Gastric antral vascular ectasia: a problem of recognition and diagnosis.

abstract：BACKGROUND AND AIMS:Low grade dysplasia (LGD) is believed to predispose to colorectal cancer (CRC), and proctocolectomy has been advocated when this is identified. Between 1978 and 1990, 160 patients with longstanding extensive ulcerative colitis (UC) were recruited for annual colonoscopic surveillance and 40 developed...

journal_title：Gut

authors： Lim CH,Dixon MF,Vail A,Forman D,Lynch DA,Axon AT

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...

journal_title：Gut

authors： Tian S,Simon I,Moreno V,Roepman P,Tabernero J,Snel M,van't Veer L,Salazar R,Bernards R,Capella G

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:Autoimmune hepatitis (AIH) is a severe necroinflammatory liver disease associated with significant mortality. Although loss of hepatocytes is generally recognised as a key trigger of liver inflammation and liver failure, the regulation of hepatic cell death causing AIH remains poorly understood. The aim of t...

journal_title：Gut

authors： He GW,Günther C,Kremer AE,Thonn V,Amann K,Poremba C,Neurath MF,Wirtz S,Becker C

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS:To establish a new colitis associated neoplasia model in p53 deficie...

journal_title：Gut

authors： Fujii S,Fujimori T,Kawamata H,Takeda J,Kitajima K,Omotehara F,Kaihara T,Kusaka T,Ichikawa K,Ohkura Y,Ono Y,Imura J,Yamaoka S,Sakamoto C,Ueda Y,Chiba T

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated c...

journal_title：Gut

authors： Parang B,Kaz AM,Barrett CW,Short SP,Ning W,Keating CE,Mittal MK,Naik RD,Washington MK,Revetta FL,Smith JJ,Chen X,Wilson KT,Brand T,Bader DM,Tansey WP,Chen R,Brentnall TA,Grady WM,Williams CS

更新日期：2017-05-01 00:00:00

abstract：:The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were obs...

journal_title：Gut

authors： Jensen SL,Holst JJ,Christiansen LA,Shokouh-Amiri MH,Lorentsen M,Beck H,Jensen HE

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND/AIM:5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut disorders. The mechanisms regulating 5-HT production in the gut remain unclear. This study investigated the T helper (Th) 1/...

journal_title：Gut

authors： Motomura Y,Ghia JE,Wang H,Akiho H,El-Sharkawy RT,Collins M,Wan Y,McLaughlin JT,Khan WI

更新日期：2008-04-01 00:00:00

abstract：:The results of bile salt treatment in patients with radiolucent stones and a functioning gall bladder have been poor. In 42 of these patients awaiting cholecystectomy we determined the value of duodenal bile examination in predicting gall stone composition, and thus identifying those less likely to respond to bile sal...

journal_title：Gut

authors： Agarwal DK,Choudhuri G,Saraswat VA,Negi TS,Kapoor VK,Saxena R

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Different acid and peptic related gastroduodenal diseases are associated with both increased gastric secretion and Helicobacter pylori infection. Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori i...

journal_title：Gut

authors： Lorente S,Doiz O,Trinidad Serrano M,Castillo J,Lanas A

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Treatments with sequential therapy (SEQ) or bismuth quadruple (QUAD) therapy have been proposed as empirical firstline regimens for Helicobacter pylori. We compared the efficacy and tolerability of 10 day SEQ with 10 day modified QUAD as both firstline and secondline treatments for H pylori in a randomised cr...

journal_title：Gut

authors： Liu KS,Hung IF,Seto WK,Tong T,Hsu AS,Lam FY,But DY,Wong SY,Leung WK

更新日期：2014-09-01 00:00:00

abstract：:Extracellular electrical and contractile activities were recorded in vitro from strips of human colonic smooth muscle obtained at the time of surgery. Serosal electrical activity of longitudinally oriented strips from the taenia and intertaenial region was characterised by continuous oscillation at a frequency of 28 +...

