Peutz-Jeghers syndrome associated with gastrointestinal carcinoma. Report of two cases in a family.


:Patients with the Peutz-Jeghers syndrome carry a slight, though definite, increased risk of gastrointestinal carcinoma. The malignant potentiality of Peutz-Jeghers hamartomatous polyps, generally considered benign, is supported by this report. Two cases of metastasising gastrointestinal carcinoma associated with the Peutz-Jeghers syndrome are described in a 56 year old female and her 29 year old son. Both mother and son died from duodenal and gastric carcinomas respectively, which developed in hamartomatous polyps with extensive metastases. Both cases also showed dysplastic areas within hamartomatous polyps. These features indicate that hamartomatous polyps may, in some cases, be the precursors of digestive tract carcinomas.






Cochet B,Carrel J,Desbaillets L,Widgren S




Has Abstract


1979-02-01 00:00:00














  • The safety of vedolizumab for ulcerative colitis and Crohn's disease.

    abstract:OBJECTIVE:Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab. DESIGN:Safety data (May 2009-June 2013) from six trials of vedolizumab were integrated. Adverse events were evaluated i...


    pub_type: 杂志文章


    authors: Colombel JF,Sands BE,Rutgeerts P,Sandborn W,Danese S,D'Haens G,Panaccione R,Loftus EV Jr,Sankoh S,Fox I,Parikh A,Milch C,Abhyankar B,Feagan BG

    更新日期:2017-05-01 00:00:00

  • Effect of carbenoxolone on the synthesis of glycoproteins and DNA in rat gastric epithelial cells.

    abstract::The influence of carbenoxolone on the synthesis of glycoproteins in the surface mucous cells and the production of new cells in the rat gastric mucosa was studied by means of a vascular perfusion system. The rate of incorporation of tritiated galactose, glucosamine, serine, and sulphate in surface mucous cells, studie...


    pub_type: 杂志文章


    authors: van Huis GA,Kramer MF

    更新日期:1981-10-01 00:00:00

  • Endoscopic mucosal resection for flat neoplasia in chronic ulcerative colitis: can we change the endoscopic management paradigm?

    abstract:BACKGROUND:The potential of endoscopic mucosal resection (EMR) for treating flat dysplastic lesions in chronic ulcerative colitis (CUC) has not been addressed so far. Historically, such lesions were referred for colectomy. Furthermore, there are only limited data to support endoscopic resection of exophytic adenoma-lik...


    pub_type: 杂志文章


    authors: Hurlstone DP,Sanders DS,Atkinson R,Hunter MD,McAlindon ME,Lobo AJ,Cross SS,Thomson M

    更新日期:2007-06-01 00:00:00

  • Immunocytochemical study of the interaction of soybean trypsin inhibitor with rat intestinal mucosa.

    abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...


    pub_type: 杂志文章


    authors: Wilson PA,Melmed RN,Hampe MM,Holt SJ

    更新日期:1978-04-01 00:00:00

  • Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas).

    abstract:OBJECTIVES:Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN:Retrospective multinational study including SCN diagnosed between 1990 and 2014. ...


    pub_type: 杂志文章


    authors: Jais B,Rebours V,Malleo G,Salvia R,Fontana M,Maggino L,Bassi C,Manfredi R,Moran R,Lennon AM,Zaheer A,Wolfgang C,Hruban R,Marchegiani G,Fernández Del Castillo C,Brugge W,Ha Y,Kim MH,Oh D,Hirai I,Kimura W,Jang JY

    更新日期:2016-02-01 00:00:00

  • Young-onset colorectal cancer risk among individuals with iron-deficiency anaemia and haematochezia.

    abstract:OBJECTIVE:Young-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA and YCRC, and haematochezia and YCRC. DESIGN:Cohort study of US Veterans aged 18-...


