Collagen proline hydroxylase activity and 35S sulphate uptake in human liver biopsies.

Abstract:

:In an effort to assess connective tissue biosynthetic activity in human liver disease, collagen proline hydroxylase (a key enzyme in collagen biosynthesis) and the uptake of (35)S sulphate (a precursor of sulphated mucopolysaccharides) were measured in hepatic tissue obtained mainly by percutaneous biopsy.A procedure is described for the quantitation of collagen proline hydroxylase in cryostat sections which allows for the simultaneous histopathological examination of the liver specimen. A three to eightfold increase in the activity of this enzyme was found in four cirrhotic livers compared with the mean value of four normal livers and two biopsies from patients with Gilbert's syndrome. Elevated hydroxylase levels were found also in five patients with hepatic dysfunction but without cirrhosis (four alcoholics and one patient with persistent hepatitis associated with serum smooth muscle antibody). It is suggested that the hepatic level of collagen proline hydroxylase may be a useful quantitative index of fibroblastic activity in human liver disease. Autoradiographic studies of radioactive sulphate uptake in biopsy specimens from patients with chronic liver disease showed an exaggerated incorporation of isotope not only at sites of established fibrogenesis but also in the walls of sinusoids throughout the liver.

journal_name

Gut

journal_title

Gut

authors

McGee JO,Patrick RS,Rodger MC,Luty CM

doi

10.1136/gut.15.4.260

subject

Has Abstract

pub_date

1974-04-01 00:00:00

pages

260-7

issue

4

eissn

0017-5749

issn

1468-3288

journal_volume

15

pub_type

杂志文章

相关文献

GUT文献大全
  • Elution of cytomegalovirus antibodies from adenocarcinoma of the colon.

    abstract::Eluates were prepared by high salt extraction from normal colonic mucosa and adenocarcinomatous tissue from 28 patients, eight more from unmatched colonic tissue and five from patients with other gastrointestinal disease. Immunoglobulins were detected by ELISA: IgG was present in 24% eluates from normal colon and 21% ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.10.1053

    authors: Grail A,Norval M

    更新日期:1985-10-01 00:00:00

  • Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy.

    abstract::This prospective study aimed to determine the prevalence of Helicobacter pylori infection in relation to the occurrence and severity of NSAIDs induced gastropathy. A total of 111 patients were studied-66 were taking NSAIDs and 45 were control patients. All patients underwent endoscopy during which antral biopsy specim...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.12.1608

    authors: Heresbach D,Raoul JL,Bretagne JF,Minet J,Donnio PY,Ramée MP,Siproudhis L,Gosselin M

    更新日期:1992-12-01 00:00:00

  • Effect of secretogogues on mucosal blood flow in the antrum and corpus of the stomach.

    abstract::Gastric mucosal blood flow in the rat was determined by the indicator fractionation technique of Sapirstein using Rb86Cl. Antral and corpus flow rates were determined in response to increasing doses of pentagastrin and histamine and the effect of vagotomy was determined. With progressive stimulation the antral:corpus ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.19.1.14

    authors: Taylor TV,Pullan BR,Goddard J,Torrance B

    更新日期:1978-01-01 00:00:00

  • Absent ileal uptake of IF-bound vitamin B12 in vivo in the Imerslund-Grasbeck syndrome (familial vitamin B12 malabsorption with proteinuria).

    abstract::A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient an...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.3.311

    authors: Burman JF,Jenkins WJ,Walker-Smith JA,Phillips AD,Sourial NA,Williams CB,Mollin DL

    更新日期:1985-03-01 00:00:00

  • Interval cancers after negative colonoscopy: population-based case-control study.

    abstract:OBJECTIVE:The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy. METHODS:A population-based case-control study was conducted in Southern Germany in 2003-...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-301531

    authors: Brenner H,Chang-Claude J,Seiler CM,Hoffmeister M

    更新日期:2012-11-01 00:00:00

  • Post-ERP pancreatitis as a model for cytokine induced acute phase response in acute pancreatitis.

