Abstract:
BACKGROUND/AIM:To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. METHODS:HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC and 248 HBV controls. RESULTS:Genotype C, CP-MT, T1653, HBV DNA levels >or=4 log(10) copies/ml and cirrhosis had a higher risk for HCC compared to patients with genotype B (p = 0.001, OR 1.9), CP wild-type (WT) (p<0.001, OR 4.1), C1653 (p = 0.028, OR 2.4), HBV DNA <4 log(10) copies/ml (p = 0.003, OR 2.1) and without cirrhosis (p<0.001, OR 4.0) respectively. Multivariate analysis showed that CP-MT, T1653, HBV DNA >or=4 log(10) copies/ml and cirrhosis were independent factors for HCC (all p<0.05). A receiver operating characteristics curve showed no cut-off HBV DNA level associated with minimal chance of HCC. Patients with CP-MT and cirrhosis had a 22.2-fold increased risk of HCC compared to patients with CP-WT and without cirrhosis. Patients with CP-MT and HBV DNA levels >or=4 log(10) copies/ml had a 7.2-fold increased risk of HCC compared to patients with CP-WT and HBV DNA levels <4 log(10) copies/ml. Patients with CP-MT and T1653 had a 9.9-fold increased risk of HCC compared to patients with wild-type for both regions. CONCLUSIONS:CP-MT, T1653, HBV DNA levels >or=4 log(10) copies/ml and cirrhosis are independent factors for development of HCC. The risks increased substantially in patients having these factors in combination.
journal_name
Gutjournal_title
Gutauthors
Yuen MF,Tanaka Y,Shinkai N,Poon RT,But DY,Fong DY,Fung J,Wong DK,Yuen JC,Mizokami M,Lai CLdoi
10.1136/gut.2007.119859subject
Has Abstractpub_date
2008-01-01 00:00:00pages
98-102issue
1eissn
0017-5749issn
1468-3288pii
gut.2007.119859journal_volume
57pub_type
杂志文章相关文献
GUT文献大全abstract::Clarithromycin, a new and well tolerated, acid stable macrolide antibiotic, has a similar antimicrobial spectrum to erythromycin but a better in vitro MIC90 (0.03 microgram/l-1) against Helicobacter pylori (H pylori). This study aimed at determining the eradication rate using clarithromycin 500 mg thrice daily and ome...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.323
更新日期:1994-03-01 00:00:00
abstract::Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchang...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.9.1107
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces apoptosis in transformed cells and is considered as an agent for cancer therapy. As there is evidence that TRAIL is also essential for apoptosis in animal models of liver injury, we investigated the role of TRAIL in viral hepat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.056929
更新日期:2005-11-01 00:00:00
abstract::Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2009.192732
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced cortical actin reorganisation. In addition, Fer participates in cytoskeletal interactions mediated by cadherins, platelet endothelial cell adhesion molecule 1 (PECAM-1),...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.061887
更新日期:2005-08-01 00:00:00
abstract::Helicobacter pylori causes chronic (type B) gastritis. The 'intestinal' form of gastric cancer arises against a background of chronic gastritis, and prospective epidemiological studies have shown that H pylori is a major risk factor for this. An increase in mucosal cell proliferation increases the likelihood of a neop...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.3.346
更新日期:1995-03-01 00:00:00
abstract::The two major forms of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been s...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2019-318448
更新日期:2019-10-01 00:00:00
abstract::We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus serotype 12 (Ad12), an adenovirus isolated from the human intestinal tract. In the present study sera from coeliac dise...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.8.995
更新日期:1987-08-01 00:00:00
abstract::In man, the main pancreatic duct is normally derived from ventral and dorsal embryological buds of the pancreas. In a minority of people, failure of fusion of the two buds results in separate drainage of the dorsal and ventral pancreas, so that the accessory duct provides the main drainage for the gland. Patients with...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.12.1066
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:The mechanisms underlying the suppression of somatostatin dependent reflexes in Helicobacter pylori infection are not fully determined. The H pylori product N alpha-methylhistamine and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) may be responsible for the alterations in somatostat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.176
更新日期:1998-08-01 00:00:00
abstract::Clinically significant liver involvement in systemic amyloidosis, especially with cholestasis, is rare. We report a case of primary amyloidosis with severe intrahepatic cholestasis leading to terminal liver failure. The present case is the first of its kind reported involving Lambda light chains only as the associated...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.7.903
更新日期:1987-07-01 00:00:00
abstract::Two patients have been studied with a two and a half and nine year history of metastatic pancreatic apudoma. In both patients the main feature was chronic watery diarrhoea with remissions after partial tumour resection and streptozotocin therapy. Plasma levels of circulating VIP and neurotensin were persistently raise...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.5.448
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVE:Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2019-318715
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:To compare performance measures across all three rounds of the English bowel cancer screening faecal occult blood test pilot and their relation to social deprivation and ethnicity. METHODS:In each round in three primary care trusts, data for a restricted population of over 48,500 aged 60-69 years were analy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.236430