    pub_type: 杂志文章


    authors: Demb J,Liu L,Murphy CC,Doubeni CA,Martínez ME,Gupta S

    更新日期:2020-12-18 00:00:00

  • Impaired lymphocyte reactivity against tumour cells in patients with Crohn's disease.

    abstract::Evidence is presented which indicates a possible reduction in recognition capacity for tumour cell antigens (EB(2) Burkitt lymphoma cell line) by lymphocytes from some patients with longstanding but inactive Crohn's disease. Three out of seven patients tested also showed diminished or absent lymphocytotoxicity when th...


    pub_type: 杂志文章


    authors: Maclaurin BP,Cooke WT,Ling NR

    更新日期:1972-08-01 00:00:00

  • Non-cryptosporidial diarrhoea in human immunodeficiency virus (HIV) infected patients.

    abstract::Thirty of 81 consecutive HIV antibody positive patients referred with non-cryptosporidial diarrhoea had no potential infectious cause; most had AIDS related complex rather than the full blown syndrome. Opportunistic infections with cytomegalovirus (CMV), mycobacterium avium-intracellulare (MAI), and herpes simplex vir...


    pub_type: 杂志文章


    authors: Connolly GM,Shanson D,Hawkins DA,Webster JN,Gazzard BG

    更新日期:1989-02-01 00:00:00

  • Management of hepatic coma complicating viral hepatitis.

    abstract::The treatment is described of 17 patients with presumed viral hepatitis who developed hepatic coma unresponsive to standard conservative measures. Five patients were considered for treatment by exchange transfusion. Four were treated, with transient improvement in two, but all died. Nine patients were considered for t...


    pub_type: 杂志文章


    authors: Pirola RC,Ham JM,Elmslie RG

    更新日期:1969-11-01 00:00:00

  • Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens.

    abstract:BACKGROUND AND AIMS:Hepatocellular carcinoma (HCC) frequently results from synergism between chemical and infectious liver carcinogens. Worldwide, the highest incidence of HCC is in regions endemic for the foodborne contaminant aflatoxin B1 (AFB1) and hepatitis B virus (HBV) infection. Recently, gut microbes have been ...


    pub_type: 杂志文章


    authors: Fox JG,Feng Y,Theve EJ,Raczynski AR,Fiala JL,Doernte AL,Williams M,McFaline JL,Essigmann JM,Schauer DB,Tannenbaum SR,Dedon PC,Weinman SA,Lemon SM,Fry RC,Rogers AB

    更新日期:2010-01-01 00:00:00

  • Association study of PHOX2B as a candidate gene for Hirschsprung's disease.

    abstract:BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...


    pub_type: 杂志文章


    authors: Garcia-Barceló M,Sham MH,Lui VC,Chen BL,Ott J,Tam PK

    更新日期:2003-04-01 00:00:00

  • Gastric antral vascular ectasia: a problem of recognition and diagnosis.

    abstract::Gastric antral vascular ectasia ('water melon stomach') is a poorly documented cause of occult upper gastrointestinal blood loss. We describe a case which emphasises the clinical and pathological difficulties that can be encountered in making this elusive diagnosis. ...


    pub_type: 杂志文章


    authors: Gouldesbrough DR,Pell AC

    更新日期:1991-08-01 00:00:00

  • Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota.

    abstract:OBJECTIVE:The gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome and nutritional environment. This study investigated whether the gut microbiota per se, aside from changes in genetic background and diet, could sign different...


    pub_type: 杂志文章


    authors: Serino M,Luche E,Gres S,Baylac A,Bergé M,Cenac C,Waget A,Klopp P,Iacovoni J,Klopp C,Mariette J,Bouchez O,Lluch J,Ouarné F,Monsan P,Valet P,Roques C,Amar J,Bouloumié A,Théodorou V,Burcelin R

    更新日期:2012-04-01 00:00:00

  • Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients.

