Small intestinal structure and passive permeability in systemic sclerosis.

abstract：:Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...

journal_title：Gut

authors： Logan RF,Gillon J,Ferrington C,Ferguson A

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q ampli...

journal_title：Gut

authors： Sillars-Hardebol AH,Carvalho B,Tijssen M,Beliën JA,de Wit M,Delis-van Diemen PM,Pontén F,van de Wiel MA,Fijneman RJ,Meijer GA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatic stellate cells (HSCs) are key participants in liver fibrosis development. 1,25(OH)(2)D(3), the active form of vitamin D, has antiproliferative properties and antifibrotic potential, as well as a role in extracellular matrix and matrix metalloproteinase (MMP) regulation in renal and lung fibro...

journal_title：Gut

authors： Abramovitch S,Dahan-Bachar L,Sharvit E,Weisman Y,Ben Tov A,Brazowski E,Reif S

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVES:Roux-en-Y gastric bypass (RYGB) has greater efficacy for weight loss in obese patients than gastric banding (BAND) surgery. We hypothesise that this may result from different effects on food hedonics via physiological changes secondary to distinct gut anatomy manipulations. DESIGN:We used functional MRI, ea...

journal_title：Gut

authors： Scholtz S,Miras AD,Chhina N,Prechtl CG,Sleeth ML,Daud NM,Ismail NA,Durighel G,Ahmed AR,Olbers T,Vincent RP,Alaghband-Zadeh J,Ghatei MA,Waldman AD,Frost GS,Bell JD,le Roux CW,Goldstone AP

更新日期：2014-06-01 00:00:00

abstract：:Visceral hypersensitivity has been recognised as a characteristic of patients with irritable bowel syndrome (IBS). It may be involved in the pathogenesis of abdominal pain/discomfort, and seems to result from the sensitisation of nerve afferent pathways originating from the gastrointestinal tract. From a clinical poin...

journal_title：Gut

authors： Delvaux M

更新日期：2002-07-01 00:00:00

abstract：:Helicobacter pylori is present worldwide but few large population studies exist on the epidemiology of the infection. A random cross sectional study was performed of H pylori infection in the adult population of San Marino, a European country with high gastric cancer rate, to assess its prevalence and to evaluate its ...

journal_title：Gut

authors： Gasbarrini G,Pretolani S,Bonvicini F,Gatto MR,Tonelli E,Mégraud F,Mayo K,Ghironzi G,Giulianelli G,Grassi M

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remain...

journal_title：Gut

authors： Lim MY,You HJ,Yoon HS,Kwon B,Lee JY,Lee S,Song YM,Lee K,Sung J,Ko G

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The intestinal epithelium is covered by a continuous layer of mucus which is secreted by well differentiated epithelial cells. Disregulation of the expression of mucins has been reported to have possible implications in the neoplastic process which affects intestinal mucosae. It is well known that preneoplas...

journal_title：Gut

authors： Buisine MP,Devisme L,Savidge TC,Gespach C,Gosselin B,Porchet N,Aubert JP

更新日期：1998-10-01 00:00:00

abstract：:Pregnancy and contraceptive steroids are associated with a raised incidence of cholesterol gall stone disease. In pregnancy there is an increase in the size of the gall bladder. Investigation of hepatobiliary function in man and mammals has not established if the enlarged gall bladder is simply dilated, or if the abso...

journal_title：Gut

authors： Rådberg G,Svanvik J

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Faecal concentrations of the protein calprotectin have been found to be elevated in patients with colorectal neoplasia, suggesting that it might be used as a screening tool for colorectal cancer as well as adenomas. AIMS:To measure the sensitivity and specificity of faecal calprotectin for the detection of ...

journal_title：Gut

authors： Kronborg O,Ugstad M,Fuglerud P,Johne B,Hardcastle J,Scholefield JH,Vellacott K,Moshakis V,Reynolds JR

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...

journal_title：Gut

authors： Moreno ML,Cebolla Á,Muñoz-Suano A,Carrillo-Carrion C,Comino I,Pizarro Á,León F,Rodríguez-Herrera A,Sousa C

更新日期：2017-02-01 00:00:00

abstract：:A case of spontaneous partial rupture of the normal large bowel causing a haemoperitoneum is described. No similar case appears to have been reported previously. ...

journal_title：Gut

authors： HOWE CT

更新日期：1960-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss). PATIENTS:A total of 266 patients, ...

journal_title：Gut

authors： Flink HJ,Sprengers D,Hansen BE,van Zonneveld M,de Man RA,Schalm SW,Janssen HL,HBV 99-01 Study Group.

