Cystic dystrophy of the gastric and duodenal wall developing in heterotopic pancreas: an unrecognised entity.


:Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammation and fibrosis. Only endosonography provided strong evidence for the diagnosis in three patients. All patients underwent surgery: a pancreaticoduodenectomy was performed in eight patients. The surgical specimen showed cystic lesions of the gut wall, occurring in inflammatory and fibrous heterotopic pancreatic tissue. The pancreas proper was normal in all patients. It is suggested that cystic dystrophy is an uncommon and serious complication of heterotopic pancreas. Similar cases associated with chronic pancreatitis of the pancreas have been observed and it is suggested that this process could be responsible for some of the chronic pancreatitis encountered in young, non-alcoholic patients.






Fléjou JF,Potet F,Molas G,Bernades P,Amouyal P,Fékété F




Has Abstract


1993-03-01 00:00:00














  • Diverticulitis of the right colon--experience from Hong Kong.

    abstract::Diverticulitis affects the right side of the colon more commonly than the left side in the Far East. A consecutive series of 35 patients (mean age 44 years) with right sided diverticulitis seen at this hospital is presented. All had localised pain in the right iliac fossa but systemic upset was uncommon. All but one w...


    pub_type: 杂志文章


    authors: Markham NI,Li AK

    更新日期:1992-04-01 00:00:00

  • The relation of sensation in the anal canal to the functional anal sphincter: a possible factor in anal continence.

    abstract::In normal subjects the length of the functional anal sphincter has been compared with the extent of sensation to light touch in the anal canal. At rest, the sphincteric zone was the longer. On distension of the rectum, a decrease in pressure in the anal canal so shortened the functional sphincter that intrarectal pres...


    pub_type: 杂志文章


    authors: Duthie HL,Bennett RC

    更新日期:1963-06-01 00:00:00

  • Herbal tea induced hepatic veno-occlusive disease: quantification of toxic alkaloid exposure in adults.

    abstract::Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...


    pub_type: 杂志文章


    authors: Kumana CR,Ng M,Lin HJ,Ko W,Wu PC,Todd D

    更新日期:1985-01-01 00:00:00

  • Immunoelectrophoretic studies on human small intestinal brush border proteins: cellular alterations in the levels of brush border enzymes after jejunoileal bypass operation.

    abstract::The amounts of lactase (EC, sucrase (EC, maltase (EC, microvillus aminopeptidase (microsomal EC3.4.11.2), and dipeptidyl peptidase IV (EC 3.4.14.X) in biopsies from proximal jejunum and distal ileum were studied by quantitative crossed immunoelectrophoresis and enzymatic assays in obese p...


    pub_type: 杂志文章


    authors: Skovbjerg H,Gudmand-Høyer E,Norén O,Sjöström H

    更新日期:1980-08-01 00:00:00

  • Is sclerosant injection mandatory after an epinephrine injection for arrest of peptic ulcer haemorrhage? A prospective, randomised, comparative study.

    abstract::A prospective, randomised, comparative study was performed to assess the need for a pure alcohol injection after an epinephrine injection in the arrest of active peptic ulcer bleeding. Sixty four patients with active ulcer bleeding were enrolled in the study. The two groups (epinephrine and epinephrine plus pure alcoh...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lin HJ,Perng CL,Lee SD

    更新日期:1993-09-01 00:00:00

  • Isolation, maturational level, and functional capacity of human colon lamina propria plasma cells.

    abstract:BACKGROUND AND AIMS:Large numbers of plasma cells (PC) localise in the intestinal lamina propria (LP) where they play a critical role in the defence against pathogens. This study analyses the level of maturation reached by normal human colon LPPC in comparison with that of bone marrow (BM) PC. METHODS:A technique was ...


    pub_type: 杂志文章


    authors: Medina F,Segundo C,Campos-Caro A,Salcedo I,García-Poley A,Brieva JA

    更新日期:2003-03-01 00:00:00

  • Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma.

    abstract:BACKGROUND:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism. AIMS:To investigate whether impaired glucose metabolism affects the growth rate of the tumour. PATIENTS AND METHODS:Tumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 pati...


    pub_type: 杂志文章


    authors: Saito K,Inoue S,Saito T,Kiso S,Ito N,Tamura S,Watanabe H,Takeda H,Misawa H,Togashi H,Matsuzawa Y,Kawata S

    更新日期:2002-07-01 00:00:00

  • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.

    abstract:BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Jeppesen PB,Gilroy R,Pertkiewicz M,Allard JP,Messing B,O'Keefe SJ

    更新日期:2011-07-01 00:00:00

  • Identification of a Crohn's disease specific transcript with potential as a diagnostic marker.

    abstract:BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...


    pub_type: 杂志文章


    authors: Lafontaine DA,Mercure S,Perreault JP

    更新日期:1998-06-01 00:00:00

  • Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.

    abstract:OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...


