Impaired lymphocyte reactivity against tumour cells in patients with Crohn's disease.

abstract：:The informational aspects of nucleic acid synthesis have attracted much more attention than the quantitative significance of DNA, rRNA, tRNA, and nucleotide synthesis. Animal and human studies suggest that in energetic terms, 5-10% of the energy used in synthesising tissue protein is expended in manufacturing an appro...

journal_title：Gut

authors： Grimble GK

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations. AIM AND METHODS:In all layers of the colon, nerve fibre densities of SP(+) and sympathetic nerve fibres were investigated (22 Crohn's disease, six diverticuliti...

journal_title：Gut

authors： Straub RH,Grum F,Strauch U,Capellino S,Bataille F,Bleich A,Falk W,Schölmerich J,Obermeier F

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects. AIMS:The aim of the present study was to investigate the response in vivo of zinc transporters in the human enterocyte to dietary zinc supple...

journal_title：Gut

authors： Cragg RA,Phillips SR,Piper JM,Varma JS,Campbell FC,Mathers JC,Ford D

更新日期：2005-04-01 00:00:00

abstract：:Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...

journal_title：Gut

authors： Kumana CR,Ng M,Lin HJ,Ko W,Wu PC,Todd D

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND AIMS:In acute liver failure (ALF), the brain is exposed to high levels of ammonia. Human studies defining the clinical significance of ammonia in ALF are lacking. This prospective study evaluated the relationship of arterial ammonia levels at admission to complications and survival among patients with AL...

journal_title：Gut

authors： Bhatia V,Singh R,Acharya SK

更新日期：2006-01-01 00:00:00

abstract：:During a four hour observation period vasoactive intestinal polypeptide (VIP) is released in increasing amounts from the feline small intestine exposed to cholera toxin. As VIP is known to be located almost exclusively in the intestinal nerves, the present findings strongly suggest that cholera toxin activates the ent...

journal_title：Gut

authors： Cassuto J,Fahrenkrug J,Jodal M,Tuttle R,Lundgren O

更新日期：1981-11-01 00:00:00

abstract：OBJECTIVE:Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection. DESIGN...

journal_title：Gut

authors： Chen HY,Shen DT,Ji DZ,Han PC,Zhang WM,Ma JF,Chen WS,Goyal H,Pan S,Xu HG

更新日期：2019-03-01 00:00:00

abstract：:The HGT-1 gastric cancer cell line was used to determine the actions of protein kinase C on the stimulation of adenylate cyclase by the human histamine H2 receptor, and the receptors for gastric inhibitory polypeptide and truncated glucagon like peptide 1 (TGLP-1). Suspensions of HGT-1 cells were preincubated with the...

journal_title：Gut

authors： McKenna P,Williams JM,Gespach CP,Hanson PJ

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Recent reports have described a modulating influence of nitric oxide (NO) on intestinal mucosal permeability and have implicated a role for mast cells in this NO mediated process. AIMS:To assess further the contribution of mast cells to the mucosal permeability changes elicited by the NO synthase (NOS) inhi...

journal_title：Gut

authors： Komatsu S,Grisham MB,Russell JM,Granger DN

更新日期：1997-11-01 00:00:00

abstract：:Nineteen patients with symptoms of upper gastrointestinal disease were assessed by endoscopy. Transmucosal potential difference (PD) in the lower oesophagus was recorded and suction biopsy specimens were obtained from the site of measurement and examined by light microscopy after haematoxylin and eosin staining. In 10...

journal_title：Gut

authors： Khamis B,Kennedy C,Finucane J,Doyle JS

更新日期：1978-05-01 00:00:00

abstract：OBJECTIVES:The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS. ...

journal_title：Gut

authors： Swan C,Duroudier NP,Campbell E,Zaitoun A,Hastings M,Dukes GE,Cox J,Kelly FM,Wilde J,Lennon MG,Neal KR,Whorwell PJ,Hall IP,Spiller RC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Serrated adenomas (SAs) of the colorectum combine architectural features of hyperplastic polyps and cytological features of classical adenomas. Molecular studies comparing SAs and classical adenomas suggest that each may be a distinct entity; in particular, it has been proposed that microsatellite instabilit...

journal_title：Gut

authors： Sawyer EJ,Cerar A,Hanby AM,Gorman P,Arends M,Talbot IC,Tomlinson IP

更新日期：2002-08-01 00:00:00

abstract：:Intravenous glucose tolerance, insulin tolerance, tolbutamide, and glucagon tests were carried out in 21 patients with postnecrotic cirrhosis. Based arbitrarily on the bromsulphthalein retention they were divided into group A, nine patients with less impaired liver function, and group B, 12 patients with greater impai...

journal_title：Gut

authors： Yeung RT,Wang CC

更新日期：1974-11-01 00:00:00

abstract：OBJECTIVE:Colorectal cancer is the second most common cause of cancer death in Europe and North America. Alarm features are used to prioritize access to urgent investigation, but there is little information concerning their utility in the diagnosis of colorectal cancer. METHODS:A systematic review and meta-analysis of...

journal_title：Gut

authors： Ford AC,Veldhuyzen van Zanten SJ,Rodgers CC,Talley NJ,Vakil NB,Moayyedi P

更新日期：2008-11-01 00:00:00

abstract：:A further patient with watery diarrhoea and hypokalaemia in association with a non-beta islet cell tumour of the pancreas is reported. The mechanism by which fluid and electrolyte losses are produced is discussed and cases previously reported are reviewed. ...

