Abstract:
BACKGROUND:Impaired iron handling in riboflavin deficiency is thought to be partially a result of significant morphological and cytokinetic changes within the small intestine. AIMS:The aim of the study was to find out if the responses of the rat small intestine to riboflavin deficiency induced at weaning could be reversed upon repletion. SUBJECTS:48 female weanling Wistar rats were used for the purpose of the study. METHODS:Rats were fed a riboflavin deficient diet or a complete control diet for a period of five weeks followed by a repletion period of up to three weeks. Rats were killed on day 0, 2, 7, or 21 of repletion. The duodenum was removed and fixed for subsequent analysis. RESULTS:Five weeks of riboflavin deficiency significantly changed the morphology and cytokinetics of the duodenum; the changes were not reversed within the 21 day repletion period despite biochemical evidence for a correction of the deficiency. CONCLUSIONS:The results show that the small intestine cannot readily recover from a period of riboflavin deficiency induced at weaning, supporting the notion that the weaning period is a critical time for gastrointestinal development and highlighting the importance of adequate nutrition during infancy.
journal_name
Gutjournal_title
Gutauthors
Williams EA,Rumsey RD,Powers HJdoi
10.1136/gut.39.2.220subject
Has Abstractpub_date
1996-08-01 00:00:00pages
220-5issue
2eissn
0017-5749issn
1468-3288journal_volume
39pub_type
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