    pub_type: 杂志文章


    authors: van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

    更新日期:2019-12-01 00:00:00

  • Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.

    abstract:OBJECTIVES:Emerging evidence from mouse models suggests that mutant Kras can drive the development of pancreatic ductal adenocarcinoma (PDA) precursors from acinar cells by enforcing ductal de-differentiation at the expense of acinar identity. Recently, human genome-wide association studies have identified NR5A2, a key...


    pub_type: 杂志文章


    authors: von Figura G,Morris JP 4th,Wright CV,Hebrok M

    更新日期:2014-04-01 00:00:00

  • Effect of cimetidine on the human lower oesophageal sphincter.

    abstract::Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrati...


    pub_type: 杂志文章


    authors: Osborne DH,Lennon J,Henderson M,Lidgard G,Creel R,Carter DC

    更新日期:1977-02-01 00:00:00

  • Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage.

    abstract:BACKGROUND:Obstructive jaundice is associated with postoperative complications related to increased endotoxaemia and the inflammatory response. In animals obstructive jaundice is associated with endotoxaemia and cytokine induction, which are reversed by internal biliary drainage. AIMS:To study endotoxaemia and the sub...


    pub_type: 杂志文章


    authors: Kimmings AN,van Deventer SJ,Obertop H,Rauws EA,Huibregtse K,Gouma DJ

    更新日期:2000-05-01 00:00:00

  • No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study.

    abstract:BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...


    pub_type: 杂志文章


    authors: Lagergren J,Bergström R,Nyrén O

    更新日期:2000-07-01 00:00:00

  • General and cancer specific mortality of a population based cohort of patients with inflammatory bowel disease: the Florence Study.

    abstract:BACKGROUND:A population based epidemiological study identified all the patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) resident in the Florence area in the period 1978-1992. AIMS:To assess the mortality of unselected patients with inflammatory bowel disease (IBD) in a Mediterranean country. ME...


    pub_type: 杂志文章


    authors: Palli D,Trallori G,Saieva C,Tarantino O,Edili E,D'Albasio G,Pacini F,Masala G

    更新日期:1998-02-01 00:00:00

  • Fluoroscopically guided laser lithotripsy versus extracorporeal shock wave lithotripsy for retained bile duct stones: a prospective randomised study.

    abstract:BACKGROUND AND AIMS:To compare extracorporeal shock wave lithotripsy (ESWL) and laser induced shock wave lithotripsy (LISL) of retained bile duct stones to stone free rate, number of therapeutic sessions, and costs. PATIENTS:Thirty four patients were randomly assigned to either ESWL or LISL therapy. The main reasons f...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jakobs R,Adamek HE,Maier M,Krömer M,Benz C,Martin WR,Riemann JF

    更新日期:1997-05-01 00:00:00

  • Pathology of the defunctioned rectum in ulcerative colitis.

    abstract::Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...


    pub_type: 杂志文章


    authors: Warren BF,Shepherd NA,Bartolo DC,Bradfield JW

    更新日期:1993-04-01 00:00:00

  • Microalbuminuria in inflammatory bowel disease.

    abstract::Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined microalbuminuria as a marker of the acute phase response in patients with inflammatory bowel dise...


    pub_type: 杂志文章


    authors: Mahmud N,Stinson J,O'Connell MA,Mantle TJ,Keeling PW,Feely J,Weir DG,Kelleher D

    更新日期:1994-11-01 00:00:00

  • Peutz-Jeghers syndrome associated with gastrointestinal carcinoma. Report of two cases in a family.

    abstract::Patients with the Peutz-Jeghers syndrome carry a slight, though definite, increased risk of gastrointestinal carcinoma. The malignant potentiality of Peutz-Jeghers hamartomatous polyps, generally considered benign, is supported by this report. Two cases of metastasising gastrointestinal carcinoma associated with the P...


    pub_type: 杂志文章


    authors: Cochet B,Carrel J,Desbaillets L,Widgren S

    更新日期:1979-02-01 00:00:00

  • Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.

    abstract:BACKGROUND:Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by perip...


    pub_type: 杂志文章


    authors: Thoree VC,Golby SJ,Boursier L,Hackett M,Dunn-Walters DK,Sanderson JD,Spencer J

    更新日期:2002-07-01 00:00:00

  • Effects of cisapride on gastric emptying of oil and aqueous meal components, hunger, and fullness.

    abstract::To evaluate the effects of cisapride on gastric emptying of extracellular fat and hunger and fullness 10 volunteers consumed a meal consisting of 60 ml technectium-99m (99mTc)-V-thiocyanate labelled olive oil and 290 ml indium-113m (113mIn) labelled soup after taking cisapride (10 mg four times daily orally) and place...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones KL,Horowitz M,Carney BI,Sun WM,Chatterton BE

    更新日期:1996-03-01 00:00:00

  • A mixed endocrine adrenal tumour causing steatorrhoea.