journal_title：Gut

authors： Stoker DJ,Wynn V

更新日期：1970-11-01 00:00:00

abstract：:The role of the proximal and distal stomach in the emptying of solids and liquids from the stomach remains unclear. We have used a dual isotope technique to quantify proximal and distal stomach emptying of a solid (100 g of 99mTc labelled liver/ground beef) liquid (either 200 ml of normal saline (eight subjects) or 25...

journal_title：Gut

authors： Collins PJ,Houghton LA,Read NW,Horowitz M,Chatterton BE,Heddle R,Dent J

更新日期：1991-06-01 00:00:00

abstract：:The extent to which monitoring breath hydrogen excretion provides information concerning the entry of the residues of a solid test meal into the colon was investigated in 89 normal subjects, and 11 patients with the irritable bowel syndrome. The profile of breath hydrogen concentration showed an early peak, that occur...

journal_title：Gut

authors： Read NW,Al-Janabi MN,Bates TE,Holgate AM,Cann PA,Kinsman RI,McFarlane A,Brown C

更新日期：1985-08-01 00:00:00

abstract：:Intestinal folate absorption was assessed in six normal subjects and in four patients with coeliac sprue who were studied before and after treatment by dietary gluten exclusion. Comparisons were made of the luminal disappearance from the perfused jejunum of 3H-pteroylmonoglutamate and pteroyl 14C-glutamylhexaglutamate...

journal_title：Gut

authors： Halsted CH,Reisenauer AM,Shane B,Tamura T

更新日期：1978-10-01 00:00:00

abstract：:This trial was undertaken to establish the long term biochemical and serological outcome of patients with acute post-transfusion hepatitis C virus infection after treatment with interferon alfa-2b. After 12 months, 12 patients (eight treated, four controls) had self limited disease and 16 patients (seven treated, nine...

journal_title：Gut

authors： Genesca J,Esteban JI,Quer J,Viladomiu LL,Gonzalez A,Esteban R,Guardia J

更新日期：1993-01-01 00:00:00

abstract：:Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization ind...

journal_title：Gut

authors： Korman MG,Soveny C,Hansky J

更新日期：1972-03-01 00:00:00

abstract：OBJECTIVE:Osteopontin (OPN) has been found to be valuable in diagnosis and predicting the prognosis of a variety of malignancies. The aims of the present study are to evaluate the usefulness of plasma OPN level for predicting gastric cancer development, invasion and survival. PATIENTS AND METHODS:One hundred and thirt...

journal_title：Gut

authors： Wu CY,Wu MS,Chiang EP,Wu CC,Chen YJ,Chen CJ,Chi NH,Chen GH,Lin JT

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazine and thymoquinone in...

journal_title：Gut

authors： Kortüm B,Campregher C,Lang M,Khare V,Pinter M,Evstatiev R,Schmid G,Mittlböck M,Scharl T,Kucherlapati MH,Edelmann W,Gasche C

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...

journal_title：Gut

authors： Hackstein CP,Assmus LM,Welz M,Klein S,Schwandt T,Schultze J,Förster I,Gondorf F,Beyer M,Kroy D,Kurts C,Trebicka J,Kastenmüller W,Knolle PA,Abdullah Z

更新日期：2017-03-01 00:00:00

abstract：:On three occasions, a 63 year old housewife with hyperthyroidism developed a reaction which included fever, pruritus, malaise, and, on one occasion, jaundice one to 17 days after taking carbimazole. Challenge with carbimazole was followed within 12 hours by abdominal pain, pruritus, and increased serum transaminase le...

journal_title：Gut

authors： Lunzer M,Huang SN,Ginsburg J,Ahmed M,Sherlock S

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:Patients with irritable bowel syndrome (IBS) have reduced pain thresholds for rectal distension. In addition, the prevalence of sexual/physical abuse in referred IBS patients is high and is associated with greater pain reporting, poorer health status, and poorer outcome. This lead to a hypothesis that abuse ...

journal_title：Gut

authors： Ringel Y,Whitehead WE,Toner BB,Diamant NE,Hu Y,Jia H,Bangdiwala SI,Drossman DA

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN:Retrospective multinational study including SCN diagnosed between 1990 and 2014. ...

journal_title：Gut

authors： Jais B,Rebours V,Malleo G,Salvia R,Fontana M,Maggino L,Bassi C,Manfredi R,Moran R,Lennon AM,Zaheer A,Wolfgang C,Hruban R,Marchegiani G,Fernández Del Castillo C,Brugge W,Ha Y,Kim MH,Oh D,Hirai I,Kimura W,Jang JY

更新日期：2016-02-01 00:00:00

abstract：:Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...

journal_title：Gut

authors： Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OF

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic aberrations and biology of this cancer may enhance disease interventions. This study aimed to use genome-wide genomic and expression data to enhance t...

journal_title：Gut

authors： Goh XY,Rees JR,Paterson AL,Chin SF,Marioni JC,Save V,O'Donovan M,Eijk PP,Alderson D,Ylstra B,Caldas C,Fitzgerald RC

更新日期：2011-10-01 00:00:00

abstract：:The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...

journal_title：Gut

authors： Thompson JN,Salem RR,Hemingway AP,Rees HC,Hodgson HJ,Wood CB,Allison DJ,Spencer J

更新日期：1987-01-01 00:00:00

abstract：:The carrier rate of hepatitis B virus (HBV) in black Africans averages 10.4% throughout the continent. Even within each country, however, there may be wide variations. HBV carriage in black Africans is largely established in early childhood, mostly through horizontal transmission. Perinatal transmission also occurs bu...

journal_title：Gut

authors： Kew MC

更新日期：1996-01-01 00:00:00