Abstract:
BACKGROUND AND AIMS:Biliary lipid absorption by the gall bladder mucosa and the cholesterol content of the gall bladder wall appear to play a role in cholesterol gall stone formation. As the scavenger receptor class B type I (SR- BI) regulates cellular cholesterol uptake, we studied its expression in human and murine gall bladders, its regulation by increased biliary lipid content, and its role in gall stone formation. METHODS AND RESULTS:Using immunohistochemistry, SR-BI was found in the apical domain of human gall bladder epithelial cells. Immunoblotting of isolated membranes from gall bladder epithelial cells showed a specific signal for the 82 kDa SR-BI protein. In C57BL/6 mice, SR-BI was also found in the gall bladder epithelium. Using western blot analysis, an inverse relationship was observed between biliary cholesterol concentration and SR-BI expression in murine gall bladder mucosa. By comparing lithogenic diet fed wild-type and SR-BI deficient mice, gall bladder wall cholesterol content and gall stone formation were not found to be dependent on SR-BI expression. CONCLUSIONS:(i) SR-BI is expressed in both human and murine gall bladder epithelium; (ii) biliary cholesterol hypersecretion is associated with decreased gall bladder SR-BI expression in mice; and (iii) murine SR-BI is not essential in controlling gall bladder wall cholesterol content and gall stone formation during diet induced cholelithiasis.
journal_name
Gutjournal_title
Gutauthors
Miquel JF,Moreno M,Amigo L,Molina H,Mardones P,Wistuba II,Rigotti Adoi
10.1136/gut.52.7.1017keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1017-24issue
7eissn
0017-5749issn
1468-3288journal_volume
52pub_type
杂志文章相关文献
GUT文献大全abstract::The aim of this study was to develop and validate an endoscopic index for assessing the severity of Crohn's disease. Endoscopic findings were prospectively collected by a multicentre group in 75 patients with Crohn's colitis according to a previously validated procedure. The presence of nine preselected lesions was re...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/gut.30.7.983
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:Loss of surface maturation and cytonuclear atypia have been regarded as the pathological 'gold standard' for the diagnosis of oesophageal squamous cell intraepithelial neoplasia. However, there has been no satisfactory endomicroscopic method similar to this pathological approach to detect surface maturation a...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gutjnl-2011-301946
更新日期:2013-11-01 00:00:00
abstract::Glucagon-like peptide 1 does not comfortably fulfil the criterion of a gut derived factor responsible for an enhanced meal related insulin response; it appears logical to add the definition of a "physiological incretin hormone". ...
journal_title:Gut
pub_type: 评论,杂志文章
doi:10.1136/gut.2005.071787
更新日期:2006-02-01 00:00:00
abstract::A further patient with watery diarrhoea and hypokalaemia in association with a non-beta islet cell tumour of the pancreas is reported. The mechanism by which fluid and electrolyte losses are produced is discussed and cases previously reported are reviewed. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.11.911
更新日期:1970-11-01 00:00:00
abstract::This paper describes opacification and identification of two surgically constructed pancreatico-jujunal shunts. A fibreoptic panendoscope was used with retrograde injection via the ampulla of Vater (ERCP). This procedure makes possible more accurate anatomical evaluation and so more precise clinical appraisal of both...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.6.439
更新日期:1976-06-01 00:00:00
abstract::Fourteen apparently healthy patients with ileostomies were found to be depleted of total exchangeable sodium and potassium, but had normal serum electrolyte concentrations and normal extracellular fluid and total body water volumes. The low exchangeable sodium and potassiums were thus primarily due to depletion of the...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.6.563
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Although peroxisome proliferator activated receptor gamma (PPARgamma) agonists have been implicated in differentiation and growth inhibition of cancer cells, the potential therapeutic and chemopreventive effects on gastric cancer are poorly defined. We examined the in vitro and in vivo effects of PP...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.021105
更新日期:2004-03-01 00:00:00
abstract::The most striking effect of Clostridium difficile infection is its degrading of the intestinal barrier. The aim of this study is to establish whether the cellular or paracellular constituent of the barrier is the initial target of the toxins produced by C difficile. Accordingly, the caecal epithelium of C3H/He mice wa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.8.1087
更新日期:1989-08-01 00:00:00
abstract::Escherichia coli strains isolated from patients with Crohn's disease (CD) with chronic ileal lesions (n=14), early endoscopic recurrent lesions (n=20), without endoscopic recurrence (n=7), and controls (n=21) were compared by ribotyping. The dendrogram generated by 50 ribotype profile analysis revealed a large cluster...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.3.320
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Hypersensitivity of gastric afferent pathways may play an aetiological role in symptoms of functional dyspepsia. AIMS:To determine whether patients with severe organic dyspepsia (associated with tissue irritation/injury) and those with functional dyspepsia (no detectable tissue irritation) differ in their p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.6.814
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND AND AIMS:One of the key components of inflammation is changes in vascular structure and function. This suggests that the microcirculation may be a key target of Helicobacter pylori released factors. It has previously been shown in vivo that pooled H pylori extracts from duodenal ulcer/gastritis patients indu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.5.641
