Intestinal permeability in patients with Crohn's disease and their first degree relatives.

abstract：BACKGROUND AND AIM:There is controversy regarding whether paramyxovirus infection is causally associated with inflammatory bowel disease (IBD). The latest cohort study claimed that atypical measles and mumps infections in childhood may be risk factors for later IBD. This study was conducted to clarify the validity of a...

journal_title：Gut

authors： Iizuka M,Saito H,Yukawa M,Itou H,Shirasaka T,Chiba M,Fukushima T,Watanabe S

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the pathophysiology of oesophageal pain syndromes and hiatus hernia formation. The aim of the current study was to elucidate further the mechanisms ...

journal_title：Gut

authors： Paterson WG,Miller DV,Dilworth N,Assini JB,Lourenssen S,Blennerhassett MG

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is associated with a marked infiltration of the gastric epithelium by neutrophils, macrophages, lymphocytes, and plasma cells. Despite the presence of phagocytes in close vicinty to H pylori microbes a great number of people are unable to eradicate bacteria. AIMS:To investigate...

journal_title：Gut

authors： Chmiela M,Czkwianianc E,Wadstrom T,Rudnicka W

更新日期：1997-01-01 00:00:00

abstract：:Some patients with diarrhoea predominant irritable bowel syndrome have increased rectal sensitivity. It is uncertain, however, whether the diarrhoea is a consequence of the rectal sensitivity or if it is sensitising the rectum in some way. The aim of this study was to assess whether inducing diarrhoea in normal health...

journal_title：Gut

authors： Houghton LA,Wych J,Whorwell PJ

更新日期：1995-08-01 00:00:00

abstract：AIM:This prospective study aimed to compare the accuracy of echo enhanced ultrasound with spiral computed tomography (CT) in assessing acute pancreatitis and to explore the correlation between ultrasound findings and clinical outcome. METHODS:Thirty one patients (24 men and 7 women, median age 39 years, range 19-67 ye...

journal_title：Gut

authors： Rickes S,Uhle C,Kahl S,Kolfenbach S,Monkemuller K,Effenberger O,Malfertheiner P

更新日期：2006-01-01 00:00:00

abstract：:Multiple endoscopic specimens were obtained from 58 patients with a columnar lined gesophagus to study the histological and histochemical features of this metaplastic epithelium. Five patients (8.6%) had presented with a primary oesophageal adenocarcinoma. Three different epithelial types, junctional, atrophic fundic ...

journal_title：Gut

authors： Rothery GA,Patterson JE,Stoddard CJ,Day DW

更新日期：1986-09-01 00:00:00

abstract：:Helicobacter pylori is present worldwide but few large population studies exist on the epidemiology of the infection. A random cross sectional study was performed of H pylori infection in the adult population of San Marino, a European country with high gastric cancer rate, to assess its prevalence and to evaluate its ...

journal_title：Gut

authors： Gasbarrini G,Pretolani S,Bonvicini F,Gatto MR,Tonelli E,Mégraud F,Mayo K,Ghironzi G,Giulianelli G,Grassi M

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. DESIGN:384 single nucleotide po...

journal_title：Gut

authors： Wouters MM,Lambrechts D,Knapp M,Cleynen I,Whorwell P,Agréus L,Dlugosz A,Schmidt PT,Halfvarson J,Simrén M,Ohlsson B,Karling P,Van Wanrooy S,Mondelaers S,Vermeire S,Lindberg G,Spiller R,Dukes G,D'Amato M,Boeckxstaens

更新日期：2014-07-01 00:00:00

abstract：:Spirits from areas of high and low incidence of cancer of the oesophagus were examined for volatile nitrosamines using a chemiluminescent detector. No nitrosamines were found, the detection limit being 0.001 microng/ml. ...

journal_title：Gut

authors： Gough TA

更新日期：1977-04-01 00:00:00

abstract：:The possibility that the mode of action of sulphasalazine and its active metabolite 5-amino-salicylic acid (5ASA) involves modification of toxic oxygen metabolite production by neutrophils has been investigated by measuring the effect of these drugs on luminol-dependent chemiluminescence, superoxide release and oxygen...

journal_title：Gut

authors： Williams JG,Hallett MB

更新日期：1989-11-01 00:00:00

abstract：:An antibody precipitating urease was found in 171 out of 180 human sera. Data obtained on limited material (50 cases) suggest that the anti-urease titre is appreciably higher in the serum of patients suffering from gastric ulcer. This is a pointer towards a possible antigen-antibody mechanism in the genesis of chronic...

journal_title：Gut

authors： FREISINGER FS

更新日期：1963-12-01 00:00:00

abstract：:Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...

journal_title：Gut

authors： Korman MG,Soveny C,Hansky J

更新日期：1971-11-01 00:00:00

abstract：:Extracellular electrical and contractile activities were recorded in vitro from strips of human colonic smooth muscle obtained at the time of surgery. Serosal electrical activity of longitudinally oriented strips from the taenia and intertaenial region was characterised by continuous oscillation at a frequency of 28 +...

journal_title：Gut

authors： Gill RC,Cote KR,Bowes KL,Kingma YJ

更新日期：1986-03-01 00:00:00

abstract：:Jejunal biopsies from 15 Greenlandic and three Danish patients with adult type hypolactasia and nine Greenlandic and 15 Danish patients with normal lactase activity were analysed quantitatively for lactase protein by crossed immunoelectrophoresis. A constant correlation between the amount of lactase activity and immun...

