Detection of subclinical autonomic neuropathy in constipated patients using a sweat test.

abstract：OBJECTIVE:Whether peginterferon α and ribavirin combination therapy reduces risk of hepatocellular carcinoma (HCC) or improves survival in patients dual-infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) is unknown. Since it is ethically impossible to conduct a randomised trial to learn the long-term eff...

journal_title：Gut

authors： Liu CJ,Chu YT,Shau WY,Kuo RN,Chen PJ,Lai MS

更新日期：2014-03-01 00:00:00

abstract：:There has been a vast increase in GI literature focused on the use of machine learning in endoscopy. The relative novelty of this field poses a challenge for reviewers and readers of GI journals. To appreciate scientific quality and novelty of machine learning studies, understanding of the technical basis and commonly...

journal_title：Gut

authors： van der Sommen F,de Groof J,Struyvenberg M,van der Putten J,Boers T,Fockens K,Schoon EJ,Curvers W,de With P,Mori Y,Byrne M,Bergman JJGHM

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the pathophysiology of oesophageal pain syndromes and hiatus hernia formation. The aim of the current study was to elucidate further the mechanisms ...

journal_title：Gut

authors： Paterson WG,Miller DV,Dilworth N,Assini JB,Lourenssen S,Blennerhassett MG

更新日期：2007-10-01 00:00:00

abstract：:Faecal fat excretion was measured on a metabolic ward in 16 patients with duodenal ulcer before operation, and in patients who were in good health more than one year after truncal vagotomy and pyloroplasty (n = 11), bilateral selective vagotomy and pyloroplasty (n = 9), or highly selective vagotomy without a drainage ...

journal_title：Gut

authors： Edwards JP,Lyndon PJ,Smith RB,Johnston D

更新日期：1974-07-01 00:00:00

abstract：BACKGROUND:Intestinal metaplasia, whether in the cardia or the distal oesophagus, has been uniformly defined as specialised columnar epithelium, suggesting a relation with Barrett's oesophagus. It is, however, not clear whether the risk factors associated with intestinal metaplasia are identical at both sites. AIMS:To...

journal_title：Gut

authors： Hackelsberger A,Günther T,Schultze V,Manes G,Dominguez-Muñoz JE,Roessner A,Malfertheiner P

更新日期：1998-07-01 00:00:00

abstract：:These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...

journal_title：Gut

authors： Tripathi D,Stanley AJ,Hayes PC,Patch D,Millson C,Mehrzad H,Austin A,Ferguson JW,Olliff SP,Hudson M,Christie JM,Clinical Services and Standards Committee of the British Society of Gastroenterology.

更新日期：2015-11-01 00:00:00

abstract：:Primary oesophageal involvement by lymphoma in two patients, one with Hodgkin's disease and one with non-Hodgkin's lymphoma is reported. In both, there were no manifestations of the disease outside the oesophagus, which is exceptionally rare. In the patient with non-Hodgkin's lymphoma, the oesophageal tumour was the f...

journal_title：Gut

authors： Taal BG,Van Heerde P,Somers R

更新日期：1993-07-01 00:00:00

abstract：:p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected im...

journal_title：Gut

authors： Collier JD,Carpenter M,Burt AD,Bassendine MF

更新日期：1994-01-01 00:00:00

abstract：:Pouchitis may complicate the construction of an ileal pouch after colectomy for ulcerative colitis (UC) but not familial adenomatous polyposis (FAP). To examine whether differences in eicosanoid metabolism might explain why pouchitis is largely confined to UC patients, this study compared arachidonic acid stimulated r...

journal_title：Gut

authors： Gertner DJ,Rampton DS,Madden MV,Talbot IC,Nicholls RJ,Lennard-Jones JE

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Gram negative septic events are the commonest source of morbidity and mortality as a result of surgery in jaundiced patients. The large intestine provides the major source of Gram negative bacteria in mammals and is implicated in the pathogenesis of systemic endotoxaemia in obstructive jaundice. Bile salts h...

journal_title：Gut

authors： Clements WD,Parks R,Erwin P,Halliday MI,Barr J,Rowlands BJ

更新日期：1996-10-01 00:00:00

abstract：:This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulce...

journal_title：Gut

authors： NEFZGER MD,ACHESON ED

更新日期：1963-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The 13C-Hiolein breath test (98% [U-13C] labelled long chain triglyceride mixture (highly labelled triolein) was evaluated as a non-invasive, non-radioactive test for exocrine pancreatic insufficiency. Accuracy and clinical validity were examined with reference to both the secretin pancreozymin test...

journal_title：Gut

authors： Lembcke B,Braden B,Caspary WF

更新日期：1996-11-01 00:00:00

abstract：:Seventeen paediatric patients with immunodeficiency syndromes (10 with selective IgA deficiency, four with panhypogammaglobulinaemia, and three with selective T cell deficiency) were investigated for bacterial overgrowth of the small intestine and gut permeability to macromolecules. Five of 12 patients showed viable b...

journal_title：Gut

authors： Pignata C,Budillon G,Monaco G,Nani E,Cuomo R,Parrilli G,Ciccimarra F

更新日期：1990-08-01 00:00:00

abstract：:Removal of the right lobe of the liver which was occupied largely by metastases, together with resection of ileal primary tumours, brought about complete remission of symptoms and signs in a 43-year-old man with a six-year history of the carcinoid syndrome. Investigations should be orientated toward surgery. When prac...

