Diverticulitis of the right colon--experience from Hong Kong.


:Diverticulitis affects the right side of the colon more commonly than the left side in the Far East. A consecutive series of 35 patients (mean age 44 years) with right sided diverticulitis seen at this hospital is presented. All had localised pain in the right iliac fossa but systemic upset was uncommon. All but one were thought to have acute appendicitis. Thirty one were explored through a right iliac fossa incision but in more than half this had to be closed and a full laparotomy performed. A correct diagnosis was then made at the time of surgery in 28 (80%). Five patients underwent simple diverticulectomy, the remainder having a right hemicolectomy. On histological analysis most (26) had a single false diverticulum. All patients made a satisfactory recovery from surgery.






Markham NI,Li AK





Has Abstract


1992-04-01 00:00:00














  • Increased phospholipase A2 and decreased lysophospholipase activity in the small intestinal mucosa after ischaemia and revascularisation.

    abstract::The influence of ischaemia and revascularisation on lipid peroxidation and phospholipid metabolism in the rat small intestinal mucosa was investigated. Two hours of total ischaemia followed by five minutes of revascularisation caused not only accumulation of malondialdehyde in the mucosa, but also increased activity o...


    pub_type: 杂志文章


    authors: Otamiri T,Franzén L,Lindmark D,Tagesson C

    更新日期:1987-11-01 00:00:00

  • Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats.

    abstract:BACKGROUND AND AIM:Hepatic stellate cells (HSCs) are key participants in liver fibrosis development. 1,25(OH)(2)D(3), the active form of vitamin D, has antiproliferative properties and antifibrotic potential, as well as a role in extracellular matrix and matrix metalloproteinase (MMP) regulation in renal and lung fibro...


    pub_type: 杂志文章


    authors: Abramovitch S,Dahan-Bachar L,Sharvit E,Weisman Y,Ben Tov A,Brazowski E,Reif S

    更新日期:2011-12-01 00:00:00

  • Antiproliferative effects of interferon alpha on human pancreatic carcinoma cell lines are associated with differential regulation of protein kinase C isoenzymes.

    abstract:BACKGROUND:The molecular mechanisms mediating the antiproliferative effects of interferon alpha on human pancreatic carcinoma cells are poorly understood. AIM:To characterise the effects of interferon alpha on protein kinase C isoenzyme expression in interferon alpha sensitive and resistant human pancreatic tumour cel...


    pub_type: 杂志文章


    authors: Rosewicz S,Weder M,Kaiser A,Riecken EO

    更新日期:1996-08-01 00:00:00

  • Studies on the effect of vagotomy on small intestinal motility using the radiotelemetering capsule.

    abstract::The radio-telemetering capsule (radio-pill) has been used to study the return of motility in the small bowel after vagotomy with a drainage procedure, gastric operations not involving vagotomy, and non-gastric operations. Small intestinal movements returned in about 10 hours after vagotomy, about four hours after the ...


    pub_type: 杂志文章


    authors: ROSS B,WATSON BW,KAY AW

    更新日期:1963-03-01 00:00:00

  • Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells.

    abstract:OBJECTIVE:Chronic pancreatitis is a progressive inflammatory disorder of the pancreas characterised by permanent destruction of acinar cells. Mutations in the chymotrypsinogen C (CTRC) gene have been linked to the development of chronic pancreatitis. The aim of the present study was to explore whether CTRC mutants indu...


    pub_type: 杂志文章


    authors: Szmola R,Sahin-Tóth M

    更新日期:2010-03-01 00:00:00

  • Studies on breath methane: the effect of ethnic origins and lactulose.

    abstract::The prevalence of methane production in an adult population of 256 subjects was 41%, but it was significantly higher in females (49%), than males (33%). When the population was subdivided into ethnic groups. Caucasians (48%) and Black (45%) had significantly more methane producers than Orientals (24%) and Indians (32%...


    pub_type: 杂志文章


    authors: Pitt P,de Bruijn KM,Beeching MF,Goldberg E,Blendis LM

    更新日期:1980-11-01 00:00:00

  • RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours.

    abstract:OBJECTIVE:We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC). DESIGN:Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational s...


