Effects of appendicectomy on the course of ulcerative colitis.

Abstract:

BACKGROUND:Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. AIM:To determine whether appendicectomy reduces the overall severity of ulcerative colitis. PATIENTS AND METHODS:Appendicectomy status and smoking habits were specified by direct interview in 638 patients seen consecutively between 1997 and 2000. Severity of ulcerative colitis was assessed by reviewing therapeutic needs from the onset of colitis. Additionally, the annual incidence of flare up was assessed prospectively between 1997 and 2000 in patients who had not been colectomised. RESULTS:The 10 year risk of colectomy was 16 (7)% in previously appendicectomised patients (n=49) compared with 33 (2)% in non-appendicectomised patients (n=589, p=0.05). Cox regression showed that previous appendicectomy and current smoking were independent factors protecting against colectomy (adjusted hazard ratio and 95% confidence intervals: 0.40 (0.20-0.78) and 0.60 (0.40-0.95), respectively). The respective proportions of appendicectomised and non-appendicectomised patients who required oral steroids and immunosuppressive therapy were not significantly different (67% v 70% and 27% v 19%, respectively). Between 1997 and 2000, ulcerative colitis was active for 48% of the time in appendicectomised patients (47 of 98 patient years) and for 62% of the time in non-appendicectomised patients (631 of 1024 patient years; p<0.01). CONCLUSION:Previous appendicectomy is associated with a less severe course of ulcerative colitis. The beneficial effect of appendicectomy on the risk of colectomy is additive to that of current smoking.

journal_name

Gut

journal_title

Gut

authors

Cosnes J,Carbonnel F,Beaugerie L,Blain A,Reijasse D,Gendre JP

doi

10.1136/gut.51.6.803

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

803-7

issue

6

eissn

0017-5749

issn

1468-3288

journal_volume

51

pub_type

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