Abstract:
BACKGROUND AND AIM:Colorectal cancer (CRC) is a multifactorial disease with both environmental and genetic factors contributing to its development. The incidence of CRC is increasing year by year in Japan. Patients with CRC in advanced stages have a poor prognosis, but detection of CRC at earlier stages can improve clinical outcome. Therefore, identification of epidemiologial factors that influence development of CRC would facilitate the prevention or early detection of disease. METHODS:To identify loci associated with CRC risk, we performed a genome-wide association study (GWAS) for CRC and sub-analyses by tumour location using 1583 Japanese CRC cases and 1898 controls. Subsequently, we conducted replication analyses using a total of 4809 CRC cases and 2973 controls including 225 Korean subjects with distal colon cancer and 377 controls. RESULTS:We identified a novel locus on 6q26-q27 region (rs7758229 in SLC22A3, p = 7.92 × 10⁻⁹, OR of 1.28) that was significantly associated with distal colon cancer. We also replicated the association between CRC and SNPs on 8q24 (rs6983267 and rs7837328, p = 1.51 × 10⁻⁸ and 7.44 × 10⁻⁸, ORs of 1.18 and 1.17, respectively). Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold. CONCLUSIONS:We found a novel susceptible locus in SLC22A3 that contributes to the risk of distal colon cancer in an Asian population. These findings would further extend our understanding of the role of common genetic variants in the aetiology of CRC.
journal_name
Gutjournal_title
Gutauthors
Cui R,Okada Y,Jang SG,Ku JL,Park JG,Kamatani Y,Hosono N,Tsunoda T,Kumar V,Tanikawa C,Kamatani N,Yamada R,Kubo M,Nakamura Y,Matsuda Kdoi
10.1136/gut.2010.215947subject
Has Abstractpub_date
2011-06-01 00:00:00pages
799-805issue
6eissn
0017-5749issn
1468-3288pii
gut.2010.215947journal_volume
60pub_type
杂志文章,meta分析相关文献
GUT文献大全abstract::Polyacrylamide gel electrophoresis of pure pancreatic juice from 14 healthy normal subjects, 11 chronic alcoholics without detectable pancreatic disease, 15 patients with pancreatitis, and two with cancer of the pancreas consistently demonstrated the presence of two variants of trypsinogen with different electrophoret...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.10.886
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-c...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316234
更新日期:2018-11-01 00:00:00
abstract::Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete two hour periods) were analysed for volume, pH, bile acids (conjugated and unconjugated), trypsin, and pepsin. The results were compare...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.10.1093
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301078
更新日期:2012-09-01 00:00:00
abstract::For the first time the endoscopist has more than one option for the management of gastro-oesophageal varices. It is now feasible to select the appropriate therapy on the basis of the clinical setting. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from oesophageal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.647
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). METHODS:A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. RESULTS:Of 563 patients with AIP, 459 (82%) received steroid treatment....
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2008.172908
更新日期:2009-11-01 00:00:00
abstract::The incidence of small intestinal colonization in unoperated duodenal ulcer patients was low and similar to that in the normal population. The majority of patients seven to 10 days following truncal vagotomy and drainage were colonized whereas none of a control group of patients following simple closure of a perforate...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.2.139
更新日期:1974-02-01 00:00:00
abstract:OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-318281
更新日期:2020-04-01 00:00:00
abstract::The nervous system in the intestine controls motility, secretion, sensory perception, and immune function. Peptidergic neurones with neurotransmitters such as substance P and nerve growth factors have been the main focus of neuroimmunomodulation research in the gut. This review summarises the present knowledge concern...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2006.091322
更新日期:2006-11-01 00:00:00
abstract::An ileitis developing years or months after ileostomy was recognised and described many years ago but has rarely been mentioned since. We describe nine patients with a non-specific preanastomotic ileitis that developed years after colectomy in patients operated on for ulcerative colitis or carcinoma. The disease devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.373
更新日期:1994-03-01 00:00:00
abstract::One-hundred-and-one normal neonates were examined manometrically in the first day of life to assess anorectal function. In order to overcome some of the difficulties in subjective interpretation of results, the stimuli used and the response pattern seen in the anal canal were measured. In the unstimulated state, all s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.12.1036
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Sodium butyrate, a product of colonic bacterial fermentation, is able to inhibit cell proliferation and to stimulate cell differentiation of colonic epithelial cell lines. It has been proposed that these cellular effects could be linked to its ability to cause hyperacetylation of histone through the inhibiti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.4.507
