Abstract:
:Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time curve, were significantly higher in the ranitidine group after oral, but not intravenous, ethanol administration. The first pass metabolism, as calculated by the difference between the area under the curves, was significantly lower in the ranitidine group. In addition, all subjects withdrawn from ranitidine (n = 6) had a significant reduction in peak blood ethanol concentration and area under the curve after repeat dosing with oral ethanol. Both groups were well matched for age, sex, indications for endoscopy, findings at endoscopy, and gastric histology. These findings show that ranitidine increases the bioavailability of low dose ethanol and has possible short term forensic, and longterm physical implications for moderate drinkers who are taking the drug.
journal_name
Gutjournal_title
Gutauthors
Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OFdoi
10.1136/gut.37.3.413subject
Has Abstractpub_date
1995-09-01 00:00:00pages
413-7issue
3eissn
0017-5749issn
1468-3288journal_volume
37pub_type
临床试验,杂志文章相关文献
GUT文献大全abstract:BACKGROUND/AIM:The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. METHODS:Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.3.374
更新日期:1996-09-01 00:00:00
abstract::The effect of sulphasalazine and olsalazine on jejunal and ileal water and electrolyte absorption was investigated in normal subjects by a steady state intestinal perfusion of a physiological glucose bicarbonate electrolyte solution in the absence and presence of increasing concentrations of each drug. (Olsalazine 0.2...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.3.270
更新日期:1991-03-01 00:00:00
abstract::Human cholera is associated with an increased luminal release of prostaglandin E2 (PGE2), but whether inhibition of increased PGE2 synthesis will reduce or control intestinal secretion is uncertain. 'Steady state' perfusions (10 ml/minute) in 12 patients with acute cholera, and repeat perfusions in nine of these patie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.5.643
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVES:To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN:A randomised, double-blind, double-dummy, parallel group, multicentre, international, ph...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2008.154302
更新日期:2009-02-01 00:00:00
abstract::An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.34.4.567
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) is initiated and perpetuated by a dysregulated immune response to unknown environmental antigens such as luminal bacteria in genetically susceptible hosts. SR-PSOX/CXCL16, a scavenger receptor that binds phosphatidylserine and oxidised lipoprotein, has both phagocyti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.221879
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. DESIGN:RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working gr...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2017-315333
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Precancerous lesion, a well-established histopathologically premalignant tissue with the highest risk for tumourigenesis, develops preferentially from activation of DNA damage checkpoint and persistent inflammation. However, little is known about the mechanisms by which precancerous lesions are initiated and ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310318
更新日期:2016-07-01 00:00:00
abstract::Previous experimental studies suggest that bile salt-induced colonic fluid secretion is mediated by adenosine 3':5'-phosphate (cyclic AMP). Two biopsy specimens of colonic mucosa were obtained endoscopically before and after different periods of therapy (five, 10, or 15 days), from each of 21 patients receiving chenod...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.20.6.489
更新日期:1979-06-01 00:00:00
abstract::Endoscopic sphincterotomy has become the first line treatment for patients with common bile duct (CBD) stones. This technique may fail, however, due to difficult anatomy, previous surgery, periampullary diverticula or the presence of a large stone. The importance of stone size to the success of endoscopic sphincteroto...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.12.1718
更新日期:1993-12-01 00:00:00
abstract::The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall st...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.6.860
更新日期:1989-06-01 00:00:00
abstract::A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.1.51
更新日期:1970-01-01 00:00:00
abstract:BACKGROUND AND AIMS:While patients with Barrett's oesophagus develop oesophageal adenocarcinoma more frequently than the general population, it has controversially been suggested that gastro-oesophageal reflux (GORD) itself is a more important determinant of risk. In order to assess the validity of this suggestion, we ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.028076
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on intestinal perm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-305690
更新日期:2014-08-01 00:00:00
abstract::We determined the ionic composition of faecal fluid from 13 patients with Crohn's disease limited to the colon, 10 with diffuse ulcerative colitis, and eight with ulcerative proctitis. The Crohn's and colitis groups had similar proportions of colon surface involved radiographically and similar 24 hour faecal weights. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.4.326
更新日期:1982-04-01 00:00:00
abstract::There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD). OBJECTIVE:To conduct a systematic review and meta-analysis to identify a biomarker for idiopathic BAD in patients with functional bowel disorder (FBD) with diarrhoea. DESIGN:We searched multiple databases through 15 May 2015. Da...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gutjnl-2015-309889
更新日期:2016-12-01 00:00:00
abstract::Chronic alcohol consumption induces cytochrome P450IIE1, enabling habitual abusers to consume far greater quantities of alcohol than normal subjects. This pathway of metabolism leads to the production of free radical species, which cause tissue damage through peroxidation of cell membranes. Groups of Wistar rats of eq...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.11.1644
更新日期:1994-11-01 00:00:00
abstract::One hundred patients who had undergone operation for duodenal ulcer (68 vagotomy and gastroenterostomy; seven vagotomy and pyloroplasty; 22 gastrectomy and three gastroenterostomy) 10 or more years previously each underwent endoscopy. Biopsies were taken and gastric juice aspirated for measurement of pH and nitrite co...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.3.246
更新日期:1984-03-01 00:00:00
abstract::The extent to which defects in protein synthesis occurred in an experimental indomethacin induced rat model of nonsteroidal enteropathy has been examined. Male rats (nine) were fed indomethacin (8 mg/kg/day) for three days mixed with a powdered form of chow. The control group of rats (nine) were fed the same diet for ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.2.242
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Chronic idiopathic intestinal pseudo-obstruction (CIIP) is characterised by severe impairment of intestinal propulsive motility that mimics bowel obstruction. JC virus (JCV) is a polyomavirus that can infect brain glial cells causing a fatal disease, but may also be found throughout the normal gastr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.152512
更新日期:2009-01-01 00:00:00
abstract::Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization ind...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.3.166
更新日期:1972-03-01 00:00:00
abstract::We investigated the distribution of the collagen band in 33 patients with collagenous colitis to estimate the likelihood of the disease being diagnosed in biopsy specimens from the left side of the colon, such as those obtained using flexible sigmoidoscopy. To be included in this study patients had a subepithelial col...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.1.65
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence of a G-->A substitution at nucleotide 113, was associated with susceptib...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066621
更新日期:2005-10-01 00:00:00
abstract::This report presents a patient with proximal small bowel cystic pneumatosis associated with poorly controlled coeliac disease and pseudo-obstruction. Cystic pneumatosis is rare in the proximal small bowel and we can find no report of its occurrence in association with coeliac disease. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.6.852
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321609
更新日期:2020-12-17 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300717
更新日期:2012-11-01 00:00:00
abstract::Studies have been made of mucus glycoprotein biosynthesis in different regions of the lower gastrointestinal tract in normal patients and those with ulcerative colitis (UC), active or inactive, by means of 3H-glucosamine (3H-GlcNH2)--35S-sulphate double labelling of epithelial biopsy specimens under culture conditions...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.7.926
更新日期:1993-07-01 00:00:00
abstract::Helicobacter pylori causes chronic (type B) gastritis. The 'intestinal' form of gastric cancer arises against a background of chronic gastritis, and prospective epidemiological studies have shown that H pylori is a major risk factor for this. An increase in mucosal cell proliferation increases the likelihood of a neop...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.3.346
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm. This is illustrated by the non-neoplastic gastric-type heteroplasias present at birth in the pericaecal region of Cdx2(+/-) mice. Furthermore...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.10.1465
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309260
更新日期:2016-08-01 00:00:00