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Targeting tumour necrosis factor alpha (TNF-alpha) has demonstrated efficacy in Crohn's disease. AIM:To evaluate CDP571, a humanised antibody to TNF-alpha, for treating active Crohn's disease. PATIENTS:A total of 396 patients with moderate to severe Crohn's disease. METHODS:In a 28 week, randomised, doubl...

journal_title：Gut

authors： Sandborn WJ,Feagan BG,Radford-Smith G,Kovacs A,Enns R,Innes A,Patel J

更新日期：2004-10-01 00:00:00

abstract：:The influence of dehydrocholate on bromsulphtalein relative-storage capacity, bilary transport maximum (Tm), and fractional transfer rates between plasma, liver and bile have been studied in unanaesthetized dogs. In six dogs, storage capacity, Tm, and fractional transfer rates from plasma to liver, liver to bile, and ...

journal_title：Gut

authors： Delage Y,Erlinger S,Duval M,Bpenhamou JP

更新日期：1975-02-01 00:00:00

abstract：:Amino acid induced acid and gastrin responses during intragastric titration at pH 2.5 and 5.5 were compared in normal subjects and duodenal ulcer patients with G-cell hyperfunction. The latter were identified on the basis of raised basal or maximal acid outputs and increased gastrin responses to feeding. In normal sub...

journal_title：Gut

authors： Cooper RG,Dockray GJ,Calam J,Walker R

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The ground squirrel on a high cholesterol diet exhibits prolonged intestinal transit, a pathogenetic factor in cholesterol gallstone formation. AIMS:To examine the effect of a high cholesterol diet on the characteristics of the migrating myoelectrical complex (MMC) and the potential benefit of erythromycin....

journal_title：Gut

authors： Xu QW,Scott RB,Tan DT,Shaffer EA

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentra...

journal_title：Gut

authors： Amaral AF,Porta M,Silverman DT,Milne RL,Kogevinas M,Rothman N,Cantor KP,Jackson BP,Pumarega JA,López T,Carrato A,Guarner L,Real FX,Malats N

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND/AIM:The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. METHODS:Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, ...

journal_title：Gut

authors： Bjarnason I,Batt R,Catt S,Macpherson A,Maxton D,Menzies IS

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVES:Novel imaging methods based on specific molecular targets to detect both established neoplasms and their precursor lesions are highly desirable in cancer medicine. Previously, we identified claudin-4, an integral constituent of tight junctions, as highly expressed in various gastrointestinal tumours includin...

journal_title：Gut

authors： Neesse A,Hahnenkamp A,Griesmann H,Buchholz M,Hahn SA,Maghnouj A,Fendrich V,Ring J,Sipos B,Tuveson DA,Bremer C,Gress TM,Michl P

更新日期：2013-07-01 00:00:00

abstract：:Virulent Helicobacter pylori strains which have been clinically associated with severe outcome induce increased gastric mucosal immune responses. Although several bacterial pathogenic factors have been shown to have a considerable role in H pylori infection, variability in host immune responses may also contribute to ...

journal_title：Gut

authors： Shimoyama T,Crabtree JE

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a therapeutic target in gastrointestinal cancer (GiC). However, its in vivo visualisation could not be achieved to date with endoscopic techniques. Confocal laser endomicroscopy (CLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo mi...