journal_title：Gut

authors： Zeegen R,Rothwell-Jackson R,Sandler M

更新日期：1969-08-01 00:00:00

abstract：BACKGROUND:Six to 12 months of ingestion of moderate amounts of oats does not have a harmful effect in adult patients with coeliac disease. As the safety of long term intake of oats in coeliac patients is not known, we continued our previous 6-12 month study for five years. AIM:To assess the safety of long term ingest...

journal_title：Gut

authors： Janatuinen EK,Kemppainen TA,Julkunen RJ,Kosma VM,Mäki M,Heikkinen M,Uusitupa MI

更新日期：2002-03-01 00:00:00

abstract：:The motor activity of the transverse, descending, and sigmoid colon was recorded for 24 hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the patients ate two 1000 kcal mixed meals and one continental breakfast. Colonic motor activity was low before meals and minimal during sleep;...

journal_title：Gut

authors： Narducci F,Bassotti G,Gaburri M,Morelli A

更新日期：1987-01-01 00:00:00

abstract：:The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhib...

journal_title：Gut

authors： Caspary WF,Kalisch H

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting. OBJECTIVE:To examine the association between green tea consumption and gastric cancer. METHODS:We anal...

journal_title：Gut

authors： Inoue M,Sasazuki S,Wakai K,Suzuki T,Matsuo K,Shimazu T,Tsuji I,Tanaka K,Mizoue T,Nagata C,Tamakoshi A,Sawada N,Tsugane S,Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of tumours and was proposed to be oncogenic, but high GATA6 levels are found in well-differentiated tumou...

journal_title：Gut

authors： Martinelli P,Carrillo-de Santa Pau E,Cox T,Sainz B Jr,Dusetti N,Greenhalf W,Rinaldi L,Costello E,Ghaneh P,Malats N,Büchler M,Pajic M,Biankin AV,Iovanna J,Neoptolemos J,Real FX

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS:The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS:The association b...

journal_title：Gut

authors： Molloy RM,Sonnenberg A

更新日期：1997-02-01 00:00:00

abstract：:Six of 25 renal transplant recipients had a duodenal ulcer at endoscopy. Histamine concentration and the activity of histamine methyltransferase, the degrading enzyme of histamine, were measured in gastric mucosal biopsies obtained at endoscopy and compared with patients with duodenal ulcer but not undergoing transpla...

journal_title：Gut

authors： Timoney AG,Man WK,Spencer J,Taylor H,Williams G

更新日期：1989-01-01 00:00:00

abstract：:Cirrhosis is associated with the development of a hyperdynamic circulation, which is secondary to the presence of systemic vasodilatation. Several mechanisms have been postulated to be involved in the development of systemic vasodilatation, including increased synthesis of nitric oxide, hyperglucagonaemia, increased c...

journal_title：Gut

authors： Ebrahimkhani MR,Mani AR,Moore K

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...

journal_title：Gut

authors： Lepage C,Bouvier AM,Phelip JM,Hatem C,Vernet C,Faivre J

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Although evidence points to a role for histamine and serotonin in visceral hypersensitivity, activation of calcium channels such as transient receptor potential vanilloid 4 (TRPV4) also causes visceral hypersensitivity. We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating...

journal_title：Gut

authors： Cenac N,Altier C,Motta JP,d'Aldebert E,Galeano S,Zamponi GW,Vergnolle N

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The gut-brain axis is considered as a major regulatory checkpoint in the control of glucose homeostasis. The detection of nutrients and/or hormones in the duodenum informs the hypothalamus of the host's nutritional state. This process may occur via hypothalamic neurons modulating central release of nitric oxi...

journal_title：Gut

authors： Fournel A,Drougard A,Duparc T,Marlin A,Brierley SM,Castro J,Le-Gonidec S,Masri B,Colom A,Lucas A,Rousset P,Cenac N,Vergnolle N,Valet P,Cani PD,Knauf C

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive immune resistance in pancreatic ductal adenocarcinoma cancer (PDAC). DESIGN:We screened 429 kinase inhibitors for ...

journal_title：Gut

authors： Huang J,Chen P,Liu K,Liu J,Zhou B,Wu R,Peng Q,Liu ZX,Li C,Kroemer G,Lotze M,Zeh H,Kang R,Tang D

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:Overexpression of tissue plasminogen activator (t-PA) in pancreatic cancer cells promotes invasion and proliferation in vitro and tumour growth and angiogenesis in vivo. AIMS:To understand the mechanisms by which t-PA favours cancer progression, we analysed the surface membrane proteins responsible for bind...

journal_title：Gut

authors： Díaz VM,Hurtado M,Thomson TM,Reventós J,Paciucci R

更新日期：2004-07-01 00:00:00

abstract：INTRODUCTION:The use of patient reported outcome measures to support routine inflammatory bowel disease (IBD) care is not widespread and suggests that existing questionnaires lack relevance to day-to-day decisions or are too cumbersome to administer. We developed a simple, generic tool for capturing disease control fro...

journal_title：Gut

authors： Bodger K,Ormerod C,Shackcloth D,Harrison M,IBD Control Collaborative.

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Hereditary forms of chronic idiopathic intestinal pseudo-obstruction (CIIP) are well described but the aetiology of most cases of sporadic CIIP is unknown. AIM:To determines whether herpes viruses can persist in the gastrointestinal tract, thereby implicating them in the pathogenesis of CIIP. METHODS:Twent...

journal_title：Gut

authors： Debinski HS,Kamm MA,Talbot IC,Khan G,Kangro HO,Jeffries DJ

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation and increased epithelial permeability. Both tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) have been implicated in IBD. AIMS:To understand better the effects of these cytokines on epithelial cell ...

journal_title：Gut

authors： Fish SM,Proujansky R,Reenstra WW

更新日期：1999-08-01 00:00:00