Hepatocellular carcinoma: clinical frontiers and perspectives.

abstract：BACKGROUND:Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited. AIM:To examine the effect of ZnC on various models of gut injury and repair, and in a clinical trial. METHODS:In vitr...

journal_title：Gut

authors： Mahmood A,FitzGerald AJ,Marchbank T,Ntatsaki E,Murray D,Ghosh S,Playford RJ

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:Lower GI bleeding (LGIB) is a common reason for emergency hospital admission, although there is paucity of data on presentations, interventions and outcomes. In this nationwide UK audit, we describe patient characteristics, interventions including endoscopy, radiology and surgery as well as clinical outcomes....

journal_title：Gut

authors： Oakland K,Guy R,Uberoi R,Hogg R,Mortensen N,Murphy MF,Jairath V,UK Lower GI Bleeding Collaborative.

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...

journal_title：Gut

authors： Hochart A,Gower-Rousseau C,Sarter H,Fumery M,Ley D,Spyckerelle C,Peyrin-Biroulet L,Laberenne JE,Vasseur F,Savoye G,Turck D,Epimad Group.

更新日期：2017-11-01 00:00:00

abstract：:A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient an...

journal_title：Gut

authors： Burman JF,Jenkins WJ,Walker-Smith JA,Phillips AD,Sourial NA,Williams CB,Mollin DL

更新日期：1985-03-01 00:00:00

abstract：:A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month...

journal_title：Gut

authors： Jackson LD,Song E

更新日期：1995-03-01 00:00:00

abstract：:The highest prevalence rates of hepatitis C virus infection in the world have been recently reported among Egyptian blood donors and frequent recipients of transfusions and other blood products. This is the first report, however, demonstrating hepatitis C as the most frequent association with chronic liver disease in ...

journal_title：Gut

authors： Waked IA,Saleh SM,Moustafa MS,Raouf AA,Thomas DL,Strickland GT

更新日期：1995-07-01 00:00:00

abstract：:To study the mechanism for the adaptive mucosal hyperplasia which occurs independent of luminal nutrition and pancreatico-biliary secretions in isolated Thiry-Vella segments of intestine from lactating rats, and to examine the effects of prolactin on small bowel mucosal structure in the rat, we used two models of expe...

journal_title：Gut

authors： Muller E,Dowling RH

更新日期：1981-07-01 00:00:00

abstract：:The effects of drugs which change the bile-salt-independent fraction of bile flow on Na(+)K(a+) and Mg(2+) activated ATPases were studied in membrane fractions rich in bile canaliculi. The administration of phenobarbital caused no induction of these enzymes which could explain the increased bile flow observed in the r...

journal_title：Gut

authors： Laperche Y,Launay A,Oudéa P

更新日期：1972-11-01 00:00:00

abstract：:Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammat...

journal_title：Gut

authors： Fléjou JF,Potet F,Molas G,Bernades P,Amouyal P,Fékété F

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...

journal_title：Gut

authors： La Bella T,Imbeaud S,Peneau C,Mami I,Datta S,Bayard Q,Caruso S,Hirsch TZ,Calderaro J,Morcrette G,Guettier C,Paradis V,Amaddeo G,Laurent A,Possenti L,Chiche L,Bioulac-Sage P,Blanc JF,Letouze E,Nault JC,Zucman-Rossi

更新日期：2020-04-01 00:00:00

abstract：:This report is of a patient with long-term small bowel regional enteritis who presented with a perforation of an adenocarcinoma involving a diseased portion of ileum. Adenocarcinoma of the small bowel is rare. The incidence of small bowel adenocarcinoma may be higher in patients with regional enteritis, but a definite...

journal_title：Gut

authors： Heathcote J,Knauer CM,Oakes D,Archibald RW

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presenc...

journal_title：Gut

authors： Combet E,Paterson S,Iijima K,Winter J,Mullen W,Crozier A,Preston T,McColl KE

更新日期：2007-12-01 00:00:00

abstract：:It has been reported that intestinal permeability to polyethylene glycol 400 is increased in patients with Crohn's disease and their apparently unaffected first degree relatives. Because of the implications that these findings have for the aetiology of Crohn's disease these studies were repeated. Patients with Crohn's...

journal_title：Gut

authors： Teahon K,Smethurst P,Levi AJ,Menzies IS,Bjarnason I

更新日期：1992-03-01 00:00:00

abstract：AIMS:To evaluate the clinical utility of two new tests for serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex (trypsin 2-AAT) in diagnosing and assessing the severity of acute pancreatitis (AP) induced by endoscopic retrograde cholangiopancreatography (ERCP). PATIENTS:Three hundred and eight consecutive pat...

journal_title：Gut

authors： Kemppainen E,Hedström J,Puolakkainen P,Halttunen J,Sainio V,Haapiainen R,Kivilaakso E,Stenman UH

更新日期：1997-11-01 00:00:00

abstract：:Nutritional status and immune function were correlated with clinical features in 56 patients with Crohn's disease. These were divided arbitrarily into either undernourished or well nourished groups according to whether their midarm circumference was below or above 90% of ideal standard. Results were also compared with...

