Abstract:
:In an endoscopic study of 90 consecutive patients with more than one peptic ulcer, the ulcers in an individual were profoundly spatially clustered. Clustering of ulcer locations was shown using a non-parametric test of clustering (Kruskal-Wallis statistic with 89 degrees of freedom = 151.31, probability of observing this extreme statistic with no clustering less than 0.0005) and a parametric test of clustering (F test statistic with 89 and 124 degrees of freedom = 5.41, probability of observing this extreme statistic with no clustering less than 0.0005). Patients having their largest ulcer in any given region had a much greater likelihood than other patients of having other ulcers in that same site. For example, the 26 patients with their largest ulcer in the proximal duodenal bulb had 20 of 33, or 61% (9) (standard error), of their other ulcers in the proximal duodenal bulb. In contrast, the 18 patients with their largest ulcer in the proximal stomach had four of 23, or 17% (8), of their other ulcers in the proximal duodenal bulb. Of the 59 patients who had two simultaneous ulcers, 28 patients had adjacent ulcers (distance between ulcers less than 4% of the distance from the gastric cardia to the apex of the duodenal bulb). These findings suggest that local factors may be important in the pathogenesis of simultaneous peptic ulcers, including infection caused by Campylobacter pylori or other microorganisms, ischaemia and mucosal barrier disruption.
journal_name
Gutjournal_title
Gutauthors
Cappell MSdoi
10.1136/gut.30.10.1329subject
Has Abstractpub_date
1989-10-01 00:00:00pages
1329-33issue
10eissn
0017-5749issn
1468-3288journal_volume
30pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:The reported cumulative risk of developing pouchitis in ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA) approaches 50% after 10 years. To date, no preoperative serological predictor of pouchitis has been found. AIMS:To assess whether preoperative perinuclear antineutrophil cy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.5.671
更新日期:2001-11-01 00:00:00
abstract::The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.1.47
更新日期:1987-01-01 00:00:00
abstract::Water and electrolyte balance has been studied in 39 patients with a permanent ileostomy, who had had a proctocolectomy for ulcerative colitis. The findings have been compared with those in 39 healthy subjects who were matched for age and sex. The ileostomists were found to lose excessive quantities of water and sodiu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.8.702
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:Patients with liver cirrhosis suffer from increased susceptibility to life-threatening bacterial infections that cause substantial morbidity. METHODS:Experimental liver fibrosis in mice induced by bile duct ligation or CCl4 application was used to characterise the mechanisms determining failure of innate imm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311224
更新日期:2017-03-01 00:00:00
abstract::The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhib...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.9.750
更新日期:1979-09-01 00:00:00
abstract:BACKGROUND:Tumour vascularisation is a determinant of the development of metastases. AIMS:To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand fac...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.45.3.341
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:Emerging evidence from mouse models suggests that mutant Kras can drive the development of pancreatic ductal adenocarcinoma (PDA) precursors from acinar cells by enforcing ductal de-differentiation at the expense of acinar identity. Recently, human genome-wide association studies have identified NR5A2, a key...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-304287
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-320185
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311970
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Familial adenomatous polyposis (FAP) is a clinically well defined hereditary disease caused by germline mutations within the adenomatous polyposis coli (APC) gene. Although several techniques are applied in the mutation analysis of FAP kindreds about 20-50% of cases remain unclear, with no APC mutation ident...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.5.675
更新日期:1998-11-01 00:00:00
abstract::In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no ev...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.2.176
更新日期:1986-02-01 00:00:00
abstract::The absorption of short chain fatty acids by the human rectum in the absence of chloride has been studied using a dialysis bag technique. Absorption rates of sodium, water, and short chain fatty acids were unchanged on replacing chloride with sulphate. Final concentrations of bicarbonate were 35.4 +/- 3.4 mmol/l in th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.5.400
更新日期:1979-05-01 00:00:00
abstract::Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.25.10.1113
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Micrometastases within bone marrow have been shown to indicate a poor prognosis in patients with epithelial tumours. However, the degree to which micrometastases represent true residual disease or cell shedding and metastatic potential, is unclear. AIM:To explore whether micrometastases represent residual d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.4.512
