Abstract:
:In an effort to assess connective tissue biosynthetic activity in human liver disease, collagen proline hydroxylase (a key enzyme in collagen biosynthesis) and the uptake of (35)S sulphate (a precursor of sulphated mucopolysaccharides) were measured in hepatic tissue obtained mainly by percutaneous biopsy.A procedure is described for the quantitation of collagen proline hydroxylase in cryostat sections which allows for the simultaneous histopathological examination of the liver specimen. A three to eightfold increase in the activity of this enzyme was found in four cirrhotic livers compared with the mean value of four normal livers and two biopsies from patients with Gilbert's syndrome. Elevated hydroxylase levels were found also in five patients with hepatic dysfunction but without cirrhosis (four alcoholics and one patient with persistent hepatitis associated with serum smooth muscle antibody). It is suggested that the hepatic level of collagen proline hydroxylase may be a useful quantitative index of fibroblastic activity in human liver disease. Autoradiographic studies of radioactive sulphate uptake in biopsy specimens from patients with chronic liver disease showed an exaggerated incorporation of isotope not only at sites of established fibrogenesis but also in the walls of sinusoids throughout the liver.
journal_name
Gutjournal_title
Gutauthors
McGee JO,Patrick RS,Rodger MC,Luty CMdoi
10.1136/gut.15.4.260subject
Has Abstractpub_date
1974-04-01 00:00:00pages
260-7issue
4eissn
0017-5749issn
1468-3288journal_volume
15pub_type
杂志文章相关文献
GUT文献大全abstract::Eluates were prepared by high salt extraction from normal colonic mucosa and adenocarcinomatous tissue from 28 patients, eight more from unmatched colonic tissue and five from patients with other gastrointestinal disease. Immunoglobulins were detected by ELISA: IgG was present in 24% eluates from normal colon and 21% ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.10.1053
更新日期:1985-10-01 00:00:00
abstract::This prospective study aimed to determine the prevalence of Helicobacter pylori infection in relation to the occurrence and severity of NSAIDs induced gastropathy. A total of 111 patients were studied-66 were taking NSAIDs and 45 were control patients. All patients underwent endoscopy during which antral biopsy specim...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.12.1608
更新日期:1992-12-01 00:00:00
abstract::Gastric mucosal blood flow in the rat was determined by the indicator fractionation technique of Sapirstein using Rb86Cl. Antral and corpus flow rates were determined in response to increasing doses of pentagastrin and histamine and the effect of vagotomy was determined. With progressive stimulation the antral:corpus ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.1.14
更新日期:1978-01-01 00:00:00
abstract::A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.3.311
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy. METHODS:A population-based case-control study was conducted in Southern Germany in 2003-...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301531
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND/AIMS:By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to determine whether endoscopic retrograde cholangiopancreaticography (ERP)-induced pancreatitis can be used as a human model fo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.1.80
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320608
更新日期:2020-10-21 00:00:00
abstract::Intragastric total bile acid concentrations were measured before and after a corn oil test meal in 16 patients with erosive oesophagitis and symptoms of gastro-oesophageal reflux. Sixteen age and sex matched control subjects were also studied. No significant difference was detected between fasting or postprandial gast...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.5.495
更新日期:1985-05-01 00:00:00
abstract::The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.9.1007
更新日期:1991-09-01 00:00:00
abstract::In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.18.9.723
更新日期:1977-09-01 00:00:00
abstract::In a single centre double blind study of 66 patients, the value of cisapride (10 mg twice daily) was compared with placebo in the prevention of duodenal ulcer relapse. Patients who remained ulcer free attended for clinical review every two months and had a mandatory endoscopy at 0, 4, 8, and 12 months or if symptoms s...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.8.1042
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:The role of the recently discovered GB virus C (GBV-C)/hepatitis G virus in fulminant hepatic failure (FHF) has been debated. Although GBV-C RNA has been detected in many cases of FHF, recent data suggest that the relation between GBV-C and FHF may be accidental. AIMS:To retrospectively investigate the poss...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.2.274
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:In hereditary pancreatitis mutations of exons 2 (N21I) and 3 (R117H) of the cationic trypsinogen gene have been described. AIMS:To investigate whether the same mutations can also be found in patients with chronic alcoholic pancreatitis. METHODS:Leucocyte DNA was prepared from 23 patients with chronic alcoh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.3.413
更新日期:1999-03-01 00:00:00
