Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response.

abstract：:To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and potent histamine H2 antagonist loxtidine for five months. The trophic ef...

journal_title：Gut

authors： Brenna E,Swarts HG,Klaassen CH,de Pont JJ,Waldum HL

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Recent reports have described a modulating influence of nitric oxide (NO) on intestinal mucosal permeability and have implicated a role for mast cells in this NO mediated process. AIMS:To assess further the contribution of mast cells to the mucosal permeability changes elicited by the NO synthase (NOS) inhi...

journal_title：Gut

authors： Komatsu S,Grisham MB,Russell JM,Granger DN

更新日期：1997-11-01 00:00:00

abstract：:Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consci...

journal_title：Gut

authors： Gazzard BG,Henderson JM,Williams R

更新日期：1976-07-01 00:00:00

abstract：:The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...

journal_title：Gut

authors： Bonino F,Colloredo Mels G,Bellati G,Ideo G,Oliveri F,Colombatto P,Brunetto MR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS:The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS:The association b...

journal_title：Gut

authors： Molloy RM,Sonnenberg A

更新日期：1997-02-01 00:00:00

abstract：:Two enzymes having lactase activity are present in the equine small intestine. The first, the digestive enzyme, neutral beta-galactosidase, declines in activity from birth to three years, disappearing completely between 3 and 4 years of age. The other, the soluble lysosomal enzyme, acid beta-galactosidase, having affi...

journal_title：Gut

authors： Roberts MC,Kidder DE,Hill FW

更新日期：1973-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Both bile salts and glutathione participate in the generation of canalicular bile flow. In this work, we have investigated the effect of different bile salts on hepatic glutathione metabolism. METHODS:Using the isolated and perfused rat liver, we studied hepatic glutathione content, and metabolism ...

journal_title：Gut

authors： Rodríguez-Ortigosa CM,Cincu RN,Sanz S,Ruiz F,Quiroga J,Prieto J

更新日期：2002-05-01 00:00:00

abstract：:Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of...

journal_title：Gut

authors： Quatrini M,Basilisco G,Bianchi PA

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND AND AIMS:A low dietary folate intake can cause genomic DNA hypomethylation and may increase the risk of colorectal neoplasia. The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma...

journal_title：Gut

authors： Pufulete M,Al-Ghnaniem R,Khushal A,Appleby P,Harris N,Gout S,Emery PW,Sanders TA

更新日期：2005-05-01 00:00:00

abstract：:A method not needing fluoroscopic control for positioning a manometric probe in the gastroduodenal tract is described. It is based on hydrostatic pressure variations occurring at each recording port of a multichannel perfused probe after changes in patient's position. The data are fed into a computer and the schematic...

journal_title：Gut

authors： Bortolotti M,Bersani G

更新日期：1988-07-01 00:00:00

abstract：:Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetica...

journal_title：Gut

authors： Morgan MY,Reshef R,Shah RR,Oates NS,Smith RL,Sherlock S

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa. AIM:To assess whether apple extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo. METHODS:Apple extracts were obtained from freeze drie...

journal_title：Gut

authors： Graziani G,D'Argenio G,Tuccillo C,Loguercio C,Ritieni A,Morisco F,Del Vecchio Blanco C,Fogliano V,Romano M

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Visceral hyperalgesia has been implicated as a factor contributing to symptom generation in irritable bowel syndrome (IBS). However, previous studies using intestinal balloon distension have used psychophysical procedures which do not provide adequate and unbiased measures of visceral sensitivity. METHODS:T...

journal_title：Gut

authors： Naliboff BD,Munakata J,Fullerton S,Gracely RH,Kodner A,Harraf F,Mayer EA

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:Therapeutic strategies silencing and reducing the hepatitis B virus (HBV) reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic HBV infection. We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylated interferon-α (peg-...

journal_title：Gut

authors： Allweiss L,Giersch K,Pirosu A,Volz T,Muench RC,Beran RK,Urban S,Javanbakht H,Fletcher SP,Lütgehetmann M,Dandri M

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers. METHOD:The Delphi method was used to develop consensus statements through identification of clinical ques...

journal_title：Gut

authors： Chiu PWY,Uedo N,Singh R,Gotoda T,Ng EKW,Yao K,Ang TL,Ho SH,Kikuchi D,Yao F,Pittayanon R,Goda K,Lau JYW,Tajiri H,Inoue H

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Crohn's disease (CD) is associated with increased risk of small bowel cancer (SBC), but previous studies have been small. We aimed to examine the risk of incident SBC and death from SBC in patients with inflammatory bowel disease (IBD). DESIGN:In a binational, population-based cohort study from Sweden and De...

journal_title：Gut

authors： Axelrad JE,Olén O,Sachs MC,Erichsen R,Pedersen L,Halfvarson J,Askling J,Ekbom A,Sørensen HT,Ludvigsson JF

更新日期：2021-02-01 00:00:00

abstract：:In a search for past or present infection with herpes viruses, serum antibody titres to herpes simplex type 1 virus, cytomegalovirus, and varicella-zoster virus were measured by complement fixation test in 58 patients with achalasia. Serum was also taken from 40 age and sex matched patients without oesophageal symptom...

