Peutz-Jeghers syndrome associated with gastrointestinal carcinoma. Report of two cases in a family.

abstract：:Clinically significant liver involvement in systemic amyloidosis, especially with cholestasis, is rare. We report a case of primary amyloidosis with severe intrahepatic cholestasis leading to terminal liver failure. The present case is the first of its kind reported involving Lambda light chains only as the associated...

journal_title：Gut

authors： Konikoff F,Mor C,Stern S,Shaklai M,Halevy J,Theodor E

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:It has been suggested that slow transit constipation (STC) may be part of a panenteric motor disorder. AIM:To evaluate motility of an upper gastrointestinal organ, the gall bladder, in 16 patients with STC and 20 healthy controls. METHODS:Gall bladder emptying (ultrasonography) was studied in response to n...

journal_title：Gut

authors： Penning C,Gielkens HA,Delemarre JB,Lamers CB,Masclee AA

更新日期：1999-08-01 00:00:00

abstract：:The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...

journal_title：Gut

authors： Staniforth DH,Rose D

更新日期：1989-02-01 00:00:00

abstract：:The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were ...

journal_title：Gut

authors： Caldara R,Barbieri C,Piepoli V,Borzio M,Masci E

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. METHODS:Nucleos(t)ide analogue (NUC) treatment was disco...

journal_title：Gut

authors： Seto WK,Liu KS,Mak LY,Cloherty G,Wong DK,Gersch J,Lam YF,Cheung KS,Chow N,Ko KL,To WP,Fung J,Yuen MF

更新日期：2020-08-05 00:00:00

abstract：:There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...

journal_title：Gut

authors： Lampe JW,Fredstrom SB,Slavin JL,Potter JD

更新日期：1993-04-01 00:00:00

abstract：:Management strategies for reflux disease are very different from those for dyspepsia and so differentiating between patients with "true" dyspepsia and those whose primary symptom is heartburn is a key step in their management. This separation has become more clear during the last decade as insights into reflux disease...

journal_title：Gut

authors： Dent J

更新日期：2002-05-01 00:00:00

abstract：:Coeliac disease is triggered by ingestion of wheat gliadin and is probably immune mediated. There is evidence by light microscopy that expression of class II major histocompatibility complex (MHC) molecules is increased in the small intestinal epithelium of patients with untreated coeliac disease and that gliadin can ...

journal_title：Gut

authors： Zimmer KP,Poremba C,Weber P,Ciclitira PJ,Harms E

更新日期：1995-05-01 00:00:00

abstract：:Because of the increasing use of immunosuppressive and biological drugs, the occurrence of opportunistic infections has become a key safety issue for patients with inflammatory bowel disease (IBD). Consequently, improvement of healthcare workers' knowledge of this domain is urgent. In this review, the preventive measu...

journal_title：Gut

authors： Viget N,Vernier-Massouille G,Salmon-Ceron D,Yazdanpanah Y,Colombel JF

更新日期：2008-04-01 00:00:00

abstract：:Peptide histidine isoleucine, a 27 amino acid peptide with close amino acid sequence homology to vasoactive intestinal peptide and secretin, is distributed throughout the mammalian intestinal tract, where it has been localised to intramural neurones. An intestinal perfusion technique has been used to study the effect ...

journal_title：Gut

authors： Moriarty KJ,Hegarty JE,Tatemoto K,Mutt V,Christofides ND,Bloom SR,Wood JR

更新日期：1984-06-01 00:00:00

abstract：:Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...

journal_title：Gut

authors： Chiba T,Taminato T,Kadowaki S,Goto Y,Mori K,Seino Y,Abe H,Chihara K,Matsukura S,Fujita T,Kondo T

更新日期：1980-02-01 00:00:00

abstract：:Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were r...

journal_title：Gut

authors： Schröder H,Evans DA

更新日期：1972-04-01 00:00:00

abstract：BACKGROUND AND AIMS:There are no available effective therapies for fatigue associated with chronic hepatitis C (CHC). The serotonin antagonist ondansetron has been shown to be effective in the chronic fatigue syndrome. In this randomised, placebo controlled, double blind trial, we investigated the effect of orally admi...

journal_title：Gut

authors： Piche T,Vanbiervliet G,Cherikh F,Antoun Z,Huet PM,Gelsi E,Demarquay JF,Caroli-Bosc FX,Benzaken S,Rigault MC,Renou C,Rampal P,Tran A

更新日期：2005-08-01 00:00:00

abstract：:In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no ev...

journal_title：Gut

authors： Giles GR,Woodhouse L,Finan PJ,Chisholm EM

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND/AIMS:To evaluate the response of endocrine cells of the gastric oxyntic mucosa in hypergastrinaemic patients to either antrectomy or treatment with the somatostatin analogue octreotide. PATIENTS:(a) Two patients with enterochromaffin-like (ECL) cell carcinoid and chronic atrophic gastritis, treated with ant...

journal_title：Gut

authors： D'Adda T,Annibale B,Delle Fave G,Bordi C

更新日期：1996-05-01 00:00:00

abstract：:Distal duodenal biopsy specimens taken from 30 white, 35 Indian, and 20 Afro-Caribbean residents of West Birmingham during routine endoscopy for dyspepsia, were assessed by dissecting microscopy and morphometry. Finger-shaped villi were significantly less frequent in the Indian and Afro-Caribbean subjects than in the ...

