Chronic intrahepatic cholestasis due to sarcoidosis.

abstract：BACKGROUND:Several pharmacological agents for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) have been studied. Clinical trials evaluating the protective effect of non-steroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results. AIM:To perform a meta-an...

journal_title：Gut

authors： Elmunzer BJ,Waljee AK,Elta GH,Taylor JR,Fehmi SM,Higgins PD

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...

journal_title：Gut

authors： van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

更新日期：2019-12-01 00:00:00

abstract：:This trial was undertaken to establish the long term biochemical and serological outcome of patients with acute post-transfusion hepatitis C virus infection after treatment with interferon alfa-2b. After 12 months, 12 patients (eight treated, four controls) had self limited disease and 16 patients (seven treated, nine...

journal_title：Gut

authors： Genesca J,Esteban JI,Quer J,Viladomiu LL,Gonzalez A,Esteban R,Guardia J

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND AIM:There is controversy regarding whether paramyxovirus infection is causally associated with inflammatory bowel disease (IBD). The latest cohort study claimed that atypical measles and mumps infections in childhood may be risk factors for later IBD. This study was conducted to clarify the validity of a...

journal_title：Gut

authors： Iizuka M,Saito H,Yukawa M,Itou H,Shirasaka T,Chiba M,Fukushima T,Watanabe S

更新日期：2001-05-01 00:00:00

abstract：:The results of bile salt treatment in patients with radiolucent stones and a functioning gall bladder have been poor. In 42 of these patients awaiting cholecystectomy we determined the value of duodenal bile examination in predicting gall stone composition, and thus identifying those less likely to respond to bile sal...

journal_title：Gut

authors： Agarwal DK,Choudhuri G,Saraswat VA,Negi TS,Kapoor VK,Saxena R

更新日期：1994-01-01 00:00:00

abstract：:The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...

journal_title：Gut

authors： Spence RW,Burns-Cox CJ

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND/AIMS:By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to determine whether endoscopic retrograde cholangiopancreaticography (ERP)-induced pancreatitis can be used as a human model fo...

journal_title：Gut

authors： Messmann H,Vogt W,Holstege A,Lock G,Heinisch A,von Fürstenberg A,Leser HG,Zirngibl H,Schölmerich J

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:IBDs have an increased risk for development of colorectal cancer (CRC). Here, we aimed at the characterisation of the functional role of Th17-associated transcription factors in sporadic and colitis-associated colon cancer in vivo. DESIGN:We used mice deficient or transgenic for the activating protein 1 fam...

journal_title：Gut

authors： Punkenburg E,Vogler T,Büttner M,Amann K,Waldner M,Atreya R,Abendroth B,Mudter J,Merkel S,Gallmeier E,Rose-John S,Neurath MF,Hildner K

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. AIMS:To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. PATIENTS:Seventy patients wh...

journal_title：Gut

authors： Kim J,Reber HA,Dry SM,Elashoff D,Chen SL,Umetani N,Kitago M,Hines OJ,Kazanjian KK,Hiramatsu S,Bilchik AJ,Yong S,Shoup M,Hoon DS

更新日期：2006-11-01 00:00:00

abstract：:This paper reviews the experience gained over the past few years in two techniques of liver support, charcoal haemoperfusion and polyacrylonitrile membrane haemodialysis. Problems with charcoal haemoperfusion have centred around platelet aggregation and hypertension, and new carbon preparations with a variety of diffe...

journal_title：Gut

authors： Williams R

更新日期：1978-06-01 00:00:00

abstract：OBJECTIVES:COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. DESIGN:This Italian prosp...

journal_title：Gut

authors： Bezzio C,Saibeni S,Variola A,Allocca M,Massari A,Gerardi V,Casini V,Ricci C,Zingone F,Amato A,Caprioli F,Lenti MV,Viganò C,Ascolani M,Bossa F,Castiglione F,Cortelezzi C,Grossi L,Milla M,Morganti D,Pastorelli L,R

更新日期：2020-07-01 00:00:00

abstract：:This study reports on the outcome of four patients having ileal pouch anal anastomosis after orthotopic liver transplantation for sclerosing cholangitis complicating ulcerative colitis. There were no deaths on follow up. Early postoperative bleeding was a complication of colectomy or rectal excision in three, one of w...

journal_title：Gut

authors： Rowley S,Candinas D,Mayer AD,Buckels JA,McMaster P,Keighley MR

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Shanghai fever, a community-acquired enteric illness associated with sepsis caused by Pseudomonas aeruginosa, was first described in 1918. The understanding of Shanghai fever is incomplete. OBJECTIVE:To delineate the clinical features and to examine the host and microbial factors associated with Shanghai fe...

journal_title：Gut

authors： Chuang CH,Wang YH,Chang HJ,Chen HL,Huang YC,Lin TY,Ozer EA,Allen JP,Hauser AR,Chiu CH

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. OBJECTIVE:To d...

journal_title：Gut

authors： Asada K,Nakajima T,Shimazu T,Yamamichi N,Maekita T,Yokoi C,Oda I,Ando T,Yoshida T,Nanjo S,Fujishiro M,Gotoda T,Ichinose M,Ushijima T

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:Cathepsin K is a lysosomal cysteine protease that has pleiotropic roles in bone resorption, arthritis, atherosclerosis, blood pressure regulation, obesity and cancer. Recently, it was demonstrated that cathepsin K-deficient (Ctsk(-/-) ) mice are less susceptible to experimental autoimmune arthritis and enceph...

