Intestinal cells produce basement membrane proteins in vitro.

abstract：OBJECTIVE:The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant...

journal_title：Gut

authors： Gutiérrez A,Scharl M,Sempere L,Holler E,Zapater P,Almenta I,González-Navajas JM,Such J,Wiest R,Rogler G,Francés R

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...

journal_title：Gut

authors： Camilleri M

更新日期：1989-04-01 00:00:00

abstract：:'Tumour response', defined as clinical or radiological evidence of tumour shrinkage is frequently regarded as an objective of chemotherapy, rather than as a predictor of prolonged survival. This study has assessed whether a fall in the serum CEA concentration after chemotherapy for disseminated colorectal cancer is a ...

journal_title：Gut

authors： Allen-Mersh TG,Kemeny N,Niedzwiecki D,Shurgot B,Daly JM

更新日期：1987-12-01 00:00:00

abstract：:This paper describes the construction and use of "radio pills" which transmit changes in intraluminar pressure. ...

journal_title：Gut

authors： CONNELL AM,ROWLANDS EN

更新日期：1960-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Chemokines are small polypeptides, a major function of which is lymphocyte recruitment and trafficking. The aim of this study was to assess the involvement of inherited variations in CCR2, CCR5, and the ligand RANTES in determining disease outcome in hepatitis C virus (HCV) infected individuals. ME...

journal_title：Gut

authors： Goulding C,McManus R,Murphy A,MacDonald G,Barrett S,Crowe J,Hegarty J,McKiernan S,Kelleher D

更新日期：2005-08-01 00:00:00

abstract：:The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Crypt...

journal_title：Gut

authors： Phillips AD,Thomas AG,Walker-Smith JA

更新日期：1992-08-01 00:00:00

abstract：:To investigate the effects of supplemental oxygen on cardiac rhythm during gastroscopy, 103 patients aged over 60 were randomised to receive either supplemental oxygen or air at 2 litres/minute during the procedure. Pulse rate, blood pressure, oxygen saturation, and a Holter cardiac trace were monitored before, during...

journal_title：Gut

authors： Bowling TE,Hadjiminas CL,Polson RJ,Baron JH,Foale RA

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the pathophysiology of oesophageal pain syndromes and hiatus hernia formation. The aim of the current study was to elucidate further the mechanisms ...

journal_title：Gut

authors： Paterson WG,Miller DV,Dilworth N,Assini JB,Lourenssen S,Blennerhassett MG

更新日期：2007-10-01 00:00:00

abstract：:Liver biopsy is required when clinically important information about the diagnosis, prognosis or management of a patient cannot be obtained by safer means, or for research purposes. There are several approaches to liver biopsy but predominantly percutaneous or transvenous approaches are used. A wide choice of needles ...

journal_title：Gut

authors： Neuberger J,Patel J,Caldwell H,Davies S,Hebditch V,Hollywood C,Hubscher S,Karkhanis S,Lester W,Roslund N,West R,Wyatt JI,Heydtmann M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:A non-invasive test for assessment of fat digestion has been developed based on the intraluminal hydrolysis of cholesteryl-[1-13C]octanoate by pancreatic esterase. AIMS:To determine the diagnostic performance of this breath test in the assessment of exocrine pancreatic function. METHODS:The test was perfor...

journal_title：Gut

authors： Ventrucci M,Cipolla A,Ubalducci GM,Roda A,Roda E

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. AIM:To determine whether appendicectomy reduces the overall severity of ulcerative colitis. PATIENTS AND METHODS:Appendicectomy status and smoking habits were sp...

journal_title：Gut

authors： Cosnes J,Carbonnel F,Beaugerie L,Blain A,Reijasse D,Gendre JP

更新日期：2002-12-01 00:00:00

abstract：:Glucosamine synthetase, the first enzyme in glycoprotein synthesis, has been measured in serial rectal biopsies in four patients with membranous colitis. In two of the patients the levels of the enzyme were very high initially and in the other two patients the enzyme levels rose to a peak above the normal range after ...

journal_title：Gut

authors： Goodman MJ,Kent PW,Truelove SC

更新日期：1977-03-01 00:00:00

abstract：:A technique for obtaining needle aspiration cytology specimens from upper gastrointestinal lesions at endoscopy is described. The validity of the technique was initially confirmed by applying it to resected gastric carcinomas. Thirty seven endoscopically visualised lesions were then sampled by forceps biopsy, brush an...

journal_title：Gut

authors： Ingoldby CJ,Mason MK,Hall RI

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVE:In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment domain 9 (CARD9), a key innate immunity gene, is required to shape a normal gut microbiota. Card9-/- mice are more susceptible to the enteric mouse pathogen C...

journal_title：Gut

authors： Lamas B,Michel ML,Waldschmitt N,Pham HP,Zacharioudaki V,Dupraz L,Delacre M,Natividad JM,Costa GD,Planchais J,Sovran B,Bridonneau C,Six A,Langella P,Richard ML,Chamaillard M,Sokol H

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. OBJECTIVE:To d...

journal_title：Gut

authors： Asada K,Nakajima T,Shimazu T,Yamamichi N,Maekita T,Yokoi C,Oda I,Ando T,Yoshida T,Nanjo S,Fujishiro M,Gotoda T,Ichinose M,Ushijima T