journal_title：Gut

authors： Gill RC,Cote KR,Bowes KL,Kingma YJ

更新日期：1986-03-01 00:00:00

abstract：:Marked decreases in 24-hour Heidenhain pouch secretion, lasting from nine to 18 days, were observed in five mongrel bitches during periods of naturally occurring oestrus. Neither oophorectomy nor control celiotomy caused significant change in Heidenhain pouch secretion in bitches who were not experiencing oestrus. The...

journal_title：Gut

authors： Landor JH,Wild RA

更新日期：1970-10-01 00:00:00

abstract：AIM:To assess the feasibility and diagnostic accuracy of endoscopic ultrasound guided fine needle biopsy (EUS-FNAB) in patients with solid pancreatic masses. METHODS:Ninety nine consecutive patients with pancreatic masses were studied. Histological findings obtained by EUS-FNAB were compared with the final diagnosis a...

journal_title：Gut

authors： Voss M,Hammel P,Molas G,Palazzo L,Dancour A,O'Toole D,Terris B,Degott C,Bernades P,Ruszniewski P

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:This study was designed to evaluate the roles of microRNAs (miRNAs) in slow transit constipation (STC). DESIGN:All human tissue samples were from the muscularis externa of the colon. Expression of 372 miRNAs was examined in a discovery cohort of four patients with STC versus three age/sex-matched controls by...

journal_title：Gut

authors： Mazzone A,Strege PR,Gibbons SJ,Alcaino C,Joshi V,Haak AJ,Tschumperlin DJ,Bernard CE,Cima RR,Larson DW,Chua HK,Graham RP,El Refaey M,Mohler PJ,Hayashi Y,Ordog T,Calder S,Du P,Farrugia G,Beyder A

更新日期：2020-05-01 00:00:00

abstract：:Intravenous glucose tolerance, insulin tolerance, tolbutamide, and glucagon tests were carried out in 21 patients with postnecrotic cirrhosis. Based arbitrarily on the bromsulphthalein retention they were divided into group A, nine patients with less impaired liver function, and group B, 12 patients with greater impai...

journal_title：Gut

authors： Yeung RT,Wang CC

更新日期：1974-11-01 00:00:00

abstract：:The effects of drugs which change the bile-salt-independent fraction of bile flow on Na(+)K(a+) and Mg(2+) activated ATPases were studied in membrane fractions rich in bile canaliculi. The administration of phenobarbital caused no induction of these enzymes which could explain the increased bile flow observed in the r...

journal_title：Gut

authors： Laperche Y,Launay A,Oudéa P

更新日期：1972-11-01 00:00:00

abstract：:The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives ...

journal_title：Gut

authors： Markowitz MM,Rozen P,Pero RW,Tobi M,Miller DG

更新日期：1988-12-01 00:00:00

abstract：:A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...

journal_title：Gut

authors： Vessey MP,Goldacre MJ,Seagroatt V,Yeates D

更新日期：1993-12-01 00:00:00

abstract：:ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals. The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group O subjects, in close agreement with many previous reports throughout the world. More detail...

journal_title：Gut

authors： Glober GA,Cantrell EG,Doll R,Peto R

更新日期：1971-07-01 00:00:00

abstract：BACKGROUND:Intestinal metaplasia, whether in the cardia or the distal oesophagus, has been uniformly defined as specialised columnar epithelium, suggesting a relation with Barrett's oesophagus. It is, however, not clear whether the risk factors associated with intestinal metaplasia are identical at both sites. AIMS:To...

journal_title：Gut

authors： Hackelsberger A,Günther T,Schultze V,Manes G,Dominguez-Muñoz JE,Roessner A,Malfertheiner P

