Abstract:
BACKGROUND AND AIMS:Chronic idiopathic intestinal pseudo-obstruction (CIIP) is characterised by severe impairment of intestinal propulsive motility that mimics bowel obstruction. JC virus (JCV) is a polyomavirus that can infect brain glial cells causing a fatal disease, but may also be found throughout the normal gastrointestinal tract. The hypothesis that JCV infects the myenteric plexuses of patients with CIIP was tested. METHODS:10 patients with CIIP and 61 normal specimens (30 ascending colon and 31 ileum) from patients with uncomplicated colon cancer were studied. DNA was extracted from the myenteric plexuses, and JCV T antigen (TAg) DNA and the viral regulatory region were detected by PCR and sequencing. Immunohistochemistry was performed to detect JCV viral protein expression, neuronal and glial markers. Fluorescence in situ hybridisation was performed for cellular localisation of the JCV infection. RESULTS:Clinical studies demonstrated neurogenic impairment, and pathological analyses showed neuropathy in each patient with CIIP. JCV TAg DNA was found in the myenteric plexuses of 8/10 (80%) of the patients with CIIP and 3/31 (9.7%) of the control patients (p<0.001). All samples were JCV Mad-1 strains. Seven of the 10 CIIP specimens expressed both JCV TAg and the JCV viral protein VP1, while none of the controls expressed either. JCV infection co-localised with glial fibrillary acidic protein expression, a marker of enteric glial cells. CONCLUSION:JCV infection occurs in the myenteric plexuses of patients with CIIP. The JCV localisation in enteroglial cells suggests a possible pathological role for this virus in enteric neuropathy.
journal_name
Gutjournal_title
Gutauthors
Selgrad M,De Giorgio R,Fini L,Cogliandro RF,Williams S,Stanghellini V,Barbara G,Tonini M,Corinaldesi R,Genta RM,Domiati-Saad R,Meyer R,Goel A,Boland CR,Ricciardiello Ldoi
10.1136/gut.2008.152512subject
Has Abstractpub_date
2009-01-01 00:00:00pages
25-32issue
1eissn
0017-5749issn
1468-3288pii
gut.2008.152512journal_volume
58pub_type
杂志文章相关文献
GUT文献大全abstract::The response of lymphocytes from peripheral blood and mesenteric lymph nodes to stimulation with phytohaemagglutinin in vitro has been studied in eight patients suffering from active Crohn's disease. Patients with Crohn's disease exhibited reduced responses when compared with similar studies performed in control subje...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.1.20
更新日期:1973-01-01 00:00:00
abstract::Clinical data and histology from the oesophagus, gastric antrum, and duodenum were collected from 36 patients undergoing surgery for duodenal ulcer. Gastritis was present in 94% of the patients (25% of atrophic type), oesophagitis in 72% and duodenitis in 39%. Abnormal biopsies were present from all three sites in 33%...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.1.95
更新日期:1985-01-01 00:00:00
abstract::Calcium in milk products stimulates gastric acid secretion and inhibits the cytolytic activity of intestinal contents. Based on these effects, it was hypothesised that calcium might lessen the severity of food borne intestinal infections. The possible differential effects of a low calcium milk and normal milk products...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.1.59
更新日期:1996-01-01 00:00:00
abstract:AIM:Magnetic resonance imaging (MRI) based colonography represents a new imaging tool which has mainly been investigated for polyp screening. To evaluate this approach for patients with inflammatory bowel disease (IBD), we compared MRI based colonography with conventional colonoscopy for assessing the presence and exte...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.037390
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:Suboptimal adenoma detection rate (ADR) at colonoscopy is associated with increased risk of interval colorectal cancer. It is uncertain how ADR might be improved. We compared the effect of leadership training versus feedback only on colonoscopy quality in a countrywide randomised trial. DESIGN:40 colonoscopy...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2014-307503
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE:To compare the performance of CE to VC for the detecti...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-313213
更新日期:2018-06-01 00:00:00
abstract::This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.12.956
更新日期:1973-12-01 00:00:00
abstract:BACKGROUND:Norovirus infection is the most frequent cause of infectious diarrhoea in the western world. This study aimed to characterise functionally and histomorphologically the diseased duodenum in human biopsies. METHODS:Norovirus infection was diagnosed by the Kaplan criteria and confirmed by PCR of stool samples....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.160150
更新日期:2009-08-01 00:00:00
abstract::When there is villus atrophy in a jejunal biopsy, intraepithelial lymphocyte (IEL) mitosis correlates with a diagnosis of coeliac disease. We have examined the significance of IEL mitosis in jejunal biopsies with normal villi. Counts of IEL per 100 villus enterocytes, and IEL mitosis per 1000 IEL, were carried out in ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.6.675
更新日期:1986-06-01 00:00:00
abstract::Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were r...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.4.278
更新日期:1972-04-01 00:00:00
abstract:BACKGROUND:The "topical" effect of non-steroidal anti-inflammatory drugs (NSAIDs) seems to be an important cause of NSAID induced gastrointestinal damage. AIM:To examine the possible mechanism of the "topical" phase of damage in the small intestine. METHODS:Electron microscopy and subcellular organelle marker enzyme ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.3.344
更新日期:1997-09-01 00:00:00
abstract::This case report describes the histological and macroscopic changes seen within a few months in the gastric mucosa of a 28 year old woman patient with upper abdominal symptoms. With hindsight these changes were the first signs of Sjögren's syndrome. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.8.1142
