Abstract:
:To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealtime ursodeoxycholic acid (UDCA, 12 mg/kg/day). An additional 10 patients treated with a combination of CDCA plus UDCA (each 6 mg/kg/day) at bedtime were matched with the 10 patients on bedtime CDCA and the 10 on bedtime UDCA. The gall stone dissolution rates at six and 12 months were determined by standardised oral cholecystography and expressed as the percentage reduction in the gall stone volume after treatment. The gall stone dissolution rate at six months was higher for UDCA than CDCA treatment (median 78% v 48%, p less than 0.01), and for bedtime than mealtime administration (69% v 39%, p less than 0.02). Both differences were greater for stones less than 8 mm diameter. The dissolution rate was faster for combination therapy than for CDCA alone at both six (82% v 36%, p less than 0.05) and 12 months (100% v 54%, p less than 0.05), but was not different from UDCA alone. We conclude that bile acid treatment should be confined to patients with small gall stones and that bedtime administration of combined UDCA and CDCA is likely to provide the most effective and safe combination.
journal_name
Gutjournal_title
Gutauthors
Jazrawi RP,Pigozzi MG,Galatola G,Lanzini A,Northfield TCdoi
10.1136/gut.33.3.381keywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
381-6issue
3eissn
0017-5749issn
1468-3288journal_volume
33pub_type
临床试验,杂志文章,随机对照试验相关文献
GUT文献大全abstract:BACKGROUND AND AIMS:While patients with Barrett's oesophagus develop oesophageal adenocarcinoma more frequently than the general population, it has controversially been suggested that gastro-oesophageal reflux (GORD) itself is a more important determinant of risk. In order to assess the validity of this suggestion, we ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.028076
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Gram negative septic events are the commonest source of morbidity and mortality as a result of surgery in jaundiced patients. The large intestine provides the major source of Gram negative bacteria in mammals and is implicated in the pathogenesis of systemic endotoxaemia in obstructive jaundice. Bile salts h...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.4.587
更新日期:1996-10-01 00:00:00
abstract::Twenty one patients with diabetic peripheral neuropathy, 18 with idiopathic faecal incontinence and 11 normal controls were studied with techniques of mucosal electrosensitivity, rectal distension for the quantitative assessment of anorectal sensation, and manometric and electromyographic tests for the assessment of a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.6.756
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Recently identified ABCG5/8 transporters are responsible in part for the different absorption rates of campesterol, sitosterol, and cholesterol. These transporters are also expressed in the liver and might regulate biliary sterol secretion. AIMS:This study was therefore conducted to determine the biliary se...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.51.6.860
更新日期:2002-12-01 00:00:00
abstract::A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.2.125
更新日期:1960-06-01 00:00:00
abstract::We have reviewed the outcome of all patients undergoing their first intestinal resection for Crohn's disease at this hospital between 1970 and 1987. Recurrence rates, defined by recurrent intestinal symptoms and radiological confirmation of mucosal disease, were calculated using survival analysis. Age, sex, anatomical...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.5.491
更新日期:1991-05-01 00:00:00
abstract::A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterolo...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2013-306578
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Surgical management of extrahepatic cholestasis is frequently complicated by bacterial translocation and severe liver injury. The aim of this study was to clarify the involvement of Toll-like receptors (TLRs) in the pathogenesis of bacterial translocation and liver injury in obstructive cholestasis....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.065318
更新日期:2006-01-01 00:00:00
abstract::Single angiodysplasias were demonstrated by preoperative angiography in four patients. In two cases the lesions were in the terminal ileum, and were situated just above the caecum in the other two patients. In three patients, contrast medium was extravasated into the bowel lumen. Histological verification was obtained...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.12.977
更新日期:1973-12-01 00:00:00
abstract::The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2_suppl.s36
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315201
更新日期:2018-10-01 00:00:00
abstract::Much research in the pathophysiology of gall stones has been devoted to various molecular species of bile salts. Recent findings have shown the importance of phospholipids in biliary pathophysiology. In the present study the addition of increasing doses of egg lecithin to human and model biles progressively prolonged ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.1.110
更新日期:1993-01-01 00:00:00
abstract::The epithelial-mesenchymal interface of the intestinal mucosa obviously plays an important role in supporting the mucosal architecture. Its significance for the process of migration and differentiation of the epithelial cells remains to be resolved. It consists of a basement membrane, the anchoring zone and the subepi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.suppl.143
