Abstract:
OBJECTIVES:Recent studies using the lactulose hydrogen breath test (LHBT) suggest most patients with irritable bowel syndrome (IBS) have small intestinal bacterial overgrowth (SIBO). However, the validity of the LHBT has been questioned, particularly as this test could reflect changes in oro-caecal transit. Therefore, we combined oro-caecal scintigraphy with LHBT in 40 patients who were Rome II positive for IBS to determine if the increase in hydrogen is due to the test meal reaching the caecum. DESIGN:Patients ingested the test meal containing (⁹⁹m)Tc and 10 g lactulose and simultaneous measurements of the location of the test meal using scintigraphic scanning and breath hydrogen levels were obtained every 10 min for 3 h. The LHBT was considered positive when the rise in H₂ above baseline was > 20 ppm within 90 and/or 180 min. The combined test was negative for SIBO if ≥ 5% of the test meal was in the caecum at the time the LHBT was positive. RESULTS:63% had an abnormal LHBT at 180 min and 35% at 90 min. The oro-caecal transit time based on scintigraphic scanning ranged from 10 to 220 min and correlated with IBS sub-type. At the time of increase in H₂, the % accumulation of (⁹⁹m)Tc in the caecum was ≥ 5% in 88% of cases (22/25). CONCLUSIONS:These findings demonstrate that an abnormal rise in H₂ measured in the LHBT can be explained by variations in oro-caecal transit time in patients with IBS and therefore do not support the diagnosis of SIBO.
journal_name
Gutjournal_title
Gutauthors
Yu D,Cheeseman F,Vanner Sdoi
10.1136/gut.2009.205476subject
Has Abstractpub_date
2011-03-01 00:00:00pages
334-40issue
3eissn
0017-5749issn
1468-3288pii
gut.2009.205476journal_volume
60pub_type
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