Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota.

abstract：BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...

journal_title：Gut

authors： Verdú EF,Bercik P,Verma-Gandhu M,Huang XX,Blennerhassett P,Jackson W,Mao Y,Wang L,Rochat F,Collins SM

更新日期：2006-02-01 00:00:00

abstract：:An endoscopical and histological study was carried out in 114 patients, treated by 'curative' resection of the terminal ileum and part of the colon for Crohn's disease, in order to study the natural history of recurrent Crohn's disease. The recurrence rate of Crohn's disease in patients examined within one year of the...

journal_title：Gut

authors： Rutgeerts P,Geboes K,Vantrappen G,Kerremans R,Coenegrachts JL,Coremans G

更新日期：1984-06-01 00:00:00

abstract：:To assess whether dietary antigens play a role in inflammatory bowel disease, 26 monozygotic twin pairs with inflammatory bowel disease and 52 healthy controls were investigated for serum antibodies (IgA, IgG, IgM) against ovalbumin, betalactoglobulin, gliadin, whole yeast (Saccharomyces cerevisiae) and yeast cell wal...

journal_title：Gut

authors： Lindberg E,Magnusson KE,Tysk C,Järnerot G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The choice of colorectal surgery in patients with familial adenomatous polyposis lies between the morbidity of proctocolectomy and ileum-pouch-anal anastomosis (IPAA) and the mortality from rectal cancer after total colectomy and ileorectal anastomosis (IRA). The aims of the present study were: (1) ...

journal_title：Gut

authors： Vasen HF,van Duijvendijk P,Buskens E,Bülow C,Björk J,Järvinen HJ,Bülow S

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Large numbers of plasma cells (PC) localise in the intestinal lamina propria (LP) where they play a critical role in the defence against pathogens. This study analyses the level of maturation reached by normal human colon LPPC in comparison with that of bone marrow (BM) PC. METHODS:A technique was ...

journal_title：Gut

authors： Medina F,Segundo C,Campos-Caro A,Salcedo I,García-Poley A,Brieva JA

更新日期：2003-03-01 00:00:00

abstract：:Nineteen patients with symptoms of upper gastrointestinal disease were assessed by endoscopy. Transmucosal potential difference (PD) in the lower oesophagus was recorded and suction biopsy specimens were obtained from the site of measurement and examined by light microscopy after haematoxylin and eosin staining. In 10...

journal_title：Gut

authors： Khamis B,Kennedy C,Finucane J,Doyle JS

更新日期：1978-05-01 00:00:00

abstract：:Two enzymes having lactase activity are present in the equine small intestine. The first, the digestive enzyme, neutral beta-galactosidase, declines in activity from birth to three years, disappearing completely between 3 and 4 years of age. The other, the soluble lysosomal enzyme, acid beta-galactosidase, having affi...

journal_title：Gut

authors： Roberts MC,Kidder DE,Hill FW

更新日期：1973-07-01 00:00:00

abstract：:In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no ev...

journal_title：Gut

authors： Giles GR,Woodhouse L,Finan PJ,Chisholm EM

更新日期：1986-02-01 00:00:00

abstract：:Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammat...

journal_title：Gut

authors： Fléjou JF,Potet F,Molas G,Bernades P,Amouyal P,Fékété F

更新日期：1993-03-01 00:00:00

abstract：:A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterolo...

journal_title：Gut

authors： Ludvigsson JF,Bai JC,Biagi F,Card TR,Ciacci C,Ciclitira PJ,Green PH,Hadjivassiliou M,Holdoway A,van Heel DA,Kaukinen K,Leffler DA,Leonard JN,Lundin KE,McGough N,Davidson M,Murray JA,Swift GL,Walker MM,Zingone F,Sa

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn's disease (CD). Recently, a novel transcription factor T-box expressed in T cells (T-bet) has been reported as the master regulator of Th1 development. This study was designed to investigate the role...