更新日期:2012-01-01 00:00:00
abstract::Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.3.344
更新日期:1990-03-01 00:00:00
abstract::Dysmotility of the duodenum and proximal jejunum has been reported in patients with irritable bowel syndrome. This study extended these findings by recording fasting ambulatory motility from electronic strain gauge sensors sited in the jejunum and ileum of eight diarrhoea predominant irritable bowel syndrome patients ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.203
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Cholera toxin produces intestinal secretion by activation of the adenylate cyclase complex. However animal studies have shown 5-hydroxytryptamine may be released after exposure to cholera toxin, and thereby contribute to the secretory state. AIM:To determine whether cholera toxin releases 5-hydroxytryptamin...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.39.4.528
更新日期:1996-10-01 00:00:00
abstract::The typical macroscopic features of Crohn's disease have been well described and are widely regarded as sufficient to diagnose the disease at laparotomy. We report six patients undergoing laparotomy for symptomatic Crohn's disease, shown radiologically, who were found to have macroscopically normal small bowel despite...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.1.140
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Intestinal allograft rejection resembles Crohn's disease clinically and pathologically. An understanding of its mechanism could impact this life-saving procedure, as well as provide insight into the pathophysiology of inflammatory bowel disease. The NOD2 protein has been implicated as a key player in intesti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.133322
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.3.434
更新日期:1996-09-01 00:00:00
abstract::Electrical activity of the colon was investigated in six healthy volunteers and 22 patients presenting functional colonic disorders associated with pain, constipation, or diarrhoea. Myoelectrical activity during 10 hours, including two daily meals, was recorded from eight groups of nickel-chrome electrodes using a 1.5...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.6.480
更新日期:1980-06-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract::This study compares the gastroprotective effects of colloidal bismuth subcitrate (De-Nol) with those of sucralfate and a methylated analogue of prostaglandin E2 (PGE2) against acute gastric lesions induced by acidified aspirin and absolute ethanol in rats. Both De-Nol and sucralfate given orally prevented dose depende...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.2.201
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:In transplant recipients with choledococholedocostomy (CDCD), endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard for the diagnosis of biliary leak or strictures. Transabdominal ultrasonography (TAUS) has been used to screen patients with suspected biliary tract complications, pri...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.6.900
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Acute pancreatitis is among the few inflammatory diseases for which no specific pharmacological treatment is available. It has previously been shown that bile acids alter pancreatic ductal secretion and these effects are probably involved in the pathogenesis of bile-induced pancreatitis. OBJECTIVE:To unders...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.214213
更新日期:2011-03-01 00:00:00
abstract::Chronic alcohol consumption induces cytochrome P450IIE1, enabling habitual abusers to consume far greater quantities of alcohol than normal subjects. This pathway of metabolism leads to the production of free radical species, which cause tissue damage through peroxidation of cell membranes. Groups of Wistar rats of eq...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.11.1644
更新日期:1994-11-01 00:00:00
abstract::One-hundred-and-one normal neonates were examined manometrically in the first day of life to assess anorectal function. In order to overcome some of the difficulties in subjective interpretation of results, the stimuli used and the response pattern seen in the anal canal were measured. In the unstimulated state, all s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.12.1036
更新日期:1977-12-01 00:00:00
abstract::The levels of plasma carcinoembryonic antigen (CEA) were estimated in 59 control subjects attending St Mark's Hospital and in 139 patients with uncomplicated ulcerative colitis. There was little difference in the CEA levels in the two groups. In the colitic patients, the actual CEA values could not be correlated with ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.4.255
更新日期:1975-04-01 00:00:00
abstract::The mechanism by which intragastric balloons induce weight loss is not known, although they may act simply by reducing the amount of food needed to induce satiety. The knowledge that a balloon is present may influence the patients' eating patterns and reduce caloric intake and weight. In order to test whether the ball...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.30.8.1054
更新日期:1989-08-01 00:00:00
abstract::Psychological treatments are increasingly being used to help patients with the irritable bowel syndrome (IBS), but the efficacy of such treatments is still debated. This review indicates that there are three ways in which they might have been effective in published studies to date; relating bowel symptoms to stress, s...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.30.11.1601
更新日期:1989-11-01 00:00:00