Rôle of calcitonin in diarrhoea associated with medullary carcinoma of the thyroid.

Abstract:

:Severe watery diarrhoea in a patient with medullary thryoid carcinoma and high calcitonin levels was associated with increased distal ileal flow. Plasma from the patient inhibited small intestinal fluid absorption in dogs without affecting mucosal cyclic AMP levels. When calcitonin was removed from the plasma, the effect in experimental bowel loops was abolished but could be restored on restitution of comparable hormone levels with pure calcitonin. These studies, combined with the failure to find evidence of increased prostaglandin activity in the patient, suggest that circulating calcitonin may be a major cause of the diarrhoea in medullary thyroid carcinoma.

journal_name

Gut

journal_title

Gut

authors

Cox TM,Fagan EA,Hillyard CJ,Allison DJ,Chadwick VS

doi

10.1136/gut.20.7.629

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

629-33

issue

7

eissn

0017-5749

issn

1468-3288

journal_volume

20

pub_type

杂志文章

相关文献

GUT文献大全
  • Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.

    abstract::We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus serotype 12 (Ad12), an adenovirus isolated from the human intestinal tract. In the present study sera from coeliac dise...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.8.995

    authors: Kagnoff MF,Paterson YJ,Kumar PJ,Kasarda DD,Carbone FR,Unsworth DJ,Austin RK

    更新日期:1987-08-01 00:00:00

  • Coeliac disease in the father affects the newborn.

    abstract:BACKGROUND AND AIMS:Untreated coeliac disease in the mother is associated with lower birth weight. We examined the risk of adverse neonatal outcome when the infant's mother, father, or other relative suffered from known coeliac disease. METHODS:Mothers answered a questionnaire a few days after the birth of their infan...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.49.2.169

    authors: Ludvigsson JF,Ludvigsson J

    更新日期:2001-08-01 00:00:00

  • Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial.

    abstract:OBJECTIVE:The aim of the study was to compare azathioprine versus mesalazine tablets for the prevention of clinical recurrence in patients with postoperative Crohn's disease (CD) with moderate or severe endoscopic recurrence. METHODS:This was a 1 year, double-blind, double-dummy, randomised study which took place in 2...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.2009.194159

    authors: Reinisch W,Angelberger S,Petritsch W,Shonova O,Lukas M,Bar-Meir S,Teml A,Schaeffeler E,Schwab M,Dilger K,Greinwald R,Mueller R,Stange EF,Herrlinger KR,International AZT-2 Study Group.

    更新日期:2010-06-01 00:00:00

  • International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.

    abstract:OBJECTIVE:In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. DESIGN:International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structu...

    journal_title:Gut

    pub_type: 共识发展会议,杂志文章

    doi:10.1136/gutjnl-2019-318556

    authors: Scott AJ,Alexander JL,Merrifield CA,Cunningham D,Jobin C,Brown R,Alverdy J,O'Keefe SJ,Gaskins HR,Teare J,Yu J,Hughes DJ,Verstraelen H,Burton J,O'Toole PW,Rosenberg DW,Marchesi JR,Kinross JM

    更新日期:2019-09-01 00:00:00

  • Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study.

    abstract:UNLABELLED:Data on the natural history of elderly-onset inflammatory bowel disease (IBD) are scarce. METHODS:In a French population-based cohort we identified 841 IBD patients >60 years of age at diagnosis from 1988 to 2006, including 367 Crohn's disease (CD) and 472 ulcerative colitis (UC). RESULTS:Median age at dia...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2012-303864

    authors: Charpentier C,Salleron J,Savoye G,Fumery M,Merle V,Laberenne JE,Vasseur F,Dupas JL,Cortot A,Dauchet L,Peyrin-Biroulet L,Lerebours E,Colombel JF,Gower-Rousseau C

    更新日期:2014-03-01 00:00:00

  • Epidemiological trends of pre-malignant gastric lesions: a long-term nationwide study in the Netherlands.

    abstract:BACKGROUND:The pre-malignant gastric lesions atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia (DYS) have long been identified as principal risk factors for gastric cancer. OBJECTIVE:To evaluate epidemiological time trends of pre-malignant gastric lesions in the Netherlands. METHODS:Patients with a fi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2007.127167

    authors: de Vries AC,Meijer GA,Looman CW,Casparie MK,Hansen BE,van Grieken NC,Kuipers EJ

    更新日期:2007-12-01 00:00:00

  • Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C.

    abstract:BACKGROUND:Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. The ability of HCV genotype 3 to promote steatosis by itself provides an unique opportunity to answer this question. AIMS:The aim of the present...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.050302

    authors: Fartoux L,Poujol-Robert A,Guéchot J,Wendum D,Poupon R,Serfaty L

    更新日期:2005-07-01 00:00:00

  • Calcium in milk and fermentation by yoghurt bacteria increase the resistance of rats to Salmonella infection.

    abstract::Calcium in milk products stimulates gastric acid secretion and inhibits the cytolytic activity of intestinal contents. Based on these effects, it was hypothesised that calcium might lessen the severity of food borne intestinal infections. The possible differential effects of a low calcium milk and normal milk products...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.38.1.59

    authors: Bovee-Oudenhoven I,Termont D,Dekker R,Van der Meer R

    更新日期:1996-01-01 00:00:00

  • Management of HBV- and HCV-induced end stage liver disease.