journal_title：Gut

authors： Matsuoka K,Inoue N,Sato T,Okamoto S,Hisamatsu T,Kishi Y,Sakuraba A,Hitotsumatsu O,Ogata H,Koganei K,Fukushima T,Kanai T,Watanabe M,Ishii H,Hibi T

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:There is a need for an improved biomarker for colorectal cancer (CRC) and advanced adenoma. We evaluated faecal microbial markers for clinical use in detecting CRC and advanced adenoma. DESIGN:We measured relative abundance of Fusobacterium nucleatum (Fn), Peptostreptococcus anaerobius (Pa) and Parvimonas mi...

journal_title：Gut

authors： Wong SH,Kwong TNY,Chow TC,Luk AKC,Dai RZW,Nakatsu G,Lam TYT,Zhang L,Wu JCY,Chan FKL,Ng SSM,Wong MCS,Ng SC,Wu WKK,Yu J,Sung JJY

更新日期：2017-08-01 00:00:00

abstract：:A fifth instance of Crohn's disease in identical twins is reported. The evidence for genetic expression of the disease is considered and the possible mechanisms involved are reviewed. ...

journal_title：Gut

authors： Hislop IG,Grant AK

更新日期：1969-12-01 00:00:00

abstract：:In an effort to assess connective tissue biosynthetic activity in human liver disease, collagen proline hydroxylase (a key enzyme in collagen biosynthesis) and the uptake of (35)S sulphate (a precursor of sulphated mucopolysaccharides) were measured in hepatic tissue obtained mainly by percutaneous biopsy.A procedure ...

journal_title：Gut

authors： McGee JO,Patrick RS,Rodger MC,Luty CM

更新日期：1974-04-01 00:00:00

abstract：:Primary oesophageal involvement by lymphoma in two patients, one with Hodgkin's disease and one with non-Hodgkin's lymphoma is reported. In both, there were no manifestations of the disease outside the oesophagus, which is exceptionally rare. In the patient with non-Hodgkin's lymphoma, the oesophageal tumour was the f...

journal_title：Gut

authors： Taal BG,Van Heerde P,Somers R

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects. AIMS:The aim of the present study was to investigate the response in vivo of zinc transporters in the human enterocyte to dietary zinc supple...

journal_title：Gut

authors： Cragg RA,Phillips SR,Piper JM,Varma JS,Campbell FC,Mathers JC,Ford D

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN:In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assig...

journal_title：Gut

authors： Hézode C,Hirschfield GM,Ghesquiere W,Sievert W,Rodriguez-Torres M,Shafran SD,Thuluvath PJ,Tatum HA,Waked I,Esmat G,Lawitz EJ,Rustgi VK,Pol S,Weis N,Pockros PJ,Bourlière M,Serfaty L,Vierling JM,Fried MW,Weiland O,B

更新日期：2015-06-01 00:00:00

abstract：:This paper reviews the experience gained over the past few years in two techniques of liver support, charcoal haemoperfusion and polyacrylonitrile membrane haemodialysis. Problems with charcoal haemoperfusion have centred around platelet aggregation and hypertension, and new carbon preparations with a variety of diffe...

journal_title：Gut

authors： Williams R

更新日期：1978-06-01 00:00:00

abstract：:40749 RP is a pyridil-2-tetrahydrothiophene derivative, belonging to a new class of gastric antisecretory drugs. We compared its effects on gastric secretion with cimetidine. Intragastric acidity, nocturnal acid output, gastrin and pepsinogen-I profiles were measured in patients with duodenal ulcer in clinical remissi...

journal_title：Gut

authors： Malè PJ,Griessen M,Cunningham MG,Frydman AM,Garoflid-Oprescu NA,De Peyer R,Loizeau E

更新日期：1986-04-01 00:00:00

abstract：:Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient w...

journal_title：Gut

authors： Beaugerie L,Luboinski J,Brousse N,Cosnes J,Chatelet FP,Gendre JP,Le Quintrec Y

