Abstract:
:The detection of pancreatic cancer or the discrimination between pancreatic cancer and chronic pancreatitis remains an important diagnostic problem. The increased glucose metabolism in malignant tumours formed the basis for this investigation, which focused on the role of positron emission tomography (PET) with 2[18F]-fluoro-2-deoxy-D-glucose (FDG) in the detection of pancreatic cancer and its differentiation from chronic pancreatitis. Eighty patients admitted for elective pancreatic surgery received preoperatively 250-350 mBq FDG intravenously and emission scans were recorded 45 minutes later. Intense focal activity in the pancreatic region was taken at the time of scanning as showing the presence of pancreatic cancer. The presence of cancer was later confirmed by histological examination of the surgical specimens and histological findings were compared with the preoperative PET results. Forty one patients with pancreatic cancer (group I: n = 42) had a focally increased FDG uptake in the pancreatic region. Two patients with a periampullary carcinoma (group II: n = 6) failed to develop FDG accumulation. In 28 patients with chronic pancreatitis (group III: n = 32) no FDG accumulation occurred. Overall sensitivity and specificity of PET for malignancy (group I + II) were 94% (45 of 48) and 88% (28 of 32), respectively. The standard uptake value of the patients with pancreatic carcinoma was significantly higher than in patients with chronic pancreatitis (3.09 (2.18) v 0.87 (0.56); p < 0.001; median (interquartile range)). These findings show that FDG-PET represents a new and non-invasive diagnostic procedure for the diagnosis of pancreatic cancer and to differentiate pancreatic cancer from chronic pancreatitis. However, the diagnostic potential of this technique requires further evaluation.
journal_name
Gutjournal_title
Gutauthors
Friess H,Langhans J,Ebert M,Beger HG,Stollfuss J,Reske SN,Büchler MWdoi
10.1136/gut.36.5.771subject
Has Abstractpub_date
1995-05-01 00:00:00pages
771-7issue
5eissn
0017-5749issn
1468-3288journal_volume
36pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:The long-term performance of colorectal cancer (CRC) screening programmes based on a 2-year faecal immunochemical test (FIT) is still unclear. METHODS:In a sample of 50 to 69-year-olds repeatedly screened with the FIT (OC-Hemodia latex agglutination test; cut-off: 20 µg haemoglobin/g faeces), we examined: (...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314753
更新日期:2018-12-01 00:00:00
abstract::Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.3.338
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVE:Hepatocellular adenomas (HCAs) classically develop in women who are taking oral contraceptives and have a risk of malignant transformation into hepatocellular carcinoma (HCC). HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.222109
更新日期:2011-01-01 00:00:00
abstract::Six of 25 renal transplant recipients had a duodenal ulcer at endoscopy. Histamine concentration and the activity of histamine methyltransferase, the degrading enzyme of histamine, were measured in gastric mucosal biopsies obtained at endoscopy and compared with patients with duodenal ulcer but not undergoing transpla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.1.65
更新日期:1989-01-01 00:00:00
abstract::To test whether there is a difference in the expression of interleukin 8 (IL8) between Crohn's disease and ulcerative colitis and to determine the main site of its synthesis this study analysed IL8 in mucosal biopsy specimens of patients with Crohn's disease and ulcerative colitis by enzyme linked immunosorbent assay ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.2.216
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Major histocompatibility complex class II deficient (Aalpha0/0) mice have decreased CD4+ T cells, making them immunologically similar to patients with acquired immunodeficiency syndrome (AIDS). Both patients with AIDS and Aalpha0/0 mice have hypertrophic gastric folds. To clarify the mechanism of ga...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.077917
更新日期:2006-05-01 00:00:00
abstract::An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.3.285
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). METHODS:A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. RESULTS:Of 563 patients with AIP, 459 (82%) received steroid treatment....
