Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial.

abstract：OBJECTIVE:Lesogaberan (AZD3355) is a novel γ-aminobutyric acid B-type receptor agonist designed to treat gastro-oesophageal reflux disease (GERD) by inhibiting transient lower oesophageal sphincter relaxations. A randomised, double-blind, placebo-controlled, multi-centre phase IIb study was performed to assess the effi...

journal_title：Gut

authors： Shaheen NJ,Denison H,Björck K,Karlsson M,Silberg DG

更新日期：2013-09-01 00:00:00

abstract：:Because of the increasing use of immunosuppressive and biological drugs, the occurrence of opportunistic infections has become a key safety issue for patients with inflammatory bowel disease (IBD). Consequently, improvement of healthcare workers' knowledge of this domain is urgent. In this review, the preventive measu...

journal_title：Gut

authors： Viget N,Vernier-Massouille G,Salmon-Ceron D,Yazdanpanah Y,Colombel JF

更新日期：2008-04-01 00:00:00

abstract：:The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Crypt...

journal_title：Gut

authors： Phillips AD,Thomas AG,Walker-Smith JA

更新日期：1992-08-01 00:00:00

abstract：:The staining of HLA class II antigens, the presence of cells positive for interleukin-2 receptors, the proportion of crypt cells in mitosis in the jejunal biopsy specimens, and the dose of coeliac disease marker HLA-DQ genes were studied in 75 healthy family members of coeliac disease patients. Eleven had silent coeli...

journal_title：Gut

authors： Holm K,Savilahti E,Koskimies S,Lipsanen V,Mäki M

更新日期：1994-01-01 00:00:00

abstract：:In a double-blind, placebo controlled and randomised secretory study the effectiveness of pirenzepine, ranitidine, and their combination was compared intraindividually in eight healthy subjects receiving intravenous bolus injections. Pirenzepine (0.15 mg/kg) plus ranitidine (0.6 mg/kg) suppressed peptone-stimulated ga...

journal_title：Gut

authors： Londong W,Londong V,Ruthe C,Weizert P

更新日期：1981-07-01 00:00:00

abstract：:By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune ;cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but v...

journal_title：Gut

authors： Maclaurin BP

更新日期：1971-06-01 00:00:00

abstract：OBJECTIVE:Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab. DESIGN:Safety data (May 2009-June 2013) from six trials of vedolizumab were integrated. Adverse events were evaluated i...

journal_title：Gut

authors： Colombel JF,Sands BE,Rutgeerts P,Sandborn W,Danese S,D'Haens G,Panaccione R,Loftus EV Jr,Sankoh S,Fox I,Parikh A,Milch C,Abhyankar B,Feagan BG

更新日期：2017-05-01 00:00:00

abstract：:Histochemical enzymatic studies were performed on 30 freshly resected large bowel carcinomas, 30 samples of normal colonic epithelium, and six samples of the histologically normal epithelium (so-called transitional epithelium) immediately adjacent to a carcinoma. Five enzymes were studied: nicotine adenine dinucleotid...

journal_title：Gut

authors： Marsden JR,Dawson IM

更新日期：1974-10-01 00:00:00

abstract：:A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...

journal_title：Gut

authors： Cummings JH,Wiggins HS

更新日期：1976-03-01 00:00:00

abstract：:This paper reviews the experience gained over the past few years in two techniques of liver support, charcoal haemoperfusion and polyacrylonitrile membrane haemodialysis. Problems with charcoal haemoperfusion have centred around platelet aggregation and hypertension, and new carbon preparations with a variety of diffe...

journal_title：Gut

authors： Williams R

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Induction of apoptosis of cancer cells through ligands of nuclear hormone receptors (NHRs) is a new approach in cancer therapy. Recently, one of the NHRs, peroxisome proliferator activated receptor gamma (PPARgamma), has been shown to influence cell growth in certain cancer cells although its effect...

journal_title：Gut

authors： Toyoda M,Takagi H,Horiguchi N,Kakizaki S,Sato K,Takayama H,Mori M

更新日期：2002-04-01 00:00:00

abstract：:Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. ...

journal_title：Gut

authors： Miettinen A,Karttunen TJ,Alavaikko M

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Dietary folate is believed to protect against colorectal cancer (CRC). However, few studies have addressed the role of circulating levels of folate. The aim of this study was to relate prediagnostic plasma folate and homocysteine concentrations and the methylenetetrahydrofolate reductase (MTHFR) 677...

journal_title：Gut

authors： Van Guelpen B,Hultdin J,Johansson I,Hallmans G,Stenling R,Riboli E,Winkvist A,Palmqvist R

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest ...

journal_title：Gut

authors： Frost F,Kacprowski T,Rühlemann M,Pietzner M,Bang C,Franke A,Nauck M,Völker U,Völzke H,Dörr M,Baumbach J,Sendler M,Schulz C,Mayerle J,Weiss FU,Homuth G,Lerch MM

更新日期：2020-11-09 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with cirrhosis. Evolving information suggests that the metabolic syndrome with non-alcoholic liver disease may be an important cause of HCC in addition to viral hepatitis and...