    abstract:BACKGROUND AND AIMS:Glucagon-like peptide 2 (GLP-2) may improve intestinal absorption in short bowel syndrome (SBS) patients with an end jejunostomy. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models. The safety and effect of t...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Jeppesen PB,Sanguinetti EL,Buchman A,Howard L,Scolapio JS,Ziegler TR,Gregory J,Tappenden KA,Holst J,Mortensen PB

    更新日期:2005-09-01 00:00:00

  • Duodenal expression of iron transport molecules in untreated haemochromatosis subjects.

    abstract:BACKGROUND AND AIMS:In HFE associated hereditary haemochromatosis, the duodenal enterocyte behaves as if iron deficient and previous reports have shown increased duodenal expression of divalent metal transporter 1 (DMT1) and iron regulated gene 1 (Ireg1) in affected subjects. In those studies, many patients had undergo...


    pub_type: 杂志文章


    authors: Stuart KA,Anderson GJ,Frazer DM,Powell LW,McCullen M,Fletcher LM,Crawford DH

    更新日期:2003-07-01 00:00:00

  • Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C.

    abstract:BACKGROUND:Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. The ability of HCV genotype 3 to promote steatosis by itself provides an unique opportunity to answer this question. AIMS:The aim of the present...


    pub_type: 杂志文章


    authors: Fartoux L,Poujol-Robert A,Guéchot J,Wendum D,Poupon R,Serfaty L

    更新日期:2005-07-01 00:00:00

  • Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation.

    abstract:BACKGROUND:Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. AIMS:The aims of this study were to determine the normal distribution of ICC within the human colon and t...


    pub_type: 杂志文章


    authors: Lyford GL,He CL,Soffer E,Hull TL,Strong SA,Senagore AJ,Burgart LJ,Young-Fadok T,Szurszewski JH,Farrugia G

    更新日期:2002-10-01 00:00:00

  • Ulcerative colitis in the United States Army in 1944. Follow-up with particular reference to mortality in cases and controls.

    abstract::This paper compares the mortality of 525 men admitted to U.S. Army hospitals in 1944 with ulcerative colitis compared with 518 controls matched for age, race, and rank. The excess mortality in the ulcerative colitis group as compared with the control group was due to approximately equal proportions of deaths from ulce...


    pub_type: 杂志文章



    更新日期:1963-06-01 00:00:00

  • CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.

    abstract:INTRODUCTION:CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. OBJECTIVE:To determine the role of CD248 in the development of liver fibrosis in the rodent and human setting. DESIGN:CD248 expression was studie...


    pub_type: 杂志文章


    authors: Wilhelm A,Aldridge V,Haldar D,Naylor AJ,Weston CJ,Hedegaard D,Garg A,Fear J,Reynolds GM,Croft AP,Henderson NC,Buckley CD,Newsome PN

    更新日期:2016-07-01 00:00:00

  • Immunoelectrophoretic studies on human small intestinal brush border proteins: cellular alterations in the levels of brush border enzymes after jejunoileal bypass operation.

    abstract::The amounts of lactase (EC, sucrase (EC, maltase (EC, microvillus aminopeptidase (microsomal EC3.4.11.2), and dipeptidyl peptidase IV (EC 3.4.14.X) in biopsies from proximal jejunum and distal ileum were studied by quantitative crossed immunoelectrophoresis and enzymatic assays in obese p...


    pub_type: 杂志文章


    authors: Skovbjerg H,Gudmand-Høyer E,Norén O,Sjöström H

    更新日期:1980-08-01 00:00:00

  • Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines.

    abstract::Multinucleated giant cells are an important feature of the granulomatous reaction in Crohn's disease (CD) but their cellular origin is poorly understood. The aim of this study was to discover if intestinal macrophages are capable of generating multinucleated giant cells in vitro in response to cytokine stimulation. Hu...


    pub_type: 杂志文章


    authors: Fais S,Pallone F

    更新日期:1995-12-01 00:00:00

  • Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian patients with chronic hepatitis B suitable for entecavir cessation.

