Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?

abstract：OBJECTIVES:Endothelial progenitor cells (EPCs) circulate with increased numbers in the peripheral blood of patients with highly-vascularised hepatocellular carcinoma (HCC) and contribute to angiogenesis and neovascularisation. We hypothesised that angiogenic EPCs, that is, colony forming unit-endothelial cells (CFU-ECs...

journal_title：Gut

authors： Shih YT,Wang MC,Zhou J,Peng HH,Lee DY,Chiu JJ

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury is unknown. Here we hypothesised that the anti-infl...

journal_title：Gut

authors： Perugorria MJ,Esparza-Baquer A,Oakley F,Labiano I,Korosec A,Jais A,Mann J,Tiniakos D,Santos-Laso A,Arbelaiz A,Gawish R,Sampedro A,Fontanellas A,Hijona E,Jimenez-Agüero R,Esterbauer H,Stoiber D,Bujanda L,Banales JM,K

更新日期：2019-03-01 00:00:00

abstract：:A case is described of non-necrotizing, epithelioid cell granulomatous synovitis of the ankle of a 22-year-old man with Crohn's disease. It appears to be the first published example of granulomatous arthritis in association with Crohn's disease. ...

journal_title：Gut

authors： Lindström C,Wramsby H,Ostberg G

更新日期：1972-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The detrimental impact of opioid agonist on the clinical management of inflammatory diseases remains elusive. Given the anti-inflammatory properties of the mu-opioid receptor (MOR) agonists at the intestinal barrier, we hypothesised that MOR activation might also dampen acute hepatic inflammation an...

journal_title：Gut

authors： Chakass D,Philippe D,Erdual E,Dharancy S,Malapel M,Dubuquoy C,Thuru X,Gay J,Gaveriaux-Ruff C,Dubus P,Mathurin P,Kieffer BL,Desreumaux P,Chamaillard M

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...

journal_title：Gut

authors： van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Cholera toxin produces intestinal secretion by activation of the adenylate cyclase complex. However animal studies have shown 5-hydroxytryptamine may be released after exposure to cholera toxin, and thereby contribute to the secretory state. AIM:To determine whether cholera toxin releases 5-hydroxytryptamin...

journal_title：Gut

authors： Bearcroft CP,Perrett D,Farthing MJ

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism. AIMS:To investigate whether impaired glucose metabolism affects the growth rate of the tumour. PATIENTS AND METHODS:Tumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 pati...

journal_title：Gut

authors： Saito K,Inoue S,Saito T,Kiso S,Ito N,Tamura S,Watanabe H,Takeda H,Misawa H,Togashi H,Matsuzawa Y,Kawata S

更新日期：2002-07-01 00:00:00

abstract：:The records of 113 consecutive patients with a suspected gastrointestinal motility disorder referred between January 1988 and July 1991 were retrospectively reviewed. The aims were to identify the prevalence of autonomic dysfunction in those with or without associated neurological disease and to determine the diagnost...

journal_title：Gut

authors： Bharucha AE,Camilleri M,Low PA,Zinsmeister AR

更新日期：1993-03-01 00:00:00

abstract：:In dogs with either vagally innervated or denervated pouches, the acid responses to a standard meal, a meal which bypassed the greater part of the small bowel, and a meal introduced directly into the small intestine were measured before and after exclusion of 75% of the small bowel.After intestinal exclusion an increa...

journal_title：Gut

authors： Buxton B,Wasunna AE,Saunders J,Gillespie IE

更新日期：1972-07-01 00:00:00

abstract：:ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals. The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group O subjects, in close agreement with many previous reports throughout the world. More detail...

journal_title：Gut

authors： Glober GA,Cantrell EG,Doll R,Peto R

更新日期：1971-07-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) and cause gastric ulceration. NSAIDs also impair granulation tissue angiogenesis and healing of established gastric ulcers in humans. The mechanism whereby NSAIDs inhibit granulation tissue angiogenesis is unknown but may involve inh...

journal_title：Gut

authors： Hull MA,Thomson JL,Hawkey CJ

更新日期：1999-10-01 00:00:00

abstract：:Helicobacter pylori possesses unusually high urease activity that lowers the urea concentration and raises the ammonium concentration of the gastric juice in infected people. The value of measuring urea and ammonium concentrations in gastric juice obtained during upper gastrointestinal endoscopy as a means of diagnosi...

journal_title：Gut

authors： Neithercut WD,Milne A,Chittajallu RS,el Nujumi AM,McColl KE

更新日期：1991-09-01 00:00:00

abstract：:Seventeen paediatric patients with immunodeficiency syndromes (10 with selective IgA deficiency, four with panhypogammaglobulinaemia, and three with selective T cell deficiency) were investigated for bacterial overgrowth of the small intestine and gut permeability to macromolecules. Five of 12 patients showed viable b...

journal_title：Gut

authors： Pignata C,Budillon G,Monaco G,Nani E,Cuomo R,Parrilli G,Ciccimarra F

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVES:Chronic gastro-oesophageal reflux might lead to the development of Barrett's oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal re...

journal_title：Gut

authors： Eusebi LH,Cirota GG,Zagari RM,Ford AC

更新日期：2020-07-30 00:00:00

abstract：OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...

journal_title：Gut

authors： Kiesslich R,Duckworth CA,Moussata D,Gloeckner A,Lim LG,Goetz M,Pritchard DM,Galle PR,Neurath MF,Watson AJ

