Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.

abstract：BACKGROUND:Studies on intestinal T cell clones from the mucosa of patients with coeliac disease have led to the identification of immunogenic gliadin epitopes. One is HLA-DQ8 restricted, its recognition by T cells being increased by introduction of negatively charged residues operated by tissue transglutaminase. AIM:T...

journal_title：Gut

authors： Mazzarella G,Maglio M,Paparo F,Nardone G,Stefanile R,Greco L,van de Wal Y,Kooy Y,Koning F,Auricchio S,Troncone R

更新日期：2003-01-01 00:00:00

abstract：:Although the development of endoscopic methods of treatment for biliary obstruction has proceeded rapidly in recent years, endoscopic retrograde cholangiopancreatographic (ERCP) services are patchily distributed. A recent survey by the British Society of Gastroenterology has shown that almost half the district general...

journal_title：Gut

authors： Gear MW,Dent NA,Colin-Jones DG,Lennard-Jones JH,Colley JR

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We analysed the in vivo role of hypervariable region 1 (HVR1) for HCV virion properties, including nAb susceptibility. DESIGN:Analysis of HCV from human liver...

journal_title：Gut

authors： Prentoe J,Verhoye L,Velázquez Moctezuma R,Buysschaert C,Farhoudi A,Wang R,Alter H,Meuleman P,Bukh J

更新日期：2016-12-01 00:00:00

abstract：:Two West Indian patients with Kveim-biopsy proven sarcoidosis developed chronic cholestatic liver disease, clinically and biochemically similar to primary biliary cirrhosis. Liver histology revealed multiple granulomas with reduction in bile ducts and, in one patient, progression to biliary cirrhosis. Portal hypertens...

journal_title：Gut

authors： Bass NM,Burroughs AK,Scheuer PJ,James DG,Sherlock S

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of triacylglycerol-rich very-low-density lipoproteins (VLDLs): (i) the most infectious HCV particles are those of lowest density due to association with triacylglycero...

journal_title：Gut

authors： Beilstein F,Lemasson M,Pène V,Rainteau D,Demignot S,Rosenberg AR

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Screening colonoscopy to monitor for early colitis-associated colon cancer (CAC) is difficult due to the aberrant mucosal patterns associated with long-standing colitis. The aim of this study was to develop a rapid fluorescent detection method for use during colonoscopy for improving the detection of CAC uti...

journal_title：Gut

authors： Mitsunaga M,Kosaka N,Choyke PL,Young MR,Dextras CR,Saud SM,Colburn NH,Sakabe M,Nagano T,Asanuma D,Urano Y,Kobayashi H

更新日期：2013-08-01 00:00:00

abstract：:The cognitive model of depression assigns a central role to negatively biased information processing in the pathogenesis of the emotional disorder. The relationship between depression and irritable bowel syndrome (IBS) was explored from a cognitive perspective. A word recognition memory task was constructed: subjects ...

journal_title：Gut

authors： Gomborone JE,Dewsnap PA,Libby GW,Farthing MJ

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Because hepatic cirrhosis is a major risk factor for hepatocellular carcinoma, recent guidelines by the European Association for the Study of the Liver (EASL) on clinical management of hepatocellular carcinoma recommend periodic ultrasound surveillance of cirrhotic patients with immediate workup for nodules ...

journal_title：Gut

authors： Caturelli E,Solmi L,Anti M,Fusilli S,Roselli P,Andriulli A,Fornari F,Del Vecchio Blanco C,de Sio I

更新日期：2004-09-01 00:00:00

abstract：:Cirrhosis is associated with the development of a hyperdynamic circulation, which is secondary to the presence of systemic vasodilatation. Several mechanisms have been postulated to be involved in the development of systemic vasodilatation, including increased synthesis of nitric oxide, hyperglucagonaemia, increased c...

journal_title：Gut

authors： Ebrahimkhani MR,Mani AR,Moore K

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Hereditary forms of chronic idiopathic intestinal pseudo-obstruction (CIIP) are well described but the aetiology of most cases of sporadic CIIP is unknown. AIM:To determines whether herpes viruses can persist in the gastrointestinal tract, thereby implicating them in the pathogenesis of CIIP. METHODS:Twent...

journal_title：Gut

authors： Debinski HS,Kamm MA,Talbot IC,Khan G,Kangro HO,Jeffries DJ

更新日期：1997-07-01 00:00:00

abstract：:As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...

journal_title：Gut

authors： Bassotti G,Gaburri M,Imbimbo BP,Rossi L,Farroni F,Pelli MA,Morelli A

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. We investigated whether plasma miRNAs could discriminate between patients with and without colorectal cancer (CRC). METHODS:This study was divided into three phases: (1) marker discovery using real-time PCR-based miRNA pr...

journal_title：Gut

authors： Ng EK,Chong WW,Jin H,Lam EK,Shin VY,Yu J,Poon TC,Ng SS,Sung JJ

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease. We previously showed that siRNA against collagen-specific chaperone protein gp46, encapsulated in vi...

journal_title：Gut

authors： Ishiwatari H,Sato Y,Murase K,Yoneda A,Fujita R,Nishita H,Birukawa NK,Hayashi T,Sato T,Miyanishi K,Takimoto R,Kobune M,Ota S,Kimura Y,Hirata K,Kato J,Niitsu Y