    abstract:BACKGROUND/AIMS:By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to determine whether endoscopic retrograde cholangiopancreaticography (ERP)-induced pancreatitis can be used as a human model fo...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.40.1.80

    authors: Messmann H,Vogt W,Holstege A,Lock G,Heinisch A,von Fürstenberg A,Leser HG,Zirngibl H,Schölmerich J

    更新日期:1997-01-01 00:00:00

  • Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.

    abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320608

    authors: Sano M,Takahashi R,Ijichi H,Ishigaki K,Yamada T,Miyabayashi K,Kimura G,Mizuno S,Kato H,Fujiwara H,Nakatsuka T,Tanaka Y,Kim J,Masugi Y,Morishita Y,Tanaka M,Ushiku T,Nakai Y,Tateishi K,Ishii Y,Isayama H,Moses HL,

    更新日期:2020-10-21 00:00:00

  • Bile acid concentrations in the gastric juice of patients with erosive oesophagitis.

    abstract::Intragastric total bile acid concentrations were measured before and after a corn oil test meal in 16 patients with erosive oesophagitis and symptoms of gastro-oesophageal reflux. Sixteen age and sex matched control subjects were also studied. No significant difference was detected between fasting or postprandial gast...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.5.495

    authors: Collins BJ,Crothers G,McFarland RJ,Love AH

    更新日期:1985-05-01 00:00:00

  • Effect of protein and lactulose on the production of gamma-aminobutyric acid by faecal Escherichia coli.

    abstract::The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.9.1007

    authors: al Mardini H,al Jumaili B,Record CO,Burke D

    更新日期:1991-09-01 00:00:00

  • Double-blind controlled trial of amylopectin sulphate (Depepsen) in the symptomatic treatment of duodenal ulcer.

    abstract::In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.18.9.723

    authors: Baron JH,Gribble RJ,Holdstock DJ,Misiewicz JJ

    更新日期:1977-09-01 00:00:00

  • Acid, motility, and ulcers: a comparison of cisapride with placebo in the prevention of duodenal ulcer relapse.

    abstract::In a single centre double blind study of 66 patients, the value of cisapride (10 mg twice daily) was compared with placebo in the prevention of duodenal ulcer relapse. Patients who remained ulcer free attended for clinical review every two months and had a mandatory endoscopy at 0, 4, 8, and 12 months or if symptoms s...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.34.8.1042

    authors: Kerrigan DD,Taylor ME,Read NW,Johnson AG

    更新日期:1993-08-01 00:00:00

  • Relation between GB virus C/hepatitis G virus and fulminant hepatic failure may be secondary to treatment with contaminated blood and/or blood products.

    abstract:BACKGROUND:The role of the recently discovered GB virus C (GBV-C)/hepatitis G virus in fulminant hepatic failure (FHF) has been debated. Although GBV-C RNA has been detected in many cases of FHF, recent data suggest that the relation between GBV-C and FHF may be accidental. AIMS:To retrospectively investigate the poss...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.44.2.274

    authors: Halasz R,Barkholt L,Lara C,Hultgren C,Ando Y,Broomé U,Fischler B,Nemeth A,Ericzon BG,Sönnerborg A,Sällberg M

    更新日期:1999-02-01 00:00:00

  • Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis?

    abstract:BACKGROUND:In hereditary pancreatitis mutations of exons 2 (N21I) and 3 (R117H) of the cationic trypsinogen gene have been described. AIMS:To investigate whether the same mutations can also be found in patients with chronic alcoholic pancreatitis. METHODS:Leucocyte DNA was prepared from 23 patients with chronic alcoh...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.44.3.413

    authors: Teich N,Mössner J,Keim V

    更新日期:1999-03-01 00:00:00

  • Restorative proctocolectomy and pouch anal anastomosis for ulcerative colitis following orthotopic liver transplantation.

