Abstract:
:Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activity and caused no reduction in total acidity. Antipeptic activity of carbenoxolone has also been demonstrated in vitro using the pepsin plate technique and the haemoglobin pepsin assay.It is suggested that these actions of carbenoxolone may contribute to the increased rate of healing of peptic ulcer in patients treated with the drug.
journal_name
Gutjournal_title
Gutauthors
Henman FDdoi
10.1136/gut.11.4.344subject
Has Abstractpub_date
1970-04-01 00:00:00pages
344-51issue
4eissn
0017-5749issn
1468-3288journal_volume
11pub_type
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