Effect of immunisation against vasoactive intestinal polypeptide on gastric corpus tone and motility in the ferret.

abstract：INTRODUCTION:Recently, we showed that the length of cardiac mucosa in healthy volunteers correlated with age and obesity. We have now examined the immunohistological characteristics of this expanded cardia to determine whether it may be due to columnar metaplasia of the distal oesophagus. METHODS:We used the squamocol...

journal_title：Gut

authors： Derakhshan MH,Robertson EV,Yeh Lee Y,Harvey T,Ferrier RK,Wirz AA,Orange C,Ballantyne SA,Hanvey SL,Going JJ,McColl KE

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:The use of patient reported outcome measures to support routine inflammatory bowel disease (IBD) care is not widespread and suggests that existing questionnaires lack relevance to day-to-day decisions or are too cumbersome to administer. We developed a simple, generic tool for capturing disease control fro...

journal_title：Gut

authors： Bodger K,Ormerod C,Shackcloth D,Harrison M,IBD Control Collaborative.

更新日期：2014-07-01 00:00:00

abstract：:The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...

journal_title：Gut

authors： Staniforth DH,Rose D

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS:We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk ...

journal_title：Gut

authors： Mocellin S,Verdi D,Pooley KA,Nitti D

更新日期：2015-08-01 00:00:00

abstract：:Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...

journal_title：Gut

authors： Moran AP,Gupta A,Joshi L

更新日期：2011-10-01 00:00:00

abstract：:Inflammatory mediators from intestinal mast cells may serve as initiators of acute and delayed inflammation. Mast cell histamine release was measured in 19 patients with inflammatory bowel diseases using gut mast cells from enzymatically dispersed endoscopic forceps biopsy specimens of macroscopically inflamed and nor...

journal_title：Gut

authors： Nolte H,Spjeldnaes N,Kruse A,Windelborg B

更新日期：1990-07-01 00:00:00

abstract：:4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remi...

journal_title：Gut

authors： Schreiber S,Howaldt S,Raedler A

更新日期：1994-08-01 00:00:00

abstract：CLINICAL PRESENTATION:A 28-year-old woman presented with a 3-year history of chronic watery diarrhoea along with abdominal pain and bloating, which could mostly be alleviated after defecation. Her symptom of diarrhoea, at least three times a day, could be relieved by neither probiotics nor antidiarrhoeal agents. She ha...

journal_title：Gut

authors： Zhou CB,Lu H,Chen YX,Fang JY

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...

journal_title：Gut

authors： Verdú EF,Bercik P,Verma-Gandhu M,Huang XX,Blennerhassett P,Jackson W,Mao Y,Wang L,Rochat F,Collins SM

更新日期：2006-02-01 00:00:00

abstract：:The effect of the unconjugated bile acids, cholic, deoxycholic, chenodeoxycholic, and ursodeoxycholic acids, and of the conjugated bile acid taurocholic acid on the mucosal-to-serosal transport and tissue uptake of the naturally occurring folate derivative, 5-methyltetrahydrofolate (5-CH3H4PteGlu) was examined in ever...

journal_title：Gut

authors： Said HM,Hollander D,Strum WB

更新日期：1984-12-01 00:00:00

abstract：:The faecal blood loss of six alcoholic subjects with normal gastric mucosa, six with superficial gastritis, and six with atrophic gastritis was studied before and during ingestion of 40% v/v ethanol using (51)Cr-tagged red blood cells. No significant change in faecal blood loss was observed in the normal mucosa and su...

journal_title：Gut

authors： Dinoso VP Jr,Meshkinpour H,Lorber SH

更新日期：1973-04-01 00:00:00

abstract：BACKGROUND:Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and histomorphologically the diseased duodenum in human biopsies. METHODS:Norovirus infection was diagnosed by the Kaplan criteria and confirmed by PCR of stool samples....

journal_title：Gut

authors： Troeger H,Loddenkemper C,Schneider T,Schreier E,Epple HJ,Zeitz M,Fromm M,Schulzke JD

更新日期：2009-08-01 00:00:00

abstract：AIM:To compare acceptability and diagnostic accuracy of a recently available faecal immunochemical test (FIT) system (HM-JACKarc) with the FIT routinely used in an established screening programme (OC-Sensor). DESIGN:Randomised controlled trial (ISRCTN20086618) within a population-based colorectal cancer (CRC) screenin...

journal_title：Gut

authors： Passamonti B,Malaspina M,Fraser CG,Tintori B,Carlani A,D'Angelo V,Galeazzi P,Di Dato E,Mariotti L,Bulletti S,D'Amico MR,Gustinucci D,Martinelli N,Spita N,Cesarini E,Rubeca T,Giaimo M,Segnan N,Senore C

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked kinase (ILK) is the binding partner of beta1 and beta3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. However, in vivo evidence for the latter...

journal_title：Gut

authors： Assi K,Mills J,Owen D,Ong C,St Arnaud R,Dedhar S,Salh B

更新日期：2008-07-01 00:00:00

abstract：:Chronic alcohol consumption induces cytochrome P450IIE1, enabling habitual abusers to consume far greater quantities of alcohol than normal subjects. This pathway of metabolism leads to the production of free radical species, which cause tissue damage through peroxidation of cell membranes. Groups of Wistar rats of eq...

journal_title：Gut

authors： Teare JP,Greenfield SM,Watson D,Punchard NA,Miller N,Rice-Evans CA,Thompson RP

更新日期：1994-11-01 00:00:00

abstract：:The aim of this study was to develop and validate an endoscopic index for assessing the severity of Crohn's disease. Endoscopic findings were prospectively collected by a multicentre group in 75 patients with Crohn's colitis according to a previously validated procedure. The presence of nine preselected lesions was re...

