Abstract:
:An endoscopical and histological study was carried out in 114 patients, treated by 'curative' resection of the terminal ileum and part of the colon for Crohn's disease, in order to study the natural history of recurrent Crohn's disease. The recurrence rate of Crohn's disease in patients examined within one year of the operation was 72%. This figure did not differ significantly from that in patients examined one to three years or three to 10 years after surgery (79% and 77% respectively). Recurrence was located in the neoterminal ileum and at the anastomosis in 88% of the patients. Early endoscopic signs of recurrence were small aphthous ulcers in the neoterminal ileum. Ileal biopsies at this stage showed an important inflammatory cell infiltrate of the lamina propria with numerous eosinophils and fusion and blunting of the villi. More advanced lesions observed in patients examined one to three years after surgery, consisted of larger, often serpiginous ulcerations and nodular thickening of folds. In patients examined three to 10 years after the operation, the anastomosis was frequently stenosed and rigid, with large ulcers extending from the stenosis into the colon. Mucosal granulomas may be found in normal appearing mucosa as well as in the obviously inflamed mucosa surrounding the ulcers. These studies suggest that recurrence of Crohn's disease almost always develops in the first year after the operation. Significant endoscopic lesions may be present without clinical symptoms, particularly in the earlier stages of the disease.
journal_name
Gutjournal_title
Gutauthors
Rutgeerts P,Geboes K,Vantrappen G,Kerremans R,Coenegrachts JL,Coremans Gdoi
10.1136/gut.25.6.665subject
Has Abstractpub_date
1984-06-01 00:00:00pages
665-72issue
6eissn
0017-5749issn
1468-3288journal_volume
25pub_type
杂志文章相关文献
GUT文献大全abstract::Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with cirrhosis. Evolving information suggests that the metabolic syndrome with non-alcoholic liver disease may be an important cause of HCC in addition to viral hepatitis and...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2013-306627
更新日期:2014-05-01 00:00:00
abstract::Bowel function was assessed in 51 subjects: 10 women and seven men who habitually consumed an omnivorous, vegetarian, or vegan diet. The subjects on these diets had a mean intake of fibre of 23 g, 37 g, and 47 g respectively. Mean transit times were variable and not significantly different between the groups. Vegans, ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.2.164
更新日期:1986-02-01 00:00:00
abstract::To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and potent histamine H2 antagonist loxtidine for five months. The trophic ef...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.11.1547
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. AIM:To determine whether appendicectomy reduces the overall severity of ulcerative colitis. PATIENTS AND METHODS:Appendicectomy status and smoking habits were sp...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.6.803
更新日期:2002-12-01 00:00:00
abstract::Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.37.3.413
更新日期:1995-09-01 00:00:00
abstract::A retrospective survey was undertaken of 228 resected Meckel's diverticula to determine if there was any evidence of Campylobacter pylori infection in diverticula containing gastric mucosa. Among the 65 diverticula with gastric mucosa one was heavily infected with organisms having the morphological appearances of C py...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.9.1233
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Helicobacter pylori (H pylori) infection is a major risk factor in the development of distal gastric adenocarcinoma. Development of the invasive phenotype is associated with the phenomenon of epithelial:mesenchymal transition (EMT). Soluble heparin-binding epidermal growth factor (HB-EGF) has been i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.199794
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Recent reports have described a modulating influence of nitric oxide (NO) on intestinal mucosal permeability and have implicated a role for mast cells in this NO mediated process. AIMS:To assess further the contribution of mast cells to the mucosal permeability changes elicited by the NO synthase (NOS) inhi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.5.636
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND/AIM:To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. METHODS:HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.119859
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV. METHODS:This nationwide cohort study screened 293,480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12,384 eligible patients who had received...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308163
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct cancers in terms of a number of clinical and epidemiological characteristics, complicating the design of clinical trials and biomarker developments. We analysed 1048 oesophageal tumour-germline pairs from both subtypes, to chara...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314607
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND AIMS:In HFE associated hereditary haemochromatosis, the duodenal enterocyte behaves as if iron deficient and previous reports have shown increased duodenal expression of divalent metal transporter 1 (DMT1) and iron regulated gene 1 (Ireg1) in affected subjects. In those studies, many patients had undergo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.7.953