    pub_type: 杂志文章


    authors: Longerich T,Endris V,Neumann O,Rempel E,Kirchner M,Abadi Z,Uhrig S,Kriegsmann M,Weiss KH,Breuhahn K,Mehrabi A,Weber TF,Wilkens L,Straub BK,Rosenwald A,Schulze F,Brors B,Froehling S,Pellegrino R,Budczies J,Schirmac

    更新日期:2019-07-01 00:00:00

  • Campylobacter colitis: histological immunohistochemical and ultrastructural findings.

    abstract::The colonic biopsy specimens of 22 patients with colitis and positive stool cultures for Campylobacter jejuni were studied in order to obtain histological and immunohistochemical criteria to differentiate Campylobacter colitis from chronic inflammatory bowel disease. In addition we tried to identify Campylobacter incl...


    pub_type: 杂志文章


    authors: van Spreeuwel JP,Duursma GC,Meijer CJ,Bax R,Rosekrans PC,Lindeman J

    更新日期:1985-09-01 00:00:00

  • Chronic pancreatitis and cystic fibrosis.

    abstract::Recent discoveries of trypsinogen and trypsin inhibitor mutations in patients with chronic pancreatitis (CP) support the hypothesis that an inappropriate activation of pancreatic zymogens to active enzymes within the pancreatic parenchyma starts the inflammatory process. Current data suggest that CP may be inherited d...


    pub_type: 杂志文章,评审


    authors: Witt H

    更新日期:2003-05-01 00:00:00

  • An investigation into the reversibility of the morphological and cytokinetic changes seen in the small intestine of riboflavin deficient rats.

    abstract:BACKGROUND:Impaired iron handling in riboflavin deficiency is thought to be partially a result of significant morphological and cytokinetic changes within the small intestine. AIMS:The aim of the study was to find out if the responses of the rat small intestine to riboflavin deficiency induced at weaning could be reve...


    pub_type: 杂志文章


    authors: Williams EA,Rumsey RD,Powers HJ

    更新日期:1996-08-01 00:00:00

  • Effect of calcium, magnesium and sodium ions on in vitro nucleation of human gall bladder bile.

    abstract::The effect of increasing the calcium, magnesium and sodium concentration in gall bladder bile samples from 21 patients with gall stones and nine controls on the in vitro rate of formation of cholesterol microcrystals and numbers of cholesterol microcrystals formed was examined. Addition of these cations to raise the m...


    pub_type: 杂志文章


    authors: Neithercut WD

    更新日期:1989-05-01 00:00:00

  • Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines.

    abstract::Multinucleated giant cells are an important feature of the granulomatous reaction in Crohn's disease (CD) but their cellular origin is poorly understood. The aim of this study was to discover if intestinal macrophages are capable of generating multinucleated giant cells in vitro in response to cytokine stimulation. Hu...


    pub_type: 杂志文章


    authors: Fais S,Pallone F

    更新日期:1995-12-01 00:00:00

  • Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man.

    abstract::A single oral dose of 4-46 mmol calcium gluconate at pH 5-6 was administered intragastrically to 15 male volunteers without gastrointestinal disease. There was a significant rise in acid output from 30-90 minutes after the calcium was given compared with the basal hourly collection. The serum gastrin level 30 minutes ...


    pub_type: 杂志文章


    authors: Brodie MJ,Ganguli PC,Fine A,Thomson TJ

    更新日期:1977-02-01 00:00:00

  • Post-ERP pancreatitis as a model for cytokine induced acute phase response in acute pancreatitis.

    abstract:BACKGROUND/AIMS:By contrast with animal models, in most cases it is not possible to examine the systemic response in patients in the first hours after onset of acute pancreatitis. The aim was to determine whether endoscopic retrograde cholangiopancreaticography (ERP)-induced pancreatitis can be used as a human model fo...


    pub_type: 杂志文章


    authors: Messmann H,Vogt W,Holstege A,Lock G,Heinisch A,von Fürstenberg A,Leser HG,Zirngibl H,Schölmerich J

    更新日期:1997-01-01 00:00:00

  • A multicentre randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia. GISMAD Achalasia Study Group.