    abstract::Hepatitis B and hepatitis C infections are important causes of end-stage liver disease and primary liver cancer. Successful antiviral treatment prior to the development of cirrhosis will prevent most of the morbidity and mortality associated with those infections. This can be achieved for a high proportion of patients...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gutjnl-2012-302076

    authors: Mutimer DJ,Lok A

    更新日期:2012-05-01 00:00:00

  • Risk of oesophageal cancer in Barrett's oesophagus and gastro-oesophageal reflux.

    abstract:BACKGROUND AND AIMS:While patients with Barrett's oesophagus develop oesophageal adenocarcinoma more frequently than the general population, it has controversially been suggested that gastro-oesophageal reflux (GORD) itself is a more important determinant of risk. In order to assess the validity of this suggestion, we ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.028076

    authors: Solaymani-Dodaran M,Logan RF,West J,Card T,Coupland C

    更新日期:2004-08-01 00:00:00

  • Endoscopic therapy of Barrett's: what more do we need to know?

    abstract::Results emerging from endoscopic treatments to ablate Barrett's oesophagus indicate that APC alone or ALA-PDT in combination with APC achieves complete clearance of Barrett's epithelium in approximately two thirds of patients. ...

    journal_title:Gut

    pub_type: 评论,杂志文章

    doi:10.1136/gut.2003.036392

    authors: Van Laethem JL,Devière J

    更新日期:2004-06-01 00:00:00

  • Omeprazole in the treatment of erosive oesophagitis refractory to high dose cimetidine and ranitidine.

    abstract::Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months' treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was o...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.7.745

    authors: Bardhan KD,Morris P,Thompson M,Dhande DS,Hinchliffe RF,Jones RB,Daly MJ,Carroll NJ

    更新日期:1990-07-01 00:00:00

  • The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach.

    abstract:BACKGROUND:TFF1 is a 6.5 kDa secreted protein that is expressed predominantly in normal gastric mucosa. It is coexpressed with mucins and it can form dimers via a free carboxy terminal cysteine residue. AIMS:To investigate the molecular forms of TFF1 that are present in normal human stomach and the association of the ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.46.3.312

    authors: Newton JL,Allen A,Westley BR,May FE

    更新日期:2000-03-01 00:00:00

  • Sex hormones, and acid gastric secretion induced with carbachol, histamine, and gastrin.

    abstract::This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained. Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine. Overiectomized rats...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.8.641

    authors: Amure BO,Omole AA

    更新日期:1970-08-01 00:00:00

  • Effect of the nitric oxide donor, glyceryl trinitrate, on human gall bladder motility.

    abstract:BACKGROUND:Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS:To study the effect of glyceryl trinitrate, a nitr...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.42.3.410

    authors: Greaves R,Miller J,O'Donnell L,McLean A,Farthing MJ

    更新日期:1998-03-01 00:00:00

  • Soluble E-cadherin is a valid prognostic marker in gastric carcinoma.

    abstract:BACKGROUND:Gastric cancer remains a major cause of cancer mortality globally but no good prognostic tumour marker is available. Soluble fragment of E-cadherin protein has been reported to increase in the sera of patients with cancer and recently was found to be elevated in 67% of patients with gastric cancer. AIMS:To ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.48.6.808

    authors: Chan AO,Lam SK,Chu KM,Lam CM,Kwok E,Leung SY,Yuen ST,Law SY,Hui WM,Lai KC,Wong CY,Hu HC,Lai CL,Wong J

    更新日期:2001-06-01 00:00:00

  • Global prevalence of Barrett's oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis.

    abstract:OBJECTIVES:Chronic gastro-oesophageal reflux might lead to the development of Barrett's oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal re...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-321365

    authors: Eusebi LH,Cirota GG,Zagari RM,Ford AC

    更新日期:2020-07-30 00:00:00

  • Mucin gene expression in human embryonic and fetal intestine.

    abstract:BACKGROUND:The intestinal epithelium is covered by a continuous layer of mucus which is secreted by well differentiated epithelial cells. Disregulation of the expression of mucins has been reported to have possible implications in the neoplastic process which affects intestinal mucosae. It is well known that preneoplas...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.43.4.519

    authors: Buisine MP,Devisme L,Savidge TC,Gespach C,Gosselin B,Porchet N,Aubert JP

    更新日期:1998-10-01 00:00:00

  • A population based study of Helicobacter pylori infection in a European country: the San Marino Study. Relations with gastrointestinal diseases.

    abstract::Helicobacter pylori is present worldwide but few large population studies exist on the epidemiology of the infection. A random cross sectional study was performed of H pylori infection in the adult population of San Marino, a European country with high gastric cancer rate, to assess its prevalence and to evaluate its ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.36.6.838

    authors: Gasbarrini G,Pretolani S,Bonvicini F,Gatto MR,Tonelli E,Mégraud F,Mayo K,Ghironzi G,Giulianelli G,Grassi M

    更新日期:1995-06-01 00:00:00

  • A comparison of the resection rate for cold and hot snare polypectomy for 4-9 mm colorectal polyps: a multicentre randomised controlled trial (CRESCENT study).

    abstract:OBJECTIVE:To investigate the success rate of cold snare polypectomy (CSP) for complete resection of 4-9 mm colorectal adenomatous polyps compared with that of hot snare polypectomy (HSP). DESIGN:A prospective, multicentre, randomised controlled, parallel, non-inferiority trial conducted in 12 Japanese endoscopy units....