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.6.878
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND/AIM:5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut disorders. The mechanisms regulating 5-HT production in the gut remain unclear. This study investigated the T helper (Th) 1/...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.129296
更新日期:2008-04-01 00:00:00
abstract::An antibody precipitating urease was found in 171 out of 180 human sera. Data obtained on limited material (50 cases) suggest that the anti-urease titre is appreciably higher in the serum of patients suffering from gastric ulcer. This is a pointer towards a possible antigen-antibody mechanism in the genesis of chronic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.4.4.339
更新日期:1963-12-01 00:00:00
abstract::The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.34.6.843
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2016-312238
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The aim of the study was to test the hypothesis that in the fasting state, proximal intestinal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, is tonically inhibited by a cholinergic atropine sensitive mechanism. SUBJECTS:The experiments were performed in 34 healthy volunteers and in ei...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.3.353
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:Endothelial progenitor cells (EPCs) circulate with increased numbers in the peripheral blood of patients with highly-vascularised hepatocellular carcinoma (HCC) and contribute to angiogenesis and neovascularisation. We hypothesised that angiogenic EPCs, that is, colony forming unit-endothelial cells (CFU-ECs...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306302
更新日期:2015-07-01 00:00:00
abstract::In this study we have ultrasonographically assessed the prevalence of sludge in a group of 48 fasting patients after gastrointestinal tract surgery. Ultrasound examinations were carried out daily in each patient, beginning on the day before surgery. The period of fasting lasted from seven to 10 days. The presence of s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.7.734
更新日期:1985-07-01 00:00:00
abstract::Eight patients with traumatic transverse lesions of the spinal cord and eight healthy controls were examined with respect to the function of the anal sphincters. Continuous recordings of anal pressure and electromyograms from the striated sphincter muscles were obtained during gradual rectal distension by means of an ...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.16.8.638
更新日期:1975-08-01 00:00:00
abstract::The effects of specific nutrients on intestinal maturation and repair after injury are practically unknown. The purpose of this work was to study the effects of dietary nucleotides on the repair of the intestinal mucosa after chronic diarrhoea induced by a lactose enriched diet in the weanling rat. One group of weanli...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.7.926
更新日期:1994-07-01 00:00:00
abstract::Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete two hour periods) were analysed for volume, pH, bile acids (conjugated and unconjugated), trypsin, and pepsin. The results were compare...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.10.1093
更新日期:1991-10-01 00:00:00
abstract::Intestinal folate absorption was assessed in six normal subjects and in four patients with coeliac sprue who were studied before and after treatment by dietary gluten exclusion. Comparisons were made of the luminal disappearance from the perfused jejunum of 3H-pteroylmonoglutamate and pteroyl 14C-glutamylhexaglutamate...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.10.886
更新日期:1978-10-01 00:00:00
abstract:OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314983
更新日期:2019-01-01 00:00:00
abstract::A retrospective study was undertaken to investigate how endoscopies yielding positive findings differ a priori from those yielding negative findings: and how those judged 'helpful' (in the sense of influencing management) differ a priori from those judged 'unhelpful'. A total of 483 patients undergoing endoscopy was s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2.187
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Micrometastases within bone marrow have been shown to indicate a poor prognosis in patients with epithelial tumours. However, the degree to which micrometastases represent true residual disease or cell shedding and metastatic potential, is unclear. AIM:To explore whether micrometastases represent residual d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.4.512
更新日期:1997-04-01 00:00:00
abstract::Stimulation of the rectal mucosa with a bipolar electrode leads to relaxation of the internal anal sphincter. Intraoperative studies in two subjects showed that transmission of the impulse was independent of extrinsic nerves and was interrupted by circular myotomy. Characteristics of the reflex were studied in 11 heal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.7.935
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention,...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319804
更新日期:2020-12-01 00:00:00
abstract::The ability of adapting ileal enterocytes to express different digestive enzymes in their brush border membranes was tested in young female Wistar rats (n = 72) receiving 60% proximal small bowel resection. In control rats with intestinal transection both neutral aminopeptidase and alpha-glucosidase activities were sh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.8.981
更新日期:1987-08-01 00:00:00