Abstract:
:Calcium in milk products stimulates gastric acid secretion and inhibits the cytolytic activity of intestinal contents. Based on these effects, it was hypothesised that calcium might lessen the severity of food borne intestinal infections. The possible differential effects of a low calcium milk and normal milk products (milk, acidified milk, and pasteurised yoghurt) on the resistance of rats to a salmonella infection was therefore studied. Rats were infected orally with Salmonella enteritidis just after food consumption. The first day after infection, faecal salmonella counts of the yoghurt fed rats were significantly lower than those of the other groups. Thereafter, faecal salmonella excretion declined rapidly in all high calcium groups, whereas rats fed the low calcium milk continued to excrete high numbers of salmonella. The reduced colonisation resistance to salmonella of rats fed low calcium milk might be caused by the high cytolytic activity of faecal water or a high iron concentration in faecal water, already present before infection, or both. The reduced resistance of these rats corresponded with a large infection induced increase in the cytolytic activity of faecal water, an appreciable reduction in apparent iron absorption, and a large increase in faecal mucin and alkaline phosphatase excretion. In yoghurt fed rats, only minor infection induced changes in luminal parameters were noticed. The rats fed milk and acidified milk always showed intermediate reactions. In conclusion, in addition to fermentation by yoghurt bacteria, calcium in milk products strongly enhanced the resistance to salmonella infection by lowering luminal cytolytic activity or diminishing the availability of iron for pathogen growth, or both.
journal_name
Gutjournal_title
Gutauthors
Bovee-Oudenhoven I,Termont D,Dekker R,Van der Meer Rdoi
10.1136/gut.38.1.59subject
Has Abstractpub_date
1996-01-01 00:00:00pages
59-65issue
1eissn
0017-5749issn
1468-3288journal_volume
38pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-318281
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Endoscopic diagnosis of short segments of Barrett's epithelium (SSBE)' is difficult and its meaning in terms of the presence of specialised columnar epithelium (SCE) has not been prospectively evaluated. AIMS:To evaluate the prevalence of SCE in patients with an endoscopic diagnosis of SSBE and in individua...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.5.659
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a therapeutic target in gastrointestinal cancer (GiC). However, its in vivo visualisation could not be achieved to date with endoscopic techniques. Confocal laser endomicroscopy (CLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo mi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.202986
更新日期:2010-08-01 00:00:00
abstract::Endoscopic sphincterotomy was undertaken in 186 patients with common bile duct stones and an intact gall bladder who were considered unfit for surgery. One hundred and seventy one patients had jaundice of whom 18 also had clinical cholangitis. The mean age of treated patients was 79.7 years (range 27-92) and only 13 w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.8.1129
更新日期:1989-08-01 00:00:00
abstract::When there is villus atrophy in a jejunal biopsy, intraepithelial lymphocyte (IEL) mitosis correlates with a diagnosis of coeliac disease. We have examined the significance of IEL mitosis in jejunal biopsies with normal villi. Counts of IEL per 100 villus enterocytes, and IEL mitosis per 1000 IEL, were carried out in ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.6.675
更新日期:1986-06-01 00:00:00
abstract::The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.8.934
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Hypersensitivity of gastric afferent pathways may play an aetiological role in symptoms of functional dyspepsia. AIMS:To determine whether patients with severe organic dyspepsia (associated with tissue irritation/injury) and those with functional dyspepsia (no detectable tissue irritation) differ in their p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.6.814
更新日期:1998-06-01 00:00:00
abstract::Seventy six patients with dysphagia caused by malignant tumours of the oesophagus or gastric cardia have been treated using the Neodymium Yttrium Aluminium Garnet (NdYag) laser. The laser was set to deliver 80-100 watts of power for 0.5-1 second pulses. To obtain improvement, patients on average needed four treatment ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.7.792
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.6.862
更新日期:1999-06-01 00:00:00
abstract::The risk of developing colorectal adenomatous polyps is probably increased by a variety of dietary and environmental factors. We found an association with current alcohol and cigarette consumption. The risk of polyps was increased three times in drinkers who did not smoke and two times in smokers who did not drink, wi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.1.70
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Intestinal metaplasia, whether in the cardia or the distal oesophagus, has been uniformly defined as specialised columnar epithelium, suggesting a relation with Barrett's oesophagus. It is, however, not clear whether the risk factors associated with intestinal metaplasia are identical at both sites. AIMS:To...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.1.17
更新日期:1998-07-01 00:00:00
abstract::Multiple endoscopic specimens were obtained from 58 patients with a columnar lined gesophagus to study the histological and histochemical features of this metaplastic epithelium. Five patients (8.6%) had presented with a primary oesophageal adenocarcinoma. Three different epithelial types, junctional, atrophic fundic ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.9.1062
