(2'-5') oligo adenylate synthetase activity in leucocytes of patients with inflammatory bowel disease.

abstract：BACKGROUND AND AIMS:Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with ...

journal_title：Gut

authors： Grippo PJ,Fitchev PS,Bentrem DJ,Melstrom LG,Dangi-Garimella S,Krantz SB,Heiferman MJ,Chung C,Adrian K,Cornwell ML,Flesche JB,Rao SM,Talamonti MS,Munshi HG,Crawford SE

更新日期：2012-10-01 00:00:00

abstract：:Oral treatment with chenodeoxycholic acid causes dissolution of cholesterol gallstones in man. In order to determine the mechanism of this effect, we have measured 24-hour biliary lipid output, lipid composition of fasting gallbladder bile, and bile acid pool sizes before and during such treatment in six patients with...

journal_title：Gut

authors： Northfield TC,LaRusso NF,Hofmann AF,Thistle JL

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:5-Lipoxygenase products play a part in inflammatory response. AIMS:The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis. METHODS:Ninety rats with trinitrobenzenesulphonic acid induced colitis...

journal_title：Gut

authors： Bertrán X,Mañé J,Fernández-Bañares F,Castellá E,Bartolí R,Ojanguren I,Esteve M,Gassull MA

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN:In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assig...

journal_title：Gut

authors： Hézode C,Hirschfield GM,Ghesquiere W,Sievert W,Rodriguez-Torres M,Shafran SD,Thuluvath PJ,Tatum HA,Waked I,Esmat G,Lawitz EJ,Rustgi VK,Pol S,Weis N,Pockros PJ,Bourlière M,Serfaty L,Vierling JM,Fried MW,Weiland O,B

更新日期：2015-06-01 00:00:00

abstract：:Intestinal adaptation (small intestinal weight and length, weight of the caecum and of the residual colon) to feeding different doses (0-5-50-500 mg/kg bw) of the absorbable, competitive alpha-glucosidase inhibitors BAY m 1099 and BAY o 1248 for three, seven, or 28 days was studied in rats. With the highest dose of ei...

journal_title：Gut

authors： Lembcke B,Löser C,Fölsch UR,Wöhler J,Creutzfeldt W

更新日期：1987-01-01 00:00:00

abstract：:Salivary amylase output in man increases after injection of synthetic human calcitonin. This effect is dose dependent. ...

journal_title：Gut

authors： Drack GT,Koelz HR,Blum AL

更新日期：1976-08-01 00:00:00

abstract：:Dysmotility of the duodenum and proximal jejunum has been reported in patients with irritable bowel syndrome. This study extended these findings by recording fasting ambulatory motility from electronic strain gauge sensors sited in the jejunum and ileum of eight diarrhoea predominant irritable bowel syndrome patients ...

journal_title：Gut

authors： Gorard DA,Libby GW,Farthing MJ

更新日期：1994-02-01 00:00:00

abstract：:All cases of Crohn's disease in the Nottingham area were ascertained and the date and place of domicile and work at the time of onset of symptoms noted. Applying the Knox and Pike and Smith tests for clustering of patients in time and space, no significant results were observed. Further analysis of differences in time...

journal_title：Gut

authors： Miller DS,Keighley A,Smith PG,Hughes AO,Langman MJ

更新日期：1975-06-01 00:00:00

abstract：:Thirty male patients (27 homosexual) with biopsy proven chronic active hepatitis B were randomised to receive lymphoblastoid interferon (Wellferon) or no treatment. All patients were HBeAg positive and had continuing viral replication. Patients receiving treatment were given a single daily intramuscular injection of i...

journal_title：Gut

authors： Anderson MG,Harrison TJ,Alexander G,Zuckerman AJ,Murray-Lyon IM

更新日期：1987-05-01 00:00:00

abstract：:Hepatitis B and hepatitis C infections are important causes of end-stage liver disease and primary liver cancer. Successful antiviral treatment prior to the development of cirrhosis will prevent most of the morbidity and mortality associated with those infections. This can be achieved for a high proportion of patients...

journal_title：Gut

authors： Mutimer DJ,Lok A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIMS:Studies in animals suggest a physiological role for glucagon-like peptide-1-(7-36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated. Subjects-Sixteen healthy male subjects were examined in a double blind placebo controlled fashio...

journal_title：Gut

authors： Gutzwiller JP,Göke B,Drewe J,Hildebrand P,Ketterer S,Handschin D,Winterhalder R,Conen D,Beglinger C

更新日期：1999-01-01 00:00:00

abstract：:Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence th...

journal_title：Gut

authors： Watts DA,Satsangi J

更新日期：2002-05-01 00:00:00

abstract：:Motilin is a hormonal peptide found in the duodenum and jejunum which potently influences gastrointestinal tract motility. Its role in human physiology is not yet established. After a standard hospital lunch the plasma concentration of motilin showed a small, transient, but significant rise in 28 healthy subjects. Ind...

journal_title：Gut

authors： Christofides ND,Bloom SR,Besterman HS,Adrian TE,Ghatei MA

更新日期：1979-02-01 00:00:00

abstract：:Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The t...

journal_title：Gut

authors： Hodgson HJ,Jewell DP

更新日期：1977-08-01 00:00:00

abstract：:In order to investigate further the reported beneficial effect of deglycyrrhizinated liquorice in gastric ulcer, a trial with a double-blind, cross-over design was performed. The patients were treated during two consecutive periods of four weeks each with either liquorice extract during the first period and placebo du...

journal_title：Gut

authors： Engqvist A,von Feilitzen F,Pyk E,Reichard H

更新日期：1973-09-01 00:00:00

abstract：OBJECTIVE:Conventional colonoscopy (CC) is considered the reference standard for detection of colorectal neoplasia, but it can still miss a substantial number of adenomas. The use of a transparent plastic cap may improve colonic visualisation. Cap-assisted colonoscopy (CAC) was compared with CC for adenoma detection. S...