journal_title：Gut

authors： Bruix J,Gores GJ,Mazzaferro V

更新日期：2014-05-01 00:00:00

abstract：:The HGT-1 gastric cancer cell line was used to determine the actions of protein kinase C on the stimulation of adenylate cyclase by the human histamine H2 receptor, and the receptors for gastric inhibitory polypeptide and truncated glucagon like peptide 1 (TGLP-1). Suspensions of HGT-1 cells were preincubated with the...

journal_title：Gut

authors： McKenna P,Williams JM,Gespach CP,Hanson PJ

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. METHODS:Nucleos(t)ide analogue (NUC) treatment was disco...

journal_title：Gut

authors： Seto WK,Liu KS,Mak LY,Cloherty G,Wong DK,Gersch J,Lam YF,Cheung KS,Chow N,Ko KL,To WP,Fung J,Yuen MF

更新日期：2020-08-05 00:00:00

abstract：:Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetica...

journal_title：Gut

authors： Morgan MY,Reshef R,Shah RR,Oates NS,Smith RL,Sherlock S

更新日期：1984-10-01 00:00:00

abstract：:The experience of The Middlesex Hospital in the investigation and management of chronic intestinal arterial occlusion (IAO) over a 20 year period is presented. Of some 100 patients referred only 28 were found to have IAO and these were critically evaluated in terms of insorptive and exsorptive function. No relation wa...

journal_title：Gut

authors： Marston A,Clarke JM,Garcia Garcia J,Miller AL

更新日期：1985-07-01 00:00:00

abstract：OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...

journal_title：Gut

authors： Hackstein CP,Assmus LM,Welz M,Klein S,Schwandt T,Schultze J,Förster I,Gondorf F,Beyer M,Kroy D,Kurts C,Trebicka J,Kastenmüller W,Knolle PA,Abdullah Z

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Despite the recent discovery of four genes responsible for up to 90% of all cases of hereditary non-polyposis colorectal cancer (HNPCC), there will still be families in whom predictive testing is not possible. A phenotypic biomarker would therefore be useful. An upwards shift of the proliferative compartment...

journal_title：Gut

authors： Green SE,Chapman P,Burn J,Burt AD,Bennett M,Appleton DR,Varma JS,Mathers JC

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...

journal_title：Gut

authors： Berrebi D,Maudinas R,Hugot JP,Chamaillard M,Chareyre F,De Lagausie P,Yang C,Desreumaux P,Giovannini M,Cézard JP,Zouali H,Emilie D,Peuchmaur M

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...

journal_title：Gut

authors： Picton R,Eggo MC,Merrill GA,Langman MJ,Singh S

更新日期：2002-02-01 00:00:00

abstract：:This prospective study aimed to determine the prevalence of Helicobacter pylori infection in relation to the occurrence and severity of NSAIDs induced gastropathy. A total of 111 patients were studied-66 were taking NSAIDs and 45 were control patients. All patients underwent endoscopy during which antral biopsy specim...

journal_title：Gut

authors： Heresbach D,Raoul JL,Bretagne JF,Minet J,Donnio PY,Ramée MP,Siproudhis L,Gosselin M

更新日期：1992-12-01 00:00:00

abstract：:Cholestasis of pregnancy is associated with increased fetal morbidity and mortality and should be treated actively. The significance attached to pruritus in pregnancy is often minimal, but it is a cardinal symptom of cholestasis of pregnancy, which may have no other clinical features. Eight women with previous cholest...

journal_title：Gut

authors： Davies MH,da Silva RC,Jones SR,Weaver JB,Elias E

更新日期：1995-10-01 00:00:00

abstract：:The effects of drugs which change the bile-salt-independent fraction of bile flow on Na(+)K(a+) and Mg(2+) activated ATPases were studied in membrane fractions rich in bile canaliculi. The administration of phenobarbital caused no induction of these enzymes which could explain the increased bile flow observed in the r...

journal_title：Gut

authors： Laperche Y,Launay A,Oudéa P

更新日期：1972-11-01 00:00:00

abstract：:The effects of different bile salts on the absorption of fluid, electrolytes, and monosaccharides have been investigated in the rat small intestine in vivo. In the jejunum, deoxycholate (1 mM) impaired absorption of water and potassium, but not of sodium or glucose; at higher concentrations (2.5 and 5 mM) secretion of...

journal_title：Gut

authors： Harries JT,Sladen GE

更新日期：1972-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are chronic multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated mucosal immune response to gut-derived bacterial antigens is thought to be involved. Toll-like receptor ligands, especially lipopolysaccharide (LPS...

journal_title：Gut

authors： Tuin A,Poelstra K,de Jager-Krikken A,Bok L,Raaben W,Velders MP,Dijkstra G

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Several pharmacological agents for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) have been studied. Clinical trials evaluating the protective effect of non-steroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results. AIM:To perform a meta-an...

journal_title：Gut

authors： Elmunzer BJ,Waljee AK,Elta GH,Taylor JR,Fehmi SM,Higgins PD

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Multiorgan failure is a severe life threatening state where present therapeutic approaches are suboptimal. Epidermal growth factor (EGF) is a potent stimulant of repair in in vitro and in vivo models. We therefore examined its potential beneficial effect in reducing mortality and injury induced by the noxiou...

journal_title：Gut

authors： Caballero ME,Berlanga J,Ramirez D,Lopez-Saura P,Gozalez R,Floyd DN,Marchbank T,Playford RJ

更新日期：2001-01-01 00:00:00