    abstract::This study reports on the outcome of four patients having ileal pouch anal anastomosis after orthotopic liver transplantation for sclerosing cholangitis complicating ulcerative colitis. There were no deaths on follow up. Early postoperative bleeding was a complication of colectomy or rectal excision in three, one of w...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.37.6.845

    authors: Rowley S,Candinas D,Mayer AD,Buckels JA,McMaster P,Keighley MR

    更新日期:1995-12-01 00:00:00

  • Feasibility of family based screening for colorectal neoplasia: experience in one general surgical practice.

    abstract::Relatives of patients with colorectal cancer have on average a two to threefold increased risk for developing bowel neoplasia although in some families the risk is much higher. This study examined the compliance for endoscopic screening and faecal occult blood testing among first degree relatives of patients with colo...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.1.96

    authors: Stephenson BM,Murday VA,Finan PJ,Quirke P,Dixon MF,Bishop DT

    更新日期:1993-01-01 00:00:00

  • Second infection with a different hepatitis C virus genotype in a intravenous drug user during interferon therapy.

    abstract::The prevalence of antibodies against hepatitis C virus (anti-HCV) among intravenous drug users (IVDU) has consistently been very high. Cross challenge studies in chimpanzees provide evidence that reinfection with different HCV strains may occur. In humans, reinfection with different HCV strains has been reported in mu...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.52.6.900

    authors: Asselah T,Vidaud D,Doloy A,Boyer N,Martinot M,Vidaud M,Valla D,Marcellin P

    更新日期:2003-06-01 00:00:00

  • Elevated plasma osteopontin associated with gastric cancer development, invasion and survival.

    abstract:OBJECTIVE:Osteopontin (OPN) has been found to be valuable in diagnosis and predicting the prognosis of a variety of malignancies. The aims of the present study are to evaluate the usefulness of plasma OPN level for predicting gastric cancer development, invasion and survival. PATIENTS AND METHODS:One hundred and thirt...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2006.109868

    authors: Wu CY,Wu MS,Chiang EP,Wu CC,Chen YJ,Chen CJ,Chi NH,Chen GH,Lin JT

    更新日期:2007-06-01 00:00:00

  • Autonomic dysfunction in gastrointestinal motility disorders.

    abstract::The records of 113 consecutive patients with a suspected gastrointestinal motility disorder referred between January 1988 and July 1991 were retrospectively reviewed. The aims were to identify the prevalence of autonomic dysfunction in those with or without associated neurological disease and to determine the diagnost...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.34.3.397

    authors: Bharucha AE,Camilleri M,Low PA,Zinsmeister AR

    更新日期:1993-03-01 00:00:00

  • Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.

    abstract:OBJECTIVE:To investigate the potential tumour suppressor functions of glutathione peroxidase 7 (GPX7) and examine the interplay between epigenetic and genetic events in regulating its expression in oesophageal adenocarcinomas (OAC). DESIGN:In vitro and in vivo cell models were developed to investigate the biological a...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2013-304612

    authors: Peng D,Hu T,Soutto M,Belkhiri A,Zaika A,El-Rifai W

    更新日期:2014-04-01 00:00:00

  • Duodenal bile examination in identifying potential non-responders to bile salt treatment and its comparison with gall bladder bile examination.

    abstract::The results of bile salt treatment in patients with radiolucent stones and a functioning gall bladder have been poor. In 42 of these patients awaiting cholecystectomy we determined the value of duodenal bile examination in predicting gall stone composition, and thus identifying those less likely to respond to bile sal...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.1.112

    authors: Agarwal DK,Choudhuri G,Saraswat VA,Negi TS,Kapoor VK,Saxena R

    更新日期:1994-01-01 00:00:00

  • Effects of cisapride on gastric emptying of oil and aqueous meal components, hunger, and fullness.

    abstract::To evaluate the effects of cisapride on gastric emptying of extracellular fat and hunger and fullness 10 volunteers consumed a meal consisting of 60 ml technectium-99m (99mTc)-V-thiocyanate labelled olive oil and 290 ml indium-113m (113mIn) labelled soup after taking cisapride (10 mg four times daily orally) and place...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.38.3.310

    authors: Jones KL,Horowitz M,Carney BI,Sun WM,Chatterton BE

    更新日期:1996-03-01 00:00:00

  • Impact of sustained virological response on the extrahepatic manifestations of chronic hepatitis C: a meta-analysis.