journal_title：Gut

authors： de Wijkerslooth TR,Stoop EM,Bossuyt PM,Mathus-Vliegen EM,Dees J,Tytgat KM,van Leerdam ME,Fockens P,Kuipers EJ,Dekker E

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...

journal_title：Gut

authors： Okugawa Y,Toiyama Y,Toden S,Mitoma H,Nagasaka T,Tanaka K,Inoue Y,Kusunoki M,Boland CR,Goel A

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. DESIGN:We conducted prospective cohort analyses i...

journal_title：Gut

authors： Chen Y,Segers S,Blaser MJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The reported cumulative risk of developing pouchitis in ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA) approaches 50% after 10 years. To date, no preoperative serological predictor of pouchitis has been found. AIMS:To assess whether preoperative perinuclear antineutrophil cy...

journal_title：Gut

authors： Fleshner PR,Vasiliauskas EA,Kam LY,Fleshner NE,Gaiennie J,Abreu-Martin MT,Targan SR

更新日期：2001-11-01 00:00:00

abstract：:Hydrogen breath tests are widely used to explore the pathophysiology of functional gastrointestinal disorders. Small intestinal bacterial overgrowth and carbohydrate malabsorption are disorders detected by these tests that have been proposed to be of great importance for symptoms in, for instance, irritable bowel synd...

journal_title：Gut

authors： Simrén M,Stotzer PO

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Integrins mediate cell matrix adhesion and regulate cell growth and survival. In colonic epithelial cells, alpha(2)beta(1) integrin controls glandular differentiation and proliferation. Butyrate stimulates differentiation and induces apoptosis in vitro. AIMS:We investigated whether butyrate induction of apo...

journal_title：Gut

authors： Buda A,Qualtrough D,Jepson MA,Martines D,Paraskeva C,Pignatelli M

更新日期：2003-05-01 00:00:00

abstract：:The role of lamina propria cells in regulating human colonic ion transport was investigated in vitro. Normal human colonic mucosae were mounted in Ussing chambers, and short circuit current changes (delta SCC) were monitored in response to immune cell activation. Anti-human immunoglobulin E (anti-IgE) and formyl-Methi...

journal_title：Gut

authors： Stack WA,Keely SJ,O'Donoghue DP,Baird AW

更新日期：1995-03-01 00:00:00

abstract：:In a study of low dose interferon alfa-2b in 587 patients expected to show a good response to treatment, 76-87% patients in different countries had alanine amino-transferase activities returned to normal after four months' treatment, 49-72% were negative for hepatitis B virus (HBV)-DNA, 51-66% were negative for hepati...

journal_title：Gut

authors： Mauracher E

更新日期：1993-01-01 00:00:00

abstract：:The quantification of gastric, pancreatic, biliary, and small bowel functions in man often requires the use of intestinal tubes. In this study, the presence of a transpyloric tube did not alter gastric emptying, acid secretion, or serum gastrin levels in response to an ordinary solid meal. ...

journal_title：Gut

authors： Longstreth GF,Malagelada JR,Go VL

更新日期：1975-10-01 00:00:00

abstract：:In a single centre double blind study of 66 patients, the value of cisapride (10 mg twice daily) was compared with placebo in the prevention of duodenal ulcer relapse. Patients who remained ulcer free attended for clinical review every two months and had a mandatory endoscopy at 0, 4, 8, and 12 months or if symptoms s...

journal_title：Gut

authors： Kerrigan DD,Taylor ME,Read NW,Johnson AG

更新日期：1993-08-01 00:00:00

abstract：:Prostaglandins (PGs) are synthesised by gastric mucosa, and have been shown to inhibit gastric acid secretion and ulcer formation in man and experimental animals. Recently exogenous PGs, mainly of the E group, have been used for the treatment of peptic ulcer disease. We therefore searched for a drug that would stimula...

journal_title：Gut

authors： Ligumsky M,Rachmilewitz D,Zor U

更新日期：1979-10-01 00:00:00

abstract：:In dogs with either vagally innervated or denervated pouches, the acid responses to a standard meal, a meal which bypassed the greater part of the small bowel, and a meal introduced directly into the small intestine were measured before and after exclusion of 75% of the small bowel.After intestinal exclusion an increa...

journal_title：Gut

authors： Buxton B,Wasunna AE,Saunders J,Gillespie IE

更新日期：1972-07-01 00:00:00

abstract：:mu-, delta- and kappa-opioid receptors are widely expressed in the central nervous system where they mediate the strong analgesic and mood-altering actions of opioids, and modulate numerous endogenous functions. To investigate the contribution of the kappa-opioid receptor (KOR) to opioid function in vivo, we have gene...

journal_title：Gut

authors： Black D,Trevethick M

更新日期：1998-09-01 00:00:00

abstract：:The actions of hydrochloric acid, natural PGE1, PGE2 and a synthetic commercial PGE1 preparation, Enisoprost (Searle) on pepsinogen synthesis and secretion were studied in canine chief cell monolayer cultures. Hydrochloric acid, applied directly to the apical surface of chief cells using culture plate inserts (Millipo...

journal_title：Gut

authors： Defize J,Hunt RH

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The liver represents one of the major sites of human glucuronidation. Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to the formation of usually inactive glucuronides. Hepatic glucuronidation undergoes significant changes during fetal and neonatal development re...

journal_title：Gut

authors： Strassburg CP,Strassburg A,Kneip S,Barut A,Tukey RH,Rodeck B,Manns MP

更新日期：2002-02-01 00:00:00