journal_title：Gut

authors： Robertson CS,Martin BA,Atkinson M

更新日期：1993-03-01 00:00:00

abstract：:Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was...

journal_title：Gut

authors： Fiasse R,Lurhuma AZ,Cambiaso CL,Masson PL,Dive C

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...

journal_title：Gut

authors： Snook JA,Dwyer L,Lee-Elliott C,Khan S,Wheeler DW,Nicholas DS

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND AND AIMS:A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn's disease (CD). The aim of the present study was to assess the predictive value of plexitis for early...

journal_title：Gut

authors： Sokol H,Polin V,Lavergne-Slove A,Panis Y,Treton X,Dray X,Bouhnik Y,Valleur P,Marteau P

更新日期：2009-09-01 00:00:00

abstract：:Five patients in whom small-intestinal bypass was performed for severe obesity had a second operation 11-19 months later because of insufficient weight loss. Mucosal enzyme activities and histological appearance were investigated in biopsies from different parts of the functioning and excluded small intestine. These w...

journal_title：Gut

authors： Asp NG,Gudmand-Høyer E,Andersen B,Berg NO

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presenc...

journal_title：Gut

authors： Combet E,Paterson S,Iijima K,Winter J,Mullen W,Crozier A,Preston T,McColl KE

更新日期：2007-12-01 00:00:00

abstract：:Typical 'pouchitis' is a well recognised complication of ileal pouches in ulcerative colitis. Infrequently, a refractory pouchitis (RP) presents with certain clinical, endoscopic, and pathological features resembling Crohn's disease and is often ascribed to misdiagnosis of the initial colitis. To test that hypothesis ...

journal_title：Gut

authors： Subramani K,Harpaz N,Bilotta J,Bodian C,Rubin PH,Janowitz HD,Gelernt IM,Sachar DB

更新日期：1993-11-01 00:00:00

abstract：:Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The t...

journal_title：Gut

authors： Hodgson HJ,Jewell DP

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Thrombosis may be an important effector mechanism in the pathogenesis of Crohn's disease. METHODS:This study therefore investigated the prevalence of independent thrombotic risk factors (factor VII coagulant activity, lipoprotein (a), fibrinogen, plasma triglycerides, and smoking) in patients with Crohn's d...

journal_title：Gut

authors： Hudson M,Chitolie A,Hutton RA,Smith MS,Pounder RE,Wakefield AJ

更新日期：1996-05-01 00:00:00

abstract：:To assess the value of pneumatic dilatation of the cardia, 63 patients with achalasia have undergone a total of 107 Rider-Moeller dilatations over the last six years. There was a marked improvement in swallowing immediately after dilatation in all but two patients, there were no deaths attributable to the procedure an...

journal_title：Gut

authors： Fellows IW,Ogilvie AL,Atkinson M

更新日期：1983-11-01 00:00:00

abstract：:Sixty three 24 hour oesophageal pH studies were performed in children with known or suspected gastro-oesophageal reflux and their progress was followed for at least a year. Forty two studies were of children who were well at follow up who were not receiving medical treatment for gastro-oesophageal reflux, and had not ...

journal_title：Gut

authors： Colson DJ,Campbell CA,Wright VA,Watson BW

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:Liver fibrosis and cirrhosis resulting from chronic liver injury represent a major healthcare burden worldwide. Growth differentiation factor (GDF) 11 has been recently investigated for its role in rejuvenation of ageing organs, but its role in chronic liver diseases has remained unknown. Here, we investigate...

journal_title：Gut

authors： Dai Z,Song G,Balakrishnan A,Yang T,Yuan Q,Möbus S,Weiss AC,Bentler M,Zhu J,Jiang X,Shen X,Bantel H,Jaeckel E,Kispert A,Vogel A,Saborowski A,Büning H,Manns M,Cantz T,Ott M,Sharma AD

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making an ideal target for cancer prevention. Our objective was to evaluate the safety, assess the activity ...

journal_title：Gut

authors： Reyes-Uribe L,Wu W,Gelincik O,Bommi PV,Francisco-Cruz A,Solis LM,Lynch PM,Lim R,Stoffel EM,Kanth P,Samadder NJ,Mork ME,Taggart MW,Milne GL,Marnett LJ,Vornik L,Liu DD,Revuelta M,Chang K,You YN,Kopelovich L,Wistub

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND AND AIM:Colorectal cancer (CRC) is a multifactorial disease with both environmental and genetic factors contributing to its development. The incidence of CRC is increasing year by year in Japan. Patients with CRC in advanced stages have a poor prognosis, but detection of CRC at earlier stages can improve cli...

journal_title：Gut

authors： Cui R,Okada Y,Jang SG,Ku JL,Park JG,Kamatani Y,Hosono N,Tsunoda T,Kumar V,Tanikawa C,Kamatani N,Yamada R,Kubo M,Nakamura Y,Matsuda K

更新日期：2011-06-01 00:00:00