更新日期：2012-08-01 00:00:00

abstract：:Little is known about chronic constipation in infants, toddlers, and preschool children and longterm outcome after treatment. The symptoms of 174 children < or = 4 years of age, who were evaluated for chronic constipation, are reported in this study together with the long-term outcome in 90 of them. Initial symptoms w...

journal_title：Gut

authors： Loening-Baucke V

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Intrasphincteric injection of botulinum toxin (Botx) has been proposed as treatment for oesophageal achalasia. However, the predictors of response and optimal dose remain unclear. AIMS:To compare the effect of different doses of Botx and to identify predictors of response. PATIENTS/METHODS:A total of 118 a...

journal_title：Gut

authors： Annese V,Bassotti G,Coccia G,Dinelli M,D'Onofrio V,Gatto G,Leandro G,Repici A,Testoni PA,Andriulli A

更新日期：2000-05-01 00:00:00

abstract：:Ileal permeability to different sized polyethyleneglycols (590-942 dalton PEG) was investigated peroperatively in 11 patients with Crohn's disease and seven with colonic carcinoma. A 15 cm ileal segment was converted into a tied loop, in which the PEG's were deposited. Absorption from the ileal segment was then measur...

journal_title：Gut

authors： Olaison G,Leandersson P,Sjödahl R,Tagesson C

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS:We conducted a randomised, double blind, placebo controlled trial of intravenous ant...

journal_title：Gut

authors： Siriwardena AK,Mason JM,Balachandra S,Bagul A,Galloway S,Formela L,Hardman JG,Jamdar S

更新日期：2007-10-01 00:00:00

abstract：:Glucagon-like peptide 1 does not comfortably fulfil the criterion of a gut derived factor responsible for an enhanced meal related insulin response; it appears logical to add the definition of a "physiological incretin hormone". ...

journal_title：Gut

authors： Horowitz M,Nauck MA

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presenc...

journal_title：Gut

authors： Combet E,Paterson S,Iijima K,Winter J,Mullen W,Crozier A,Preston T,McColl KE

更新日期：2007-12-01 00:00:00

abstract：:The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal injury induced by indomethacin. Indomethacin caused acute gastroduodenal ...

journal_title：Gut

authors： Shorrock CJ,Rees WD

更新日期：1992-02-01 00:00:00

abstract：INTRODUCTION:In pancreatic cancer, preoperative biliary drainage (PBD) increases complications compared with surgery without PBD, demonstrated by a recent randomised controlled trial (RCT). This outcome might be related to the plastic endoprosthesis used. Metal stents may reduce the PBD-related complications risk. MET...

journal_title：Gut

authors： Tol JA,van Hooft JE,Timmer R,Kubben FJ,van der Harst E,de Hingh IH,Vleggaar FP,Molenaar IQ,Keulemans YC,Boerma D,Bruno MJ,Schoon EJ,van der Gaag NA,Besselink MG,Fockens P,van Gulik TM,Rauws EA,Busch OR,Gouma DJ

更新日期：2016-12-01 00:00:00

abstract：:Coeliac disease is triggered by ingestion of wheat gliadin and is probably immune mediated. There is evidence by light microscopy that expression of class II major histocompatibility complex (MHC) molecules is increased in the small intestinal epithelium of patients with untreated coeliac disease and that gliadin can ...

journal_title：Gut

authors： Zimmer KP,Poremba C,Weber P,Ciclitira PJ,Harms E

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS:To study the effect of glyceryl trinitrate, a nitr...

journal_title：Gut

authors： Greaves R,Miller J,O'Donnell L,McLean A,Farthing MJ

更新日期：1998-03-01 00:00:00

abstract：:There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...

journal_title：Gut

authors： Lampe JW,Fredstrom SB,Slavin JL,Potter JD

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. AIM:To determine whether appendicectomy reduces the overall severity of ulcerative colitis. PATIENTS AND METHODS:Appendicectomy status and smoking habits were sp...

journal_title：Gut

authors： Cosnes J,Carbonnel F,Beaugerie L,Blain A,Reijasse D,Gendre JP

更新日期：2002-12-01 00:00:00

abstract：:Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury. ...

journal_title：Gut

authors： Gionchetti P,Lammers KM,Rizzello F,Campieri M

更新日期：2005-07-01 00:00:00

abstract：:The effects on gastric emptying of a solid meal of the specific 5-HT3-receptor antagonist ICS 205-930, 10 mg and 20 mg intravenously were assessed with a scintigraphic technique in 12 normals. The 50% emptying time was less, the lag phase was shorter and the post lag emptying rate was faster after 20 mg ICS 205-930 (p...

journal_title：Gut

authors： Akkermans LM,Vos A,Hoekstra A,Roelofs JM,Horowitz M

更新日期：1988-09-01 00:00:00

abstract：:The role of lamina propria cells in regulating human colonic ion transport was investigated in vitro. Normal human colonic mucosae were mounted in Ussing chambers, and short circuit current changes (delta SCC) were monitored in response to immune cell activation. Anti-human immunoglobulin E (anti-IgE) and formyl-Methi...

journal_title：Gut

authors： Stack WA,Keely SJ,O'Donoghue DP,Baird AW

更新日期：1995-03-01 00:00:00