更新日期：1998-07-01 00:00:00

abstract：:Thirty of 81 consecutive HIV antibody positive patients referred with non-cryptosporidial diarrhoea had no potential infectious cause; most had AIDS related complex rather than the full blown syndrome. Opportunistic infections with cytomegalovirus (CMV), mycobacterium avium-intracellulare (MAI), and herpes simplex vir...

journal_title：Gut

authors： Connolly GM,Shanson D,Hawkins DA,Webster JN,Gazzard BG

更新日期：1989-02-01 00:00:00

abstract：:In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH was monitored continuously for three hours after a s...

journal_title：Gut

authors： Kaufman SE,Kaye MD

更新日期：1978-04-01 00:00:00

abstract：:Cholecystokinin (CCK) release and gall bladder emptying in response to a fatty meal are completely abolished in coeliac disease. To determine the effect of lipid digestion on CCK release and gall bladder motility, six patients with untreated coeliac disease and a flat jejunal mucosa were studied on two separate days. ...

journal_title：Gut

authors： Hopman WP,Rosenbusch G,Hectors MP,Jansen JB

更新日期：1995-01-01 00:00:00

abstract：BACKGROUNDS AND AIMS:Telomerase is significantly reactivated in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Our previous studies showed that the transactivation unit of HBV surface (S) gene, preS2, could upregulate human telomerase reverse transcriptase (hTERT) expression and telomerase activity ...

journal_title：Gut

authors： Luan F,Liu H,Gao L,Liu J,Sun Z,Ju Y,Hou N,Guo C,Liang X,Zhang L,Sun W,Ma C

更新日期：2009-11-01 00:00:00

abstract：:The proliferative effects of histamine were examined on the human gastric tumour cell lines; MKN45, the gastrin producing subline, MKN45G, and the colorectal lines; LoVo and C170. The proliferation of MKN45 as assessed by 75[Se] selenomethionine uptake and cell counts was increased by histamine concentrations of 10(-7...

journal_title：Gut

authors： Watson SA,Wilkinson LJ,Robertson JF,Hardcastle JD

更新日期：1993-08-01 00:00:00

abstract：:The two major forms of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been s...

journal_title：Gut

authors： Danese S,Argollo M,Le Berre C,Peyrin-Biroulet L

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Many patients with Crohn's disease (CD) have low bone mineral density (BMD) that may not be solely attributable to glucocorticoid use. We hypothesised that low BMD in patients with CD is associated with elevated circulating levels of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D). We fu...

journal_title：Gut

authors： Abreu MT,Kantorovich V,Vasiliauskas EA,Gruntmanis U,Matuk R,Daigle K,Chen S,Zehnder D,Lin YC,Yang H,Hewison M,Adams JS

更新日期：2004-08-01 00:00:00

abstract：:Transiliac biopsies from 34 female patients with corticosteroid treated chronic active hepatitis have been examined to determine the contributions made by decreased bone formation and increased bone resorption to bone loss associated with this condition and to determine the structural basis of the bone loss. Mean wall...

journal_title：Gut

authors： Stellon AJ,Webb A,Compston JE

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Intestinal allograft rejection resembles Crohn's disease clinically and pathologically. An understanding of its mechanism could impact this life-saving procedure, as well as provide insight into the pathophysiology of inflammatory bowel disease. The NOD2 protein has been implicated as a key player in intesti...

journal_title：Gut

authors： Fishbein T,Novitskiy G,Mishra L,Matsumoto C,Kaufman S,Goyal S,Shetty K,Johnson L,Lu A,Wang A,Hu F,Kallakury B,Lough D,Zasloff M

更新日期：2008-03-01 00:00:00

abstract：:With oral and intravenous doses of metoclopramide there was no constant effect on the gastric emptying of test meals of glucose or sodium citrate, nor was secretion of acid by the stomach in response to test meals of glucose or sodium citrate affected. Apomorphine, in subnauseous doses (0.25 mg intravenously) slowed t...

journal_title：Gut

authors： Ramsbottom N,Hunt JN

更新日期：1970-12-01 00:00:00