    abstract:BACKGROUND:Intrasphincteric injection of botulinum toxin (Botx) has been proposed as treatment for oesophageal achalasia. However, the predictors of response and optimal dose remain unclear. AIMS:To compare the effect of different doses of Botx and to identify predictors of response. PATIENTS/METHODS:A total of 118 a...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Annese V,Bassotti G,Coccia G,Dinelli M,D'Onofrio V,Gatto G,Leandro G,Repici A,Testoni PA,Andriulli A

    更新日期:2000-05-01 00:00:00

  • Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection.

    abstract:OBJECTIVE:As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, TLR9 promoter polymorphisms (single nucleotide polymorphisms (SNPs)) rs187084 and rs5743836 ...


    pub_type: 杂志文章,多中心研究


    authors: Fischer J,Weber ANR,Böhm S,Dickhöfer S,El Maadidi S,Deichsel D,Knop V,Klinker H,Möller B,Rasenack J,Wang L,Sharma M,Hinrichsen H,Spengler U,Buggisch P,Sarrazin C,Pawlita M,Waterboer T,Wiese M,Probst-Müller E,Malin

    更新日期:2017-10-01 00:00:00

  • Persistent systemic inflammatory response after stent insertion in patients with malignant bile duct obstruction.

    abstract:BACKGROUND:Surgery in patients with malignant bile duct obstruction is associated with high postoperative morbidity and mortality. Tumour necrosis factor alpha (TNF-alpha) plays a key role in the pathogenesis of these complications. AIMS:To determine the effect of biliary drainage on plasma concentrations of TNF-alpha...


    pub_type: 杂志文章


    authors: Ballinger AB,Woolley JA,Ahmed M,Mulcahy H,Alstead EM,Landon J,Clark ML,Farthing MJ

    更新日期:1998-04-01 00:00:00

  • Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon.

    abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...


    pub_type: 杂志文章


    authors: Berrebi D,Maudinas R,Hugot JP,Chamaillard M,Chareyre F,De Lagausie P,Yang C,Desreumaux P,Giovannini M,Cézard JP,Zouali H,Emilie D,Peuchmaur M

    更新日期:2003-06-01 00:00:00

  • Global prevalence of Barrett's oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis.

    abstract:OBJECTIVES:Chronic gastro-oesophageal reflux might lead to the development of Barrett's oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal re...


    pub_type: 杂志文章


    authors: Eusebi LH,Cirota GG,Zagari RM,Ford AC

    更新日期:2020-07-30 00:00:00

  • Do IgA antigliadin and IgA antiendomysium antibodies show there is latent coeliac disease in primary IgA nephropathy?

    abstract::The finding in primary IgA nephropathy of increased levels of IgA to food antigens and particularly to gliadin prompted the hypothesis that a subgroup of these patients may have latent coeliac disease. The observation that gliadin may experimentally induce IgA mesangial deposits supported this hypothesis. We evaluated...


    pub_type: 杂志文章


    authors: Sategna-Guidetti C,Ferfoglia G,Bruno M,Pulitano R,Roccatello D,Amore A,Coppo R

    更新日期:1992-04-01 00:00:00

  • Differential preventive activity of sulindac and atorvastatin in Apc+/Min-FCCCmice with or without colorectal adenomas.

    abstract:OBJECTIVE:The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc+/Min-FCCC mice with known tu...


    pub_type: 杂志文章


    authors: Chang WL,Jackson C,Riel S,Cooper HS,Devarajan K,Hensley HH,Zhou Y,Vanderveer LA,Nguyen MT,Clapper ML

    更新日期:2018-07-01 00:00:00

  • Fate of pancreatic nodules induced by raw soya flour in rats.

    abstract::We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...


    pub_type: 杂志文章


    authors: McGuinness EE,Morgan RG,Wormsley KG

    更新日期:1987-01-01 00:00:00

  • Serological diagnosis of Helicobacter pylori--evaluation of four tests in the presence or absence of non-steroidal anti-inflammatory drugs.