journal_title：Gut

authors： Mary JY,Modigliani R

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Portal systemic encephalopathy (PSE) is a complex neuropsychiatric syndrome associated with hepatic failure. Small scale studies have shown the benzodiazepine receptor antagonist flumazenil to be effective in ameliorating PSE. AIMS:To determine the efficacy of flumazenil in patients with non-comatous mild t...

journal_title：Gut

authors： Gyr K,Meier R,Häussler J,Boulétreau P,Fleig WE,Gatta A,Holstege A,Pomier-Layrargues G,Schalm SW,Groeneweg M,Scollo-Lavizzari G,Ventura E,Zeneroli ML,Williams R,Yoo Y,Amrein R

更新日期：1996-08-01 00:00:00

abstract：:Large numbers of cells are shed from small intestinal mucosa but they are so rapidly destroyed that there is little direct information about their morphological types. Material obtained by washing the human and rat small intestine was immediately processed and examined by light and electron microscopy. Small intestina...

journal_title：Gut

authors： Pink IJ,Croft DN,Creamer B

更新日期：1970-03-01 00:00:00

abstract：:The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...

journal_title：Gut

authors： CLARKE SD,NEILL DW,WELBOURN RB

更新日期：1960-03-01 00:00:00

abstract：:Helicobacter pylori is present worldwide but few large population studies exist on the epidemiology of the infection. A random cross sectional study was performed of H pylori infection in the adult population of San Marino, a European country with high gastric cancer rate, to assess its prevalence and to evaluate its ...

journal_title：Gut

authors： Gasbarrini G,Pretolani S,Bonvicini F,Gatto MR,Tonelli E,Mégraud F,Mayo K,Ghironzi G,Giulianelli G,Grassi M

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate whether patients with increased or decreased gastric motility can be differentiated from healthy volunteers by means of real time magnetic resonance imaging (MRI). PATIENTS AND METHODS:Ten healthy volunteers, 10 patients with gastroparesis, and 10 patients with function...

journal_title：Gut

authors： Ajaj W,Goehde SC,Papanikolaou N,Holtmann G,Ruehm SG,Debatin JF,Lauenstein TC

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Faecal concentrations of the protein calprotectin have been found to be elevated in patients with colorectal neoplasia, suggesting that it might be used as a screening tool for colorectal cancer as well as adenomas. AIMS:To measure the sensitivity and specificity of faecal calprotectin for the detection of ...

journal_title：Gut

authors： Kronborg O,Ugstad M,Fuglerud P,Johne B,Hardcastle J,Scholefield JH,Vellacott K,Moshakis V,Reynolds JR

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Increased expression of proinflammatory cytokines, including tumour necrosis factor alpha, interleukin 6, and interferon gamma, as well as activation of proinflammatory signalling molecules such as nuclear factor kappa B, is characteristic of inflammatory bowel disease (IBD). AIMS:To investigate expression ...

journal_title：Gut

authors： Schreiber S,Rosenstiel P,Hampe J,Nikolaus S,Groessner B,Schottelius A,Kühbacher T,Hämling J,Fölsch UR,Seegert D

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying. AIMS:To assess the effects of endogenous GLP-1 on endocrine pancreatic secretion and antro-pyloro-duodenal motility by utilising the GLP-...

journal_title：Gut

authors： Schirra J,Nicolaus M,Roggel R,Katschinski M,Storr M,Woerle HJ,Göke B

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND/AIM:5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut disorders. The mechanisms regulating 5-HT production in the gut remain unclear. This study investigated the T helper (Th) 1/...

journal_title：Gut

authors： Motomura Y,Ghia JE,Wang H,Akiho H,El-Sharkawy RT,Collins M,Wan Y,McLaughlin JT,Khan WI

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Suicide gene therapy consists of the transfer into tumour cells of a "suicide" gene that can convert a non-toxic compound into a lethal drug. Expression of the cytosine deaminase gene leads to the conversion of the non-toxic compound 5-fluorocytosine to 5-fluorouracil. We have recently shown that "suicide ce...

journal_title：Gut

authors： Pierrefite-Carle V,Baqué P,Gavelli A,Brossette N,Benchimol D,Bourgeon A,Saint Paul MC,Staccini P,Rossi B

更新日期：2002-03-01 00:00:00

abstract：:Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchang...

journal_title：Gut

authors： Olsen PS,Pedersen JH,Poulsen SS,Yamashita Y,Kirkegaard P

更新日期：1987-09-01 00:00:00

abstract：:To determine the optimum dose of ispaghula husk in patients with irritable bowel syndrome (IBS) and to assess the correlation, if any between the relief in patients' symptoms and the whole gut transit time, and the increase in stool weight, a two part study was carried out. In part 1, 14 male patients were given ispag...

journal_title：Gut

authors： Kumar A,Kumar N,Vij JC,Sarin SK,Anand BS

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:The mechanisms underlying the suppression of somatostatin dependent reflexes in Helicobacter pylori infection are not fully determined. The H pylori product N alpha-methylhistamine and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) may be responsible for the alterations in somatostat...

journal_title：Gut

authors： Beales IL,Calam J

更新日期：1998-08-01 00:00:00

abstract：:To assist in the prediction of variceal bleeding we examined 12 clinical, endoscopic and haemodynamic variables in 126 patients with portal hypertension (72 bleeders and 54 non-bleeders). Multiple regression and discriminant analysis were utilised for 101 patients. Stepwise regression among the 12 variables explained ...

journal_title：Gut

authors： Sarin SK,Sundaram KR,Ahuja RK

更新日期：1989-12-01 00:00:00