Abstract:
BACKGROUND:Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes. Sex linked anaemia (sla) mice have a defect in the release of iron from intestinal enterocytes into the circulation due to an interstitial deletion in the hephaestin gene (heph). RESULTS:We have demonstrated that hephaestin is primarily localised to a supranuclear compartment in both intestinal enterocytes and in cultured cells. In normal intestinal enterocytes, hephaestin was also present on the basolateral surface. In sla mice, hephaestin was present only in the supranuclear compartment. In contrast, the iron permease Ireg1 localised to the basolateral membrane in both control and sla mice. CONCLUSION:We suggest that mislocalisation of hephaestin likely contributes to the functional defect in sla intestinal epithelium.
journal_name
Gutjournal_title
Gutauthors
Kuo YM,Su T,Chen H,Attieh Z,Syed BA,McKie AT,Anderson GJ,Gitschier J,Vulpe CDdoi
10.1136/gut.2003.019026keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
201-6issue
2eissn
0017-5749issn
1468-3288journal_volume
53pub_type
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