Abstract:
:The response of lymphocytes from peripheral blood and mesenteric lymph nodes to stimulation with phytohaemagglutinin in vitro has been studied in eight patients suffering from active Crohn's disease. Patients with Crohn's disease exhibited reduced responses when compared with similar studies performed in control subjects. The impaired responses of circulating lymphocytes from these patients were marked on culture in autologous serum and were not improved by culture in homologous AB serum. Lymphocytes from lymph nodes directly draining diseased bowel exhibited lower responses than those from nodes at the root of the mesentery, which in turn were lower than those of circulating lymphocytes.
journal_name
Gutjournal_title
Gutauthors
Guillou PJ,Brennan TG,Giles GRdoi
10.1136/gut.14.1.20subject
Has Abstractpub_date
1973-01-01 00:00:00pages
20-4issue
1eissn
0017-5749issn
1468-3288journal_volume
14pub_type
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