A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis.


BACKGROUND:Non-selective cyclooxygenase (COX) inhibitors (non-steroidal anti-inflammatory drugs) inhibit large bowel carcinogenesis in patients with familial adenomatous polyposis (FAP). Their role in the duodenum of these patients is less certain. The disease modifying activity of specific COX-2 inhibitors has not been explored in humans. PATIENTS AND METHODS:This was a randomised, double blind, placebo controlled study of celecoxib (100 mg twice daily (n=34) or 400 mg twice daily (n=32)) versus placebo (n=17), given orally twice daily for six months to patients with FAP. Efficacy was assessed qualitatively by blinded review of shuffled endoscopy videotapes comparing the extent of duodenal polyposis at entry and at six months and quantitatively by measurement of the percentage change in duodenal area covered by discrete and plaque-like adenomas from photographs of high and low density polyposis. RESULTS:Shuffled and blinded video review showed a statistically significant effect of 400 mg twice daily celecoxib compared with placebo treatment (p=0.033) with all five independent observers scoring a beneficial effect. Overall, patients taking celecoxib 400 mg twice daily showed a 14.5% reduction in involved areas compared with a 1.4% for placebo (p=0.436). However, patients with clinically significant disease at baseline (greater than 5% covered by polyps) showed a 31% reduction in involved areas with celecoxib 400 mg twice daily compared with 8% on placebo (p=0.049). CONCLUSIONS:A panel of five endoscopists found a significant reduction in duodenal polyposis after six months of treatment with celecoxib 400 mg twice daily. COX-2 inhibition may help this otherwise untreatable condition.






Phillips RK,Wallace MH,Lynch PM,Hawk E,Gordon GB,Saunders BP,Wakabayashi N,Shen Y,Zimmerman S,Godio L,Rodrigues-Bigas M,Su LK,Sherman J,Kelloff G,Levin B,Steinbach G,FAP Study Group.





Has Abstract


2002-06-01 00:00:00














  • Chronic painless pancreatitis.

    abstract::This paper describes four patients whose chief symptoms were steatorrhoea and loss of weight. Despite the absence of a history of abdominal pain investigations showed that these patients had chronic pancreatitis, which responded to medical treatment. The pathological findings in two of these cases and in six which cam...


    pub_type: 杂志文章



    更新日期:1962-09-01 00:00:00

  • After portal branch ligation in the rat, cellular proliferation is associated with selective induction of c-Ha-ras, p53, cyclin E, and Cdk2.

    abstract:BACKGROUND:In liver regeneration after portal branch ligation we previously showed that early cellular changes are observed in both the proliferating and atrophying liver lobes. They are therefore not indicative of future proliferative response. In this study we attempted to define precisely, in the same model, the tim...


    pub_type: 杂志文章


    authors: Stärkel P,Lambotte L,Sempoux C,De Saeger C,Saliez A,Maiter D,Horsmans Y

    更新日期:2001-07-01 00:00:00

  • Anticomplement receptor activity in the serum of patients with primary biliary cirrhosis.

    abstract::Patients with primary biliary cirrhosis have a defect in the receptor mediated clearance of complement coated erythrocytes by fixed macrophages of the reticuloendothelial system. To investigate the probable mechanism of this defect peripheral blood monocytes were isolated from nine patients with primary biliary cirrho...


    pub_type: 杂志文章


    authors: Minuk GY,Vergalla J,Hanson RG,Hoofnagle JH,Frank MM,Jones EA

    更新日期:1986-03-01 00:00:00

  • Reduction of gastrointestinal protein loss by elemental diet in Crohn's disease of the small bowel.

    abstract::Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...


    pub_type: 杂志文章


    authors: Logan RF,Gillon J,Ferrington C,Ferguson A

    更新日期:1981-05-01 00:00:00

  • Diffuse enterochromaffin-like (ECL) cell hyperplasia and multiple gastric carcinoids: a complication of pernicious anaemia.

    abstract::A man with long-standing pernicious anaemia developed multiple gastric carcinoid tumours with a background of diffuse enterochromaffin-like cell hyperplasia. There is evidence that enterochromaffin-like cells synthesis and store histamine and that their proliferation is stimulated by high serum gastrin levels. Gastric...


