Peutz-Jeghers syndrome associated with gastrointestinal carcinoma. Report of two cases in a family.

Abstract:

:Patients with the Peutz-Jeghers syndrome carry a slight, though definite, increased risk of gastrointestinal carcinoma. The malignant potentiality of Peutz-Jeghers hamartomatous polyps, generally considered benign, is supported by this report. Two cases of metastasising gastrointestinal carcinoma associated with the Peutz-Jeghers syndrome are described in a 56 year old female and her 29 year old son. Both mother and son died from duodenal and gastric carcinomas respectively, which developed in hamartomatous polyps with extensive metastases. Both cases also showed dysplastic areas within hamartomatous polyps. These features indicate that hamartomatous polyps may, in some cases, be the precursors of digestive tract carcinomas.

journal_name

Gut

journal_title

Gut

authors

Cochet B,Carrel J,Desbaillets L,Widgren S

doi

10.1136/gut.20.2.169

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

169-75

issue

2

eissn

0017-5749

issn

1468-3288

journal_volume

20

pub_type

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