    abstract:BACKGROUND AND AIMS:Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-c...

    journal_title:Gut

    pub_type: 杂志文章,meta分析

    doi:10.1136/gutjnl-2018-316234

    authors: Cacoub P,Desbois AC,Comarmond C,Saadoun D

    更新日期:2018-11-01 00:00:00

  • Short chain fatty acids in human large intestine, portal, hepatic and venous blood.

    abstract::Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within fou...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.10.1221

    authors: Cummings JH,Pomare EW,Branch WJ,Naylor CP,Macfarlane GT

    更新日期:1987-10-01 00:00:00

  • Ranitidine increases the bioavailability of postprandial ethanol by the reduction of first pass metabolism.

    abstract::Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...

    journal_title:Gut

    pub_type: 临床试验,杂志文章

    doi:10.1136/gut.37.3.413

    authors: Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OF

    更新日期:1995-09-01 00:00:00

  • Paraproteins with antibody activity in acute viral hepatitis and chronic autoimmune liver diseases.

    abstract::Of 27 patients with liver disease and cryoglobulinaemia 18 proved to have paraproteins. Six of these monoclonal immunoglobulins were shown to have antibody activity, directed to human gamma globulin, alpha(1)-fetoprotein, smooth muscle, and mitochondria.Eight of the patients suffered from acute viral hepatitis, five o...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.15.5.396

    authors: Roux ME,Florin-Christensen A,Arana RM,Doniach D

    更新日期:1974-05-01 00:00:00

  • Hepatocellular carcinoma in Central Europe: prognostic features and survival.

    abstract:BACKGROUND AND AIMS:We investigated the influence of baseline characteristics of patients with hepatocellular carcinoma (HCC) on prognosis and developed a multivariate Cox model predicting survival. All patients were from Central Europe. METHODS:All 245 patients seen at the Department of Gastroenterology and Hepatolog...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.48.1.103

    authors: Schöniger-Hekele M,Müller C,Kutilek M,Oesterreicher C,Ferenci P,Gangl A

    更新日期:2001-01-01 00:00:00

  • The effects of corticotrophin and corticoids on secretion from denervated gastric pouches in dogs.

    abstract::The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.1.1.36

    authors: CLARKE SD,NEILL DW,WELBOURN RB

    更新日期:1960-03-01 00:00:00

  • Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis.

    abstract:OBJECTIVE:Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2016-312888

    authors: Sierra JC,Asim M,Verriere TG,Piazuelo MB,Suarez G,Romero-Gallo J,Delgado AG,Wroblewski LE,Barry DP,Peek RM Jr,Gobert AP,Wilson KT

    更新日期:2018-07-01 00:00:00

  • Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion.

    abstract:BACKGROUND:Recently identified ABCG5/8 transporters are responsible in part for the different absorption rates of campesterol, sitosterol, and cholesterol. These transporters are also expressed in the liver and might regulate biliary sterol secretion. AIMS:This study was therefore conducted to determine the biliary se...

    journal_title:Gut

    pub_type: 临床试验,杂志文章

    doi:10.1136/gut.51.6.860

    authors: Sudhop T,Sahin Y,Lindenthal B,Hahn C,Lüers C,Berthold HK,von Bergmann K

    更新日期:2002-12-01 00:00:00

  • Portopulmonary hypertension in decompensated cirrhosis with refractory ascites.

    abstract:BACKGROUND:The prevalence of portopulmonary hypertension (PPHTN) in patients with cirrhosis and refractory ascites is unknown. Its presence may preclude patients from receiving a transjugular intrahepatic portosystemic shunt or liver transplantation as a definitive treatment for their end stage cirrhosis. PURPOSE:To d...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.52.9.1355

    authors: Benjaminov FS,Prentice M,Sniderman KW,Siu S,Liu P,Wong F

    更新日期:2003-09-01 00:00:00