    abstract:BACKGROUND:Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. METHODS:Nucleos(t)ide analogue (NUC) treatment was disco...


    pub_type: 杂志文章


    authors: Seto WK,Liu KS,Mak LY,Cloherty G,Wong DK,Gersch J,Lam YF,Cheung KS,Chow N,Ko KL,To WP,Fung J,Yuen MF

    更新日期:2020-08-05 00:00:00

  • Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma.

    abstract:BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...


    pub_type: 杂志文章


    authors: Cravo M,Pinto R,Fidalgo P,Chaves P,Glória L,Nobre-Leitão C,Costa Mira F

    更新日期:1996-09-01 00:00:00

  • Soluble E-cadherin is a valid prognostic marker in gastric carcinoma.

    abstract:BACKGROUND:Gastric cancer remains a major cause of cancer mortality globally but no good prognostic tumour marker is available. Soluble fragment of E-cadherin protein has been reported to increase in the sera of patients with cancer and recently was found to be elevated in 67% of patients with gastric cancer. AIMS:To ...


    pub_type: 杂志文章


    authors: Chan AO,Lam SK,Chu KM,Lam CM,Kwok E,Leung SY,Yuen ST,Law SY,Hui WM,Lai KC,Wong CY,Hu HC,Lai CL,Wong J

    更新日期:2001-06-01 00:00:00

  • Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat.

    abstract::Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91%; ...


    pub_type: 杂志文章


    authors: Conlon JM,Bailey CJ,Flatt PR

    更新日期:1987-01-01 00:00:00

  • Sex hormones, and acid gastric secretion induced with carbachol, histamine, and gastrin.

    abstract::This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained. Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine. Overiectomized rats...


    pub_type: 杂志文章


    authors: Amure BO,Omole AA

    更新日期:1970-08-01 00:00:00

  • Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis.

    abstract:OBJECTIVE:Precancerous lesion, a well-established histopathologically premalignant tissue with the highest risk for tumourigenesis, develops preferentially from activation of DNA damage checkpoint and persistent inflammation. However, little is known about the mechanisms by which precancerous lesions are initiated and ...


    pub_type: 杂志文章


    authors: Yang Y,Lin X,Lu X,Luo G,Zeng T,Tang J,Jiang F,Li L,Cui X,Huang W,Hou G,Chen X,Ouyang Q,Tang S,Sun H,Chen L,Gonzalez FJ,Wu M,Cong W,Chen L,Wang H

    更新日期:2016-07-01 00:00:00

  • Selective deficiency of pancreatic amylase.

    abstract::Two patients with specific pancreatic amylase deficiency are described. The greatly reduced pancreatic amylase activity was not due to an enzymatically inactive amylase molecule but to an almost complete absence of the molecule itself. The findings are of diagnostic importance as they show that low pancreatic amylase ...


    pub_type: 杂志文章


    authors: Sjölund K,Häggmark A,Ihse I,Skude G,Kärnström U,Wikander M

    更新日期:1991-05-01 00:00:00

  • Development of biliary sludge in patients on intensive care unit: results of a prospective ultrasonographic study.

    abstract::Biliary sludge may be a precursor of gall stones in man. The aim of this study was to determine the incidence of biliary sludge in a prospective study of 36 patients admitted to the intensive care unit for longer than two days. The presence of biliary sludge was determined by ultrasonography. Biliary sludge developed ...


    pub_type: 杂志文章


    authors: Murray FE,Stinchcombe SJ,Hawkey CJ

    更新日期:1992-08-01 00:00:00

  • The gastric response to a transpyloric duodenal tube.

    abstract::The quantification of gastric, pancreatic, biliary, and small bowel functions in man often requires the use of intestinal tubes. In this study, the presence of a transpyloric tube did not alter gastric emptying, acid secretion, or serum gastrin levels in response to an ordinary solid meal. ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Longstreth GF,Malagelada JR,Go VL

    更新日期:1975-10-01 00:00:00