An interim report on the production of colonic diverticula in the rabbit.

abstract：OBJECTIVE:Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determined effects of caffeine an...

journal_title：Gut

authors： Huang W,Cane MC,Mukherjee R,Szatmary P,Zhang X,Elliott V,Ouyang Y,Chvanov M,Latawiec D,Wen L,Booth DM,Haynes AC,Petersen OH,Tepikin AV,Criddle DN,Sutton R

更新日期：2017-02-01 00:00:00

abstract：:Severe watery diarrhoea in a patient with medullary thryoid carcinoma and high calcitonin levels was associated with increased distal ileal flow. Plasma from the patient inhibited small intestinal fluid absorption in dogs without affecting mucosal cyclic AMP levels. When calcitonin was removed from the plasma, the eff...

journal_title：Gut

authors： Cox TM,Fagan EA,Hillyard CJ,Allison DJ,Chadwick VS

更新日期：1979-07-01 00:00:00

abstract：OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...

journal_title：Gut

authors： La Bella T,Imbeaud S,Peneau C,Mami I,Datta S,Bayard Q,Caruso S,Hirsch TZ,Calderaro J,Morcrette G,Guettier C,Paradis V,Amaddeo G,Laurent A,Possenti L,Chiche L,Bioulac-Sage P,Blanc JF,Letouze E,Nault JC,Zucman-Rossi

更新日期：2020-04-01 00:00:00

abstract：:The bacterial flora intimately associated with the intestinal mucosa of patients with Crohn's disease has been examined and compared with the mucosal flora of a control group. Specimens were obtained at operation from patients undergoing intestinal surgery. Whole thickness intestinal sections were taken from the disea...

journal_title：Gut

authors： Peach S,Lock MR,Katz D,Todd IP,Tabaqchali S

更新日期：1978-11-01 00:00:00

abstract：:The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a signif...

journal_title：Gut

authors： Jones AL,Bangash IH,Bouchier IA,Hayes PC

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Treatment of Helicobacter pylori infection prevents duodenal ulcer relapse. It has not been established if treatment of the infection heals duodenal ulcer. AIM:To test the hypothesis that treatment of the infection was associated with healing of duodenal ulcer. METHODS:A randomised, double blind placebo co...

journal_title：Gut

authors： Lam SK,Ching CK,Lai KC,Wong BC,Lai CL,Chan CK,Ong L

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVES:COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. DESIGN:This Italian prosp...

journal_title：Gut

authors： Bezzio C,Saibeni S,Variola A,Allocca M,Massari A,Gerardi V,Casini V,Ricci C,Zingone F,Amato A,Caprioli F,Lenti MV,Viganò C,Ascolani M,Bossa F,Castiglione F,Cortelezzi C,Grossi L,Milla M,Morganti D,Pastorelli L,R

更新日期：2020-07-01 00:00:00

abstract：:The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogene...

journal_title：Gut

authors： Moore K

更新日期：2004-02-01 00:00:00

abstract：:Seventy six patients with dysphagia caused by malignant tumours of the oesophagus or gastric cardia have been treated using the Neodymium Yttrium Aluminium Garnet (NdYag) laser. The laser was set to deliver 80-100 watts of power for 0.5-1 second pulses. To obtain improvement, patients on average needed four treatment ...

journal_title：Gut

authors： Krasner N,Barr H,Skidmore C,Morris AI

更新日期：1987-07-01 00:00:00

abstract：:Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differen...

journal_title：Gut

authors： Laakso M,Suhonen M,Julkunen R,Pyörälä K

更新日期：1990-03-01 00:00:00

abstract：:The effects of proximal gastric vagotomy (PGV) and vagotomy with pyloroplasty (V and P) on gastric motility were studied using a solid meal labelled with a radiopharmaceutical agent. In having on-line computer facilities it was possible not only to record the rate of emptying but also to analyse the relative roles of ...

journal_title：Gut

authors： Sheiner HJ,Quinlan MF,Thompson IJ

更新日期：1980-09-01 00:00:00

abstract：OBJECTIVE:Conventional colonoscopy (CC) is considered the reference standard for detection of colorectal neoplasia, but it can still miss a substantial number of adenomas. The use of a transparent plastic cap may improve colonic visualisation. Cap-assisted colonoscopy (CAC) was compared with CC for adenoma detection. S...

journal_title：Gut

authors： de Wijkerslooth TR,Stoop EM,Bossuyt PM,Mathus-Vliegen EM,Dees J,Tytgat KM,van Leerdam ME,Fockens P,Kuipers EJ,Dekker E

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Genetic haemochromatosis is a common hereditary iron loading disorder in humans. The disease is associated with loss of function mutations in the HFE gene. This is thought to change iron stores via increased iron absorption. AIMS:In this study we investigated how adaptation of mucosal reductase activity is ...

journal_title：Gut

authors： Simpson RJ,Debnam E,Beaumont N,Bahram S,Schümann K,Srai SK

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this unce...

journal_title：Gut

authors： Black CJ,Thakur ER,Houghton LA,Quigley EMM,Moayyedi P,Ford AC

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2) and matrix metalloproteinases (MMPs) have been implicated in tissue injury and fibrogenesis in animal models but little is known regarding their role in hepatitis C virus (HCV) related liver disease in humans. AIMS:To characterise the intrahepatic expression pattern of COX-2 and MMP...