journal_title：Gut

authors： Harries AD,Danis VA,Heatley RV

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered to be a novel anticancer agent; however, recent studies have shown th...

journal_title：Gut

authors： Kallifatidis G,Rausch V,Baumann B,Apel A,Beckermann BM,Groth A,Mattern J,Li Z,Kolb A,Moldenhauer G,Altevogt P,Wirth T,Werner J,Schemmer P,Büchler MW,Salnikov AV,Herr I

更新日期：2009-07-01 00:00:00

abstract：:Forty two white patients of British or Irish descent with coeliac disease and 28 with dermatitis herpetiformis were typed for class I HLA-A, B, and C, and class II DR and DQ antigens. In coeliac disease there was a significant increase in the frequencies of A1, B8, DR3, DR7, and DQw2 compared with controls but no incr...

journal_title：Gut

authors： Sachs JA,Awad J,McCloskey D,Navarrete C,Festenstein H,Elliot E,Walker-Smith JA,Griffiths CE,Leonard JN,Fry L

更新日期：1986-05-01 00:00:00

abstract：:We investigated the distribution of short chain fatty acids (SCFA) in enema samples taken from subjects before sigmoidoscopy as an indicator of possible microbial community differences between subjects subsequently diagnosed as normal or having colonic disorders. The major SCFA in all groups were acetic, propionic, an...

journal_title：Gut

authors： Weaver GA,Krause JA,Miller TL,Wolin MJ

更新日期：1988-11-01 00:00:00

abstract：:Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absorption, it delivered chyme with nearly ...

journal_title：Gut

authors： Miller LJ,Malagelada JR,Go VL

更新日期：1978-08-01 00:00:00

abstract：:Gastrointestinal fistulae most frequently occur as complications after abdominal surgery (75-85%) although they can also occur spontaneously--for example, in patients with inflammatory bowel disease (IBD) such as diverticulitis or following radiation therapy. Abdominal trauma can also lead to fistula formation althoug...

journal_title：Gut

authors： Falconi M,Pederzoli P

更新日期：2001-12-01 00:00:00

abstract：:One-hundred-and-one normal neonates were examined manometrically in the first day of life to assess anorectal function. In order to overcome some of the difficulties in subjective interpretation of results, the stimuli used and the response pattern seen in the anal canal were measured. In the unstimulated state, all s...

journal_title：Gut

authors： Boston VE,Cywes S,Davies MR

更新日期：1977-12-01 00:00:00

abstract：:An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients...

journal_title：Gut

authors： Heilmann KL,Borchard F

更新日期：1991-02-01 00:00:00

abstract：:To determine whether primary biliary cirrhosis differed in men and women we reviewed the presenting features and clinical course of 39 men and 191 women with primary biliary cirrhosis followed at this unit between 1970 and 1984. Age and severity of disease at time of diagnosis were similar in both groups. Pruritus was...

journal_title：Gut

authors： Lucey MR,Neuberger JM,Williams R

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:The transcriptional profile of gastric epithelial cell lines cocultured with Helicobacter pylori and the global gene expression of whole gastric mucosa has been described previously. We aimed to overcome limitations of previous studies by determining the effects of H pylori eradication on the transcriptome of...

journal_title：Gut

authors： Resnick MB,Sabo E,Meitner PA,Kim SS,Cho Y,Kim HK,Tavares R,Moss SF

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with ...

journal_title：Gut

authors： Grippo PJ,Fitchev PS,Bentrem DJ,Melstrom LG,Dangi-Garimella S,Krantz SB,Heiferman MJ,Chung C,Adrian K,Cornwell ML,Flesche JB,Rao SM,Talamonti MS,Munshi HG,Crawford SE

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....

journal_title：Gut

authors： Ford AC,Yuan Y,Moayyedi P

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Tumour vascularisation is a determinant of the development of metastases. AIMS:To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand fac...

journal_title：Gut

authors： Schilling MK,Redaelli C,Friess H,Blum B,Signer C,Maurer CA,Büchler MW

更新日期：1999-09-01 00:00:00

abstract：INTRODUCTION:Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence of a G-->A substitution at nucleotide 113, was associated with susceptib...

journal_title：Gut

authors： Noble CL,Nimmo ER,Drummond H,Smith L,Arnott ID,Satsangi J

更新日期：2005-10-01 00:00:00

abstract：:Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...

journal_title：Gut

authors： Altomare D,Pilot MA,Scott M,Williams N,Rubino M,Ilincic L,Waldron D

更新日期：1992-11-01 00:00:00

abstract：:Two West Indian patients with Kveim-biopsy proven sarcoidosis developed chronic cholestatic liver disease, clinically and biochemically similar to primary biliary cirrhosis. Liver histology revealed multiple granulomas with reduction in bile ducts and, in one patient, progression to biliary cirrhosis. Portal hypertens...

journal_title：Gut

authors： Bass NM,Burroughs AK,Scheuer PJ,James DG,Sherlock S

更新日期：1982-05-01 00:00:00