Abstract:
:The effects of drugs which change the bile-salt-independent fraction of bile flow on Na(+)K(a+) and Mg(2+) activated ATPases were studied in membrane fractions rich in bile canaliculi. The administration of phenobarbital caused no induction of these enzymes which could explain the increased bile flow observed in the rat. Rose bengal, in addition to its strong photoxidative inhibition of both ATPases, inhibits the Na(+)K(+) ATPase of rat and rabbit bile canaliculi in the absence of light. A closely related substance, uranine, inhibits neither bile flow nor Na(+)K(+)ATPase. Inhibition of this enzyme by rose bengal may therefore be responsible for the observed effects of this dye on bile flow independent of bile salts.
journal_name
Gutjournal_title
Gutauthors
Laperche Y,Launay A,Oudéa Pdoi
10.1136/gut.13.11.920subject
Has Abstractpub_date
1972-11-01 00:00:00pages
920-5issue
11eissn
0017-5749issn
1468-3288journal_volume
13pub_type
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