Specialist investigation of obscure gastrointestinal bleeding.

abstract：:The isoenzyme pattern of lactic dehydrogenase was measured in rectal biopsies from six patients with ulcerative colitis in whom precancerous histological changes had been independently recognized. There was a highly significant increase in the ratio of isoenzymes IV + V to I + II. This suggests that lactic dehydrogena...

journal_title：Gut

authors： Lewis B,Morson BC,February AW,Jones JH,Misiewicz JJ

更新日期：1971-01-01 00:00:00

abstract：:A family is described in which there occurred two cases of the lupoid type of active chronic hepatitis with cirrhosis, one of chronic persistent hepatitis, and one of myasthenia gravis. The two cases of lupoid hepatitis were in the proposita, a schoolgirl aged 16 years, and her great-aunt aged 69 years whom she had ne...

journal_title：Gut

authors： Whittingham S,Mackay IR,Kiss ZS

更新日期：1970-10-01 00:00:00

abstract：:Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...

journal_title：Gut

authors： Korman MG,Soveny C,Hansky J

更新日期：1971-11-01 00:00:00

abstract：:A technique has been developed which allows the position of the upper gastrointestinal tract, as determined radiographically, to be superimposed on the pancreatic photoscan, performed after an injection of (75)Se-selenomethionine. Results of the technique applied to 27 ;abnormal' and 23 ;normal' subjects are described...

journal_title：Gut

authors： McCarthy DM,Kreel L,Agnew JE,Bouchier IA

更新日期：1969-08-01 00:00:00

abstract：:Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...

journal_title：Gut

authors： Moran AP,Gupta A,Joshi L

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...

journal_title：Gut

authors： Wong VW,Wong GL,Yip GW,Lo AO,Limquiaco J,Chu WC,Chim AM,Yu CM,Yu J,Chan FK,Sung JJ,Chan HL

更新日期：2011-12-01 00:00:00

abstract：:Colorectal cancer is the fourth commonest form of cancer in men with 678 000 estimated new cases per year worldwide, representing 8.9% of all new cancers. The disease is most frequent in Occidental countries and particularly so in North America, Australia, New Zealand, and parts of Europe. Prospects for colorectal can...

journal_title：Gut

authors： Langman M,Boyle P

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Most colon cancers start with dysregulated Wnt/β-catenin signalling and remain a major therapeutic challenge. Examining whether HAMLET (human α-lactalbumin made lethal to tumour cells) may be used for colon cancer treatment is logical, based on the properties of the complex and its biological context. OBJEC...

journal_title：Gut

authors： Puthia M,Storm P,Nadeem A,Hsiung S,Svanborg C

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...

journal_title：Gut

authors： Hochart A,Gower-Rousseau C,Sarter H,Fumery M,Ley D,Spyckerelle C,Peyrin-Biroulet L,Laberenne JE,Vasseur F,Savoye G,Turck D,Epimad Group.

更新日期：2017-11-01 00:00:00

abstract：:Earlier studies regarding possible primary immune disturbances participating in the pathogenesis of Crohn's disease yielded conflicting results. Peripheral blood lymphocyte subsets and lymphocyte proliferative responses to five soluble recall antigens and to the polyclonal stimulator phythaemagglutinin were therefore ...

journal_title：Gut

authors： D'Haens G,Hiele M,Rutgeerts P,Geboes K,Ceuppens JL

更新日期：1994-12-01 00:00:00

abstract：:Large numbers of cells are shed from small intestinal mucosa but they are so rapidly destroyed that there is little direct information about their morphological types. Material obtained by washing the human and rat small intestine was immediately processed and examined by light and electron microscopy. Small intestina...

journal_title：Gut

authors： Pink IJ,Croft DN,Creamer B

更新日期：1970-03-01 00:00:00

abstract：BACKGROUND:Integrins mediate cell matrix adhesion and regulate cell growth and survival. In colonic epithelial cells, alpha(2)beta(1) integrin controls glandular differentiation and proliferation. Butyrate stimulates differentiation and induces apoptosis in vitro. AIMS:We investigated whether butyrate induction of apo...

journal_title：Gut

authors： Buda A,Qualtrough D,Jepson MA,Martines D,Paraskeva C,Pignatelli M

更新日期：2003-05-01 00:00:00

abstract：:This paper reports the association between severe, prolonged, watery diarrhoea and islet cell tumours of the pancreas. There appear to be significant differences between patients with these symptoms and those with the classical Zollinger-Ellison syndrome. ...

journal_title：Gut

authors： TELLING M,SMIDDY FG

更新日期：1961-03-01 00:00:00

abstract：BACKGROUND:Several pharmacological agents for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) have been studied. Clinical trials evaluating the protective effect of non-steroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results. AIM:To perform a meta-an...

journal_title：Gut

authors： Elmunzer BJ,Waljee AK,Elta GH,Taylor JR,Fehmi SM,Higgins PD

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Impaired iron handling in riboflavin deficiency is thought to be partially a result of significant morphological and cytokinetic changes within the small intestine. AIMS:The aim of the study was to find out if the responses of the rat small intestine to riboflavin deficiency induced at weaning could be reve...