abstract::This study reports on the outcome of four patients having ileal pouch anal anastomosis after orthotopic liver transplantation for sclerosing cholangitis complicating ulcerative colitis. There were no deaths on follow up. Early postoperative bleeding was a complication of colectomy or rectal excision in three, one of w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.6.845
更新日期:1995-12-01 00:00:00
abstract::Relatives of patients with colorectal cancer have on average a two to threefold increased risk for developing bowel neoplasia although in some families the risk is much higher. This study examined the compliance for endoscopic screening and faecal occult blood testing among first degree relatives of patients with colo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.1.96
更新日期:1993-01-01 00:00:00
abstract::The prevalence of antibodies against hepatitis C virus (anti-HCV) among intravenous drug users (IVDU) has consistently been very high. Cross challenge studies in chimpanzees provide evidence that reinfection with different HCV strains may occur. In humans, reinfection with different HCV strains has been reported in mu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.900
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:Osteopontin (OPN) has been found to be valuable in diagnosis and predicting the prognosis of a variety of malignancies. The aims of the present study are to evaluate the usefulness of plasma OPN level for predicting gastric cancer development, invasion and survival. PATIENTS AND METHODS:One hundred and thirt...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2006.109868
更新日期:2007-06-01 00:00:00
abstract::The records of 113 consecutive patients with a suspected gastrointestinal motility disorder referred between January 1988 and July 1991 were retrospectively reviewed. The aims were to identify the prevalence of autonomic dysfunction in those with or without associated neurological disease and to determine the diagnost...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.3.397
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:To investigate the potential tumour suppressor functions of glutathione peroxidase 7 (GPX7) and examine the interplay between epigenetic and genetic events in regulating its expression in oesophageal adenocarcinomas (OAC). DESIGN:In vitro and in vivo cell models were developed to investigate the biological a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-304612
更新日期:2014-04-01 00:00:00
abstract::The results of bile salt treatment in patients with radiolucent stones and a functioning gall bladder have been poor. In 42 of these patients awaiting cholecystectomy we determined the value of duodenal bile examination in predicting gall stone composition, and thus identifying those less likely to respond to bile sal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.1.112
更新日期:1994-01-01 00:00:00
abstract::To evaluate the effects of cisapride on gastric emptying of extracellular fat and hunger and fullness 10 volunteers consumed a meal consisting of 60 ml technectium-99m (99mTc)-V-thiocyanate labelled olive oil and 290 ml indium-113m (113mIn) labelled soup after taking cisapride (10 mg four times daily orally) and place...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.38.3.310
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-c...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316234
更新日期:2018-11-01 00:00:00
abstract::Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within fou...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.10.1221
更新日期:1987-10-01 00:00:00
abstract::Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.37.3.413
更新日期:1995-09-01 00:00:00
abstract::Of 27 patients with liver disease and cryoglobulinaemia 18 proved to have paraproteins. Six of these monoclonal immunoglobulins were shown to have antibody activity, directed to human gamma globulin, alpha(1)-fetoprotein, smooth muscle, and mitochondria.Eight of the patients suffered from acute viral hepatitis, five o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.5.396
更新日期:1974-05-01 00:00:00
abstract:BACKGROUND AND AIMS:We investigated the influence of baseline characteristics of patients with hepatocellular carcinoma (HCC) on prognosis and developed a multivariate Cox model predicting survival. All patients were from Central Europe. METHODS:All 245 patients seen at the Department of Gastroenterology and Hepatolog...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.1.103
更新日期:2001-01-01 00:00:00
abstract::The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.1.36
更新日期:1960-03-01 00:00:00
abstract:OBJECTIVE:Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312888
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Recently identified ABCG5/8 transporters are responsible in part for the different absorption rates of campesterol, sitosterol, and cholesterol. These transporters are also expressed in the liver and might regulate biliary sterol secretion. AIMS:This study was therefore conducted to determine the biliary se...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.51.6.860
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:The prevalence of portopulmonary hypertension (PPHTN) in patients with cirrhosis and refractory ascites is unknown. Its presence may preclude patients from receiving a transjugular intrahepatic portosystemic shunt or liver transplantation as a definitive treatment for their end stage cirrhosis. PURPOSE:To d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.9.1355
更新日期:2003-09-01 00:00:00