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS:The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS:The association b...

journal_title：Gut

authors： Molloy RM,Sonnenberg A

更新日期：1997-02-01 00:00:00

abstract：:Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is ...

journal_title：Gut

authors： Sanderson IR,Phillips AD,Spencer J,Walker-Smith JA

更新日期：1991-11-01 00:00:00

abstract：:There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...

journal_title：Gut

authors： Lampe JW,Fredstrom SB,Slavin JL,Potter JD

更新日期：1993-04-01 00:00:00

abstract：:A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...

journal_title：Gut

authors： Carré IJ,Froggatt P

更新日期：1970-01-01 00:00:00

abstract：:Pouchitis may complicate the construction of an ileal pouch after colectomy for ulcerative colitis (UC) but not familial adenomatous polyposis (FAP). To examine whether differences in eicosanoid metabolism might explain why pouchitis is largely confined to UC patients, this study compared arachidonic acid stimulated r...

journal_title：Gut

authors： Gertner DJ,Rampton DS,Madden MV,Talbot IC,Nicholls RJ,Lennard-Jones JE

更新日期：1994-10-01 00:00:00

abstract：:A patient with myelofibrosis developed repeated gastrointestinal haemorrhage from the small intestine, which was found to be infiltrated with extramedullary haemopoiesis. Nineteen months later he presented with subacute intestinal obstruction; radiology and laparotomy documented progressive infiltration of the small b...

journal_title：Gut

authors： Sharma BK,Pounder RE,Cruse JP,Knowles SM,Lewis AA

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Low grade dysplasia (LGD) is believed to predispose to colorectal cancer (CRC), and proctocolectomy has been advocated when this is identified. Between 1978 and 1990, 160 patients with longstanding extensive ulcerative colitis (UC) were recruited for annual colonoscopic surveillance and 40 developed...

journal_title：Gut

authors： Lim CH,Dixon MF,Vail A,Forman D,Lynch DA,Axon AT

更新日期：2003-08-01 00:00:00

abstract：:In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...

journal_title：Gut

authors： Zargar SA,Khuroo MS,Mahajan R,Jan GM,Dewani K,Koul V

更新日期：1991-07-01 00:00:00

abstract：:Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization ind...

journal_title：Gut

authors： Korman MG,Soveny C,Hansky J

更新日期：1972-03-01 00:00:00

abstract：:The mechanism by which intragastric balloons induce weight loss is not known, although they may act simply by reducing the amount of food needed to induce satiety. The knowledge that a balloon is present may influence the patients' eating patterns and reduce caloric intake and weight. In order to test whether the ball...

journal_title：Gut

authors： Ramhamadany EM,Fowler J,Baird IM

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVES:Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. DESIGN:We collected complete symptom data from co...

journal_title：Gut

authors： Black CJ,Craig O,Gracie DJ,Ford AC

更新日期：2020-09-24 00:00:00

abstract：BACKGROUND AND AIMS:Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-c...

journal_title：Gut

authors： Cacoub P,Desbois AC,Comarmond C,Saadoun D

更新日期：2018-11-01 00:00:00

abstract：:The typical macroscopic features of Crohn's disease have been well described and are widely regarded as sufficient to diagnose the disease at laparotomy. We report six patients undergoing laparotomy for symptomatic Crohn's disease, shown radiologically, who were found to have macroscopically normal small bowel despite...

journal_title：Gut

authors： Butterworth RJ,Williams GT,Hughes LE

更新日期：1992-01-01 00:00:00

abstract：:The effects of sulphasalazine, 5-aminosalicylic acid (5-ASA), and sulphapyridine on peroxidation of red cell membrane lipids, measured as malondialdehyde production, were assessed. Sulphasalazine and 5-ASA, at concentrations of 10(-5)-10(-3) M significantly inhibit lipid peroxidation, suggesting an antioxidant action ...

journal_title：Gut

authors： Greenfield SM,Punchard NA,Thompson RP

更新日期：1991-10-01 00:00:00

abstract：:To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealti...

journal_title：Gut

authors： Jazrawi RP,Pigozzi MG,Galatola G,Lanzini A,Northfield TC

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:Non-coeliac gluten sensitivity (NCGS) is characterised by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing foods, in the absence of coeliac disease (CD) and wheat allergy. No biomarkers are available to diagnose NCGS and the gold standard double-blind placebo-controlled gl...

journal_title：Gut

authors： Barbaro MR,Cremon C,Morselli-Labate AM,Di Sabatino A,Giuffrida P,Corazza GR,Di Stefano M,Caio G,Latella G,Ciacci C,Fuschi D,Mastroroberto M,Bellacosa L,Stanghellini V,Volta U,Barbara G

更新日期：2020-11-01 00:00:00

abstract：:Ileal disease or resection causes bile salt malabsorption and a reduction in the bile salt content of bile. Since cholesterol solubility requires adequate bile salt concentrations, depletion of the bile salt content of bile might, therefore, jeopardize cholesterol solubility and predispose to cholesterol gallstone for...

journal_title：Gut

authors： Dowling RH,Bell GD,White J

更新日期：1972-06-01 00:00:00