The risk of subsequent primary cancers after colorectal cancer in southeast England.

abstract：:The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...

journal_title：Gut

authors： Thompson JN,Salem RR,Hemingway AP,Rees HC,Hodgson HJ,Wood CB,Allison DJ,Spencer J

更新日期：1987-01-01 00:00:00

abstract：:Synthetic 13-norleucine-motilin (13-nle-motilin), structural and biological analogue of the naturally-occurring duodenal polypeptide, motilin, is known to stimulate antral and duodenal motor activity in vitro, but delays gastric emptying in man. In this study the direct actions of the synthetic polypeptide on myoelect...

journal_title：Gut

authors： Green WE,Ruppin H,Wingate DL,Domschke W,Wünsch DE,Demling L,Ritchie HD

更新日期：1976-05-01 00:00:00

abstract：:Earlier studies have reported that faecal pH is more alkaline in patients with colonic cancer, indicating a reduction in colonic carbohydrate fermentation to organic acids. The pH of faeces from 11 pre and 14 postoperative, selected colonic cancer patients without intestinal obstruction, major loss of appetite or weig...

journal_title：Gut

authors： Hove H,Rye Clausen M,Brøbech Mortensen P

更新日期：1993-05-01 00:00:00

abstract：:A manometric method was developed to study the motor activity in the unprepared human colon, and the results in eight healthy subjects were compared with those obtained in the same subjects after bowel cleansing with a non-absorbable solution containing polyethylene glycol 4000 (PEG). A tube assembly (4.5 m long, 12 l...

journal_title：Gut

authors： Lémann M,Flourié B,Picon L,Coffin B,Jian R,Rambaud JC

更新日期：1995-11-01 00:00:00

abstract：:Faecal chymotrypsin was measured in patients with chronic pancreatitis and in healthy black urban and rural control subjects. In the patients, significantly lower values of faecal chymotrypsin were obtained (mean (SD) 2.4 1.79 U/g stool) whereas in urban control subjects, values were within the normal range (mean (SD)...

journal_title：Gut

authors： Riedel L,Walker AR,Segal I,Mohamed AE,Smyth AE,Daya B,Naik I

更新日期：1991-03-01 00:00:00

abstract：:Data concerning the effects of morphine on human pancreatic secretion are fragmentary and inconclusive. In the present study, we evaluated the effects of morphine on pure pancreatic secretion in nine subjects with external transduodenal drainage of the main pancreatic duct performed after biliary tract surgery. Intrav...

journal_title：Gut

authors： Gullo L,Priori P,Costa PL,Garcea D,Baldoni F,Mattioli G,Labo G

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk of colorectal cancer is increased in ulcerative colitis (UC). Patients with UC have diverse colonoscopic appearances. Determining colonoscopic markers for cancer risk could allow patient risk stratification. PATIENTS AND METHODS:Following on from an earlier study which demonstrated a corre...

journal_title：Gut

authors： Rutter MD,Saunders BP,Wilkinson KH,Rumbles S,Schofield G,Kamm MA,Williams CB,Price AB,Talbot IC,Forbes A

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C. DESIGN:We analysed 1461 patients with chronic hepatitis C with an estimat...

journal_title：Gut

authors： Rüeger S,Bochud PY,Dufour JF,Müllhaupt B,Semela D,Heim MH,Moradpour D,Cerny A,Malinverni R,Booth DR,Suppiah V,George J,Argiro L,Halfon P,Bourlière M,Talal AH,Jacobson IM,Patin E,Nalpas B,Poynard T,Pol S,Abel L,

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...

journal_title：Gut

authors： de Vries AC,Meijer GA,Looman CW,Casparie MK,Hansen BE,van Grieken NC,Kuipers EJ

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expressio...

journal_title：Gut

authors： Zhou Q,Yang L,Larson S,Basra S,Merwat S,Tan A,Croce C,Verne GN

更新日期：2016-05-01 00:00:00

abstract：:The records of 113 consecutive patients with a suspected gastrointestinal motility disorder referred between January 1988 and July 1991 were retrospectively reviewed. The aims were to identify the prevalence of autonomic dysfunction in those with or without associated neurological disease and to determine the diagnost...

journal_title：Gut

authors： Bharucha AE,Camilleri M,Low PA,Zinsmeister AR

更新日期：1993-03-01 00:00:00

abstract：:The effects of pentagastrin and the putative gastrin antagonist proglumide on interdigestive motility of the upper small bowel were studied in a randomised double blind study in 10 healthy human volunteers. Intraluminal pressures were recorded manometrically in the duodenum and jejunum for five hours. Sixty minutes af...

journal_title：Gut

authors： Erckenbrecht JF,Caspari J,Wienbeck M

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS:In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, an...

journal_title：Gut

authors： Farinati F,Cardin R,Degan P,Rugge M,Mario FD,Bonvicini P,Naccarato R

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy. METHODS:A population-based case-control study was conducted in Southern Germany in 2003-...

journal_title：Gut

authors： Brenner H,Chang-Claude J,Seiler CM,Hoffmeister M

更新日期：2012-11-01 00:00:00

abstract：:Gastric cancer is a major health burden worldwide and prevention is the most promising strategy to control the disease. The available scientific evidence indicates that curing Helicobacter pylori infection results in a modest retardation of the precancerous process but does not prevent all cancers. Individuals at the ...

journal_title：Gut

authors： Correa P

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic therapies, there is a need for cell lines that preserve the in vivo phenotype of human HSCs to elucidate pathways of human...

