Abstract:
BACKGROUND:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism.
AIMS:To investigate whether impaired glucose metabolism affects the growth rate of the tumour.
PATIENTS AND METHODS:Tumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 patients with single small HCC (diameter <30 mm). DT was compared with plasma insulin and glucose concentrations following the oral glucose tolerance test (OGTT). The effect of continuous infusion of octreotide (a somatostatin analogue 200 microg/day) for three months on DT in five cases was assessed.
RESULTS:The 60 patients were divided into two groups because the median DT was 140 days: rapid growth group (DT
journal_name
Gutjournal_title
Gutauthors
Saito K,Inoue S,Saito T,Kiso S,Ito N,Tamura S,Watanabe H,Takeda H,Misawa H,Togashi H,Matsuzawa Y,Kawata Sdoi
10.1136/gut.51.1.100keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
100-4issue
1eissn
0017-5749issn
1468-3288journal_volume
51pub_type
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