    pub_type: 杂志文章


    authors: Hodges JR,Isaacson P,Wright R

    更新日期:1981-03-01 00:00:00

  • The effect of heritability and host genetics on the gut microbiota and metabolic syndrome.

    abstract:OBJECTIVE:Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remain...


    pub_type: 杂志文章


    authors: Lim MY,You HJ,Yoon HS,Kwon B,Lee JY,Lee S,Song YM,Lee K,Sung J,Ko G

    更新日期:2017-06-01 00:00:00

  • Acid, motility, and ulcers: a comparison of cisapride with placebo in the prevention of duodenal ulcer relapse.

    abstract::In a single centre double blind study of 66 patients, the value of cisapride (10 mg twice daily) was compared with placebo in the prevention of duodenal ulcer relapse. Patients who remained ulcer free attended for clinical review every two months and had a mandatory endoscopy at 0, 4, 8, and 12 months or if symptoms s...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kerrigan DD,Taylor ME,Read NW,Johnson AG

    更新日期:1993-08-01 00:00:00

  • Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.

    abstract:BACKGROUND:Although evidence points to a role for histamine and serotonin in visceral hypersensitivity, activation of calcium channels such as transient receptor potential vanilloid 4 (TRPV4) also causes visceral hypersensitivity. We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating...


    pub_type: 杂志文章


    authors: Cenac N,Altier C,Motta JP,d'Aldebert E,Galeano S,Zamponi GW,Vergnolle N

    更新日期:2010-04-01 00:00:00

  • Variability of colonic function in healthy subjects.

    abstract::Twenty healthy subjects eating normal diets made repeated five-day stool collections, the 10 females making their collections in four to six successive weeks. In most subjects there were striking variations in transit time, measured by Hinton's method. The variability of average faecal wet and dry weight, faecal volum...


    pub_type: 杂志文章


    authors: Wyman JB,Heaton KW,Manning AP,Wicks AC

    更新日期:1978-02-01 00:00:00

  • Enhanced mucosal permeability and nitric oxide synthase activity in jejunum of mast cell deficient mice.

    abstract:BACKGROUND:Recent reports have described a modulating influence of nitric oxide (NO) on intestinal mucosal permeability and have implicated a role for mast cells in this NO mediated process. AIMS:To assess further the contribution of mast cells to the mucosal permeability changes elicited by the NO synthase (NOS) inhi...


    pub_type: 杂志文章


    authors: Komatsu S,Grisham MB,Russell JM,Granger DN

    更新日期:1997-11-01 00:00:00

  • Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis.

    abstract::Ultrastructural examination of biopsies showing Helicobacter pylori associated chronic gastritis reveals close attachment between gastric surface epithelial cells and the organism. The finding of 'adhesion pedestals', which represents a cellular response to the presence of the organism, is analogous to the response of...


    pub_type: 杂志文章


    authors: Hessey SJ,Spencer J,Wyatt JI,Sobala G,Rathbone BJ,Axon AT,Dixon MF

    更新日期:1990-02-01 00:00:00

  • Histopathologist features predictive of diagnostic concordance at expert level among a large international sample of pathologists diagnosing Barrett's dysplasia using digital pathology.

    abstract:OBJECTIVE:Guidelines mandate expert pathology review of Barrett's oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance. DESIGN:Pathologists (n=5...


    pub_type: 杂志文章,多中心研究


    authors: van der Wel MJ,Coleman HG,Bergman JJGHM,Jansen M,Meijer SL,BOLERO working group.