journal_title：Gut

authors： Xu L,Hui AY,Albanis E,Arthur MJ,O'Byrne SM,Blaner WS,Mukherjee P,Friedman SL,Eng FJ

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Endothelial progenitor cells (EPCs) circulate with increased numbers in the peripheral blood of patients with highly-vascularised hepatocellular carcinoma (HCC) and contribute to angiogenesis and neovascularisation. We hypothesised that angiogenic EPCs, that is, colony forming unit-endothelial cells (CFU-ECs...

journal_title：Gut

authors： Shih YT,Wang MC,Zhou J,Peng HH,Lee DY,Chiu JJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Increased expression of proinflammatory cytokines, including tumour necrosis factor alpha, interleukin 6, and interferon gamma, as well as activation of proinflammatory signalling molecules such as nuclear factor kappa B, is characteristic of inflammatory bowel disease (IBD). AIMS:To investigate expression ...

journal_title：Gut

authors： Schreiber S,Rosenstiel P,Hampe J,Nikolaus S,Groessner B,Schottelius A,Kühbacher T,Hämling J,Fölsch UR,Seegert D

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Patients with liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between liver cirrhosis and pyogenic liver abscess. AIMS:To estimate the risk and case fatality rate of pyogenic liver abscess in Danish patients...

journal_title：Gut

authors： Mølle I,Thulstrup AM,Vilstrup H,Sørensen HT

更新日期：2001-02-01 00:00:00

abstract：:Liver regeneration is the common mechanism whereby a patient recovers form a liver injury. In the western world, ethanol is the single most important aetiological factor associated with liver disease, and it appears crucial to determine if ethanol interferes with liver regeneration. We studied the response to a 70% he...

journal_title：Gut

authors： Duguay L,Coutu D,Hetu C,Joly JG

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:The prognosis of patients with hepatocellular carcinoma (HCC) remains poor, and new alternative treatments are needed. AIMS:To comparatively test the angiostatic and antitumour effects of adenoviral gene transfer of angiostatin (PlgK1-4, amino acids 1-440) and full kringles 1-5 (PlgK1-5, amino acids 1-546) ...

journal_title：Gut

authors： Schmitz V,Raskopf E,Gonzalez-Carmona MA,Vogt A,Rabe C,Leifeld L,Kornek M,Sauerbruch T,Caselmann WH

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. METHODS:The fate of BMDCs was ...

journal_title：Gut

authors： Marrache F,Pendyala S,Bhagat G,Betz KS,Song Z,Wang TC

更新日期：2008-08-01 00:00:00

abstract：:The mechanism by which intragastric balloons induce weight loss is not known, although they may act simply by reducing the amount of food needed to induce satiety. The knowledge that a balloon is present may influence the patients' eating patterns and reduce caloric intake and weight. In order to test whether the ball...

journal_title：Gut

authors： Ramhamadany EM,Fowler J,Baird IM

更新日期：1989-08-01 00:00:00

abstract：:Colorectal cancer is the fourth commonest form of cancer in men with 678 000 estimated new cases per year worldwide, representing 8.9% of all new cancers. The disease is most frequent in Occidental countries and particularly so in North America, Australia, New Zealand, and parts of Europe. Prospects for colorectal can...

journal_title：Gut

authors： Langman M,Boyle P

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:IBDs have an increased risk for development of colorectal cancer (CRC). Here, we aimed at the characterisation of the functional role of Th17-associated transcription factors in sporadic and colitis-associated colon cancer in vivo. DESIGN:We used mice deficient or transgenic for the activating protein 1 fam...

journal_title：Gut

authors： Punkenburg E,Vogler T,Büttner M,Amann K,Waldner M,Atreya R,Abendroth B,Mudter J,Merkel S,Gallmeier E,Rose-John S,Neurath MF,Hildner K

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...

journal_title：Gut

authors： Miki C,Mayer AD,Buckels JA,Iriyama K,Suzuki H,McMaster P

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on intestinal perm...

journal_title：Gut

authors： Vanuytsel T,van Wanrooy S,Vanheel H,Vanormelingen C,Verschueren S,Houben E,Salim Rasoel S,Tόth J,Holvoet L,Farré R,Van Oudenhove L,Boeckxstaens G,Verbeke K,Tack J

更新日期：2014-08-01 00:00:00

abstract：:Two peptides which are potent stimulants of gastric acid secretion are isolated from Zollinger-Ellison tumour tissue. They have aminoacid constitutions identical with those of human gastrin types I and II as isolated from human antral mucosa, and they are present in similar proportions. Their electrophoretic and chrom...

journal_title：Gut

authors： Gregory RA,Tracy HJ,Agarwal KL,Grossman MI

更新日期：1969-08-01 00:00:00

abstract：:This study was done to determine the severity and extent of abnormalities of duodenal mucosal architecture in non-specific (non-ulcerative) and ulcer-associated duodenitis. The effect of successful treatment with cimetidine on these changes has also been assessed. A method of microdissection and measurement of villus ...

journal_title：Gut

authors： Hasan M,Sircus W,Ferguson A

更新日期：1981-08-01 00:00:00

abstract：:This study reports on a group of 20 patients with an initial diagnosis of primary biliary cirrhosis (PBC) whose serum tested negative for antimitochondrial antibodies by immunofluorescence. All had a clinical history compatible with primary biliary cirrhosis, and results of biochemical, histological, and radiological ...

journal_title：Gut

authors： Michieletti P,Wanless IR,Katz A,Scheuer PJ,Yeaman SJ,Bassendine MF,Palmer JM,Heathcote EJ

更新日期：1994-02-01 00:00:00