    abstract::A 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. Raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. Adrenoreceptor blockade reversed...


    pub_type: 杂志文章


    authors: Thesleff P,Benoni C,Mårtensson H,Nilsson A,Sundler F,Akesson B

    更新日期:1987-10-01 00:00:00

  • The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines.

    abstract::Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. Both genetic and environmental influences are...


    pub_type: 指南,杂志文章,实务指引


    authors: Hirschfield GM,Dyson JK,Alexander GJM,Chapman MH,Collier J,Hübscher S,Patanwala I,Pereira SP,Thain C,Thorburn D,Tiniakos D,Walmsley M,Webster G,Jones DEJ

    更新日期:2018-09-01 00:00:00

  • Five-year risk for advanced colorectal neoplasia after initial colonoscopy according to the baseline risk stratification: a prospective study in 2452 asymptomatic Koreans.

    abstract:OBJECTIVE:Postpolypectomy surveillance guidelines for colorectal cancer introduced the concept of 'risk stratification'; however, few studies have been conducted for validation of its usefulness. The aim of this study was to assess the 5-year incidence of advanced neoplasia recurrence based on the risk stratification s...


    pub_type: 杂志文章


    authors: Chung SJ,Kim YS,Yang SY,Song JH,Kim D,Park MJ,Kim SG,Song IS,Kim JS

    更新日期:2011-11-01 00:00:00

  • An Asian consensus on standards of diagnostic upper endoscopy for neoplasia.

    abstract:BACKGROUND:This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers. METHOD:The Delphi method was used to develop consensus statements through identification of clinical ques...


    pub_type: 共识发展会议,杂志文章


    authors: Chiu PWY,Uedo N,Singh R,Gotoda T,Ng EKW,Yao K,Ang TL,Ho SH,Kikuchi D,Yao F,Pittayanon R,Goda K,Lau JYW,Tajiri H,Inoue H

    更新日期:2019-02-01 00:00:00

  • Prostaglandin E2 formation by the gall bladder in experimental cholecystitis.

    abstract::Both experimental cholecystitis and luminal distension inhibit fluid absorption and stimulate motor activity in the gall bladder. These functional alterations are mimicked by exogenous prostaglandins (PGs) and inhibited by potent cyclooxygenase inhibitors, but direct evidence of a primary role of endogenous PGs is not...


    pub_type: 杂志文章


    authors: Thornell E,Jivegård L,Bukhave K,Rask-Madsen J,Svanvik J

    更新日期:1986-04-01 00:00:00

  • First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying.

    abstract:BACKGROUND:Ethanol undergoes a first pass metabolism (FPM) in the stomach and liver. Gastric FPM of ethanol primarily depends on the activity of gastric alcohol dehydrogenase (ADH). In addition, the speed of gastric emptying (GE) may modulate both gastric and hepatic FPM of ethanol. AIMS:To study the effect of modulat...


    pub_type: 杂志文章


    authors: Oneta CM,Simanowski UA,Martinez M,Allali-Hassani A,Parés X,Homann N,Conradt C,Waldherr R,Fiehn W,Coutelle C,Seitz HK

    更新日期:1998-11-01 00:00:00

  • Phenotypic differences in familial adenomatous polyposis based on APC gene mutation status.

    abstract:BACKGROUND:Familial adenomatous polyposis (FAP) is a clinically well defined hereditary disease caused by germline mutations within the adenomatous polyposis coli (APC) gene. Although several techniques are applied in the mutation analysis of FAP kindreds about 20-50% of cases remain unclear, with no APC mutation ident...


    pub_type: 杂志文章


    authors: Heinimann K,Müllhaupt B,Weber W,Attenhofer M,Scott RJ,Fried M,Martinoli S,Müller H,Dobbie Z

    更新日期:1998-11-01 00:00:00

  • Differential preventive activity of sulindac and atorvastatin in Apc+/Min-FCCCmice with or without colorectal adenomas.

    abstract:OBJECTIVE:The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc+/Min-FCCC mice with known tu...


    pub_type: 杂志文章


    authors: Chang WL,Jackson C,Riel S,Cooper HS,Devarajan K,Hensley HH,Zhou Y,Vanderveer LA,Nguyen MT,Clapper ML

    更新日期:2018-07-01 00:00:00

  • Shanghai fever: a distinct Pseudomonas aeruginosa enteric disease.

    abstract:BACKGROUND:Shanghai fever, a community-acquired enteric illness associated with sepsis caused by Pseudomonas aeruginosa, was first described in 1918. The understanding of Shanghai fever is incomplete. OBJECTIVE:To delineate the clinical features and to examine the host and microbial factors associated with Shanghai fe...


    pub_type: 杂志文章


    authors: Chuang CH,Wang YH,Chang HJ,Chen HL,Huang YC,Lin TY,Ozer EA,Allen JP,Hauser AR,Chiu CH

    更新日期:2014-05-01 00:00:00