    abstract::The host's humoral immune response to Helicobacter pylori has been used in the diagnosis of active infection with these organisms. Several commercial tests are available but there are few and unconfirmed reports of their efficacy. This study aimed to assess and compare the efficacy of the following H pylori serologica...


    pub_type: 杂志文章


    authors: Taha AS,Reid J,Boothmann P,Gemmell CG,Lee FD,Sturrock RD,Russell RI

    更新日期:1993-04-01 00:00:00

  • Guidelines on the use of liver biopsy in clinical practice from the British Society of Gastroenterology, the Royal College of Radiologists and the Royal College of Pathology.

    abstract::Liver biopsy is required when clinically important information about the diagnosis, prognosis or management of a patient cannot be obtained by safer means, or for research purposes. There are several approaches to liver biopsy but predominantly percutaneous or transvenous approaches are used. A wide choice of needles ...


    pub_type: 杂志文章


    authors: Neuberger J,Patel J,Caldwell H,Davies S,Hebditch V,Hollywood C,Hubscher S,Karkhanis S,Lester W,Roslund N,West R,Wyatt JI,Heydtmann M

    更新日期:2020-08-01 00:00:00

  • Non-cryptosporidial diarrhoea in human immunodeficiency virus (HIV) infected patients.

    abstract::Thirty of 81 consecutive HIV antibody positive patients referred with non-cryptosporidial diarrhoea had no potential infectious cause; most had AIDS related complex rather than the full blown syndrome. Opportunistic infections with cytomegalovirus (CMV), mycobacterium avium-intracellulare (MAI), and herpes simplex vir...


    pub_type: 杂志文章


    authors: Connolly GM,Shanson D,Hawkins DA,Webster JN,Gazzard BG

    更新日期:1989-02-01 00:00:00

  • Predictors of variceal bleeding: an analysis of clinical, endoscopic, and haemodynamic variables, with special reference to intravariceal pressure.

    abstract::To assist in the prediction of variceal bleeding we examined 12 clinical, endoscopic and haemodynamic variables in 126 patients with portal hypertension (72 bleeders and 54 non-bleeders). Multiple regression and discriminant analysis were utilised for 101 patients. Stepwise regression among the 12 variables explained ...


    pub_type: 杂志文章


    authors: Sarin SK,Sundaram KR,Ahuja RK

    更新日期:1989-12-01 00:00:00

  • Cyclosporin in the treatment of corticosteroid resistant autoimmune chronic active hepatitis.

    abstract::A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month...


    pub_type: 杂志文章


    authors: Jackson LD,Song E

    更新日期:1995-03-01 00:00:00

  • Intercellular adhesion molecule-1 and MHC antigens on human intrahepatic bile duct cells: effect of pro-inflammatory cytokines.

    abstract::Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from normal livers and established in primary culture. The in vitro expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on biliary epithelial cells was studied in response...


    pub_type: 杂志文章


    authors: Ayres RC,Neuberger JM,Shaw J,Joplin R,Adams DH

    更新日期:1993-09-01 00:00:00

  • Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine.

    abstract::The proliferative effects of histamine were examined on the human gastric tumour cell lines; MKN45, the gastrin producing subline, MKN45G, and the colorectal lines; LoVo and C170. The proliferation of MKN45 as assessed by 75[Se] selenomethionine uptake and cell counts was increased by histamine concentrations of 10(-7...


    pub_type: 杂志文章


    authors: Watson SA,Wilkinson LJ,Robertson JF,Hardcastle JD

    更新日期:1993-08-01 00:00:00

  • Effects of eight weeks' continuous treatment with oral ranitidine and cimetidine on gastric acid secretion, pepsin secretion, and fasting serum gastrin.

    abstract::Gastric acid secretion, pepsin secretion, and fasting serum gastrin levels were measured in 23 patients with duodenal ulcer disease, divided into three groups which received either cimetidine 800 mg daily, cimetidine 1600 mg daily, or ranitidine hydrochloride 300 mg daily for eight weeks. Pentagastrin tests were carri...


    pub_type: 杂志文章


    authors: Mohammed R,Holden RJ,Hearns JB,McKibben BM,Buchanan KD,Crean GP

    更新日期:1983-01-01 00:00:00