HIV enteropathy: comparative morphometry of the jejunal mucosa of HIV infected patients resident in the United Kingdom and Uganda.

abstract：:This study compares the gastroprotective effects of colloidal bismuth subcitrate (De-Nol) with those of sucralfate and a methylated analogue of prostaglandin E2 (PGE2) against acute gastric lesions induced by acidified aspirin and absolute ethanol in rats. Both De-Nol and sucralfate given orally prevented dose depende...

journal_title：Gut

authors： Konturek SJ,Radecki T,Piastucki I,Brzozowski T,Drozdowicz D

更新日期：1987-02-01 00:00:00

abstract：:In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no ev...

journal_title：Gut

authors： Giles GR,Woodhouse L,Finan PJ,Chisholm EM

更新日期：1986-02-01 00:00:00

abstract：:Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absenc...

journal_title：Gut

authors： Robinson DC,Watson AJ,Wyatt EH,Marks JM,Roberts DF

更新日期：1971-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role of leptin and energy expenditure in CHC. Our aims were to analyse fatigue in CHC and to determine its relationship with diseas...

journal_title：Gut

authors： Piche T,Gelsi E,Schneider SM,Hébuterne X,Giudicelli J,Ferrua B,Laffont C,Benzaken S,Hastier P,Montoya ML,Longo F,Rampal P,Tran A

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Colonoscopy is the current reference standard for the detection of colorectal neoplasia, but nevertheless adenomas remain undetected. The Endocuff, an endoscopic cap with plastic projections, may improve colonic visualisation and adenoma detection. The aim of this study was to compare the mean numbe...

journal_title：Gut

authors： van Doorn SC,van der Vlugt M,Depla A,Wientjes CA,Mallant-Hent RC,Siersema PD,Tytgat K,Tuynman H,Kuiken SD,Houben G,Stokkers P,Moons L,Bossuyt P,Fockens P,Mundt MW,Dekker E

更新日期：2017-03-01 00:00:00

abstract：:Stimulation of the rectal mucosa with a bipolar electrode leads to relaxation of the internal anal sphincter. Intraoperative studies in two subjects showed that transmission of the impulse was independent of extrinsic nerves and was interrupted by circular myotomy. Characteristics of the reflex were studied in 11 heal...

journal_title：Gut

authors： Kamm MA,Lennard-Jones JE,Nicholls RJ

更新日期：1989-07-01 00:00:00

abstract：:Upper gastrointestinal function in response to a mixed nutrient meal was evaluated in hyperthyroid patients, both before and after therapy, and in healthy controls. Gastric secretion, gastric emptying, and pancreatic secretion were all normal and normally integrated postprandially in the hyperthyroid patients. Bile ac...

journal_title：Gut

authors： Miller LJ,Owyang C,Malagelada JR,Gorman CA,Go VL

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC) metastasis. DESIGN:We performed miRNA microarrays using primary CRC tissues from patients with and without metastasis, and validated selected candida...

journal_title：Gut

authors： Ling H,Pickard K,Ivan C,Isella C,Ikuo M,Mitter R,Spizzo R,Bullock M,Braicu C,Pileczki V,Vincent K,Pichler M,Stiegelbauer V,Hoefler G,Almeida MI,Hsiao A,Zhang X,Primrose J,Packham G,Liu K,Bojja K,Gafà R,Xiao L

更新日期：2016-06-01 00:00:00

abstract：:The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives ...

journal_title：Gut

authors： Markowitz MM,Rozen P,Pero RW,Tobi M,Miller DG

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:Assessment of disease extension and activity is crucial to guide treatment in Crohn's disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment. DESIGN:50 patients with clinically active (n = 35) or inactive (n = 15) Crohn's disease underwent ileocolo...

journal_title：Gut

authors： Rimola J,Rodriguez S,García-Bosch O,Ordás I,Ayala E,Aceituno M,Pellisé M,Ayuso C,Ricart E,Donoso L,Panés J

更新日期：2009-08-01 00:00:00

abstract：:A family is described in which there occurred two cases of the lupoid type of active chronic hepatitis with cirrhosis, one of chronic persistent hepatitis, and one of myasthenia gravis. The two cases of lupoid hepatitis were in the proposita, a schoolgirl aged 16 years, and her great-aunt aged 69 years whom she had ne...

journal_title：Gut

authors： Whittingham S,Mackay IR,Kiss ZS

更新日期：1970-10-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid cells 2 (TREM-2) is predominantly expressed in hepatic non-parenchymal cells and i...

journal_title：Gut

authors： Esparza-Baquer A,Labiano I,Sharif O,Agirre-Lizaso A,Oakley F,Rodrigues PM,Zhuravleva E,O'Rourke CJ,Hijona E,Jimenez-Agüero R,Riaño I,Landa A,La Casta A,Zaki MYW,Munoz-Garrido P,Azkargorta M,Elortza F,Vogel A,Schabbaue

更新日期：2020-09-09 00:00:00

abstract：AIM:The aim of this study was to implement an imaging protocol for positron emission tomography/computed tomography (PET/CT) colonography and to combine this protocol with whole body PET/CT tumour staging for a single whole body examination for routine clinical use. SUBJECTS AND METHODS:A whole body PET/CT protocol fo...

journal_title：Gut

authors： Veit P,Kühle C,Beyer T,Kuehl H,Herborn CU,Börsch G,Stergar H,Barkhausen J,Bockisch A,Antoch G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by perip...

journal_title：Gut

authors： Thoree VC,Golby SJ,Boursier L,Hackett M,Dunn-Walters DK,Sanderson JD,Spencer J

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) i...

journal_title：Gut

authors： Urribarri AD,Munoz-Garrido P,Perugorria MJ,Erice O,Merino-Azpitarte M,Arbelaiz A,Lozano E,Hijona E,Jiménez-Agüero R,Fernandez-Barrena MG,Jimeno JP,Marzioni M,Marin JJ,Masyuk TV,LaRusso NF,Prieto J,Bujanda L,Banales JM

更新日期：2014-10-01 00:00:00

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's ...

journal_title：Gut

authors： Stournaras E,Qian W,Pappas A,Hong YY,Shawky R,UK IBD BioResource Investigators.,Raine T,Parkes M,UK IBD Bioresource Investigators.