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation i...

journal_title：Gut

authors： Tanaka S,Chu S,Hirokawa M,Montrose MH,Kaunitz JD

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Integrins are transmembrane cell surface receptors that mediate cell-cell and cell-matrix contacts. Integrin-linked kinase (ILK) is the binding partner of beta1 and beta3 integrins, and has been ascribed essential roles in development, angiogenesis and tumourigenesis. However, in vivo evidence for the latter...

journal_title：Gut

authors： Assi K,Mills J,Owen D,Ong C,St Arnaud R,Dedhar S,Salh B

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss). PATIENTS:A total of 266 patients, ...

journal_title：Gut

authors： Flink HJ,Sprengers D,Hansen BE,van Zonneveld M,de Man RA,Schalm SW,Janssen HL,HBV 99-01 Study Group.

更新日期：2005-11-01 00:00:00

abstract：:In June 1990 a survey of members of the endoscopy section of the British Society of Gastroenterology showed that 47% of respondents were offering some form of open access gastroscopy (OAG). Only 10% offered true (non-censored) OAG. The survey was repeated in June 1994. The overall provision of OAG had risen to 74%, mo...

journal_title：Gut

authors： Silcock JG,Bramble MG

更新日期：1997-02-01 00:00:00

abstract：:Patients with ulcerative colitis and coeliac disease who had been shown by impaired clearance of heat damaged red cells to have diminished splenic phagocytosis, were examined for evidence of more generalised reticuloendothelial malfunction by measuring their circulatory clearance of micro-aggregated albumin. Although ...

journal_title：Gut

authors： Palmer KR,Barber DC,Sherriff SB,Holdsworth CD

更新日期：1983-05-01 00:00:00

abstract：:There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD). OBJECTIVE:To conduct a systematic review and meta-analysis to identify a biomarker for idiopathic BAD in patients with functional bowel disorder (FBD) with diarrhoea. DESIGN:We searched multiple databases through 15 May 2015. Da...

journal_title：Gut

authors： Valentin N,Camilleri M,Altayar O,Vijayvargiya P,Acosta A,Nelson AD,Murad MH

更新日期：2016-12-01 00:00:00

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：:The possibility that the mode of action of sulphasalazine and its active metabolite 5-amino-salicylic acid (5ASA) involves modification of toxic oxygen metabolite production by neutrophils has been investigated by measuring the effect of these drugs on luminol-dependent chemiluminescence, superoxide release and oxygen...

journal_title：Gut

authors： Williams JG,Hallett MB

更新日期：1989-11-01 00:00:00

abstract：:Thirty two patients with empyema of the gall bladder were identified among 1327 cases of gall-bladder disease presenting to one hospital over a six year period. Abdominal pain had been present for a median of eight days and, in eight cases, for between one and four months. In a few cases, the disease was painless and ...

journal_title：Gut

authors： Thornton JR,Heaton KW,Espiner HJ,Eltringham WK

更新日期：1983-12-01 00:00:00

abstract：:We have determined the relative importance of day and night time gastric acid inhibition for duodenal ulcer healing by comparing the anti-ulcer efficacy of a single morning with that of a single bedtime dose of ranitidine. One hundred and thirty patients with active duodenal ulcer were randomly assigned to a double-bl...

journal_title：Gut

authors： Bianchi Porro G,Parente F,Sangaletti O

更新日期：1990-04-01 00:00:00

abstract：:Water and electrolyte balance has been studied in 39 patients with a permanent ileostomy, who had had a proctocolectomy for ulcerative colitis. The findings have been compared with those in 39 healthy subjects who were matched for age and sex. The ileostomists were found to lose excessive quantities of water and sodiu...

journal_title：Gut

authors： Kennedy HJ,Al-Dujaili EA,Edwards CR,Truelove SC

更新日期：1983-08-01 00:00:00

abstract：:The biomechanical properties of the oesophageal wall were investigated in a rabbit model using a four electrode impedance technique. A specially designed probe with the electrodes inside a low pressure expandable insulating latex balloon was introduced in the oesophagus. Stepwise inflation and deflation was done for a...

journal_title：Gut

authors： Gregersen H,Jensen LS,Djurhuus JC

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Assessing the presence and degree of intestinal inflammation objectively, simply, and reliably is a significant problem in gastroenterology. We assessed faecal excretion of calprotectin, a stable neutrophil specific marker, as an index of intestinal inflammation and its potential use as a screening ...

journal_title：Gut

authors： Tibble J,Teahon K,Thjodleifsson B,Roseth A,Sigthorsson G,Bridger S,Foster R,Sherwood R,Fagerhol M,Bjarnason I

更新日期：2000-10-01 00:00:00

abstract：:Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activ...

journal_title：Gut

authors： Henman FD

更新日期：1970-04-01 00:00:00

abstract：BACKGROUND:In human acute pancreatitis two different types of secretory phospholipase A2 (PLA2) have been found. AIM:To analyse the specific pattern of distribution of these PLA2 activities and their pathophysiological role in experimental acute pancreatitis. SUBJECTS AND METHODS:Catalytic activities of secretory typ...

journal_title：Gut

authors： Uhl W,Schrag HJ,Schmitter N,Nevalainen TJ,Aufenanger J,Wheatley AM,Büchler MW

更新日期：1997-03-01 00:00:00