journal_title：Gut

authors： Sina C,Lipinski S,Gavrilova O,Aden K,Rehman A,Till A,Rittger A,Podschun R,Meyer-Hoffert U,Haesler R,Midtling E,Pütsep K,McGuckin MA,Schreiber S,Saftig P,Rosenstiel P

更新日期：2013-04-01 00:00:00

abstract：:Pectin has been shown to minimise the fall in blood glucose seen in patients who are troubled by hypoglycaemia attacks after gastric surgery. We therefore performed 50 g glucose tolerance tests with and without 14.5 g pectin on 11 post-gastric surgery patients. After pectin, the high postprandial levels of glucose, in...

journal_title：Gut

authors： Jenkins DJ,Bloom SR,Albuquerque RH,Leeds AR,Sarson DL,Metz GL,Alberti KG

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...

journal_title：Gut

authors： Wan L,Yu W,Shen E,Sun W,Liu Y,Kong J,Wu Y,Han F,Zhang L,Yu T,Zhou Y,Xie S,Xu E,Zhang H,Lai M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The choice of colorectal surgery in patients with familial adenomatous polyposis lies between the morbidity of proctocolectomy and ileum-pouch-anal anastomosis (IPAA) and the mortality from rectal cancer after total colectomy and ileorectal anastomosis (IRA). The aims of the present study were: (1) ...

journal_title：Gut

authors： Vasen HF,van Duijvendijk P,Buskens E,Bülow C,Björk J,Järvinen HJ,Bülow S

更新日期：2001-08-01 00:00:00

abstract：:A 22 year old woman presenting with recurrent intestinal pseudo-obstruction is reported. Jejunal biopsy showed subtotal villous atrophy which improved markedly during a period of total parenteral nutrition and with steroid treatment. It did not relapse on a gluten free diet. The reasons why this patient represents a c...

journal_title：Gut

authors： Dawson DJ,Sciberras CM,Whitwell H

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. AIMS:To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells. METHODS:Diff...

journal_title：Gut

authors： Jordinson M,El-Hariry I,Calnan D,Calam J,Pignatelli M

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. METHODS:Nucleos(t)ide analogue (NUC) treatment was disco...

journal_title：Gut

authors： Seto WK,Liu KS,Mak LY,Cloherty G,Wong DK,Gersch J,Lam YF,Cheung KS,Chow N,Ko KL,To WP,Fung J,Yuen MF

更新日期：2020-08-05 00:00:00

abstract：:The epidemiology of hepatitis C virus (HCV) infection was studied in an English teaching hospital over an 18 month period. A total of 104 HCV antibody positive patients were referred for further investigation. They were divided into those diagnosed through screening (blood donors and intravenous drug abusers) and thos...

journal_title：Gut

authors： Watson JP,Brind AM,Chapman CE,Bates CL,Gould FK,Johnson SJ,Burt AD,Ferguson J,Simmonds P,Bassendine MF

更新日期：1996-02-01 00:00:00

abstract：:Thirty-two patients with diarrhoea, on average four years following truncal vagotomy and drainage, were studied. A comparison was made with 24 patients without postvagotomy diarrhoea. The incidence of bacterial colonization of the upper small intestine was no different in the two groups, though patients with a gastroe...

journal_title：Gut

authors： Browning GG,Buchan KA,Mackay C

更新日期：1974-08-01 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a chronic ulcerating skin condition that often occurs in association with inflammatory bowel disease. There have been a number of reports of PG responding to infliximab, a monoclonal antibody against tumour necrosis factor alpha. AIM:In the first randomised placebo controlled tr...

journal_title：Gut

authors： Brooklyn TN,Dunnill MG,Shetty A,Bowden JJ,Williams JD,Griffiths CE,Forbes A,Greenwood R,Probert CS

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS:In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, an...

journal_title：Gut

authors： Farinati F,Cardin R,Degan P,Rugge M,Mario FD,Bonvicini P,Naccarato R

更新日期：1998-03-01 00:00:00

abstract：AIMS:To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer. METHODS:150 251 people were randomly allocated either to receive biennial Haemoccult FOB tests (n =75 253) or not to be contacted (n=74 998). Study group patients returning positive tests were offered colonic investi...

journal_title：Gut

authors： Robinson MH,Hardcastle JD,Moss SM,Amar SS,Chamberlain JO,Armitage NC,Scholefield JH,Mangham CM

更新日期：1999-10-01 00:00:00

abstract：:Options for managing the common bile duct during laparoscopic cholecystectomy include routine peroperative cholangiography and selected preoperative endoscopic retrograde cholangiopancreatography (ERCP). The use of these methods was reviewed in 350 patients with symptomatic gall stones referred for laparoscopic cholec...

journal_title：Gut

authors： Hainsworth PJ,Rhodes M,Gompertz RH,Armstrong CP,Lennard TW

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Intestinal metaplasia, whether in the cardia or the distal oesophagus, has been uniformly defined as specialised columnar epithelium, suggesting a relation with Barrett's oesophagus. It is, however, not clear whether the risk factors associated with intestinal metaplasia are identical at both sites. AIMS:To...

journal_title：Gut

authors： Hackelsberger A,Günther T,Schultze V,Manes G,Dominguez-Muñoz JE,Roessner A,Malfertheiner P

更新日期：1998-07-01 00:00:00

abstract：:The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a signif...

journal_title：Gut

authors： Jones AL,Bangash IH,Bouchier IA,Hayes PC

更新日期：1994-09-01 00:00:00

abstract：:Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...

journal_title：Gut

authors： Moran AP,Gupta A,Joshi L

更新日期：2011-10-01 00:00:00