microRNA overexpression in slow transit constipation leads to reduced NaV1.5 current and altered smooth muscle contractility.

abstract：OBJECTIVES:Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum of genomic alterations and identified recurrent mutations in the ErbB pathway in GBC. Here, we aime...

journal_title：Gut

authors： Li M,Liu F,Zhang F,Zhou W,Jiang X,Yang Y,Qu K,Wang Y,Ma Q,Wang T,Bai L,Wang Z,Song X,Zhu Y,Yuan R,Gao Y,Liu Y,Jin Y,Li H,Xiang S,Ye Y,Zhang Y,Jiang L,Hu Y,Hao Y,Lu W,Chen S,Gu J,Zhou J,Gong W,Z

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:A high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM). DESIGN:We used register data from more than 1.2 million Swedi...

journal_title：Gut

authors： Hagström H,Tynelius P,Rasmussen F

更新日期：2018-08-01 00:00:00

abstract：:Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the...

journal_title：Gut

authors： Phillpotts RJ,Hermon-Taylor J,Teich NM,Brooke BN

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...

journal_title：Gut

authors： Ogawa T,Enomoto M,Fujii H,Sekiya Y,Yoshizato K,Ikeda K,Kawada N

更新日期：2012-11-01 00:00:00

abstract：:Three-day faecal collections were obtained from 87 patients with a variety of gastroenterological diagnoses and 12 control subjects while consuming normal diets. Faecal weight, total fatty acids, and the proportion of hydroxystearic (OHSA) acid were measured. All patients had some easily detectable hydroxystearic acid...

journal_title：Gut

authors： Wiggins HS,Pearson JR,Walker JG,Russell RI,Kellock TD

更新日期：1974-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Insulin-like growth factor (IGF) I receptor (IGF-Ir) signalling is required for carcinogenicity and proliferation of many tumours but this pathway has not been studied in detail in gastric cancer. We have previously shown successful therapy for colorectal, pancreatic, and lung cancer using recombina...

journal_title：Gut

authors： Min Y,Adachi Y,Yamamoto H,Imsumran A,Arimura Y,Endo T,Hinoda Y,Lee CT,Nadaf S,Carbone DP,Imai K

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The diagnosis of genetic haemochromatosis (GH) before iron overload has developed is difficult. However a convincing candidate gene for GH, HFE (previously HLA-H), has been described recently. AIMS:To determine the prevalence of the haemochromatosis associated HFE mutations C282Y and H63D in United Kingdom ...

journal_title：Gut

authors：

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Although peroxisome proliferator activated receptor gamma (PPARgamma) agonists have been implicated in differentiation and growth inhibition of cancer cells, the potential therapeutic and chemopreventive effects on gastric cancer are poorly defined. We examined the in vitro and in vivo effects of PP...

journal_title：Gut

authors： Leung WK,Bai AH,Chan VY,Yu J,Chan MW,To KF,Wu JR,Chan KK,Fu YG,Chan FK,Sung JJ

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Substance P (SP) is a pro-inflammatory neuropeptide in colitis, whereas sympathetic neurotransmitters are anti-inflammatory at high concentrations. AIM AND METHODS:In all layers of the colon, nerve fibre densities of SP(+) and sympathetic nerve fibres were investigated (22 Crohn's disease, six diverticuliti...

journal_title：Gut

authors： Straub RH,Grum F,Strauch U,Capellino S,Bataille F,Bleich A,Falk W,Schölmerich J,Obermeier F

更新日期：2008-07-01 00:00:00

abstract：:A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...

journal_title：Gut

authors： Vessey MP,Goldacre MJ,Seagroatt V,Yeates D

更新日期：1993-12-01 00:00:00

abstract：AIM:Magnetic resonance imaging (MRI) based colonography represents a new imaging tool which has mainly been investigated for polyp screening. To evaluate this approach for patients with inflammatory bowel disease (IBD), we compared MRI based colonography with conventional colonoscopy for assessing the presence and exte...

journal_title：Gut

authors： Schreyer AG,Rath HC,Kikinis R,Völk M,Schölmerich J,Feuerbach S,Rogler G,Seitz J,Herfarth H

更新日期：2005-02-01 00:00:00

abstract：:Training to contract the abdominal muscles effectively and to relax the pelvic floor during defecation straining helps some patients with severe constipation. Hitherto all such training has used a visible or audible signal of sphincter muscle activity as a biofeedback method to assist in relaxation. A randomised contr...

journal_title：Gut

authors： Koutsomanis D,Lennard-Jones JE,Roy AJ,Kamm MA

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...

journal_title：Gut

authors： Fujii S,Fujimori T,Kawamata H,Takeda J,Kitajima K,Omotehara F,Kaihara T,Kusaka T,Ichikawa K,Ohkura Y,Ono Y,Imura J,Yamaoka S,Sakamoto C,Ueda Y,Chiba T

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Several cases of acute colitis induced by non-steroidal anti-inflammatory drugs (NSAIDs) have been reported but the general role of recent NSAID intake as a risk factor for acute diarrhoea has not been studied to date. The aim of our study was to determine whether the risk of acute diarrhoea is incr...

journal_title：Gut

authors： Etienney I,Beaugerie L,Viboud C,Flahault A

更新日期：2003-02-01 00:00:00

abstract：:An epidemiological survey of Crohn's disease in the city of Derby showed that the incidence of the condition increased from 0.7/10(5) per year between 1951 and 1955 to 6.67/10(5) per year between 1981 and 1985 but seemed to reach a plateau between 1976 and 1985. Large bowel Crohn's disease was more common in patients ...