更新日期:1986-09-01 00:00:00
abstract::A retrospective study was undertaken to investigate how endoscopies yielding positive findings differ a priori from those yielding negative findings: and how those judged 'helpful' (in the sense of influencing management) differ a priori from those judged 'unhelpful'. A total of 483 patients undergoing endoscopy was s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2.187
更新日期:1993-02-01 00:00:00
abstract::Acute fulminant pancreatitis is associated with significant morbidity and mortality. To examine the outcome of conservative and surgical treatment of this disorder, 36 patients who survived an initial episode were restudied after a mean of six years. Fifty three per cent had developed diabetes mellitus, half of whom r...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.6.843
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2011.242016
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The relation of demographic and psychological factors to the presence and extent of gut transit impairment in the functional gastrointestinal disorders has received little attention. AIMS:To compare the psychosocial and demographic features of patients with functional gastrointestinal disorders and delayed ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.1.83
更新日期:2000-01-01 00:00:00
abstract::Pathogenic E coli have adhesive properties which are mirrored by an increase in their surface hydrophobicity. E coli isolated from patients with ulcerative colitis possess a mannose resistant adhesin similar to that found in pathogenic E coli. In this study 42 E coli isolates from patients with colitis have been compa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.1.41
更新日期:1988-01-01 00:00:00
abstract::A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.1.51
更新日期:1970-01-01 00:00:00
abstract::Spontaneous basal rectal activity, recorded after resection of the sigmoid colon for diverticular disease, was more than twice the normal. The rectum of post-resection cases yielded a markedly exaggerated overall response to prostigmine, in addition to producing abundant fast wave patterns. The response to stretch of ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.2.121
更新日期:1970-02-01 00:00:00
abstract:BACKGROUND AND AIMS:It is not known why some reflux episodes evoke symptoms and others do not. We investigated the determinants of perception of gastro-oesophageal reflux. METHODS:In 32 patients with symptoms suggestive of gastro-oesophageal reflux, 24 hour ambulatory pH and impedance monitoring was performed after ce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.074690
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Biliary lipid absorption by the gall bladder mucosa and the cholesterol content of the gall bladder wall appear to play a role in cholesterol gall stone formation. As the scavenger receptor class B type I (SR- BI) regulates cellular cholesterol uptake, we studied its expression in human and murine g...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.7.1017
更新日期:2003-07-01 00:00:00
abstract::Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2010.212704
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:The identification of gastric superficial cancerous lesions based on conventional white-light endoscopy (WLE) is challenging, and histological analysis remains the 'gold standard' for the final diagnosis. Confocal laser endomicroscopy (CLE) can provide in vivo histological observation without the need for bi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.223586
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. The study aims to compare the effectiveness and safety of these therapies for Helicobacter pylori treatment. DESIGN:Prospective randomised clinical trial in 11 Spanish hospit...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2013-304820
更新日期:2014-02-01 00:00:00
abstract::Peak plasma levels were reduced after an oral dose of 40 mg prednisolone in six patients with severe acute colitis as compared with six normal subjects, though total absorption appeared to be similar; the findings suggest that prednisolone absorption was delayed in acute colitis. A dilutional fall in plasma albumin wa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.1.49
更新日期:1980-01-01 00:00:00
abstract::Multinucleated giant cells are an important feature of the granulomatous reaction in Crohn's disease (CD) but their cellular origin is poorly understood. The aim of this study was to discover if intestinal macrophages are capable of generating multinucleated giant cells in vitro in response to cytokine stimulation. Hu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.6.798
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND AND AIMS:The detrimental impact of opioid agonist on the clinical management of inflammatory diseases remains elusive. Given the anti-inflammatory properties of the mu-opioid receptor (MOR) agonists at the intestinal barrier, we hypothesised that MOR activation might also dampen acute hepatic inflammation an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2006.105122
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320839
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women. METHODS:A double blind, placebo controlled, intervention study was performed with 30 obese women treated with ITF prebiotics (inulin/oligofructose 50/50 mi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-303304
更新日期:2013-08-01 00:00:00
abstract::The detection of pancreatic cancer or the discrimination between pancreatic cancer and chronic pancreatitis remains an important diagnostic problem. The increased glucose metabolism in malignant tumours formed the basis for this investigation, which focused on the role of positron emission tomography (PET) with 2[18F]...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.771
更新日期:1995-05-01 00:00:00