journal_title：Gut

authors： Williams EA,Rumsey RD,Powers HJ

更新日期：1996-08-01 00:00:00

abstract：:Introduction of a radioactive gastrointestinal marker (51CrCl3) into a combined study (75SeHCAT + 58CoB12) of ileal function by whole body counting has been undertaken. The technique was assessed in 23 subjects (15 patients with inflammatory bowel disease, six on non-steroidal anti-inflammatory drugs for rheumatoid ar...

journal_title：Gut

authors： Smith T,Bjarnason I

更新日期：1990-10-01 00:00:00

abstract：:Strains of E. coli from the faeces of patients with active ulcerative colitis and with colitis in remission were examined for haemolysin and necrotoxin production. Cultures from 63 patients with active colitis grew haemolytic E. coli in 23 (37%) as compared with 24 (21%) from 115 patients whose disease was in remissio...

journal_title：Gut

authors： Cooke EM,Ewins SP,Hywel-Jones J,Lennard-Jones JE

更新日期：1974-02-01 00:00:00

abstract：:In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH was monitored continuously for three hours after a s...

journal_title：Gut

authors： Kaufman SE,Kaye MD

更新日期：1978-04-01 00:00:00

abstract：:Small intestinal mucosa obtained from six fasting patients with cholera by a peroral biopsy technique was studied with the electron microscope. The cultures of their rectal swabs were all positive for Vibrio cholerae. In the absorptive cells, large pseudopod-like cytoplasmic processes with deformed microvilli or witho...

journal_title：Gut

authors： Asakura H,Tsuchiya M,Watanabe Y,Enomoto Y,Morita A

更新日期：1974-07-01 00:00:00

abstract：:Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient w...

journal_title：Gut

authors： Beaugerie L,Luboinski J,Brousse N,Cosnes J,Chatelet FP,Gendre JP,Le Quintrec Y

更新日期：1994-03-01 00:00:00

abstract：:The association between Cryptosporidium, chronic diarrhoea and a proximal small intestinal mucosal enteropathy was reviewed over a six and a half year period. One hundred and twenty three children with cryptosporidiosis and no clinical evidence of immune deficiency were identified. 50% of children excreting only Crypt...

journal_title：Gut

authors： Phillips AD,Thomas AG,Walker-Smith JA

更新日期：1992-08-01 00:00:00

abstract：:A simple technique for measuring gastrointestinal transit times using radioopaque pellets of barium-impregnated polythene has been developed and validated. A normal range has been established by studying 25 normal subjects; all passed the first marker within three days and most passed 80% of the markers within five da...

journal_title：Gut

authors： Hinton JM,Lennard-Jones JE,Young AC

更新日期：1969-10-01 00:00:00

abstract：:The host's humoral immune response to Helicobacter pylori has been used in the diagnosis of active infection with these organisms. Several commercial tests are available but there are few and unconfirmed reports of their efficacy. This study aimed to assess and compare the efficacy of the following H pylori serologica...

journal_title：Gut

authors： Taha AS,Reid J,Boothmann P,Gemmell CG,Lee FD,Sturrock RD,Russell RI

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited. AIM:To examine the effect of ZnC on various models of gut injury and repair, and in a clinical trial. METHODS:In vitr...

journal_title：Gut

authors： Mahmood A,FitzGerald AJ,Marchbank T,Ntatsaki E,Murray D,Ghosh S,Playford RJ

更新日期：2007-02-01 00:00:00

abstract：:A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...

journal_title：Gut

authors： Vessey MP,Goldacre MJ,Seagroatt V,Yeates D

更新日期：1993-12-01 00:00:00

abstract：:Bran, ispaghula (Fybogel), and lactulose were given to three groups of patients with diverticular disease for four weeks. Faecal weights, bile acids, fat and electrolytes, transit time, and colonic motility were estimated before and after treatment. Stool weight increased, notably with Fybogel. Cereal bran had the gre...

journal_title：Gut

authors： Eastwood MA,Smith AN,Brydon WG,Pritchard J

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS:We conducted a randomised, double blind, placebo controlled trial of intravenous ant...

journal_title：Gut

authors： Siriwardena AK,Mason JM,Balachandra S,Bagul A,Galloway S,Formela L,Hardman JG,Jamdar S

更新日期：2007-10-01 00:00:00

abstract：:A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...

journal_title：Gut

authors： Cummings JH,Wiggins HS

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:5-Lipoxygenase products play a part in inflammatory response. AIMS:The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis. METHODS:Ninety rats with trinitrobenzenesulphonic acid induced colitis...

journal_title：Gut

authors： Bertrán X,Mañé J,Fernández-Bañares F,Castellá E,Bartolí R,Ojanguren I,Esteve M,Gassull MA

更新日期：1996-06-01 00:00:00

abstract：:Evidence for the occurrence of microbial breakdown of carbohydrate in the human colon has been sought by measuring short chain fatty acid (SCFA) concentrations in the contents of all regions of the large intestine and in portal, hepatic and peripheral venous blood obtained at autopsy of sudden death victims within fou...

journal_title：Gut

authors： Cummings JH,Pomare EW,Branch WJ,Naylor CP,Macfarlane GT

更新日期：1987-10-01 00:00:00