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2008.172908
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Obstructive jaundice is associated with postoperative complications related to increased endotoxaemia and the inflammatory response. In animals obstructive jaundice is associated with endotoxaemia and cytokine induction, which are reversed by internal biliary drainage. AIMS:To study endotoxaemia and the sub...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.5.725
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. AIMS:To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats. METHODS:Wistar rats, aged eight weeks, underwent 60% proximal resection or transection ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.1.89
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066100
更新日期:2006-02-01 00:00:00
abstract::Hydrogen breath tests are widely used to explore the pathophysiology of functional gastrointestinal disorders. Small intestinal bacterial overgrowth and carbohydrate malabsorption are disorders detected by these tests that have been proposed to be of great importance for symptoms in, for instance, irritable bowel synd...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2005.075127
更新日期:2006-03-01 00:00:00
abstract::An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.2.137
更新日期:1991-02-01 00:00:00
abstract::Five patients in whom small-intestinal bypass was performed for severe obesity had a second operation 11-19 months later because of insufficient weight loss. Mucosal enzyme activities and histological appearance were investigated in biopsies from different parts of the functioning and excluded small intestine. These w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.7.553
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.127167
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312019
更新日期:2017-10-01 00:00:00
abstract::HLA antigens and various aspects of atopy were studied in 42 Finnish children and adolescents with coeliac disease, and the results were compared with findings of recent population studies. The HLA associations were as expected: relative risks for coeliac disease in individuals with HLA-B8, DR3, and DR7 were 8 . 0, 18...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.4.306
更新日期:1983-04-01 00:00:00
abstract::The value of four tests to detect occult alimentary blood loss has been compared in normal subjects, in patients with and without alimentary disease, and in patients with congestive heart failure, and the sensitivities of these tests have been compared using suspensions of blood alone and blood in faeces. The Occultes...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2.1.75
更新日期:1961-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with cirrhosis. Evolving information suggests that the metabolic syndrome with non-alcoholic liver disease may be an important cause of HCC in addition to viral hepatitis and...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2013-306627
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317571
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:In human acute pancreatitis two different types of secretory phospholipase A2 (PLA2) have been found. AIM:To analyse the specific pattern of distribution of these PLA2 activities and their pathophysiological role in experimental acute pancreatitis. SUBJECTS AND METHODS:Catalytic activities of secretory typ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.3.386
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role of leptin and energy expenditure in CHC. Our aims were to analyse fatigue in CHC and to determine its relationship with diseas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.3.434
更新日期:2002-09-01 00:00:00
abstract::Colorectal cancer is the fourth commonest form of cancer in men with 678 000 estimated new cases per year worldwide, representing 8.9% of all new cancers. The disease is most frequent in Occidental countries and particularly so in North America, Australia, New Zealand, and parts of Europe. Prospects for colorectal can...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.43.4.578
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Escherichia coli is part of the normal gastrointestinal microflora which exerts a barrier effect against enteropathogens. Several E coli strains develop a protective effect against other Enterobacteriaceae. AIMS:Two E coli strains, EM0, a human faecal strain, and JM105 K-12 were tested for their ability to ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.1.47
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Bovine immunoglobulin concentrate (BIC)-Clostridium difficile is prepared from the colostrum of cows immunised against C difficile toxins and contains high concentrations of neutralising IgG antitoxin. AIMS:To determine the proportion of BIC-C difficile which survives passage through the human stomach and s...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.44.2.212
更新日期:1999-02-01 00:00:00
abstract::Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorpti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.6.480
更新日期:1977-06-01 00:00:00
abstract:OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311970
更新日期:2017-11-01 00:00:00
abstract::Continued bleeding or early rebleeding is associated with a poor prognosis in patients with variceal haemorrhage. It is not clear why bleeding stops in some patients and continues or restarts in others. It is suggested that secondary haemodynamic changes in the splanchnic circulation after a bleed may contribute to th...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.36.1.100
更新日期:1995-01-01 00:00:00
abstract::Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury. ...
journal_title:Gut
pub_type: 评论,杂志文章,评审
doi:10.1136/gut.2004.060640
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Osteopontin (OPN) has been found to be valuable in diagnosis and predicting the prognosis of a variety of malignancies. The aims of the present study are to evaluate the usefulness of plasma OPN level for predicting gastric cancer development, invasion and survival. PATIENTS AND METHODS:One hundred and thirt...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2006.109868
更新日期:2007-06-01 00:00:00