journal_title：Gut

authors： Skovbjerg H,Gudmand-Høyer E,Fenger HJ

更新日期：1980-05-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori affects gastric epithelium integrity by acceleration of apoptosis. However, it remains unclear what product of the bacteria causes apoptosis, or whether or not the apoptosis is involved in the development of ulcers. AIMS:To elucidate the factor from H pylori that causes acceleration of a...

journal_title：Gut

authors： Kohda K,Tanaka K,Aiba Y,Yasuda M,Miwa T,Koga Y

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Early events in the progression of 90% of sporadic colorectal cancers depend on constitutive activation of Wnt signalling. Recent data also indicate a close association between the Hedgehog (Hh) and Wnt pathways in colonic epithelial cell differentiation. AIMS:To investigate whether expression of Gli1, a tr...

journal_title：Gut

authors： Akiyoshi T,Nakamura M,Koga K,Nakashima H,Yao T,Tsuneyoshi M,Tanaka M,Katano M

更新日期：2006-07-01 00:00:00

abstract：:A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...

journal_title：Gut

authors： Cummings JH,Wiggins HS

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. DESIGN:We conducted prospective cohort analyses i...

journal_title：Gut

authors： Chen Y,Segers S,Blaser MJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Escherichia coli is part of the normal gastrointestinal microflora which exerts a barrier effect against enteropathogens. Several E coli strains develop a protective effect against other Enterobacteriaceae. AIMS:Two E coli strains, EM0, a human faecal strain, and JM105 K-12 were tested for their ability to ...

journal_title：Gut

authors： Hudault S,Guignot J,Servin AL

更新日期：2001-07-01 00:00:00

abstract：:Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...

journal_title：Gut

authors： Warren BF,Shepherd NA,Bartolo DC,Bradfield JW

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Several cases of acute colitis induced by non-steroidal anti-inflammatory drugs (NSAIDs) have been reported but the general role of recent NSAID intake as a risk factor for acute diarrhoea has not been studied to date. The aim of our study was to determine whether the risk of acute diarrhoea is incr...

journal_title：Gut

authors： Etienney I,Beaugerie L,Viboud C,Flahault A

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. The study aims to compare the effectiveness and safety of these therapies for Helicobacter pylori treatment. DESIGN:Prospective randomised clinical trial in 11 Spanish hospit...

journal_title：Gut

authors： McNicholl AG,Marin AC,Molina-Infante J,Castro M,Barrio J,Ducons J,Calvet X,de la Coba C,Montoro M,Bory F,Perez-Aisa A,Forné M,Gisbert JP,Participant Centres.

更新日期：2014-02-01 00:00:00

abstract：:An association between duodenal ulceration and a low fibre intake and a high refined carbohydrate diet has been reported. We therefore compared the current diet, smoking habits, social class, and possible other risk factors of 78 patients with duodenal ulcer and a community control group matched for age and sex. Logis...

journal_title：Gut

authors： Katschinski BD,Logan RF,Edmond M,Langman MJ

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant...

journal_title：Gut

authors： Gutiérrez A,Scharl M,Sempere L,Holler E,Zapater P,Almenta I,González-Navajas JM,Such J,Wiest R,Rogler G,Francés R

更新日期：2014-02-01 00:00:00

abstract：:Pathogenic E coli have adhesive properties which are mirrored by an increase in their surface hydrophobicity. E coli isolated from patients with ulcerative colitis possess a mannose resistant adhesin similar to that found in pathogenic E coli. In this study 42 E coli isolates from patients with colitis have been compa...

journal_title：Gut

authors： Burke DA,Axon AT

更新日期：1988-01-01 00:00:00

abstract：:Thirty male patients (27 homosexual) with biopsy proven chronic active hepatitis B were randomised to receive lymphoblastoid interferon (Wellferon) or no treatment. All patients were HBeAg positive and had continuing viral replication. Patients receiving treatment were given a single daily intramuscular injection of i...

journal_title：Gut

authors： Anderson MG,Harrison TJ,Alexander G,Zuckerman AJ,Murray-Lyon IM

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated. METHODS:Eleven adult...

journal_title：Gut

authors： Straumann A,Conus S,Grzonka P,Kita H,Kephart G,Bussmann C,Beglinger C,Smith DA,Patel J,Byrne M,Simon HU

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Early detection and early treatment are of vital importance to the successful treatment of various cancers. The development of a novel screening method that is as economical and non-invasive as the faecal occult blood test (FOBT) for early detection of colorectal cancer (CRC) is needed. A study was undertaken...

journal_title：Gut

authors： Sonoda H,Kohnoe S,Yamazato T,Satoh Y,Morizono G,Shikata K,Morita M,Watanabe A,Morita M,Kakeji Y,Inoue F,Maehara Y

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND AIMS:There are no available effective therapies for fatigue associated with chronic hepatitis C (CHC). The serotonin antagonist ondansetron has been shown to be effective in the chronic fatigue syndrome. In this randomised, placebo controlled, double blind trial, we investigated the effect of orally admi...

journal_title：Gut

authors： Piche T,Vanbiervliet G,Cherikh F,Antoun Z,Huet PM,Gelsi E,Demarquay JF,Caroli-Bosc FX,Benzaken S,Rigault MC,Renou C,Rampal P,Tran A

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by perip...

journal_title：Gut

authors： Thoree VC,Golby SJ,Boursier L,Hackett M,Dunn-Walters DK,Sanderson JD,Spencer J

更新日期：2002-07-01 00:00:00