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND AND AIMS:CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has be...

journal_title：Gut

authors： Fitzmaurice K,Petrovic D,Ramamurthy N,Simmons R,Merani S,Gaudieri S,Sims S,Dempsey E,Freitas E,Lea S,McKiernan S,Norris S,Long A,Kelleher D,Klenerman P

更新日期：2011-11-01 00:00:00

abstract：:Gastroparesis is defined by the presence of delayed gastric emptying (GE) in the absence of mechanical obstruction. Symptoms that have been attributed to gastroparesis include postprandial fullness, early satiation nausea and vomiting. Gastroprokinetic drugs are the preferred treatment option. A number of problems wit...

journal_title：Gut

authors： Stanghellini V,Tack J

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...

journal_title：Gut

authors： Zhao Y,Shuen TWH,Toh TB,Chan XY,Liu M,Tan SY,Fan Y,Yang H,Lyer SG,Bonney GK,Loh E,Chang KTE,Tan TC,Zhai W,Chan JKY,Chow EK,Chee CE,Lee GH,Dan YY,Chow PK,Toh HC,Lim SG,Chen Q

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC). DESIGN:Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational s...

journal_title：Gut

authors： Longerich T,Endris V,Neumann O,Rempel E,Kirchner M,Abadi Z,Uhrig S,Kriegsmann M,Weiss KH,Breuhahn K,Mehrabi A,Weber TF,Wilkens L,Straub BK,Rosenwald A,Schulze F,Brors B,Froehling S,Pellegrino R,Budczies J,Schirmac

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The development of endocrine tumours of the duodenopancreatic area (ETDP) is thought to be slow, but their natural history is not well known. The aim of this study was to determine the factors that influence survival of patients with ETDP. PATIENTS/METHODS:Eighty two patients with ETDP (44 non-functioning t...

journal_title：Gut

authors： Madeira I,Terris B,Voss M,Denys A,Sauvanet A,Flejou JF,Vilgrain V,Belghiti J,Bernades P,Ruszniewski P

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Ethanol undergoes a first pass metabolism (FPM) in the stomach and liver. Gastric FPM of ethanol primarily depends on the activity of gastric alcohol dehydrogenase (ADH). In addition, the speed of gastric emptying (GE) may modulate both gastric and hepatic FPM of ethanol. AIMS:To study the effect of modulat...

journal_title：Gut

authors： Oneta CM,Simanowski UA,Martinez M,Allali-Hassani A,Parés X,Homann N,Conradt C,Waldherr R,Fiehn W,Coutelle C,Seitz HK

更新日期：1998-11-01 00:00:00

abstract：:In a Danish multicentre trial we compared the relapse preventing effects of olsalazine and sulphasalazine in patients with ulcerative colitis over a 12 month treatment period. Two hundred and twenty seven patients (118 men) with at least two previous attacks of ulcerative colitis were randomly allocated according to a...

journal_title：Gut

authors： Kiilerich S,Ladefoged K,Rannem T,Ranløv PJ

更新日期：1992-02-01 00:00:00

abstract：:Six New Zealand white rabbits were given gas induction anaesthetics and maintained on glucochloralose (Merck) 60 mg/kg given intravenously. Intracolonic pressures were measured after a standard dose of prostigmine, 0.05 mg/kg, using fluid-filled, open-tipped, narrow-bore polythene tubes. Then the rabbits were put on a...

journal_title：Gut

authors： Hodgson WJ

更新日期：1972-10-01 00:00:00

abstract：:Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieve...

journal_title：Gut

authors： Richardson D,Wyatt JI,Miloszewski KJ

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mu...

journal_title：Gut

authors： Sievers CK,Zou LS,Pickhardt PJ,Matkowskyj KA,Albrecht DM,Clipson L,Bacher JW,Pooler BD,Moawad FJ,Cash BD,Reichelderfer M,Vo TN,Newton MA,Larget BR,Halberg RB

更新日期：2017-12-01 00:00:00