Abstract:
:Spirits from areas of high and low incidence of cancer of the oesophagus were examined for volatile nitrosamines using a chemiluminescent detector. No nitrosamines were found, the detection limit being 0.001 microng/ml.
journal_name
Gutjournal_title
Gutauthors
Gough TAdoi
10.1136/gut.18.4.301subject
Has Abstractpub_date
1977-04-01 00:00:00pages
301-2issue
4eissn
0017-5749issn
1468-3288journal_volume
18pub_type
杂志文章相关文献
GUT文献大全abstract::The effect of a long-term treatment (one to two years) with cimetidine (1.6 g per day) and an antacid (Regla pH) was evaluated in nine patients with a Barrett's oesophagus. The results showed that such long-term treatment had a beneficial effect on the symptoms and endoscopic signs of oesophagitis and on the healing o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.9.724
更新日期:1981-09-01 00:00:00
abstract::During the clinical investigation of patients with gastrointestinal disease by exhaled breath hydrogen measurement, the occurrence of inexplicable variations in recorded hydrogen values led to a search for extra intestinal factors which were capable of adversely influencing breath hydrogen concentration and impairing ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.12.1349
更新日期:1985-12-01 00:00:00
abstract::The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted flu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.1.78
更新日期:1986-01-01 00:00:00
abstract::Heat shock proteins (HSPs) are a highly conserved family of proteins which inhabit almost all subcellular locations and cellular membranes. Depending on their location, these proteins perform a variety of chaperoning functions including folding of newly synthesised polypeptides. HSPs also play a major role in the prot...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2007.140194
更新日期:2009-07-01 00:00:00
abstract::The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.34.6.843
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314205
更新日期:2018-02-01 00:00:00
abstract::Liver regeneration is the common mechanism whereby a patient recovers form a liver injury. In the western world, ethanol is the single most important aetiological factor associated with liver disease, and it appears crucial to determine if ethanol interferes with liver regeneration. We studied the response to a 70% he...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.1.8
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.4.563
更新日期:2003-04-01 00:00:00
abstract::Fifteen patients with severe intractable irritable bowel syndrome previously reported as successfully treated with hypnotherapy, have now been followed up for a mean duration of 18 months. All patients remain in remission although two have experienced a single relapse overcome by an additional session of hypnotherapy....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.4.423
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presenc...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.128587
更新日期:2007-12-01 00:00:00
abstract::This report assesses the value of cholinesterase (ChE) activity as an indicator of liver function and analyses its usefulness in the diagnosis of jaundice. A rapid method of determination has been used, and alterations in ChE activity in conditions other than liver disease have been studied to permit a fuller and more...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.4.294
更新日期:1960-12-01 00:00:00
abstract:OBJECTIVE:The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-322753
更新日期:2020-11-09 00:00:00
abstract::Forty six patients with endoscopically diagnosed duodenal ulceration were randomly allocated to treatment with either sucralfate 1 g qds (n = 24) or cimetidine 200 mg tds and 400 mg nocte (n = 22). When the ulcers healed, a maintenance dose of sucralfate 1 g bd or cimetidine 400 mg nocte was given for one year (or unt...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.30.5.586
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP. DESIGN:We ...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-312049
更新日期:2017-03-01 00:00:00
abstract::The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.2.147
更新日期:1991-02-01 00:00:00
abstract:BACKGROUND:The development of endocrine tumours of the duodenopancreatic area (ETDP) is thought to be slow, but their natural history is not well known. The aim of this study was to determine the factors that influence survival of patients with ETDP. PATIENTS/METHODS:Eighty two patients with ETDP (44 non-functioning t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.3.422
更新日期:1998-09-01 00:00:00
abstract::Endoscopic sphincterotomy was undertaken in 186 patients with common bile duct stones and an intact gall bladder who were considered unfit for surgery. One hundred and seventy one patients had jaundice of whom 18 also had clinical cholangitis. The mean age of treated patients was 79.7 years (range 27-92) and only 13 w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.8.1129
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:Opioids are increasingly prescribed in the West and have deleterious GI consequences. Pharmacological therapies to treat opioid-induced constipation (OIC) are available, but their relative efficacy is unclear. We performed a systematic review and network meta-analysis to address this deficit in current knowle...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316001
更新日期:2019-03-01 00:00:00
abstract::The role of Helicobacter pylori infection in the pathogenesis of functional dyspepsia is debated. It is known that a substantial fraction of dyspeptic patients manifest a low discomfort threshold to gastric distension. This study investigated the symptomatic pattern in 27 H pylori positive and 23 H pylori negative pat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.1.47
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310148
更新日期:2017-02-01 00:00:00
abstract::Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.1.54
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Different acid and peptic related gastroduodenal diseases are associated with both increased gastric secretion and Helicobacter pylori infection. Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.1.13
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. OBJECTIVE:To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. DESIGN:The regulated miRNAs in human livers infected with hepatitis C virus were identified...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300717
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Human growth factors are potential therapeutic agents for various inflammatory disorders affecting the gastrointestinal tract. However, they are unstable when administered orally and systemic administration requires high doses increasing the risk of unwanted side effects. Live microorganism-based delivery sy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.176131
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:A non-invasive test for assessment of fat digestion has been developed based on the intraluminal hydrolysis of cholesteryl-[1-13C]octanoate by pancreatic esterase. AIMS:To determine the diagnostic performance of this breath test in the assessment of exocrine pancreatic function. METHODS:The test was perfor...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.1.81
更新日期:1998-01-01 00:00:00
abstract::Patients with ulcerative colitis and coeliac disease who had been shown by impaired clearance of heat damaged red cells to have diminished splenic phagocytosis, were examined for evidence of more generalised reticuloendothelial malfunction by measuring their circulatory clearance of micro-aggregated albumin. Although ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.5.384
更新日期:1983-05-01 00:00:00
abstract::The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.1.36
更新日期:1960-03-01 00:00:00
abstract::Sixty three 24 hour oesophageal pH studies were performed in children with known or suspected gastro-oesophageal reflux and their progress was followed for at least a year. Forty two studies were of children who were well at follow up who were not receiving medical treatment for gastro-oesophageal reflux, and had not ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.4.370
更新日期:1990-04-01 00:00:00
abstract::Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence th...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.suppl_3.iii31
更新日期:2002-05-01 00:00:00
abstract::Pregnancy and contraceptive steroids are associated with a raised incidence of cholesterol gall stone disease. In pregnancy there is an increase in the size of the gall bladder. Investigation of hepatobiliary function in man and mammals has not established if the enlarged gall bladder is simply dilated, or if the abso...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.1.10
更新日期:1986-01-01 00:00:00