Abstract:
:Eight patients with diffuse plasma cell infiltration of the small bowel who had the clinical features of immunoproliferative small intestinal disease (IPSID), but whose serum was negative for free alpha-heavy chains, were investigated for evidence of a non-secretory form of alpha-chain disease (alpha-CD). Molecular sieving and immunoblotting of serum, immunoperoxidase staining of biopsy specimens, and in vitro protein synthesis studies utilising an immunoprecipitation technique and polyacrylamide gel electrophoresis, failed to detect any new cases of alpha-CD. Four of the eight cases were found to have diffuse intestinal lymphoma. The remaining four patients, who were unsuccessfully investigated for evidence of a significant abnormality in cellular immunity, have not developed detectable alpha-CD protein or lymphoma over a mean of 143 months. Despite continuing exposure to possible environmental stimuli, it is concluded that not all cases of IPSID elaborate detectable alpha-CD protein or evolve to lymphoma.
journal_name
Gutjournal_title
Gutauthors
Gilinsky NH,Mee AS,Beatty DW,Novis BH,Young G,Price S,Purves LR,Marks INdoi
10.1136/gut.26.9.928subject
Has Abstractpub_date
1985-09-01 00:00:00pages
928-34issue
9eissn
0017-5749issn
1468-3288journal_volume
26pub_type
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