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:Magnetic resonance imaging (MRI) enables accurate assessment of inflammatory bowel diseases (IBD), but its main limitation is the need for bowel preparation. Diffusion-weighted imaging is feasible in Crohn's disease. We evaluated the accuracy of MRI in combination with diffusion-weighted imaging (DWI-MRI) wit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.197665
更新日期:2010-08-01 00:00:00
abstract:AIM:This prospective study aimed to compare the accuracy of echo enhanced ultrasound with spiral computed tomography (CT) in assessing acute pancreatitis and to explore the correlation between ultrasound findings and clinical outcome. METHODS:Thirty one patients (24 men and 7 women, median age 39 years, range 19-67 ye...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.070276
更新日期:2006-01-01 00:00:00
abstract::Thirty eight patients with Crohn's disease and 30 patients with ulcerative colitis have been assessed using the technique of faecal excretion of 111Indium granulocytes to quantify precisely acute inflammatory activity. At the time of each faecal granulocyte measurement the serum concentration of the acute phase protei...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.7.809
更新日期:1986-07-01 00:00:00
abstract::In an effort to assess connective tissue biosynthetic activity in human liver disease, collagen proline hydroxylase (a key enzyme in collagen biosynthesis) and the uptake of (35)S sulphate (a precursor of sulphated mucopolysaccharides) were measured in hepatic tissue obtained mainly by percutaneous biopsy.A procedure ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.4.260
更新日期:1974-04-01 00:00:00
abstract::As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.9.1173
更新日期:1988-09-01 00:00:00
abstract::Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microb...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2017-315542
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The diagnosis and classification of oesophageal motility disorders is currently based on assessment of the phasic contractile activity of the oesophagus. Tonic muscular contraction of the oesophageal body (oesophageal tone) has not been well characterised. AIM:To quantify oesophageal tonic activity in healt...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.3.291
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations. AIM AND METHODS:In all layers of the colon, nerve fibre densities of SP(+) and sympathetic nerve fibres were investigated (22 Crohn's disease, six diverticuliti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.125401
更新日期:2008-07-01 00:00:00
abstract::Synthetic 13-norleucine-motilin (13-nle-motilin), structural and biological analogue of the naturally-occurring duodenal polypeptide, motilin, is known to stimulate antral and duodenal motor activity in vitro, but delays gastric emptying in man. In this study the direct actions of the synthetic polypeptide on myoelect...
journal_title:Gut
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:The mechanisms underlying the suppression of somatostatin dependent reflexes in Helicobacter pylori infection are not fully determined. The H pylori product N alpha-methylhistamine and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) may be responsible for the alterations in somatostat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.176
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Large numbers of plasma cells (PC) localise in the intestinal lamina propria (LP) where they play a critical role in the defence against pathogens. This study analyses the level of maturation reached by normal human colon LPPC in comparison with that of bone marrow (BM) PC. METHODS:A technique was ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.3.383
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the onset of experimental colitis prevents intestinal inflammation by induction...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.193177
更新日期:2010-10-01 00:00:00
abstract:CLINICAL PRESENTATION:A 28-year-old woman presented with a 3-year history of chronic watery diarrhoea along with abdominal pain and bloating, which could mostly be alleviated after defecation. Her symptom of diarrhoea, at least three times a day, could be relieved by neither probiotics nor antidiarrhoeal agents. She ha...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316182
更新日期:2019-03-01 00:00:00
abstract::Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and has been suggested to maintain mucosal integrity through continuous generation of prostaglandins. COX-2 is induced pred...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.49.3.443
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.2.201
更新日期:2002-02-01 00:00:00
abstract::To determine the optimum dose of ispaghula husk in patients with irritable bowel syndrome (IBS) and to assess the correlation, if any between the relief in patients' symptoms and the whole gut transit time, and the increase in stool weight, a two part study was carried out. In part 1, 14 male patients were given ispag...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.28.2.150
更新日期:1987-02-01 00:00:00
abstract::A retrospective survey was undertaken of 228 resected Meckel's diverticula to determine if there was any evidence of Campylobacter pylori infection in diverticula containing gastric mucosa. Among the 65 diverticula with gastric mucosa one was heavily infected with organisms having the morphological appearances of C py...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.9.1233
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.6.862
更新日期:1999-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have b...
journal_title:Gut
pub_type:
doi:10.1136/gutjnl-2017-315068
更新日期:2018-02-01 00:00:00