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:Polycystic liver diseases (PCLDs) are genetic disorders characterised by progressive bile duct dilatation and/or cyst development. Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-305281
更新日期:2014-10-01 00:00:00
abstract::The thoracic duct was cannulated in six patients who were actively bleeding from varices and had not responded to conservative treatment but draining lymph from the thoracic duct did not control bleeding in five patients. There was no drop in intrasplenic pulp pressure following this procedure when recorded in three o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.1.48
更新日期:1971-01-01 00:00:00
abstract::In duodenal ulceration the Alcian blue staining acid mucosubstances in goblet cells are reduced and the goblet cells themselves disappear. At the same time periodic acid-Schiff (PAS) staining neutral mucosubstances appear in the cells of the surface epithelium. These changes have been measured quantitatively with the ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.10.909
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Overexpression of tissue plasminogen activator (t-PA) in pancreatic cancer cells promotes invasion and proliferation in vitro and tumour growth and angiogenesis in vivo. AIMS:To understand the mechanisms by which t-PA favours cancer progression, we analysed the surface membrane proteins responsible for bind...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.026831
更新日期:2004-07-01 00:00:00
abstract::The quantification of gastric, pancreatic, biliary, and small bowel functions in man often requires the use of intestinal tubes. In this study, the presence of a transpyloric tube did not alter gastric emptying, acid secretion, or serum gastrin levels in response to an ordinary solid meal. ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.16.10.777
更新日期:1975-10-01 00:00:00
abstract::Multinucleated giant cells are an important feature of the granulomatous reaction in Crohn's disease (CD) but their cellular origin is poorly understood. The aim of this study was to discover if intestinal macrophages are capable of generating multinucleated giant cells in vitro in response to cytokine stimulation. Hu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.6.798
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND AND AIMS:There are no available effective therapies for fatigue associated with chronic hepatitis C (CHC). The serotonin antagonist ondansetron has been shown to be effective in the chronic fatigue syndrome. In this randomised, placebo controlled, double blind trial, we investigated the effect of orally admi...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.2004.055251
更新日期:2005-08-01 00:00:00
abstract::Plasminogen activator activity was studied in bile and perfusate during extracorporeal pig liver perfusion. Plasminogen activator activity in bile was up to 58 times greater than in perfusate. A high level of plasminogen activator activity in bile was also found after the addition of urokinase to the perfusate. These ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.1.54
更新日期:1972-01-01 00:00:00
abstract:BACKGROUND:Somatostatin has been used to prevent pancreatitis after endoscopic retrograde cholangiopancreatography but its effect on acute non-biliary pancreatitis is still unclear. AIM:The purpose of this study was to evaluate the function of the sphincter of Oddi (SO) and the effect of somatostatin on patients with ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.6.843
更新日期:2001-12-01 00:00:00
abstract::The treatment is described of 17 patients with presumed viral hepatitis who developed hepatic coma unresponsive to standard conservative measures. Five patients were considered for treatment by exchange transfusion. Four were treated, with transient improvement in two, but all died. Nine patients were considered for t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.11.898
更新日期:1969-11-01 00:00:00
abstract:BACKGROUND:Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations. AIM AND METHODS:In all layers of the colon, nerve fibre densities of SP(+) and sympathetic nerve fibres were investigated (22 Crohn's disease, six diverticuliti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.125401
更新日期:2008-07-01 00:00:00
abstract::Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.4.344
更新日期:1970-04-01 00:00:00
abstract:OBJECTIVE:Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. DESIGN:RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working gr...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2017-315333
更新日期:2018-01-01 00:00:00
abstract::The extent to which monitoring breath hydrogen excretion provides information concerning the entry of the residues of a solid test meal into the colon was investigated in 89 normal subjects, and 11 patients with the irritable bowel syndrome. The profile of breath hydrogen concentration showed an early peak, that occur...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.8.834
更新日期:1985-08-01 00:00:00
abstract::Sera from patients with Crohn's disease have been reported to show positive immunofluorescence with lymph nodes of nude mice primed with a filtrate of intestinal tissue affected with Crohn's disease. An indirect immunofluorescence assay was used to test sera of 63 unrelated patients with Crohn's disease, 21 with ulcer...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.12.1426
更新日期:1986-12-01 00:00:00
abstract::Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.7.611
更新日期:1978-07-01 00:00:00