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:An increasing number of case reports indicate potential nephrotoxicity of 5-aminosalicylic acid (5-ASA), which shares similarities with the chemical structures of both phenacetin and acetylsalicylic acid. AIM:In a point prevalence study the occurrence of sensitive indices indicative of early kidney malfunct...

journal_title：Gut

authors： Schreiber S,Hämling J,Zehnter E,Howaldt S,Daerr W,Raedler A,Kruis W

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:The identification of gastric superficial cancerous lesions based on conventional white-light endoscopy (WLE) is challenging, and histological analysis remains the 'gold standard' for the final diagnosis. Confocal laser endomicroscopy (CLE) can provide in vivo histological observation without the need for bi...

journal_title：Gut

authors： Li WB,Zuo XL,Li CQ,Zuo F,Gu XM,Yu T,Chu CL,Zhang TG,Li YQ

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...

journal_title：Gut

authors： Sano M,Takahashi R,Ijichi H,Ishigaki K,Yamada T,Miyabayashi K,Kimura G,Mizuno S,Kato H,Fujiwara H,Nakatsuka T,Tanaka Y,Kim J,Masugi Y,Morishita Y,Tanaka M,Ushiku T,Nakai Y,Tateishi K,Ishii Y,Isayama H,Moses HL,

更新日期：2020-10-21 00:00:00

abstract：:This study was undertaken to determine the effect of cyclophosphamide, methotrexate, hydrocortisone, and cyclosporin A on a model of granulomatous infiltration in the terminal ileum and draining lymph nodes of the guinea pig. Treatment groups of six animals were used and compared to untreated groups of 12. Epithelioid...

journal_title：Gut

authors： Mitchell IC,Turk JL

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...

journal_title：Gut

authors： Bedossa P,Tordjman J,Aron-Wisnewsky J,Poitou C,Oppert JM,Torcivia A,Bouillot JL,Paradis V,Ratziu V,Clément K

更新日期：2017-09-01 00:00:00

abstract：:mu-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood-altering actions of opioids, and modulate numerous endogenous functions. To investigate the contribution of the kappa-opioid receptor (KOR) to opioid function in vivo, we have gene...

journal_title：Gut

authors： Black D,Trevethick M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND AIM:The treatment of ulcerative colitis (UC) with 5-aminosalicylic acid (5-ASA) does not have the same therapeutic effect in all patients. We tested the hypothesis that the effectiveness of the drug is related to its mucosal concentration. PATIENTS:Twenty one UC patients receiving oral 5-ASA (2.4-3.2 g/...

journal_title：Gut

authors： Frieri G,Giacomelli R,Pimpo M,Palumbo G,Passacantando A,Pantaleoni G,Caprilli R

更新日期：2000-09-01 00:00:00

abstract：:Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...

journal_title：Gut

authors： Kumana CR,Ng M,Lin HJ,Ko W,Wu PC,Todd D

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Many neuroendocrine gastrointestinal tumours express receptors for the regulatory peptide somatostatin. Among the five existing somatostatin receptor (sst) subtypes, sst2A is the most frequently expressed in these tumours. However, little information is available about the cellular location of sst2A...

journal_title：Gut

authors： Gugger M,Waser B,Kappeler A,Schonbrunn A,Reubi JC

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Caroli's disease is a rare congenital disorder characterised by cystic dilatation of the intrahepatic bile ducts and an increased risk of cholangiocellular carcinoma. The cause is unknown, but occasional familial clustering suggests that some cases are inherited, in particular when occurring in association w...

journal_title：Gut

authors： Parada LA,Hallén M,Hägerstrand I,Tranberg KG,Johansson B

更新日期：1999-11-01 00:00:00

abstract：:Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment. They act through diverse mechanisms affecting the composition or function of the commensal microbiota and by altering host epithelial and immunological responses. Certain probiotic interventions have shown prom...

journal_title：Gut

authors： Sanders ME,Guarner F,Guerrant R,Holt PR,Quigley EM,Sartor RB,Sherman PM,Mayer EA

更新日期：2013-05-01 00:00:00

abstract：:40749 RP is a pyridil-2-tetrahydrothiophene derivative, belonging to a new class of gastric antisecretory drugs. We compared its effects on gastric secretion with cimetidine. Intragastric acidity, nocturnal acid output, gastrin and pepsinogen-I profiles were measured in patients with duodenal ulcer in clinical remissi...

journal_title：Gut

authors： Malè PJ,Griessen M,Cunningham MG,Frydman AM,Garoflid-Oprescu NA,De Peyer R,Loizeau E

更新日期：1986-04-01 00:00:00

abstract：:In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...

journal_title：Gut

authors： Zargar SA,Khuroo MS,Mahajan R,Jan GM,Dewani K,Koul V

更新日期：1991-07-01 00:00:00