journal_title：Gut

authors： Foersch S,Kiesslich R,Waldner MJ,Delaney P,Galle PR,Neurath MF,Goetz M

更新日期：2010-08-01 00:00:00

abstract：:'Tumour response', defined as clinical or radiological evidence of tumour shrinkage is frequently regarded as an objective of chemotherapy, rather than as a predictor of prolonged survival. This study has assessed whether a fall in the serum CEA concentration after chemotherapy for disseminated colorectal cancer is a ...

journal_title：Gut

authors： Allen-Mersh TG,Kemeny N,Niedzwiecki D,Shurgot B,Daly JM

更新日期：1987-12-01 00:00:00

abstract：:Earlier studies have reported that faecal pH is more alkaline in patients with colonic cancer, indicating a reduction in colonic carbohydrate fermentation to organic acids. The pH of faeces from 11 pre and 14 postoperative, selected colonic cancer patients without intestinal obstruction, major loss of appetite or weig...

journal_title：Gut

authors： Hove H,Rye Clausen M,Brøbech Mortensen P

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:This study was designed to evaluate the roles of microRNAs (miRNAs) in slow transit constipation (STC). DESIGN:All human tissue samples were from the muscularis externa of the colon. Expression of 372 miRNAs was examined in a discovery cohort of four patients with STC versus three age/sex-matched controls by...

journal_title：Gut

authors： Mazzone A,Strege PR,Gibbons SJ,Alcaino C,Joshi V,Haak AJ,Tschumperlin DJ,Bernard CE,Cima RR,Larson DW,Chua HK,Graham RP,El Refaey M,Mohler PJ,Hayashi Y,Ordog T,Calder S,Du P,Farrugia G,Beyder A

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Patients with chronic hepatitis B (CHB) infection are at an increased risk of developing hepatocellular carcinoma (HCC). Risk scores have been developed in Asian populations to predict HCC risk over time. AIM:To assess the performance of HCC risk prediction models in a heterogeneous population of patients w...

journal_title：Gut

authors： Abu-Amara M,Cerocchi O,Malhi G,Sharma S,Yim C,Shah H,Wong DK,Janssen HL,Feld JJ

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC) metastasis. DESIGN:We performed miRNA microarrays using primary CRC tissues from patients with and without metastasis, and validated selected candida...

journal_title：Gut

authors： Ling H,Pickard K,Ivan C,Isella C,Ikuo M,Mitter R,Spizzo R,Bullock M,Braicu C,Pileczki V,Vincent K,Pichler M,Stiegelbauer V,Hoefler G,Almeida MI,Hsiao A,Zhang X,Primrose J,Packham G,Liu K,Bojja K,Gafà R,Xiao L

更新日期：2016-06-01 00:00:00

abstract：:Patients with chronic active hepatitis or alcoholic cirrhosis have serum antibodies to many more serotypes of Escherichia coli than do patients with primary biliary cirrhosis or cryptogenic cirrhosis, or normal controls. They also have antibodies against more serotypes than cirrhotic patients with a portacaval shunt. ...

journal_title：Gut

authors： Simjee AE,Hamilton-Miller JM,Thomas HC,Brumfitt W,Sherlock S

更新日期：1975-11-01 00:00:00

abstract：OBJECTIVE:Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury is unknown. Here we hypothesised that the anti-infl...

journal_title：Gut

authors： Perugorria MJ,Esparza-Baquer A,Oakley F,Labiano I,Korosec A,Jais A,Mann J,Tiniakos D,Santos-Laso A,Arbelaiz A,Gawish R,Sampedro A,Fontanellas A,Hijona E,Jimenez-Agüero R,Esterbauer H,Stoiber D,Bujanda L,Banales JM,K

更新日期：2019-03-01 00:00:00

abstract：:Human cholera is associated with an increased luminal release of prostaglandin E2 (PGE2), but whether inhibition of increased PGE2 synthesis will reduce or control intestinal secretion is uncertain. 'Steady state' perfusions (10 ml/minute) in 12 patients with acute cholera, and repeat perfusions in nine of these patie...

journal_title：Gut

authors： Van Loon FP,Rabbani GH,Bukhave K,Rask-Madsen J

更新日期：1992-05-01 00:00:00