Abstract:
:Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The typical clinical course and histology in these two patients suggest that IgA-mediated responses in the mucosa are not involved in the pathogenesis of Crohn's disease.
journal_name
Gutjournal_title
Gutauthors
Hodgson HJ,Jewell DPdoi
10.1136/gut.18.8.644subject
Has Abstractpub_date
1977-08-01 00:00:00pages
644-6issue
8eissn
0017-5749issn
1468-3288journal_volume
18pub_type
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