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:An increasing number of case reports indicate potential nephrotoxicity of 5-aminosalicylic acid (5-ASA), which shares similarities with the chemical structures of both phenacetin and acetylsalicylic acid. AIM:In a point prevalence study the occurrence of sensitive indices indicative of early kidney malfunct...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.6.761
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:The gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome and nutritional environment. This study investigated whether the gut microbiota per se, aside from changes in genetic background and diet, could sign different...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301012
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:Enterochromaffin cell-derived serotonin (5-HT) promotes intestinal inflammation. We tested hypotheses that peripheral tryptophan hydroxylase (TPH) inhibitors, administered orally, block 5-HT biosynthesis and deplete 5-HT from enterochromaffin cells sufficiently to ameliorate intestinal inflammation; moreover,...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-304901
更新日期:2014-06-01 00:00:00
abstract::Both carbachol (10(-4)-10(-3) mol/l) and cholecystokinin octapeptide (CCK-8) (10(-8)-10(-6) mol/l) significantly stimulated the release of pepsinogen from rabbit gastric mucosa maintained in organ culture (213-216% and 143-261% of control, respectively, p less than 0.05-0.01). The secretion was not affected by removin...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.1.21
更新日期:1992-01-01 00:00:00
abstract::In conditions with increased neutrophil production, the serum total vitamin B(12)-binding capacity (TBBC) is considered to correlate with the blood pool size of neutrophil granulocytes. The serum lysozyme, on the other hand, is a measure of neutrophil (and monocyte) turnover. The mean serum TBBC was significantly rais...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.12.953
更新日期:1974-12-01 00:00:00
abstract:BACKGROUND:Collagenous colitis and lymphocytic colitis present with a similar clinical picture. Whether these conditions are separate entities or whether they represent different pathological stages of the same condition is an unresolved issue. PATIENT:This is a case of collagenous colitis following a fulminant course...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.5.788
更新日期:1996-05-01 00:00:00
abstract:INTRODUCTION:CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. OBJECTIVE:To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. DESIGN:CD248 expression was studie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308325
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentra...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301086
更新日期:2012-11-01 00:00:00
abstract::Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.94
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Bovine immunoglobulin concentrate (BIC)-Clostridium difficile is prepared from the colostrum of cows immunised against C difficile toxins and contains high concentrations of neutralising IgG antitoxin. AIMS:To determine the proportion of BIC-C difficile which survives passage through the human stomach and s...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.44.2.212
更新日期:1999-02-01 00:00:00
abstract::Two enzymes having lactase activity are present in the equine small intestine. The first, the digestive enzyme, neutral beta-galactosidase, declines in activity from birth to three years, disappearing completely between 3 and 4 years of age. The other, the soluble lysosomal enzyme, acid beta-galactosidase, having affi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.7.535
更新日期:1973-07-01 00:00:00
abstract:OBJECTIVES:Recent studies using the lactulose hydrogen breath test (LHBT) suggest most patients with irritable bowel syndrome (IBS) have small intestinal bacterial overgrowth (SIBO). However, the validity of the LHBT has been questioned, particularly as this test could reflect changes in oro-caecal transit. Therefore, ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.205476
更新日期:2011-03-01 00:00:00
abstract::These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309262
更新日期:2015-11-01 00:00:00
abstract::The hormones secretin and cholecystokinin-pancreozymin (CCK) have been shown to release brush-border alkaline phosphatase into the small-intestinal lumen in the human subject. In contrast to the disaccharidases, large amounts of alkaline phosphatase are present in human duodenal juice. The range has been established i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.1.39
更新日期:1974-01-01 00:00:00
abstract::In an endoscopic study of 90 consecutive patients with more than one peptic ulcer, the ulcers in an individual were profoundly spatially clustered. Clustering of ulcer locations was shown using a non-parametric test of clustering (Kruskal-Wallis statistic with 89 degrees of freedom = 151.31, probability of observing t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.10.1329
更新日期:1989-10-01 00:00:00
abstract:OBJECTIVE:Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remain...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311326
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Colonoscopy is the current reference standard for the detection of colorectal neoplasia, but nevertheless adenomas remain undetected. The Endocuff, an endoscopic cap with plastic projections, may improve colonic visualisation and adenoma detection. The aim of this study was to compare the mean numbe...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2015-310097
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To develop an affordable and robust pipeline for selection of patient-specific somatic structural variants (SSVs) being informative about radicality of the primary resection, response to adjuvant therapy, incipient recurrence and response to treatment performed in relation to diagnosis of recurrence. DESIGN:...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308859
更新日期:2016-04-01 00:00:00