更新日期:2000-04-01 00:00:00
abstract::Although changes in T lymphocyte subset distribution in the peripheral blood of patients infected with human immunodeficiency virus (HIV) are well defined it is not known whether these changes reflect changes in lymphoid compartments clearly involved in HIV related disease like the intestinal mucosa. This study analys...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.4.524
更新日期:1995-10-01 00:00:00
abstract::We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.7.838
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Dyspepsia is a chronic disease with significant impact on the use of health care resources. A management strategy based on Helicobacter pylori testing has been recommended but the long term effect is unknown. AIM:To investigate the long term effect of a test and treat strategy compared with prompt endoscopy...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.2004.043570
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN:A randomised, double-blind, double-dummy, parallel group, multicentre, international, ph...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2008.154302
更新日期:2009-02-01 00:00:00
abstract::Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.94
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS:We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk ...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gutjnl-2015-309168
更新日期:2015-08-01 00:00:00
abstract::Measurements of cell proliferation can be used as biomarkers of preneoplastic change. In this study, two immunocytochemical methods that measure different components of the cell cycle were compared to assess cell proliferation on biopsy samples from human colonic mucosa. These methods are based on a monoclonal antibod...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.11.1587
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:The death rate of mature hepatocytes is chronically increased in various liver diseases, triggering responses that prevent liver atrophy, but often cause fibrosis. Mice with targeted disruption of inhibitor kappa B kinase (Ikk) in hepatocytes (HEP mice) provide a model to investigate this process because inhi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.204354
更新日期:2010-05-01 00:00:00
abstract::A single oral dose of 4-46 mmol calcium gluconate at pH 5-6 was administered intragastrically to 15 male volunteers without gastrointestinal disease. There was a significant rise in acid output from 30-90 minutes after the calcium was given compared with the basal hourly collection. The serum gastrin level 30 minutes ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.2.111
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:A high prevalence of osteoporosis is reported in Crohn's disease. The pathogenesis is not completely understood but is probably multifactorial. Longstanding Crohn's disease is associated with a deficiency of fat soluble vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of osteocalc...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.4.473
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of triacylglycerol-rich very-low-density lipoproteins (VLDLs): (i) the most infectious HCV particles are those of lowest density due to association with triacylglycero...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311508
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311224
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The role of the recently discovered GB virus C (GBV-C)/hepatitis G virus in fulminant hepatic failure (FHF) has been debated. Although GBV-C RNA has been detected in many cases of FHF, recent data suggest that the relation between GBV-C and FHF may be accidental. AIMS:To retrospectively investigate the poss...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.2.274
更新日期:1999-02-01 00:00:00
abstract::This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.4.2.183
更新日期:1963-06-01 00:00:00
abstract:BACKGROUND:In hereditary pancreatitis mutations of exons 2 (N21I) and 3 (R117H) of the cationic trypsinogen gene have been described. AIMS:To investigate whether the same mutations can also be found in patients with chronic alcoholic pancreatitis. METHODS:Leucocyte DNA was prepared from 23 patients with chronic alcoh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.3.413
更新日期:1999-03-01 00:00:00
abstract::Eight patients with diffuse plasma cell infiltration of the small bowel who had the clinical features of immunoproliferative small intestinal disease (IPSID), but whose serum was negative for free alpha-heavy chains, were investigated for evidence of a non-secretory form of alpha-chain disease (alpha-CD). Molecular si...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.9.928
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Cyclooxygenase 2 (COX-2) and matrix metalloproteinases (MMPs) have been implicated in tissue injury and fibrogenesis in animal models but little is known regarding their role in hepatitis C virus (HCV) related liver disease in humans. AIMS:To characterise the intrahepatic expression pattern of COX-2 and MMP...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.038364
更新日期:2004-11-01 00:00:00
abstract::We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus serotype 12 (Ad12), an adenovirus isolated from the human intestinal tract. In the present study sera from coeliac dise...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.8.995
更新日期:1987-08-01 00:00:00