Abstract:
:Studies have been made of mucus glycoprotein biosynthesis in different regions of the lower gastrointestinal tract in normal patients and those with ulcerative colitis (UC), active or inactive, by means of 3H-glucosamine (3H-GlcNH2)--35S-sulphate double labelling of epithelial biopsy specimens under culture conditions. The time based rate of 3H-GlcNH2 labelling of mucus in rectal tissue was similar to that in active or inactive UC whereas the rate of 35SO4(2) labelling was significantly increased in active disease. The 3H specific activities measuring the amount of isotopic incorporation into surface and tissue mucus glycoproteins were increased in patients with active UC compared with normal or inactive subjects. The 35S specific activities did not differ significantly between patients with active UC and those in remission. In the rectum, glycosylation of mucus glycoproteins decreases with the increasing age of the patient. Regional differences in 3H-labelling of mucus components are reported for ascending colon, transverse colon, sigmoid colon, and rectum. Sulphation (35S-labelling) was higher in all parts of the colon in left sided UC. Results point to accelerated glycosylation of core proteins in the active phase of UC.
journal_name
Gutjournal_title
Gutauthors
Morita H,Kettlewell MG,Jewell DP,Kent PWdoi
10.1136/gut.34.7.926subject
Has Abstractpub_date
1993-07-01 00:00:00pages
926-32issue
7eissn
0017-5749issn
1468-3288journal_volume
34pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection. DESIGN...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316601
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event after ESD. We aimed to develop and externally validate a clinically useful prediction model (BEST-J score: Bleeding after ESD Trend from Japan) for bleeding after ESD for EGC. DESIGN:This retrospe...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319926
更新日期:2020-06-04 00:00:00
abstract:BACKGROUND:Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. METHODS:The fate of BMDCs was ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.143271
更新日期:2008-08-01 00:00:00
abstract::The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted flu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.1.78
更新日期:1986-01-01 00:00:00
abstract::The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.11.1338
更新日期:1986-11-01 00:00:00
abstract::Fifteen patients with peptic ulcer underwent 24 hour studies of gastric contents: before and on completing six weeks' treatment with oral ranitidine 150 mg bd, twice on maintenance treatment for nine to 12 months and one month after stopping the drug. For comparison, 11 patients underwent identical 24 hour studies thr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.6.726
更新日期:1987-06-01 00:00:00
abstract::An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.3.285
更新日期:2002-03-01 00:00:00
abstract::The amounts of lactase (EC 3.2.1.23), sucrase (EC 3.2.1.48), maltase (EC 3.2.1.20), microvillus aminopeptidase (microsomal EC3.4.11.2), and dipeptidyl peptidase IV (EC 3.4.14.X) in biopsies from proximal jejunum and distal ileum were studied by quantitative crossed immunoelectrophoresis and enzymatic assays in obese p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.8.662
更新日期:1980-08-01 00:00:00
abstract:OBJECTIVE:To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC. DESIGN:A systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gutjnl-2015-310888
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN:In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assig...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2014-307498
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Eradication of Barrett's mucosa by thermal or photoablation combined with high doses of proton pump inhibitors is a potentially attractive strategy in the management of this preneoplastic condition. However, major concerns of this method are the persistence of residual metaplastic glands beneath the new squa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.4.574
更新日期:2000-04-01 00:00:00
abstract::Using immune electron microscopy, an attempt has been made to visualise viral particles in Crohn's disease tissue and faeces. No particles resembling viruses were observed, but in the absence of a specific antiserum a negative result does not exclude the presence of a virus, particularly if it is sparsely distributed....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.9.696
更新日期:1976-09-01 00:00:00
abstract::As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.9.1173
更新日期:1988-09-01 00:00:00
abstract::Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.2.99
更新日期:1977-02-01 00:00:00
abstract::Earlier studies have reported that faecal pH is more alkaline in patients with colonic cancer, indicating a reduction in colonic carbohydrate fermentation to organic acids. The pH of faeces from 11 pre and 14 postoperative, selected colonic cancer patients without intestinal obstruction, major loss of appetite or weig...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.5.625
更新日期:1993-05-01 00:00:00
abstract::The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was used as a model to study the expression of the growth promoting peptide, transforming growth factor alpha (TGF alpha), during experimental gastric carcinogenesis. TGF alpha was iden...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.5.604
更新日期:1994-05-01 00:00:00
abstract::In conditions with increased neutrophil production, the serum total vitamin B(12)-binding capacity (TBBC) is considered to correlate with the blood pool size of neutrophil granulocytes. The serum lysozyme, on the other hand, is a measure of neutrophil (and monocyte) turnover. The mean serum TBBC was significantly rais...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.12.953
更新日期:1974-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300821
更新日期:2012-10-01 00:00:00
abstract::The size of the related lymph nodes and their histology has been correlated in 34 specimens of Crohn's disease. Granulomata were shown not to affect the maximum diameter of the lymph nodes nor to be more frequent in large nodes. The enlargement of lymph nodes appeared to be due to simple, non-specific, reactive change...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.12.970
更新日期:1972-12-01 00:00:00
abstract::Rats were subjects to right hemicolectomy (including removal of the caecum), left hemicolectomy or subtotal colectomy. Body weight resumed and maintained a rate of increase very similar to that in control rats. After hemicolectomy, food intake showed no change. Faecal weight increased by about one-third after right he...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.1.37
更新日期:1977-01-01 00:00:00
abstract::Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and derma...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.8.929
更新日期:1986-08-01 00:00:00
abstract::Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient. The patient described here, who had clear-cut clinical and histological features of chronic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.161
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVE:To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. DESIGN:We set-up a unique animal model of periodontitis in C57Bl/6 female mice by infecting the periodontal tissue with specific and alive pathogens...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309897
更新日期:2017-05-01 00:00:00
abstract::Five cases of volvulus of varying lengths of the small intestine are described. The incidence and the aetiology of the condition are briefly discussed. Shock as a feature of extensive volvulus is stressed, and its cause in these cases is related to the previous animal experimental work of others. The other clinical fe...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.1.76
更新日期:1960-03-01 00:00:00
abstract:BACKGROUND:Integrins mediate cell matrix adhesion and regulate cell growth and survival. In colonic epithelial cells, alpha(2)beta(1) integrin controls glandular differentiation and proliferation. Butyrate stimulates differentiation and induces apoptosis in vitro. AIMS:We investigated whether butyrate induction of apo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.5.729
更新日期:2003-05-01 00:00:00
abstract::Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.94
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.840
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Conventional colonoscopy (CC) is considered the reference standard for detection of colorectal neoplasia, but it can still miss a substantial number of adenomas. The use of a transparent plastic cap may improve colonic visualisation. Cap-assisted colonoscopy (CAC) was compared with CC for adenoma detection. S...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2011-301327
更新日期:2012-10-01 00:00:00
abstract::The barium enemas of 23 cases of end-to-end anastomosis following resection of a colonic carcinoma demonstrated that the normal anastomosis should be smooth, symmetrical, and have a regular mucosal pattern. In contrast the three patients reported with proven recurrent carcinoma at the anastomosis showed irregular asym...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.9.778
更新日期:1970-09-01 00:00:00
abstract:BACKGROUND:A population based epidemiological study identified all the patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) resident in the Florence area in the period 1978-1992. AIMS:To assess the mortality of unselected patients with inflammatory bowel disease (IBD) in a Mediterranean country. ME...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.2.175
更新日期:1998-02-01 00:00:00