journal_title：Gut

authors： Núñez O,Fernández-Martínez A,Majano PL,Apolinario A,Gómez-Gonzalo M,Benedicto I,López-Cabrera M,Boscá L,Clemente G,García-Monzón C,Martín-Sanz P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited. AIM:To examine the effect of ZnC on various models of gut injury and repair, and in a clinical trial. METHODS:In vitr...

journal_title：Gut

authors： Mahmood A,FitzGerald AJ,Marchbank T,Ntatsaki E,Murray D,Ghosh S,Playford RJ

更新日期：2007-02-01 00:00:00

abstract：:The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...

journal_title：Gut

authors： Spence RW,Burns-Cox CJ

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND AND AIMS:CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has be...

journal_title：Gut

authors： Fitzmaurice K,Petrovic D,Ramamurthy N,Simmons R,Merani S,Gaudieri S,Sims S,Dempsey E,Freitas E,Lea S,McKiernan S,Norris S,Long A,Kelleher D,Klenerman P

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in stem cell activity in rapidly proliferating isthmus stem cells in the stomach corpus. DESIGN:We uncovered the specific expression of Iqgap3 in proliferating isthm...

journal_title：Gut

authors： Matsuo J,Douchi D,Myint K,Mon NN,Yamamura A,Kohu K,Heng DL,Chen S,Mawan NA,Nuttonmanit N,Li Y,Srivastava S,Ho SWT,Lee NYS,Lee HK,Adachi M,Tamura A,Chen J,Yang H,Teh M,So JB,Yong WP,Tan P,Yeoh KG,Chuang LSH

更新日期：2020-12-08 00:00:00

abstract：OBJECTIVE:Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. DESIGN:Through analysis of...

journal_title：Gut

authors： Hutchinson SJ,Valerio H,McDonald SA,Yeung A,Pollock K,Smith S,Barclay S,Dillon JF,Fox R,Bramley P,Fraser A,Kennedy N,Gunson RN,Templeton K,Innes H,McLeod A,Weir A,Hayes PC,Goldberg D

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women. METHODS:A double blind, placebo controlled, intervention study was performed with 30 obese women treated with ITF prebiotics (inulin/oligofructose 50/50 mi...

journal_title：Gut

authors： Dewulf EM,Cani PD,Claus SP,Fuentes S,Puylaert PG,Neyrinck AM,Bindels LB,de Vos WM,Gibson GR,Thissen JP,Delzenne NM

更新日期：2013-08-01 00:00:00

abstract：:Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...

journal_title：Gut

authors： Korman MG,Soveny C,Hansky J

更新日期：1971-11-01 00:00:00

abstract：:Escherichia coli strains isolated from patients with Crohn's disease (CD) with chronic ileal lesions (n=14), early endoscopic recurrent lesions (n=20), without endoscopic recurrence (n=7), and controls (n=21) were compared by ribotyping. The dendrogram generated by 50 ribotype profile analysis revealed a large cluster...

journal_title：Gut

authors： Masseret E,Boudeau J,Colombel JF,Neut C,Desreumaux P,Joly B,Cortot A,Darfeuille-Michaud A

更新日期：2001-03-01 00:00:00

abstract：:A study of HLA-DR antigen in 75 patients with primary biliary cirrhosis has been carried out in order to test the hypothesis that genetic factors related to genes controlling immune responses might be important in the pathogenesis of primary biliary cirrhosis. The frequencies of HLA-DR locus antigens was not significa...

journal_title：Gut

authors： Bassendine MF,Dewar PJ,James OF

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-c...

journal_title：Gut

authors： Cacoub P,Desbois AC,Comarmond C,Saadoun D

更新日期：2018-11-01 00:00:00

abstract：:In an endoscopic study of 90 consecutive patients with more than one peptic ulcer, the ulcers in an individual were profoundly spatially clustered. Clustering of ulcer locations was shown using a non-parametric test of clustering (Kruskal-Wallis statistic with 89 degrees of freedom = 151.31, probability of observing t...

journal_title：Gut

authors： Cappell MS

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND AND AIMS:While patients with Barrett's oesophagus develop oesophageal adenocarcinoma more frequently than the general population, it has controversially been suggested that gastro-oesophageal reflux (GORD) itself is a more important determinant of risk. In order to assess the validity of this suggestion, we ...

journal_title：Gut

authors： Solaymani-Dodaran M,Logan RF,West J,Card T,Coupland C

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:The efficacy of a levofloxacin-based regimen as the first-line treatment and a clarithromycin-based regimen as the second-line treatment for Helicobacter pylori infection remains unknown. The aim of this study was to assess the eradication rates of these two regimens using different administration sequences....

journal_title：Gut

authors： Liou JM,Lin JT,Chang CY,Chen MJ,Cheng TY,Lee YC,Chen CC,Sheng WH,Wang HP,Wu MS

更新日期：2010-05-01 00:00:00

abstract：:The host's humoral immune response to Helicobacter pylori has been used in the diagnosis of active infection with these organisms. Several commercial tests are available but there are few and unconfirmed reports of their efficacy. This study aimed to assess and compare the efficacy of the following H pylori serologica...

journal_title：Gut

authors： Taha AS,Reid J,Boothmann P,Gemmell CG,Lee FD,Sturrock RD,Russell RI

更新日期：1993-04-01 00:00:00

abstract：:The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related ...

journal_title：Gut

authors： Poynter D,Selway SA,Papworth SA,Riches SR

更新日期：1986-11-01 00:00:00