to be slow, but their natural history is not well known. The aim of this study was to determine the factors that influence survival of patients with ETDP. PATIENTS/METHODS:Eighty two patients with ETDP (44 non-functioning t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.3.422
更新日期:1998-09-01 00:00:00
abstract::Histochemical enzymatic studies were performed on 30 freshly resected large bowel carcinomas, 30 samples of normal colonic epithelium, and six samples of the histologically normal epithelium (so-called transitional epithelium) immediately adjacent to a carcinoma. Five enzymes were studied: nicotine adenine dinucleotid...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.10.783
更新日期:1974-10-01 00:00:00
abstract:BACKGROUND:Melanoma inhibitory activity 2 (MIA2) is a novel gene of the MIA gene family. The selective expression of MIA2 in hepatocytes is controlled by hepatocyte nuclear factor (HNF) 1 binding sites in the MIA2 promotor. In contrast, in most hepatocellular carcinomas (HCC) MIA2 expression is down-regulated or lost. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.129544
更新日期:2008-02-01 00:00:00
abstract:AIMS:To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer. METHODS:150 251 people were randomly allocated either to receive biennial Haemoccult FOB tests (n =75 253) or not to be contacted (n=74 998). Study group patients returning positive tests were offered colonic investi...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.45.4.588
更新日期:1999-10-01 00:00:00
abstract::A 90 year old woman with alveolar rhabdomyosarcoma of the gall bladder is described. The patient died with tumour metastasis four months after diagnosis despite complete excision of the tumour. The histological, immunohistochemical, and ultrastructural features of the tumour are summarised and published works are revi...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.35.6.854
更新日期:1994-06-01 00:00:00
abstract::Over 90% of patients with inoperable carcinoma of the pancreas are successfully palliated by endoscopic retrograde cholangiopancreatography and stent insertion. Treatment of the residual 10% of patients often entails a laparotomy, which is difficult to justify when median survival of these patients is only 150 days. L...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.778
更新日期:1995-05-01 00:00:00