    更新日期:2020-05-01 00:00:00

  • Validation of a specific quality of life questionnaire for functional digestive disorders.

    abstract:BACKGROUND:Dyspepsia and irritable bowel syndrome are suitable conditions for assessment of quality of life. Their similarities justify the elaboration of a single specific questionnaire for the two conditions. AIMS:To examine the process leading to the validation of the psychometric properties of the functional diges...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Chassany O,Marquis P,Scherrer B,Read NW,Finger T,Bergmann JF,Fraitag B,Geneve J,Caulin C

    更新日期:1999-04-01 00:00:00

  • Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis.

    abstract:BACKGROUND:The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. Howe...


    pub_type: 杂志文章,随机对照试验


    authors: Kühbacher T,Ott SJ,Helwig U,Mimura T,Rizzello F,Kleessen B,Gionchetti P,Blaut M,Campieri M,Fölsch UR,Kamm MA,Schreiber S

    更新日期:2006-06-01 00:00:00

  • Duodenal mucosal architecture in non-specific and ulcer-associated duodenitis.

    abstract::This study was done to determine the severity and extent of abnormalities of duodenal mucosal architecture in non-specific (non-ulcerative) and ulcer-associated duodenitis. The effect of successful treatment with cimetidine on these changes has also been assessed. A method of microdissection and measurement of villus ...


    pub_type: 杂志文章


    authors: Hasan M,Sircus W,Ferguson A

    更新日期:1981-08-01 00:00:00

  • Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis.

    abstract::Because of the increasing use of immunosuppressive and biological drugs, the occurrence of opportunistic infections has become a key safety issue for patients with inflammatory bowel disease (IBD). Consequently, improvement of healthcare workers' knowledge of this domain is urgent. In this review, the preventive measu...


    pub_type: 杂志文章,评审


    authors: Viget N,Vernier-Massouille G,Salmon-Ceron D,Yazdanpanah Y,Colombel JF

    更新日期:2008-04-01 00:00:00

  • An analysis of the learning curve to achieve competency at colonoscopy using the JETS database.

    abstract:OBJECTIVE:The number of colonoscopies required to reach competency is not well established. The primary aim of this study was to determine the number of colonoscopies trainees need to perform to attain competency, defined by a caecal intubation rate (CIR) ≥90%. As competency depends on completion, we also investigated ...


    pub_type: 杂志文章


    authors: Ward ST,Mohammed MA,Walt R,Valori R,Ismail T,Dunckley P

    更新日期:2014-11-01 00:00:00

  • Interferon alfa-2b for decompensated liver disease caused by either chronic hepatitis B or C: preliminary results of a pilot study.

    abstract::This pilot study was designed to assess the tolerance and effectiveness of interferon alfa-2b in patients with decompensated liver disease caused by chronic hepatitis B (n = 7) or C (n = 5). Preliminary results suggest that patients may benefit from small doses of interferon (improvement in liver function tests and re...


    pub_type: 杂志文章


    authors: Dimopoulou M,Fafoutis K,Basiliou K,Ketikoglou J,Karvountzis G

    更新日期:1993-01-01 00:00:00

  • Inhibition of liver regeneration by chronic alcohol administration.

    abstract::Liver regeneration is the common mechanism whereby a patient recovers form a liver injury. In the western world, ethanol is the single most important aetiological factor associated with liver disease, and it appears crucial to determine if ethanol interferes with liver regeneration. We studied the response to a 70% he...


    pub_type: 杂志文章


    authors: Duguay L,Coutu D,Hetu C,Joly JG

    更新日期:1982-01-01 00:00:00

  • A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction.

    abstract:OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...


    pub_type: 杂志文章


    authors: Tian S,Simon I,Moreno V,Roepman P,Tabernero J,Snel M,van't Veer L,Salazar R,Bernards R,Capella G

    更新日期:2013-04-01 00:00:00

  • Isolation, maturational level, and functional capacity of human colon lamina propria plasma cells.

    abstract:BACKGROUND AND AIMS:Large numbers of plasma cells (PC) localise in the intestinal lamina propria (LP) where they play a critical role in the defence against pathogens. This study analyses the level of maturation reached by normal human colon LPPC in comparison with that of bone marrow (BM) PC. METHODS:A technique was ...


    pub_type: 杂志文章


    authors: Medina F,Segundo C,Campos-Caro A,Salcedo I,García-Poley A,Brieva JA

    更新日期:2003-03-01 00:00:00

  • Portal and peripheral blood short chain fatty acid concentrations after caecal lactulose instillation at surgery.

    abstract::The major end products of fermentation, short chain fatty acids (acetate, propionate, butyrate) were measured in portal and peripheral venous blood after the caecal instillation of lactulose at surgery in patients undergoing elective cholecystectomy. Blood samples for short chain fatty acid measurement were taken befo...