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gutjnl-2017-314215

    authors: Kawamura T,Takeuchi Y,Asai S,Yokota I,Akamine E,Kato M,Akamatsu T,Tada K,Komeda Y,Iwatate M,Kawakami K,Nishikawa M,Watanabe D,Yamauchi A,Fukata N,Shimatani M,Ooi M,Fujita K,Sano Y,Kashida H,Hirose S,Iwagami H,

    更新日期:2018-11-01 00:00:00

  • Risk factors for extensive ulcerative colitis and ulcerative proctitis: a population based case-control study.

    abstract::To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.12.1526

    authors: Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

    更新日期:1991-12-01 00:00:00

  • Ranitidine, diarrhoea, and lymphocytic colitis.

    abstract::A 69 year old woman developed chronic diarrhoea while being treated with ranitidine. Sigmoidoscopy was performed after six weeks and showed typical histological features of lymphocytic colitis. Ranitidine was withdrawn and the diarrhoea resolved. Eight months later, a 72 hour oral rechallenge period of ranitidine, was...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.37.5.708

    authors: Beaugerie L,Patey N,Brousse N

    更新日期:1995-11-01 00:00:00

  • Immune regulation of human colonic electrolyte transport in vitro.

    abstract::The role of lamina propria cells in regulating human colonic ion transport was investigated in vitro. Normal human colonic mucosae were mounted in Ussing chambers, and short circuit current changes (delta SCC) were monitored in response to immune cell activation. Anti-human immunoglobulin E (anti-IgE) and formyl-Methi...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.36.3.395

    authors: Stack WA,Keely SJ,O'Donoghue DP,Baird AW

    更新日期:1995-03-01 00:00:00

  • Distribution of collagenous colitis: utility of flexible sigmoidoscopy.

    abstract::We investigated the distribution of the collagen band in 33 patients with collagenous colitis to estimate the likelihood of the disease being diagnosed in biopsy specimens from the left side of the colon, such as those obtained using flexible sigmoidoscopy. To be included in this study patients had a subepithelial col...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.1.65

    authors: Tanaka M,Mazzoleni G,Riddell RH

    更新日期:1992-01-01 00:00:00

  • Helicobacter pylori stimulates pepsinogen secretion from isolated human peptic cells.

    abstract:BACKGROUND:Different acid and peptic related gastroduodenal diseases are associated with both increased gastric secretion and Helicobacter pylori infection. Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori i...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.50.1.13

    authors: Lorente S,Doiz O,Trinidad Serrano M,Castillo J,Lanas A

    更新日期:2002-01-01 00:00:00

  • Urea breath tests in the management of Helicobacter pylori infection.

    abstract::The 13/14C-Urea breath test (UBT) is based on the simple principle that a solution of isotopically labelled urea will be rapidly hydrolysed by the abundantly expressed urease of H pylori. The released 13/14CO2 is absorbed across the mucus layer to the gastric mucosa and hence, via the systemic circulation, excreted in...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.43.2008.s47

    authors: Logan RP

    更新日期:1998-07-01 00:00:00

  • Laboratory diagnosis of gastrointestinal bleeding.

    abstract::The value of four tests to detect occult alimentary blood loss has been compared in normal subjects, in patients with and without alimentary disease, and in patients with congestive heart failure, and the sensitivities of these tests have been compared using suspensions of blood alone and blood in faeces. The Occultes...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2.1.75

    authors: Steingold L,Roberts AA

    更新日期:1961-03-01 00:00:00

  • Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case.

    abstract::Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subseq...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.14.1.25

    authors: Cowley DJ,Dymock IW,Boyes BE,Wilson RY,Stagg BH,Lewin MR,Polak JM,Pearse AG

    更新日期:1973-01-01 00:00:00

  • The relevance of gastrointestinal fistulae in clinical practice: a review.

    abstract::Gastrointestinal fistulae most frequently occur as complications after abdominal surgery (75-85%) although they can also occur spontaneously--for example, in patients with inflammatory bowel disease (IBD) such as diverticulitis or following radiation therapy. Abdominal trauma can also lead to fistula formation althoug...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.49.suppl_4.iv2

    authors: Falconi M,Pederzoli P

    更新日期:2001-12-01 00:00:00

  • Palliative removal of a giant polypoid 'carcinosarcoma' of the oesophagus by YAG laser photocoagulation of the tumour stalk.

    abstract::Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieve...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.8.1146

    authors: Richardson D,Wyatt JI,Miloszewski KJ

    更新日期:1992-08-01 00:00:00