journal_title：Gut

authors： Fellows IW,Freeman JG,Holmes GK

更新日期：1990-11-01 00:00:00

abstract：:This study investigated the mechanisms by which TAGH solution (a mixture of triiodothyronine, amino acids, glucagon, and heparin) induces DNA synthesis in hepatocytes in the liver of intact rats, with particular reference to events at the epidermal growth factor (EGF) receptor. Both partial hepatectomy and infusion of...

journal_title：Gut

authors： Vesey DA,Selden AC,Hodgson HJ

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...

journal_title：Gut

authors： Jung D,Fantin AC,Scheurer U,Fried M,Kullak-Ublick GA

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Endoscopic surveillance for Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of evidence that it prevents advanced oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the impact of endoscopic BO surveillance on tumour stage an...

journal_title：Gut

authors： Kastelein F,van Olphen SH,Steyerberg EW,Spaander MC,Bruno MJ,ProBar-Study Group.

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE:To compare the performance of CE to VC for the detecti...

journal_title：Gut

authors： Bisschops R,Bessissow T,Joseph JA,Baert F,Ferrante M,Ballet V,Willekens H,Demedts I,Geboes K,De Hertogh G,Vermeire S,Rutgeerts P,Van Assche G

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut disorders. The mechanisms regulating 5-HT production in the gut remain unclear. This study investigated the T helper (Th) 1/...

journal_title：Gut

authors： Motomura Y,Ghia JE,Wang H,Akiho H,El-Sharkawy RT,Collins M,Wan Y,McLaughlin JT,Khan WI

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy. METHODS:A population-based case-control study was conducted in Southern Germany in 2003-...

journal_title：Gut

authors： Brenner H,Chang-Claude J,Seiler CM,Hoffmeister M

更新日期：2012-11-01 00:00:00

abstract：:In 19 subjects (four controls, one gastric ulcer and 14 duodenal ulcer) maximal gastric secretion was evoked with histamine 0.13 mumol/kg/h (0.04 mg/kg/h) for two to two and a half hours. A slow intravenous bolus dose of 200 mg cimetidine was given at the beginning of the last hour. Gastric secretion was measured befo...

journal_title：Gut

authors： Melville RJ,Suleiman SI,Whitfield PF,Parkin JV,Nwabunike TO,Hobsley M

更新日期：1985-08-01 00:00:00

abstract：:CLINICAL PRESENTATION: A 51-year-old man, who had no previous disease, underwent a screening oesophagogastroduodenoscopy, which revealed multiple yellowish lesions in the middle thoracic oesophagus. All lesions were ≤3 mm in size and slightly elevated. Each lesion showed one or two white protrusions on the surface (fi...

journal_title：Gut

authors： Hamada K,Yamasaki Y,Kubota JI,Okada H

更新日期：2019-01-01 00:00:00

abstract：:Human cholera is associated with an increased luminal release of prostaglandin E2 (PGE2), but whether inhibition of increased PGE2 synthesis will reduce or control intestinal secretion is uncertain. 'Steady state' perfusions (10 ml/minute) in 12 patients with acute cholera, and repeat perfusions in nine of these patie...

journal_title：Gut

authors： Van Loon FP,Rabbani GH,Bukhave K,Rask-Madsen J

更新日期：1992-05-01 00:00:00

abstract：:Two enzymes having lactase activity are present in the equine small intestine. The first, the digestive enzyme, neutral beta-galactosidase, declines in activity from birth to three years, disappearing completely between 3 and 4 years of age. The other, the soluble lysosomal enzyme, acid beta-galactosidase, having affi...

journal_title：Gut

authors： Roberts MC,Kidder DE,Hill FW

更新日期：1973-07-01 00:00:00

abstract：BACKGROUND AND AIMS:A low dietary folate intake can cause genomic DNA hypomethylation and may increase the risk of colorectal neoplasia. The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma...

journal_title：Gut

authors： Pufulete M,Al-Ghnaniem R,Khushal A,Appleby P,Harris N,Gout S,Emery PW,Sanders TA

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND AIMS:In acute liver failure (ALF), the brain is exposed to high levels of ammonia. Human studies defining the clinical significance of ammonia in ALF are lacking. This prospective study evaluated the relationship of arterial ammonia levels at admission to complications and survival among patients with AL...

journal_title：Gut

authors： Bhatia V,Singh R,Acharya SK

更新日期：2006-01-01 00:00:00

abstract：:A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient an...

journal_title：Gut

authors： Burman JF,Jenkins WJ,Walker-Smith JA,Phillips AD,Sourial NA,Williams CB,Mollin DL

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...

journal_title：Gut

authors： Miki C,Mayer AD,Buckels JA,Iriyama K,Suzuki H,McMaster P

更新日期：1999-06-01 00:00:00

abstract：:During a four hour observation period vasoactive intestinal polypeptide (VIP) is released in increasing amounts from the feline small intestine exposed to cholera toxin. As VIP is known to be located almost exclusively in the intestinal nerves, the present findings strongly suggest that cholera toxin activates the ent...

journal_title：Gut

authors： Cassuto J,Fahrenkrug J,Jodal M,Tuttle R,Lundgren O

更新日期：1981-11-01 00:00:00