Abstract:
:In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no evidence, however, that some patients had a selectively increased ability to incorporate 5-FU into their tumours. Overall higher concentrations of tumour incorporation of 5-FU were found after bolus injection rather than the infusion method, although this difference is statistically not significant.
journal_name
Gutjournal_title
Gutauthors
Giles GR,Woodhouse L,Finan PJ,Chisholm EMdoi
10.1136/gut.27.2.176subject
Has Abstractpub_date
1986-02-01 00:00:00pages
176-81issue
2eissn
0017-5749issn
1468-3288journal_volume
27pub_type
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