journal_title：Gut

authors： Wood GM,Gearty JC,Cooper BT

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. DESIGN:By utilising large ...

journal_title：Gut

authors： Chan TH,Lin CH,Qi L,Fei J,Li Y,Yong KJ,Liu M,Song Y,Chow RK,Ng VH,Yuan YF,Tenen DG,Guan XY,Chen L

更新日期：2014-05-01 00:00:00

abstract：:The effect of increasing the calcium, magnesium and sodium concentration in gall bladder bile samples from 21 patients with gall stones and nine controls on the in vitro rate of formation of cholesterol microcrystals and numbers of cholesterol microcrystals formed was examined. Addition of these cations to raise the m...

journal_title：Gut

authors： Neithercut WD

更新日期：1989-05-01 00:00:00

abstract：:This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...

journal_title：Gut

authors： Lagarriga J,Bouchier IA

更新日期：1973-12-01 00:00:00

abstract：:The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approxi...

journal_title：Gut

authors： Olsen PS,Kirkegaard P,Poulsen SS,Nexø E

更新日期：1984-11-01 00:00:00

abstract：:Recent discoveries of trypsinogen and trypsin inhibitor mutations in patients with chronic pancreatitis (CP) support the hypothesis that an inappropriate activation of pancreatic zymogens to active enzymes within the pancreatic parenchyma starts the inflammatory process. Current data suggest that CP may be inherited d...

journal_title：Gut

authors： Witt H

更新日期：2003-05-01 00:00:00

abstract：:Partial gastrectomy and intestinal resection significantly impaired glucose tolerance (p < 0.05) and significantly decreased the release of insulin by intravenous glucose (p < 0.05) or a meal of minced beef (p < 0.01). There was a significantly greater release of insulin one hour after oral glucose in the gastrectomy ...

journal_title：Gut

authors： Wapnick S,Jones JJ

更新日期：1972-11-01 00:00:00

abstract：BACKGROUND:The mechanisms of aspirin induced gastroduodenal injury are not fully understood. Aspirin induces the release of reactive oxygen metabolites in animal models, which may contribute to mucosal injury. AIMS:To investigate the effects of aspirin administered with placebo or antioxidants on gastric mucosal react...

journal_title：Gut

authors： McAlindon ME,Muller AF,Filipowicz B,Hawkey CJ

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-me...

journal_title：Gut

authors： Costa L,Corre S,Michel V,Le Luel K,Fernandes J,Ziveri J,Jouvion G,Danckaert A,Mouchet N,Da Silva Barreira D,Torres J,Camorlinga M,D'Elios MM,Fiette L,De Reuse H,Galibert MD,Touati E

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND AIM:The lymphatic network plays a major role in maintaining tissue fluid homoeostasis. Therefore several pathological conditions associated with oedema formation result in deficient lymphatic function. However, the role of the lymphatic system in the pathogenesis of ascites and oedema formation in cirrho...

journal_title：Gut

authors： Ribera J,Pauta M,Melgar-Lesmes P,Tugues S,Fernández-Varo G,Held KF,Soria G,Tudela R,Planas AM,Fernández-Hernando C,Arroyo V,Jiménez W,Morales-Ruiz M

更新日期：2013-01-01 00:00:00

abstract：:Seventy six patients with dysphagia caused by malignant tumours of the oesophagus or gastric cardia have been treated using the Neodymium Yttrium Aluminium Garnet (NdYag) laser. The laser was set to deliver 80-100 watts of power for 0.5-1 second pulses. To obtain improvement, patients on average needed four treatment ...

journal_title：Gut

authors： Krasner N,Barr H,Skidmore C,Morris AI

更新日期：1987-07-01 00:00:00

abstract：:Alcohol tolerance has been studied in 10 patients after proximal gastric vagotomy and six patients after truncal vagotomy and antrectomy. No difference in alcohol tolerance was found before and after proximal gastric vagotomy, while an increased rate of absorption with higher blood levels of alcohol were found after t...

journal_title：Gut

authors： Moodie AF,Royston CM,Spencer J

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS:We conducted a randomised, double blind, placebo controlled trial of intravenous ant...

journal_title：Gut

authors： Siriwardena AK,Mason JM,Balachandra S,Bagul A,Galloway S,Formela L,Hardman JG,Jamdar S

更新日期：2007-10-01 00:00:00

abstract：:Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver. ...

journal_title：Gut

authors： Lau AH,de Creus A,Lu L,Thomson AW

更新日期：2003-08-01 00:00:00

abstract：:The incorporation of the fatty acids in fish and olive oil into the colonic mucosa of patients with inflammatory bowel disease was examined during 12 weeks' dietary supplementation with the oils, and the influence on colonic mucosal prostaglandin and thromboxane generation was measured. With a dietary supplement of 18...

journal_title：Gut

authors： Hillier K,Jewell R,Dorrell L,Smith CL

更新日期：1991-10-01 00:00:00