更新日期:1987-01-01 00:00:00
abstract::The effect of sodium taurocholate instillation on the stimulated stomachs of patients with duodenal ulceration has been investigated. Instillation into the stomach of sodium taurocholate significantly reduced pentagastrin stimulated volume and outputs of both acid and sodium, with no change in the calculated volume of...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.1.28
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. AIMS:To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats. METHODS:Wistar rats, aged eight weeks, underwent 60% proximal resection or transection ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.1.89
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Colorectal carcinoids are often described as low-grade malignant. However, no study has compared the survival between patients with colorectal carcinoids and those with carcinomas, in a large series. In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2006.109157
更新日期:2007-06-01 00:00:00
abstract::The role of the proximal and distal stomach in the emptying of solids and liquids from the stomach remains unclear. We have used a dual isotope technique to quantify proximal and distal stomach emptying of a solid (100 g of 99mTc labelled liver/ground beef) liquid (either 200 ml of normal saline (eight subjects) or 25...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.6.615
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS:We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk ...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gutjnl-2015-309168
更新日期:2015-08-01 00:00:00
abstract::This study compares the gastroprotective effects of colloidal bismuth subcitrate (De-Nol) with those of sucralfate and a methylated analogue of prostaglandin E2 (PGE2) against acute gastric lesions induced by acidified aspirin and absolute ethanol in rats. Both De-Nol and sucralfate given orally prevented dose depende...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.2.201
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC) metastasis. DESIGN:We performed miRNA microarrays using primary CRC tissues from patients with and without metastasis, and validated selected candida...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2015-309372
更新日期:2016-06-01 00:00:00
abstract::Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.2.99
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The detrimental impact of opioid agonist on the clinical management of inflammatory diseases remains elusive. Given the anti-inflammatory properties of the mu-opioid receptor (MOR) agonists at the intestinal barrier, we hypothesised that MOR activation might also dampen acute hepatic inflammation an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2006.105122
更新日期:2007-07-01 00:00:00
abstract::Colonic exfoliated epithelial cells in faecal material provide a source of human DNA which has been analysed for the presence of the tumour marker ras, in order to detect early tumour cells. The stool samples were subjected to a preliminary sample preparation step followed by centrifugation. DNA was extracted from bot...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.1.81
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND AIMS:We followed a population based cohort of patients with inflammatory bowel disease (IBD) from Olmsted County, Minnesota, in order to analyse long term survival and cause specific mortality. MATERIAL AND METHODS:A total of 692 patients were followed for a median of 14 years. Standardised mortality ra...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.079350
更新日期:2006-09-01 00:00:00
abstract::Dysmotility of the duodenum and proximal jejunum has been reported in patients with irritable bowel syndrome. This study extended these findings by recording fasting ambulatory motility from electronic strain gauge sensors sited in the jejunum and ileum of eight diarrhoea predominant irritable bowel syndrome patients ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.203
更新日期:1994-02-01 00:00:00
abstract::The effects of sulphasalazine, 5-aminosalicylic acid (5-ASA), and sulphapyridine on peroxidation of red cell membrane lipids, measured as malondialdehyde production, were assessed. Sulphasalazine and 5-ASA, at concentrations of 10(-5)-10(-3) M significantly inhibit lipid peroxidation, suggesting an antioxidant action ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.10.1156
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. AIMS:To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. PATIENTS:Seventy patients wh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.083063
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.840
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Gastric acid secretion is downregulated by Helicobacter pylori infection and upregulated after its eradication, but the mechanisms are still unclear. We examined the effects of H pylori eradication on the number of parietal cells and on expression of molecules functioning in acid secretion in the hu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066464
更新日期:2006-02-01 00:00:00
abstract::Serrated polyps have been recognised in the last decade as important premalignant lesions accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical need for guidance on how to manage these lesions; however, the evidence base is limited. A working group was commission by the British Societ...
journal_title:Gut
pub_type: 杂志文章,实务指引,评审
doi:10.1136/gutjnl-2017-314005
更新日期:2017-07-01 00:00:00