    pub_type: 杂志文章


    authors: Peters SG,Pomare EW,Fisher CA

    更新日期:1992-09-01 00:00:00

  • Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.

    abstract::We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus serotype 12 (Ad12), an adenovirus isolated from the human intestinal tract. In the present study sera from coeliac dise...


    pub_type: 杂志文章


    authors: Kagnoff MF,Paterson YJ,Kumar PJ,Kasarda DD,Carbone FR,Unsworth DJ,Austin RK

    更新日期:1987-08-01 00:00:00

  • Pneumatic dilatation in achalasia.

    abstract::To assess the value of pneumatic dilatation of the cardia, 63 patients with achalasia have undergone a total of 107 Rider-Moeller dilatations over the last six years. There was a marked improvement in swallowing immediately after dilatation in all but two patients, there were no deaths attributable to the procedure an...


    pub_type: 杂志文章


    authors: Fellows IW,Ogilvie AL,Atkinson M

    更新日期:1983-11-01 00:00:00

  • The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa.

    abstract:BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...


    pub_type: 杂志文章


    authors: Lemoine M,Shimakawa Y,Nayagam S,Khalil M,Suso P,Lloyd J,Goldin R,Njai HF,Ndow G,Taal M,Cooke G,D'Alessandro U,Vray M,Mbaye PS,Njie R,Mallet V,Thursz M

    更新日期:2016-08-01 00:00:00

  • Human colonic smooth muscle: electrical and contractile activity in vitro.

    abstract::Extracellular electrical and contractile activities were recorded in vitro from strips of human colonic smooth muscle obtained at the time of surgery. Serosal electrical activity of longitudinally oriented strips from the taenia and intertaenial region was characterised by continuous oscillation at a frequency of 28 +...


    pub_type: 杂志文章


    authors: Gill RC,Cote KR,Bowes KL,Kingma YJ

    更新日期:1986-03-01 00:00:00

  • Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells.

    abstract:OBJECTIVE:Liver fibrosis and cirrhosis resulting from chronic liver injury represent a major healthcare burden worldwide. Growth differentiation factor (GDF) 11 has been recently investigated for its role in rejuvenation of ageing organs, but its role in chronic liver diseases has remained unknown. Here, we investigate...


    pub_type: 杂志文章


    authors: Dai Z,Song G,Balakrishnan A,Yang T,Yuan Q,Möbus S,Weiss AC,Bentler M,Zhu J,Jiang X,Shen X,Bantel H,Jaeckel E,Kispert A,Vogel A,Saborowski A,Büning H,Manns M,Cantz T,Ott M,Sharma AD

    更新日期:2020-06-01 00:00:00

  • Soluble E-cadherin is a valid prognostic marker in gastric carcinoma.

    abstract:BACKGROUND:Gastric cancer remains a major cause of cancer mortality globally but no good prognostic tumour marker is available. Soluble fragment of E-cadherin protein has been reported to increase in the sera of patients with cancer and recently was found to be elevated in 67% of patients with gastric cancer. AIMS:To ...


    pub_type: 杂志文章


    authors: Chan AO,Lam SK,Chu KM,Lam CM,Kwok E,Leung SY,Yuen ST,Law SY,Hui WM,Lai KC,Wong CY,Hu HC,Lai CL,Wong J

    更新日期:2001-06-01 00:00:00

  • Effect of alpha-glucosidehydrolase inhibition and intestinal absorption of sucrose, water, and sodium in man.

    abstract::The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhib...


    pub_type: 杂志文章


    authors: Caspary WF,Kalisch H

    更新日期:1979-09-01 00:00:00

  • Increased activity of digestive enzymes in ileal enterocytes adapting to proximal small bowel resection.

    abstract::The ability of adapting ileal enterocytes to express different digestive enzymes in their brush border membranes was tested in young female Wistar rats (n = 72) receiving 60% proximal small bowel resection. In control rats with intestinal transection both neutral aminopeptidase and alpha-glucosidase activities were sh...


    pub_type: 杂志文章


    authors: Chaves M,Smith MW,Williamson RC

    更新日期:1987-08-01 00:00:00